Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Adel Rafeh El Boueiz, M.D.

Title
Institution
Department
Address
Profile Picture

Mentoring
Available: 01/10/22, Expires: 12/31/22

Emphysema, irreversible alveolar destruction commonly associated with COPD, leads to rapid disease progression and increased morbidity and mortality in this patient population. Considered an end-stage condition, there are limited treatment options once diagnosed. As such, there is a clear unmet need to identify biomarkers that predict the early onset of emphysema, shed light on its pathogenesis, and enable the discovery of distinct disease subtypes. Recent advances in quantitative computer tomography (CT) analyses, high throughput multi-omics assays, and machine learning methods now provide an unprecedented opportunity for more accurate data-driven prediction and molecular subtyping. In this project, we hypothesize that multiple omics measures from blood and lung tissue from well-characterized cohorts of subjects with emphysema will lead to the identification of novel biomarkers, a deeper understanding of disease pathogenesis, more accurate clinical prediction from blood samples, and discovery of new molecular subtypes. To that end, we will leverage available whole genome sequencing (WGS), DNA methylation, RNA sequencing (RNA-seq), and proteomics data in two large cohorts of smokers (COPDGene study and Lung Tissue Research Consortium (LTRC)) and integrate multi-level omics scale data using innovative machine learning approaches. Methods: We will perform single-variant and set-based analyses to detect common and rare genetic determinants of CT-quantified emphysema. We will also test for associations between CT-emphysema and genome-wide DNA methylation marks, transcriptome-wide gene expression, and proteomics levels. We will then apply machine learning methods to develop blood-based multi-omics prediction of emphysema presence and severity and to discover new molecular subtypes of emphysema. Potential roles for students: Under the direction of faculty members and research staff, the student will independently carry out daily the following research activities remotely from home: - Review the literature and become familiar with epidemiologic, genomics, and epigenomics studies - Program and analyze data using R and Linux - Write abstracts and manuscripts This project will provide students with the opportunity to: - Gain experience in R and Unix programming, performing analyses, interpreting results, and writing manuscripts. - Build relationships with members of the research community and find mentors who can provide insight and guidance concerning future endeavors in the biomedical arena. - Participate in regular lab meetings and educational activities in the Channing Division of Network Medicine to gain a better understanding of the overall lab activity and meet others working in the lab. - Present the research findings at our lab meetings and at national and international conferences. - Meet with the mentors at least twice a week to discuss research findings, solicit feedback, evaluate progress, and provide appropriate training support and mentoring. Prior skills the student will need: Some computer programming experience is required. Most of our research projects use R or Python.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08HL141601 (EL BOUEIZ, ADEL) Jul 1, 2018 - Jun 30, 2023
    NIH
    Clinical significance and genetic determinants of novel imaging measures of emphysema distribution in 9,743 smokers
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gregory A, Xu Z, Pratte K, Lee S, Liu C, Chase R, Yun J, Saferali A, Hersh CP, Bowler R, Silverman E, Castaldi PJ, Boueiz A. Clustering-based COPD subtypes have distinct longitudinal outcomes and multi-omics biomarkers. BMJ Open Respir Res. 2022 08; 9(1). PMID: 35999035; PMCID: PMC9403129.
    Citations: 1     Translation:HumansCTClinical Trials
  2. Boueiz A, Xu Z, Chang Y, Masoomi A, Gregory A, Lutz SM, Qiao D, Crapo JD, Dy JG, Silverman EK, Castaldi PJ. Machine Learning Prediction of Progression in Forced Expiratory Volume in 1 Second in the COPDGene® Study. Chronic Obstr Pulm Dis. 2022 Jul 29; 9(3):349-365. PMID: 35649102; PMCID: PMC9448009.
    Citations:    
  3. Ghosh AJ, Hobbs BD, Moll M, Saferali A, Boueiz A, Yun JH, Sciurba F, Barwick L, Limper AH, Flaherty K, Criner G, Brown KK, Wise R, Martinez FJ, Lomas D, Castaldi PJ, Carey VJ, DeMeo DL, Cho MH, Silverman EK, Hersh CP. Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2022 02 01; 205(3):313-323. PMID: 34762809; PMCID: PMC8886988.
