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David Miles Meredith, M.D.,Ph.D.

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University of Tulsa, Tulsa, OKBA, BS06/2004Biology, Physics
University of Texas Southwestern Medical Center, Dallas, TXMD, PhD06/2012Genetics and Development
Brigham and Women's Hospital, Boston, MA06/2014Anatomic Pathology
Brigham and Women's Hospital, Boston, MA06/2016Neuropathology

David Meredith, MD, PhD, is a Neuropathologist at Brigham and Women's Hospital, whose clinical responsibilities include neuropathology, bone and soft tissue pathology, and molecular diagnostics. He is also a founding member of the DF/HCC CNS Lymphoma Center. His research interests focus on uncovering genomic signatures and novel biomarkers for CNS neoplasms and translating these into routine clinical care. Main areas of current investigation include:
1) Genomic and clinicopathologic analysis of rare glioma subtypes.
2) Genomic characterization of fusion-negative and novel intracranial mesenchymal tumors.
3) Identification of novel therapeutic vulnerabilities in gliomas and CNS lymphomas using patient derived xenograft and cell line models.

Available: 07/01/22, Expires: 06/30/23

Evidenced by the widespread incorporation of histomolecular entities into the recent WHO classification of CNS tumors, accurate diagnosis and prognostic assessment of brain tumors is heavily reliant on integration with molecular data. Despite advances in the understanding of pathogenic mechanisms leading to gliomagenesis in both adult and pediatric tumors, there remains uncertainty as to how adult tumors with drivers in the MAPK pathway, which are more characteristic of pediatric tumors, present and behave. At BWH, we routinely perform NGS testing of all gliomas seen in practice and have accumulated over 2,000 cases with molecular profiling and detailed clinicopathologic data. Approximately 10% of these tumors show activating genomic alterations in the MAPK pathway, often producing unusual pathology. While current WHO classification relies heavily on methylation cluster analysis to assign diagnoses, we propose using existing comprehensive genomic and transcriptomic profiles to generate diagnostic signatures of existing and novel entities. Furthermore, we have generated many patient-derived models from these tumors, facilitating our ability to test drug sensitivities in vitro and explore novel treatment options. Students interested in joining this project will have the opportunity to collect and organize clinical and pathologic data, as well as analyze multiple modalities of molecular data. Toward this end, some proficiency with bioinformatics, mainly using and optimizing various R packages and generating simple custom scripts for large cohort data analysis is encouraged. Contribution to manuscripts resulting from these efforts will also be expected in exchange for prominent authorship positions.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P50CA165962 (BATCHELOR, TRACY T) Sep 19, 2013 - Aug 31, 2024
    SPORE: Targeted Therapies for Glioma
    Role: Co-Investigator
  2. F31NS061440 (MEREDITH, DAVID M) Apr 1, 2009 - Mar 31, 2011
    Regulation of Ptf1a in the Developing Nervous System
    Role: Principal Investigator

Featured Content

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ahrendsen JT, Ta R, Li J, Weinberg OK, Ferry JA, Hasserjian RP, Meredith DM, Varma H, Sadigh S, Michaels PD. Primary Central Nervous System Anaplastic Large Cell Lymphoma, ALK Positive. Am J Clin Pathol. 2022 08 04; 158(2):300-310. PMID: 35460414.
    Citations:    Fields:    Translation:Humans
  2. Lim-Fat MJ, Youssef GC, Touat M, Iorgulescu JB, Whorral S, Allen M, Rahman R, Chukwueke U, McFaline-Figueroa JR, Nayak L, Lee EQ, Batchelor TT, Arnaout O, Peruzzi PP, Chiocca EA, Reardon DA, Meredith D, Santagata S, Beroukhim R, Bi WL, Ligon KL, Wen PY. Clinical utility of targeted next-generation sequencing assay in IDH-wildtype glioblastoma for therapy decision-making. Neuro Oncol. 2022 07 01; 24(7):1140-1149. PMID: 34878541; PMCID: PMC9248387.
