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Chanu Rhee, M.D.

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Overview
Dr. Rhee is an Assistant Professor of Population Medicine at Harvard Medical School / Harvard Pilgrim Health Care Institute and an infectious disease and critical care physician at Brigham and Women's Hospital. His research interest is sepsis and infections in critically ill patients, with a focus on using electronic health record data to improve disease surveillance, prevention, and quality of care. He has received grant funding from the Centers for Disease Control and Prevention and is currently supported by a K08 career development award from the Agency for Healthcare Research and Quality.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rhee C, Jentzsch MS, Kadri SS, Seymour CW, Angus DC, Murphy DJ, Martin GS, Dantes RB, Epstein L, Fiore AE, Jernigan JA, Danner RL, Warren DK, Septimus EJ, Hickok J, Poland RE, Jin R, Fram D, Schaaf R, Wang R, Klompas M. Variation in Identifying Sepsis and Organ Dysfunction Using Administrative Versus Electronic Clinical Data and Impact on Hospital Outcome Comparisons. Crit Care Med. 2019 Apr; 47(4):493-500. PMID: 30431493.
    Citations:    Fields:    
  2. Rhee C, Zhang Z, Kadri SS, Murphy DJ, Martin GS, Overton E, Seymour CW, Angus DC, Dantes R, Epstein L, Fram D, Schaaf R, Wang R, Klompas M. Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria. Crit Care Med. 2019 Mar; 47(3):307-314. PMID: 30768498.
    Citations:    
  3. Pepper D, Sun J, Rhee C, Welsh J, Powers JH, Danner RL, Kadri SS. Procalcitonin-Guided Antibiotic Discontinuation and Mortality in Critically Ill Adults: A Systematic Review and Meta-Analysis. Chest. 2019 Feb 14. PMID: 30772386.
    Citations:    
  4. Pepper DJ, Demirkale CY, Sun J, Rhee C, Fram D, Eichacker P, Klompas M, Suffredini AF, Kadri SS. Does Obesity Protect Against Death in Sepsis? A Retrospective Cohort Study of 55,038 Adult Patients. Crit Care Med. 2019 Feb 14. PMID: 30789403.
    Citations:    
  5. Hsu HE, Wang R, Jentzsch MS, Jin R, Goldmann D, Rhee C, Lee GM. Association Between Value-Based Incentive Programs and Catheter-Associated Urinary Tract Infection Rates in the Critical Care Setting. JAMA. 2019 02 05; 321(5):509-511. PMID: 30721286.
    Citations:    
  6. Rhee C, Jones TM, Hamad Y, Pande A, Varon J, O'Brien C, Anderson DJ, Warren DK, Dantes RB, Epstein L, Klompas M. Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals. JAMA Netw Open. 2019 Feb 01; 2(2):e187571. PMID: 30768188.
    Citations:    
  7. Rhee C, Kalil AC. Toward a More Nuanced Approach to the Early Administration of Intravenous Fluids in Patients With Sepsis. JAMA Netw Open. 2018 Dec 07; 1(8):e185844. PMID: 30646288.
    Citations:    
  8. Rhee C, Wang R, Jentzsch MS, Broadwell C, Hsu H, Jin R, Horan K, Lee GM. Comparison of hospital surgical site infection rates and rankings using claims versus National Healthcare Safety Network surveillance data. Infect Control Hosp Epidemiol. 2019 Feb; 40(2):208-210. PMID: 30509332.
    Citations:    Fields:    
  9. Klompas M, Rhee C. Current Sepsis Mandates Are Overly Prescriptive, and Some Aspects May Be Harmful. Crit Care Med. 2018 Dec 04. PMID: 30865616.
    Citations:    
  10. Kadri SS, Adjemian J, Lai YL, Spaulding AB, Ricotta E, Prevots DR, Palmore TN, Rhee C, Klompas M, Dekker JP, Powers JH, Suffredini AF, Hooper DC, Fridkin S, Danner RL. Difficult-to-Treat Resistance in Gram-negative Bacteremia at 173 US Hospitals: Retrospective Cohort Analysis of Prevalence, Predictors, and Outcome of Resistance to All First-line Agents. Clin Infect Dis. 2018 Nov 28; 67(12):1803-1814. PMID: 30052813.