    Citations: 3     Fields:    Translation:Humans
  4. Moll M, Boueiz A, Ghosh AJ, Saferali A, Lee S, Xu Z, Yun JH, Hobbs BD, Hersh CP, Sin DD, Tal-Singer R, Silverman EK, Cho MH, Castaldi PJ. Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2022 01 15; 205(2):161-170. PMID: 34739356; PMCID: PMC8787248.
    Citations: 2     Fields:    Translation:Humans
  5. Huang CH, Batarseh FA, Boueiz A, Kulkarni A, Su PH, Aman J. Measuring outcomes in healthcare economics using Artificial Intelligence: With application to resource management. Data Policy. 2021; 3. PMID: 35083434.
    Citations:    
  6. Xu Z, Platig J, Lee S, Boueiz A, Chase R, Jain D, Gregory A, Suryadevara R, Berman S, Bowler R, Hersh CP, Laederach A, Castaldi PJ. Cigarette smoking-associated isoform switching and 3' UTR lengthening via alternative polyadenylation. Genomics. 2021 11; 113(6):4184-4195. PMID: 34763026; PMCID: PMC8722433.
    Citations:    Fields:    Translation:Cells
  7. Wang Z, Masoomi A, Xu Z, Boueiz A, Lee S, Zhao T, Bowler R, Cho M, Silverman EK, Hersh C, Dy J, Castaldi PJ. Improved prediction of smoking status via isoform-aware RNA-seq deep learning models. PLoS Comput Biol. 2021 10; 17(10):e1009433. PMID: 34634029; PMCID: PMC8530282.
    Citations:    Fields:    Translation:Humans
  8. Wade RC, Simmons JP, Boueiz A, Gregory A, Wan ES, Regan EA, Bhatt SP, Han MK, Bowler RP, Crapo JD, Silverman EK, Washko GR, Dransfield MT, Wells JM. Pulmonary Artery Enlargement Is Associated with Exacerbations and Mortality in Ever-Smokers with Preserved Ratio Impaired Spirometry. Am J Respir Crit Care Med. 2021 08 15; 204(4):481-485. PMID: 34014810; PMCID: PMC8480250.
    Citations: 1     Fields:    Translation:Humans
  9. Tejwani V, Fawzy A, Putcha N, Castaldi PJ, Cho MH, Pratte KA, Bhatt SP, Lynch DA, Humphries SM, Kinney GL, D'Alessio FR, Hansel NN. Emphysema Progression and Lung Function Decline Among Angiotensin Converting Enzyme Inhibitors and Angiotensin-Receptor Blockade Users in the COPDGene Cohort. Chest. 2021 10; 160(4):1245-1254. PMID: 34029566; PMCID: PMC8546238.
    Citations:    Fields:    Translation:Humans
  10. Kasela S, Ortega VE, Martorella M, Garudadri S, Nguyen J, Ampleford E, Pasanen A, Nerella S, Buschur KL, Barjaktarevic IZ, Barr RG, Bleecker ER, Bowler RP, Comellas AP, Cooper CB, Couper DJ, Criner GJ, Curtis JL, Han MK, Hansel NN, Hoffman EA, Kaner RJ, Krishnan JA, Martinez FJ, McDonald MN, Meyers DA, Paine R, Peters SP, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Levy BD, Li X, Moore WC, Wenzel SE, Zein J, Langelier C, Woodruff PG, Lappalainen T, Christenson SA. Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium. Genome Med. 2021 04 21; 13(1):66. PMID: 33883027; PMCID: PMC8059115.
    Citations: 5     Fields:    Translation:HumansCells
  11. Kim V, Dolliver WR, Nath HP, Grumley SA, Terry N, Ahmed A, Yen A, Jacobs K, Kligerman S, Diaz AA. Mucus plugging on computed tomography and chronic bronchitis in chronic obstructive pulmonary disease. Respir Res. 2021 04 17; 22(1):110. PMID: 33865371; PMCID: PMC8053272.