    Citations: 2     Fields:    Translation:Humans
  3. St Pierre R, Collings CK, Samé Guerra DD, Widmer CJ, Bolonduro O, Mashtalir N, Sankar A, Liang Y, Bi WL, Gerkes EH, Ramesh V, Qi J, Smith MJ, Meredith DM, Kadoch C. SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma. Nat Genet. 2022 06; 54(6):861-873. PMID: 35681054.
    Citations: 4     Fields:    Translation:AnimalsCells
  4. Liu KX, Shang HH, Cacciotti C, Everdell E, Aizer AA, Rahman R, Malinowski S, Meredith DM, Kamihara J, Wen PY, Ligon KL, Chi SN, Marcus KJ, Yeo KK, Alexandrescu S, Haas-Kogan DA. DICER1 mutations in primary central nervous system tumors: new insights into histologies, mutations, and prognosis. J Neurooncol. 2022 May; 157(3):499-510. PMID: 35384518.
    Citations:    Fields:    Translation:Humans
  5. Meredith DM, Alexandrescu S. Embryonal and non-meningothelial mesenchymal tumors of the central nervous system - Advances in diagnosis and prognostication. Brain Pathol. 2022 07; 32(4):e13059. PMID: 35266242; PMCID: PMC9245947.
    Citations: 3     Fields:    Translation:Humans
  6. Bi WL, Nayak L, Meredith DM, Driver J, Du Z, Hoffman S, Li Y, Lee EQ, Beroukhim R, Rinne M, McFaline-Figueroa R, Chukwueke U, McCluskey C, Gaffey S, Cherniack AD, Stefanik J, Doherty L, Taubert C, Cifrino M, LaFrankie D, Graillon T, Wen PY, Ligon KL, Al-Mefty O, Huang RY, Muzikansky A, Chiocca EA, Santagata S, Dunn IF, Reardon DA. Activity of PD-1 blockade with nivolumab among patients with recurrent atypical/anaplastic meningioma: phase II trial results. Neuro Oncol. 2022 01 05; 24(1):101-113. PMID: 34015129; PMCID: PMC8730772.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
  7. Ahrendsen JT, Sinai C, Meredith DM, Malinowski SW, Cooney TM, Bandopadhayay P, Ligon KL, Alexandrescu S. Molecular Alterations in Pediatric Low-Grade Gliomas That Led to Death. J Neuropathol Exp Neurol. 2021 11 19; 80(11):1052–1059. PMID: 34580728.
    Citations: 4     Fields:    Translation:HumansCells
  8. Spurr LF, Touat M, Taylor AM, Dubuc AM, Shih J, Meredith DM, Pisano WV, Meyerson ML, Ligon KL, Cherniack AD, Li YY, Beroukhim R. Quantification of aneuploidy in targeted sequencing data using ASCETS. Bioinformatics. 2021 08 25; 37(16):2461-2463. PMID: 33247715; PMCID: PMC8388019.
    Citations: 4     Fields:    Translation:Humans
  9. Meredith DM, Charville GW, Fletcher CDM, Hornick JL. Distantly Metastatic Retinoblastoma to Soft Tissue and Bone: A Challenging Diagnosis Highlighting the Utility of CRX. Am J Surg Pathol. 2021 06 01; 45(6):820-824. PMID: 33165094.
    Citations:    Fields:    Translation:Humans
  10. Ahrendsen JT, Torre M, Meredith DM, Hornick JL, Reardon DA, Wen PY, Yeo KK, Malinowski S, Ligon KL, Ramkissoon S, Alexandrescu S. IDH-mutant gliomas with additional class-defining molecular events. Mod Pathol. 2021 07; 34(7):1236-1244. PMID: 33772213.