    Citations: 1     Fields:    
  11. Filbin MR, Lynch J, Gillingham TD, Thorsen JE, Pasakarnis CL, Nepal S, Matsushima M, Rhee C, Heldt T, Reisner AT. Presenting Symptoms Independently Predict Mortality in Septic Shock: Importance of a Previously Unmeasured Confounder. Crit Care Med. 2018 Oct; 46(10):1592-1599. PMID: 29965833.
    Citations: 2     Fields:    
  12. Rhee C, Filbin MR, Massaro AF, Bulger AL, McEachern D, Tobin KA, Kitch BT, Thurlo-Walsh B, Kadar A, Koffman A, Pande A, Hamad Y, Warren DK, Jones TM, O'Brien C, Anderson DJ, Wang R, Klompas M. Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study. Crit Care Med. 2018 Oct; 46(10):1585-1591. PMID: 30015667.
    Citations:    Fields:    
  13. Rhee C, Dantes RB, Epstein L, Klompas M. Using objective clinical data to track progress on preventing and treating sepsis: CDC's new 'Adult Sepsis Event' surveillance strategy. BMJ Qual Saf. 2018 Sep 25. PMID: 30254095.
    Citations:    Fields:    
  14. Rhee C, Wang R, Jentzsch MS, Hsu H, Kawai AT, Jin R, Horan K, Broadwell C, Lee GM. Impact of the 2012 Medicaid Health Care-Acquired Conditions Policy on Catheter-Associated Urinary Tract Infection and Vascular Catheter-Associated Infection Billing Rates. Open Forum Infect Dis. 2018 Sep; 5(9):ofy204. PMID: 30191157.
    Citations:    
  15. Hume PS, Varon J, Englert JA, Hurwitz S, Klompas M, Baron RM, Rhee C. Trends in "usual care" for septic shock. Infect Control Hosp Epidemiol. 2018 Sep; 39(9):1125-1126. PMID: 30022742.
    Citations:    Fields:    
  16. Rhee C, Brown SR, Jones TM, O'Brien C, Pande A, Hamad Y, Bulger AL, Tobin KA, Massaro AF, Anderson DJ, Warren DK, Klompas M. Variability in determining sepsis time zero and bundle compliance rates for the centers for medicare and medicaid services SEP-1 measure. Infect Control Hosp Epidemiol. 2018 08; 39(8):994-996. PMID: 29932042.
    Citations:    Fields:    
  17. Hsu HE, Kawai AT, Wang R, Jentzsch MS, Rhee C, Horan K, Jin R, Goldmann D, Lee GM. The Impact of the Medicaid Healthcare-Associated Condition Program on Mediastinitis Following Coronary Artery Bypass Graft. Infect Control Hosp Epidemiol. 2018 06; 39(6):694-700. PMID: 29669607.
    Citations:    Fields:    
  18. Klompas M, Rhee C. Missed Opportunities for Better Sepsis Care or Misplaced Blame? Deconstructing Patients' Encounters in the Week Before Sepsis Hospitalizations. Crit Care Med. 2018 Apr; 46(4):644-645. PMID: 29538115.
    Citations:    Fields:    
  19. Rhee C, Dantes R, Epstein L, Murphy DJ, Seymour CW, Iwashyna TJ, Kadri SS, Angus DC, Danner RL, Fiore AE, Jernigan JA, Martin GS, Septimus E, Warren DK, Karcz A, Chan C, Menchaca JT, Wang R, Gruber S, Klompas M. Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014. JAMA. 2017 10 03; 318(13):1241-1249. PMID: 28903154.
    Citations: 23     Fields:    Translation:Humans
  20. Rhee C, Klompas M. What Is the National Burden of Sepsis in U.S. Emergency Departments? It Depends on the Definition. Crit Care Med. 2017 Sep; 45(9):1569-1571. PMID: 28816842.
    Citations:    Fields:    
  21. Rhee C, Klompas M. New Sepsis and Septic Shock Definitions: Clinical Implications and Controversies. Infect Dis Clin North Am. 2017 09; 31(3):397-413. PMID: 28687209.
    Citations:    Fields:    Translation:Humans
  22. Kadri SS, Swihart BJ, Bonne SL, Hohmann SF, Hennessy LV, Louras P, Evans HL, Rhee C, Suffredini AF, Hooper DC, Follmann DA, Bulger EM, Danner RL. Impact of Intravenous Immunoglobulin on Survival in Necrotizing Fasciitis With Vasopressor-Dependent Shock: A Propensity Score-Matched Analysis From 130 US Hospitals. Clin Infect Dis. 2017 Apr 01; 64(7):877-885. PMID: 28034881.