    Citations: 2     Fields:    Translation:Humans
  12. Mason SE, Moreta-Martinez R, Labaki WW, Strand M, Baraghoshi D, Regan EA, Bon J, San Jose Estepar R, Casaburi R, McDonald MN, Rossiter H, Make BJ, Dransfield MT, Han MK, Young KA, Kinney G, Hokanson JE, San Jose Estepar R, Washko GR. Respiratory exacerbations are associated with muscle loss in current and former smokers. Thorax. 2021 06; 76(6):554-560. PMID: 33574123; PMCID: PMC8222105.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  13. Taliun D, Harris DN, Kessler MD, Carlson J, Szpiech ZA, Torres R, Taliun SAG, Corvelo A, Gogarten SM, Kang HM, Pitsillides AN, LeFaive J, Lee SB, Tian X, Browning BL, Das S, Emde AK, Clarke WE, Loesch DP, Shetty AC, Blackwell TW, Smith AV, Wong Q, Liu X, Conomos MP, Bobo DM, Aguet F, Albert C, Alonso A, Ardlie KG, Arking DE, Aslibekyan S, Auer PL, Barnard J, Barr RG, Barwick L, Becker LC, Beer RL, Benjamin EJ, Bielak LF, Blangero J, Boehnke M, Bowden DW, Brody JA, Burchard EG, Cade BE, Casella JF, Chalazan B, Chasman DI, Chen YI, Cho MH, Choi SH, Chung MK, Clish CB, Correa A, Curran JE, Custer B, Darbar D, Daya M, de Andrade M, DeMeo DL, Dutcher SK, Ellinor PT, Emery LS, Eng C, Fatkin D, Fingerlin T, Forer L, Fornage M, Franceschini N, Fuchsberger C, Fullerton SM, Germer S, Gladwin MT, Gottlieb DJ, Guo X, Hall ME, He J, Heard-Costa NL, Heckbert SR, Irvin MR, Johnsen JM, Johnson AD, Kaplan R, Kardia SLR, Kelly T, Kelly S, Kenny EE, Kiel DP, Klemmer R, Konkle BA, Kooperberg C, Köttgen A, Lange LA, Lasky-Su J, Levy D, Lin X, Lin KH, Liu C, Loos RJF, Garman L, Gerszten R, Lubitz SA, Lunetta KL, Mak ACY, Manichaikul A, Manning AK, Mathias RA, McManus DD, McGarvey ST, Meigs JB, Meyers DA, Mikulla JL, Minear MA, Mitchell BD, Mohanty S, Montasser ME, Montgomery C, Morrison AC, Murabito JM, Natale A, Natarajan P, Nelson SC, North KE, O'Connell JR, Palmer ND, Pankratz N, Peloso GM, Peyser PA, Pleiness J, Post WS, Psaty BM, Rao DC, Redline S, Reiner AP, Roden D, Rotter JI, Ruczinski I, Sarnowski C, Schoenherr S, Schwartz DA, Seo JS, Seshadri S, Sheehan VA, Sheu WH, Shoemaker MB, Smith NL, Smith JA, Sotoodehnia N, Stilp AM, Tang W, Taylor KD, Telen M, Thornton TA, Tracy RP, Van Den Berg DJ, Vasan RS, Viaud-Martinez KA, Vrieze S, Weeks DE, Weir BS, Weiss ST, Weng LC, Willer CJ, Zhang Y, Zhao X, Arnett DK, Ashley-Koch AE, Barnes KC, Boerwinkle E, Gabriel S, Gibbs R, Rice KM, Rich SS, Silverman EK, Qasba P, Gan W, Papanicolaou GJ, Nickerson DA, Browning SR, Zody MC, Zöllner S, Wilson JG, Cupples LA, Laurie CC, Jaquish CE, Hernandez RD, O'Connor TD, Abecasis GR. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 2021 02; 590(7845):290-299. PMID: 33568819; PMCID: PMC7875770.