    Citations: 2     Fields:    Translation:Humans
  11. Chua MMJ, Bazarek SF, Meredith DM, Hsu L, Saris SC. Falcine chondroma: illustrative case. J Neurosurg Case Lessons. 2021 Feb 08; 1(6):CASE20124. PMID: 36045938; PMCID: PMC9394178.
  12. Mei Y, Bi WL, Agolia J, Hu C, Giantini Larsen AM, Meredith DM, Al Abdulmohsen S, Bale T, Dunn GP, Abedalthagafi M, Dunn IF. Immune profiling of pituitary tumors reveals variations in immune infiltration and checkpoint molecule expression. Pituitary. 2021 Jun; 24(3):359-373. PMID: 33492612.
    Citations: 2     Fields:    Translation:Humans
  13. Baker TG, Alden J, Dubuc AM, Welsh CT, Znoyko I, Cooley LD, Farooqi MS, Schwartz S, Li YY, Cherniack AD, Lindhorst SM, Gener M, Wolff DJ, Meredith DM. Near haploidization is a genomic hallmark which defines a molecular subgroup of giant cell glioblastoma. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa155. PMID: 33392505; PMCID: PMC7764500.
    Citations: 2     
  14. Alexandrescu S, Meredith DM, Lidov HG, Alaggio R, Novello M, Ligon KL, Vargas SO. Loss of histone H3 trimethylation on lysine 27 and nuclear expression of transducin-like enhancer 1 in primary intracranial sarcoma, DICER1-mutant. Histopathology. 2021 Jan; 78(2):265-275. PMID: 32692439.
    Citations: 6     Fields:    Translation:HumansCells
  15. Giannikou K, Zhu Z, Kim J, Winden KD, Tyburczy ME, Marron D, Parker JS, Hebert Z, Bongaarts A, Taing L, Long HW, Pisano WV, Alexandrescu S, Godlewski B, Nellist M, Kotulska K, Jozwiak S, Roszkowski M, Mandera M, Thiele EA, Lidov H, Getz G, Devinsky O, Lawrence MS, Ligon KL, Ellison DW, Sahin M, Aronica E, Meredith DM, Kwiatkowski DJ. Subependymal giant cell astrocytomas are characterized by mTORC1 hyperactivation, a very low somatic mutation rate, and a unique gene expression profile. Mod Pathol. 2021 02; 34(2):264-279. PMID: 33051600; PMCID: PMC9361192.
    Citations: 5     Fields:    Translation:HumansCells
  16. Catalino MP, Meredith DM, De Girolami U, Tavakol S, Min L, Laws ER. Corticotroph hyperplasia and Cushing disease: diagnostic features and surgical management. J Neurosurg. 2020 Sep 04; 1-12. PMID: 32886921.
    Citations:    Fields:    
  17. Torre M, Vasudevaraja V, Serrano J, DeLorenzo M, Malinowski S, Blandin AF, Pages M, Ligon AH, Dong F, Meredith DM, Nasrallah MP, Horbinski C, Dahiya S, Ligon KL, Santi M, Ramkissoon SH, Filbin MG, Snuderl M, Alexandrescu S. Molecular and clinicopathologic features of gliomas harboring NTRK fusions. Acta Neuropathol Commun. 2020 07 14; 8(1):107. PMID: 32665022; PMCID: PMC7362646.
    Citations: 37     Fields:    Translation:Humans
  18. Hoffman SE, Al Abdulmohsen SA, Gupta S, Hauser BM, Meredith DM, Dunn IF, Bi WL. Translational Windows in Chordoma: A Target Appraisal. Front Neurol. 2020; 11:657. PMID: 32733369.
    Citations: 2     
  19. Meredith DM. Advances in Diagnostic Immunohistochemistry for Primary Tumors of the Central Nervous System. Adv Anat Pathol. 2020 May; 27(3):206-219. PMID: 30720470.