    Citations: 6     Fields:    Translation:HumansCells
  23. Rhee C. Using Procalcitonin to Guide Antibiotic Therapy. Open Forum Infect Dis. 2017; 4(1):ofw249. PMID: 28480245.
    Citations: 1     
  24. Klompas M, Rhee C. Sepsis and the theory of relativity: measuring a moving target with a moving measuring stick. Crit Care. 2016 11 21; 20(1):396. PMID: 27923393.
    Citations: 2     Fields:    Translation:Humans
  25. Kadri SS, Rhee C, Strich JR, Morales MK, Hohmann S, Menchaca J, Suffredini AF, Danner RL, Klompas M. Estimating Ten-Year Trends in Septic Shock Incidence and Mortality in United States Academic Medical Centers Using Clinical Data. Chest. 2017 02; 151(2):278-285. PMID: 27452768.
    Citations: 11     Fields:    Translation:Humans
  26. Klompas M, Rhee C. We Need Better Tools for Sepsis Surveillance. Crit Care Med. 2016 07; 44(7):1441-2. PMID: 27309169.
    Citations: 2     Fields:    Translation:Humans
  27. Kadri SS, Rhee C, Magda G, Strich JR, Cai R, Sun J, Decker BK, O'Grady NP. Synergy, Salary, and Satisfaction: Benefits of Training in Critical Care Medicine and Infectious Diseases Gleaned From a National Pilot Survey of Dually Trained Physicians. Clin Infect Dis. 2016 10 01; 63(7):868-875. PMID: 27358351.
    Citations:    Fields:    Translation:Humans
  28. Klompas M, Rhee C. The CMS Sepsis Mandate: Right Disease, Wrong Measure. Ann Intern Med. 2016 Oct 04; 165(7):517-518. PMID: 27294338.
    Citations: 3     Fields:    Translation:Humans
  29. Rhee C, Kadri SS, Danner RL, Suffredini AF, Massaro AF, Kitch BT, Lee G, Klompas M. Diagnosing sepsis is subjective and highly variable: a survey of intensivists using case vignettes. Crit Care. 2016 Apr 06; 20:89. PMID: 27048508; PMCID: PMC4822273.
    Citations: 13     Fields:    Translation:Humans
  30. Rhee C. Cytokine Imbalance Predicts Poor Outcomes in Staphylococcus aureus Bacteremia--But What Can We Do About It? Crit Care Med. 2016 Apr; 44(4):846-7. PMID: 26974448.
    Citations:    Fields:    Translation:HumansCells
  31. Seymour CW, Coopersmith CM, Deutschman CS, Gesten F, Klompas M, Levy M, Martin GS, Osborn TM, Rhee C, Warren DK, Watson RS, Angus DC. Application of a Framework to Assess the Usefulness of Alternative Sepsis Criteria. Crit Care Med. 2016 Mar; 44(3):e122-30. PMID: 26901560; PMCID: PMC4765919.
    Citations: 11     Fields:    Translation:Humans
  32. Angus DC, Seymour CW, Coopersmith CM, Deutschman CS, Klompas M, Levy MM, Martin GS, Osborn TM, Rhee C, Watson RS. A Framework for the Development and Interpretation of Different Sepsis Definitions and Clinical Criteria. Crit Care Med. 2016 Mar; 44(3):e113-21. PMID: 26901559; PMCID: PMC4765912.
    Citations: 17     Fields:    Translation:Humans
  33. Gohil SK, Cao C, Phelan M, Tjoa T, Rhee C, Platt R, Huang SS. Impact of Policies on the Rise in Sepsis Incidence, 2000-2010. Clin Infect Dis. 2016 Mar 15; 62(6):695-703. PMID: 26787173; PMCID: PMC4772840.
    Citations: 8     Fields:    Translation:Humans
  34. Rhee C, Kadri S, Huang SS, Murphy MV, Li L, Platt R, Klompas M. Objective Sepsis Surveillance Using Electronic Clinical Data. Infect Control Hosp Epidemiol. 2016 Feb; 37(2):163-71. PMID: 26526737; PMCID: PMC4743875.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  35. Rhee C, Murphy MV, Li L, Platt R, Klompas M. Improving documentation and coding for acute organ dysfunction biases estimates of changing sepsis severity and burden: a retrospective study. Crit Care. 2015 Sep 14; 19:338. PMID: 26369326.