    Citations: 249     Fields:    Translation:Humans
  14. Li X, Li Z, Zhou H, Gaynor SM, Liu Y, Chen H, Sun R, Dey R, Arnett DK, Aslibekyan S, Ballantyne CM, Bielak LF, Blangero J, Boerwinkle E, Bowden DW, Broome JG, Conomos MP, Correa A, Cupples LA, Curran JE, Freedman BI, Guo X, Hindy G, Irvin MR, Kardia SLR, Kathiresan S, Khan AT, Kooperberg CL, Laurie CC, Liu XS, Mahaney MC, Manichaikul AW, Martin LW, Mathias RA, McGarvey ST, Mitchell BD, Montasser ME, Moore JE, Morrison AC, O'Connell JR, Palmer ND, Pampana A, Peralta JM, Peyser PA, Psaty BM, Redline S, Rice KM, Rich SS, Smith JA, Tiwari HK, Tsai MY, Vasan RS, Wang FF, Weeks DE, Weng Z, Wilson JG, Yanek LR, Neale BM, Sunyaev SR, Abecasis GR, Rotter JI, Willer CJ, Peloso GM, Natarajan P, Lin X. Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. Nat Genet. 2020 09; 52(9):969-983. PMID: 32839606; PMCID: PMC7483769.
    Citations: 27     Fields:    Translation:Humans
  15. Ghosh AJ, Moll M, Hayden LP, Bon J, Regan E, Hersh CP. Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: a prospective cohort study. BMC Pulm Med. 2020 May 04; 20(1):123. PMID: 32366316.
    Citations: 8     Fields:    Translation:Humans
  16. Young AL, Bragman FJS, Rangelov B, Han MK, Galbán CJ, Lynch DA, Hawkes DJ, Alexander DC, Hurst JR. Disease Progression Modeling in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2020 02 01; 201(3):294-302. PMID: 31657634; PMCID: PMC6999095.
    Citations: 20     Fields:    Translation:Humans
  17. Kessler MD, Loesch DP, Perry JA, Heard-Costa NL, Taliun D, Cade BE, Wang H, Daya M, Ziniti J, Datta S, Celedón JC, Soto-Quiros ME, Avila L, Weiss ST, Barnes K, Redline SS, Vasan RS, Johnson AD, Mathias RA, Hernandez R, Wilson JG, Nickerson DA, Abecasis G, Browning SR, Zöllner S, O'Connell JR, Mitchell BD, O'Connor TD. De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population. Proc Natl Acad Sci U S A. 2020 02 04; 117(5):2560-2569. PMID: 31964835; PMCID: PMC7007577.
    Citations: 20     Fields:    Translation:Humans
  18. Castaldi PJ, Boueiz A, Yun J, Estepar RSJ, Ross JC, Washko G, Cho MH, Hersh CP, Kinney GL, Young KA, Regan EA, Lynch DA, Criner GJ, Dy JG, Rennard SI, Casaburi R, Make BJ, Crapo J, Silverman EK, Hokanson JE. Machine Learning Characterization of COPD Subtypes: Insights From the COPDGene Study. Chest. 2020 05; 157(5):1147-1157. PMID: 31887283; PMCID: PMC7242638.
    Citations: 13     Fields:    Translation:Humans
  19. Lowe KE, Regan EA, Anzueto A, Austin E, Austin JHM, Beaty TH, Benos PV, Benway CJ, Bhatt SP, Bleecker ER, Bodduluri S, Bon J, Boriek AM, Boueiz AR, Bowler RP, Budoff M, Casaburi R, Castaldi PJ, Charbonnier JP, Cho MH, Comellas A, Conrad D, Costa Davis C, Criner GJ, Curran-Everett D, Curtis JL, DeMeo DL, Diaz AA, Dransfield MT, Dy JG, Fawzy A, Fleming M, Flenaugh EL, Foreman MG, Fortis S, Gebrekristos H, Grant S, Grenier PA, Gu T, Gupta A, Han MK, Hanania NA, Hansel NN, Hayden LP, Hersh CP, Hobbs BD, Hoffman EA, Hogg JC, Hokanson JE, Hoth KF, Hsiao A, Humphries S, Jacobs K, Jacobson FL, Kazerooni EA, Kim V, Kim WJ, Kinney GL, Koegler H, Lutz SM, Lynch DA, MacIntye NR, Make BJ, Marchetti N, Martinez FJ, Maselli DJ, Mathews AM, McCormack MC, McDonald MN, McEvoy CE, Moll M, Molye SS, Murray S, Nath H, Newell JD, Occhipinti M, Paoletti M, Parekh T, Pistolesi M, Pratte KA, Putcha N, Ragland M, Reinhardt JM, Rennard SI, Rosiello RA, Ross JC, Rossiter HB, Ruczinski I, San Jose Estepar R, Sciurba FC, Sieren JC, Singh H, Soler X, Steiner RM, Strand MJ, Stringer WW, Tal-Singer R, Thomashow B, Vegas Sánchez-Ferrero G, Walsh JW, Wan ES, Washko GR, Michael Wells J, Wendt CH, Westney G, Wilson A, Wise RA, Yen A, Young K, Yun J, Silverman EK, Crapo JD. COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2019 Nov; 6(5):384-399. PMID: 31710793; PMCID: PMC7020846.