    Citations: 12     Fields:    Translation:Humans
  36. Rhee C, Murphy MV, Li L, Platt R, Klompas M. Lactate Testing in Suspected Sepsis: Trends and Predictors of Failure to Measure Levels. Crit Care Med. 2015 Aug; 43(8):1669-76. PMID: 25962082; PMCID: PMC4506241.
    Citations: 5     Fields:    Translation:Humans
  37. Rhee C, Klompas M, Tamburini FB, Fremin BJ, Chea N, Epstein L, Halpin AL, Guh A, Gallen R, Coulliette A, Gee J, Hsieh C, Desjardins CA, Pedamullu CS, DeAngelo DJ, Manzo VE, Folkerth RD, Milner DA, Pecora N, Osborne M, Chalifoux-Judge D, Bhatt AS, Yokoe DS. Epidemiologic Investigation of a Cluster of Neuroinvasive Bacillus cereus Infections in 5 Patients With Acute Myelogenous Leukemia. Open Forum Infect Dis. 2015 Sep; 2(3):ofv096. PMID: 26269794; PMCID: PMC4531223.
    Citations: 1     
  38. Kadri SS, Rhee C, Fortna GS, O'Grady NP. Critical Care Medicine and Infectious Diseases: An Emerging Combined Subspecialty in the United States. Clin Infect Dis. 2015 Aug 15; 61(4):609-14. PMID: 25944345; PMCID: PMC4542599.
    Citations: 2     Fields:    Translation:Humans
  39. Rhee C, Huang SS, Berríos-Torres SI, Kaganov R, Bruce C, Lankiewicz J, Platt R, Yokoe DS. Surgical site infection surveillance following ambulatory surgery. Infect Control Hosp Epidemiol. 2015 Feb; 36(2):225-8. PMID: 25633008; PMCID: PMC4439188.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  40. Rhee C, Murphy MV, Li L, Platt R, Klompas M. Comparison of trends in sepsis incidence and coding using administrative claims versus objective clinical data. Clin Infect Dis. 2015 Jan 01; 60(1):88-95. PMID: 25258352; PMCID: PMC4318944.
    Citations: 30     Fields:    Translation:Humans
  41. Rhee C, Sax PE. Evaluation of fever and infections in cardiac surgery patients. Semin Cardiothorac Vasc Anesth. 2015 Jun; 19(2):143-53. PMID: 24958717.
    Citations: 1     Fields:    Translation:Humans
  42. Rhee C, Gohil S, Klompas M. Regulatory mandates for sepsis care--reasons for caution. N Engl J Med. 2014 May 01; 370(18):1673-6. PMID: 24738642; PMCID: PMC4718398.
    Citations: 45     Fields:    Translation:HumansPHPublic Health
  43. Guillamet MC, Rhee C, Patterson AJ. Cardiovascular management of septic shock in 2012. Curr Infect Dis Rep. 2012 Oct; 14(5):493-502. PMID: 22941043.
    Citations: 3     
  44. Rhee C, Eaton EF, Concepcion W, Blackburn BG. West Nile virus encephalitis acquired via liver transplantation and clinical response to intravenous immunoglobulin: case report and review of the literature. Transpl Infect Dis. 2011 Jun; 13(3):312-7. PMID: 21235711.
    Citations: 16     Fields:    Translation:HumansCells
  45. Schaenman JM, Shashidhar S, Rhee C, Wong J, Navato S, Wong RM, Ho DY, Arai S, Johnston L, Brown JM. Early CMV viremia is associated with impaired viral control following nonmyeloablative hematopoietic cell transplantation with a total lymphoid irradiation and antithymocyte globulin preparative regimen. Biol Blood Marrow Transplant. 2011 May; 17(5):693-702. PMID: 20736077.
    Citations: 4     Fields:    Translation:HumansCells
  46. Zhang H, Rhee C, Bebenek A, Drake JW, Wang J, Konigsberg W. The L561A substitution in the nascent base-pair binding pocket of RB69 DNA polymerase reduces base discrimination. Biochemistry. 2006 Feb 21; 45(7):2211-20. PMID: 16475809; PMCID: PMC3373012.
    Citations: 16     Fields:    Translation:Cells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.