    Citations: 53     
  20. Fortis S, Comellas A, Make BJ, Hersh CP, Bodduluri S, Georgopoulos D, Kim V, Criner GJ, Dransfield MT, Bhatt SP. Combined Forced Expiratory Volume in 1 Second and Forced Vital Capacity Bronchodilator Response, Exacerbations, and Mortality in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2019 07; 16(7):826-835. PMID: 30908927.
    Citations: 13     Fields:    Translation:Humans
  21. Kim V, Zhao H, Regan E, Han MK, Make BJ, Crapo JD, Jones PW, Curtis JL, Silverman EK, Criner GJ. The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition. Chest. 2019 10; 156(4):685-695. PMID: 31047955; PMCID: PMC6859248.
    Citations: 16     Fields:    Translation:Humans
  22. Boueiz A, Pham B, Chase R, Lamb A, Lee S, Naing ZZC, Cho MH, Parker MM, Sakornsakolpat P, Hersh CP, Crapo JD, Stergachis AB, Tal-Singer R, DeMeo DL, Silverman EK, Zhou X, Castaldi PJ. Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution. Am J Respir Cell Mol Biol. 2019 04; 60(4):388-398. PMID: 30335480; PMCID: PMC6444627.
    Citations: 6     Fields:    Translation:HumansCells
  23. Wu Q, Boueiz A, Bozkurt A, Masoomi A, Wang A, DeMeo DL, Weiss ST, Qiu W. Deep Learning Methods for Predicting Disease Status Using Genomic Data. J Biom Biostat. 2018; 9(5). PMID: 31131151; PMCID: PMC6530791.
    Citations: 3     
  24. Wan ES, Fortis S, Regan EA, Hokanson J, Han MK, Casaburi R, Make BJ, Crapo JD, DeMeo DL, Silverman EK. Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study. Am J Respir Crit Care Med. 2018 12 01; 198(11):1397-1405. PMID: 29874098; PMCID: PMC6290948.
    Citations: 53     Fields:    Translation:Humans
  25. Hayden LP, Cho MH, Raby BA, Beaty TH, Silverman EK, Hersh CP. Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study. Respir Res. 2018 Oct 29; 19(1):209. PMID: 30373671; PMCID: PMC6206739.
    Citations: 13     Fields:    Translation:Humans
  26. Ekström M, Bornefalk-Hermansson A, Wysham N, Currow DC, MacIntyre N. Spirometric Volumes and Breathlessness across Levels of Airflow Limitation: The COPDGene Study. Am J Respir Crit Care Med. 2018 Sep 01; 198(5):678-681. PMID: 29702011; PMCID: PMC6118014.
    Citations: 2     Fields:    
  27. Yun JH, Lamb A, Chase R, Singh D, Parker MM, Saferali A, Vestbo J, Tal-Singer R, Castaldi PJ, Silverman EK, Hersh CP. Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2018 06; 141(6):2037-2047.e10. PMID: 29709670.
    Citations: 58     Fields:    Translation:HumansCells
  28. Hayden LP, Hardin ME, Qiu W, Lynch DA, Strand MJ, van Beek EJ, Crapo JD, Silverman EK, Hersh CP. Asthma Is a Risk Factor for Respiratory Exacerbations Without Increased Rate of Lung Function Decline: Five-Year Follow-up in Adult Smokers From the COPDGene Study. Chest. 2018 02; 153(2):368-377. PMID: 29248621.
    Citations: 5     Fields:    Translation:Humans
  29. Boueiz A, Chang Y, Cho MH, Washko GR, San José Estépar R, Bowler RP, Crapo JD, DeMeo DL, Dy JG, Silverman EK, Castaldi PJ. Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression. Chest. 2018 01; 153(1):65-76. PMID: 28943279.
    Citations: 18     Fields:    Translation:Humans
  30. Boueiz A, Lutz SM, Cho MH, Hersh CP, Bowler RP, Washko GR, Halper-Stromberg E, Bakke P, Gulsvik A, Laird NM, Beaty TH, Coxson HO, Crapo JD, Silverman EK, Castaldi PJ, DeMeo DL. Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Am J Respir Crit Care Med. 2017 03 15; 195(6):757-771. PMID: 27669027; PMCID: PMC5363968.
    Citations: 23     Fields:    Translation:Humans
  31. Busch R, Han MK, Bowler RP, Dransfield MT, Wells JM, Regan EA, Hersh CP. Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort. BMC Pulm Med. 2016 Feb 10; 16:28. PMID: 26861867.
    Citations: 10     Fields:    Translation:Humans
  32. Idrees MM, Saleemi S, Azem MA, Aldammas S, Alhazmi M, Khan J, Gari A, Aldabbagh M, Sakkijha H, Aldalaan A, Alnajashi K, Alhabeeb W, Nizami I, Kouatli A, Chehab M, Tamimi O, Banjar H, Kashour T, Lopes A, Minai O, Hassoun P, Pasha Q, Mayer E, Butrous G, Bhagavathula S, Ghio S, Swiston J, Boueiz A, Tonelli A, Levy RD, Hoeper M, Levy RD. Saudi guidelines on the diagnosis and treatment of pulmonary hypertension: 2014 updates. Ann Thorac Med. 2014 07; 9(Suppl 1):S1-S15. PMID: 25076987; PMCID: PMC4114283.
    Citations: 7     
  33. Boueiz A, Hassoun PM. Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Pulmonary arterial hypertension associated with connective tissue diseases. Ann Thorac Med. 2014 Jul; 9(Suppl 1):S26-37. PMID: 25076994.
    Citations: 2     
  34. Beydoun MA, Beydoun HA, Boueiz A, Shroff MR, Zonderman AB. Antioxidant status and its association with elevated depressive symptoms among US adults: National Health and Nutrition Examination Surveys 2005-6. Br J Nutr. 2013 May; 109(9):1714-29. PMID: 22935166.
    Citations: 15     Fields:    Translation:Humans
  35. Eid SM, Boueiz A, Paranji S, Mativo C, Landis R, Abougergi MS. Patterns and predictors of proton pump inhibitor overuse among academic and non-academic hospitalists. Intern Med. 2010; 49(23):2561-8. PMID: 21139293.
    Citations: 32     Fields:    Translation:Humans
  36. Boueiz A, Mathai SC, Hummers LK, Hassoun PM. Cardiac complications of systemic sclerosis: recent progress in diagnosis. Curr Opin Rheumatol. 2010 Nov; 22(6):696-703. PMID: 20657283.
    Citations: 15     Fields:    Translation:Humans
  37. Beydoun MA, Boueiz A, Abougergi MS, Kitner-Triolo MH, Beydoun HA, Resnick SM, O'Brien R, Zonderman AB. Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline. Neurobiol Aging. 2012 Apr; 33(4):720-731.e4. PMID: 20619505.
    Citations: 59     Fields:    Translation:Humans
  38. Beydoun MA, Boueiz A, Shroff MR, Beydoun HA, Wang Y, Zonderman AB. Associations among 25-hydroxyvitamin D, diet quality, and metabolic disturbance differ by adiposity in adults in the United States. J Clin Endocrinol Metab. 2010 Aug; 95(8):3814-27. PMID: 20463091; PMCID: PMC2913037.
    Citations: 26     Fields:    Translation:Humans
  39. Beydoun HA, Dail J, Ugwu B, Boueiz A, Beydoun MA. Socio-demographic and behavioral correlates of herpes simplex virus type 1 and 2 infections and co-infections among adults in the USA. Int J Infect Dis. 2010 Sep; 14 Suppl 3:e154-60. PMID: 20418142.
    Citations: 10     Fields:    Translation:HumansCells
  40. Peng XQ, Damarla M, Skirball J, Nonas S, Wang XY, Han EJ, Hasan EJ, Cao X, Boueiz A, Damico R, Tuder RM, Sciuto AM, Anderson DR, Garcia JG, Kass DA, Hassoun PM, Zhang JT. Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogen-activated protein kinase in mouse lung. Acta Pharmacol Sin. 2010 Feb; 31(2):175-83. PMID: 20139900.
    Citations: 26     Fields:    Translation:AnimalsCells
  41. Boueiz A, Abougergi MS, Noujeim C, Bousamra A, Sfeir P, Zaatari G, Bou-Khalil P. Primary dedifferentiated chondrosarcoma of the lung. South Med J. 2009 Aug; 102(8):861-3. PMID: 19593290.
    Citations: 2     Fields:    Translation:Humans
  42. Finigan JH, Boueiz A, Wilkinson E, Damico R, Skirball J, Pae HH, Damarla M, Hasan E, Pearse DB, Reddy SP, Grigoryev DN, Cheadle C, Esmon CT, Garcia JG, Hassoun PM. Activated protein C protects against ventilator-induced pulmonary capillary leak. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L1002-11. PMID: 19363121.
    Citations: 25     Fields:    Translation:Animals
  43. Boueiz A, Abougergi MS, Noujeim C, Assaf EB, Jamaleddine G. Fatal bilateral pneumothoraces complicating dyskeratosis congenita: a case report. J Med Case Rep. 2009 Mar 26; 3:6622. PMID: 19830116.
    Citations: 2     Fields:    
  44. Damarla M, Hasan E, Boueiz A, Le A, Pae HH, Montouchet C, Kolb T, Simms T, Myers A, Kayyali US, Gaestel M, Peng X, Reddy SP, Damico R, Hassoun PM. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury. PLoS One. 2009; 4(2):e4600. PMID: 19240800.
    Citations: 32     Fields:    Translation:AnimalsCells
  45. Boueiz A, Hassoun PM. Regulation of endothelial barrier function by reactive oxygen and nitrogen species. Microvasc Res. 2009 Jan; 77(1):26-34. PMID: 19041330.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  46. Le A, Damico R, Damarla M, Boueiz A, Pae HH, Skirball J, Hasan E, Peng X, Chesley A, Crow MT, Reddy SP, Tuder RM, Hassoun PM. Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury. J Appl Physiol (1985). 2008 Oct; 105(4):1282-90. PMID: 18669934.
    Citations: 31     Fields:    Translation:AnimalsCells
  47. Kurban MS, Boueiz A, Kibbi AG. Cutaneous manifestations of chronic kidney disease. Clin Dermatol. 2008 May-Jun; 26(3):255-64. PMID: 18640522.
    Citations: 14     Fields:    Translation:Humans
  48. Boueiz A, Damarla M, Hassoun PM. Xanthine oxidoreductase in respiratory and cardiovascular disorders. Am J Physiol Lung Cell Mol Physiol. 2008 May; 294(5):L830-40. PMID: 18344415.
    Citations: 31     Fields:    Translation:HumansAnimals
  49. Traboulsi R, Boueiz A, Kanj SS. Catastrophic aortic thrombosis due to Toxocara infection. Scand J Infect Dis. 2007; 39(3):283-5. PMID: 17366070.
    Citations: 1     Fields:    Translation:HumansAnimals
  50. Wu Q, Boueiz A, Bozkurt A, Masoomi A, Wang A, DeMeo DL, Weiss ST, Qiu W. . Journal of biometrics & biostatistics 2018, Vol 9(5): 417. 2018. Deep Learning Methods for Predicting Disease Status Using Genomic Data.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
El Boueiz's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (224)
Explore
_
Co-Authors (48)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.