    Citations: 2     Fields:    Translation:Humans
  20. Touat M, Li YY, Boynton AN, Spurr LF, Iorgulescu JB, Bohrson CL, Cortes-Ciriano I, Birzu C, Geduldig JE, Pelton K, Lim-Fat MJ, Pal S, Ferrer-Luna R, Ramkissoon SH, Dubois F, Bellamy C, Currimjee N, Bonardi J, Qian K, Ho P, Malinowski S, Taquet L, Jones RE, Shetty A, Chow KH, Sharaf R, Pavlick D, Albacker LA, Younan N, Baldini C, Verreault M, Giry M, Guillerm E, Ammari S, Beuvon F, Mokhtari K, Alentorn A, Dehais C, Houillier C, Laigle-Donadey F, Psimaras D, Lee EQ, Nayak L, McFaline-Figueroa JR, Carpentier A, Cornu P, Capelle L, Mathon B, Barnholtz-Sloan JS, Chakravarti A, Bi WL, Chiocca EA, Fehnel KP, Alexandrescu S, Chi SN, Haas-Kogan D, Batchelor TT, Frampton GM, Alexander BM, Huang RY, Ligon AH, Coulet F, Delattre JY, Hoang-Xuan K, Meredith DM, Santagata S, Duval A, Sanson M, Cherniack AD, Wen PY, Reardon DA, Marabelle A, Park PJ, Idbaih A, Beroukhim R, Bandopadhayay P, Bielle F, Ligon KL. Mechanisms and therapeutic implications of hypermutation in gliomas. Nature. 2020 04; 580(7804):517-523. PMID: 32322066; PMCID: PMC8235024.
    Citations: 177     Fields:    Translation:HumansAnimalsCells
  21. Lim-Fat MJ, Nayak L, Meredith DM. Genomic Biomarker Assessment in Gliomas: Impacts of Molecular Testing on Clinical Practice and Trial Design. Surg Pathol Clin. 2020 Jun; 13(2):209-215. PMID: 32389262.
    Citations: 1     Fields:    Translation:Humans
  22. Meredith DM. Molecular Diagnostics in Lymphoid Neoplasms of the Central Nervous System. Surg Pathol Clin. 2020 Jun; 13(2):267-276. PMID: 32389266.
    Citations: 1     Fields:    Translation:Humans
  23. Meredith DM. Preface: Current Trends in Neuropathology. Surg Pathol Clin. 2020 06; 13(2):ix-x. PMID: 32389273.
    Citations:    Fields:    Translation:Humans
  24. Rahman R, Davies L, Mohareb AM, Peçanha-Pietrobom PM, Patel NJ, Solomon IH, Meredith DM, Tsai HK, Guenette JP, Bhattacharyya S, Urday S, Velásquez GE. Delayed Relapse of Paracoccidioidomycosis in the Central Nervous System: A Case Report. Open Forum Infect Dis. 2020 Apr; 7(4):ofaa077. PMID: 32258208; PMCID: PMC7112725.
    Citations: 4     
  25. Torre M, Alexandrescu S, Dubuc AM, Ligon AH, Hornick JL, Meredith DM. Characterization of molecular signatures of supratentorial ependymomas. Mod Pathol. 2020 01; 33(1):47-56. PMID: 31375768.
    Citations: 6     Fields:    Translation:Humans
  26. Moreira Ferreira VF, Meredith D, Stankiewicz JM. Tumefactive demyelination in a patient with relapsing-remitting MS on ocrelizumab. Neurol Neuroimmunol Neuroinflamm. 2019 09; 6(5). PMID: 31454764.
    Citations: 3     Fields:    Translation:Humans
  27. Torre M, Meredith DM, Dubuc A, Solomon DA, Perry A, Vasudevaraja V, Serrano J, Snuderl M, Ligon KL, Alexandrescu S. Recurrent EP300-BCOR Fusions in Pediatric Gliomas With Distinct Clinicopathologic Features. J Neuropathol Exp Neurol. 2019 04 01; 78(4):305-314. PMID: 30816933.
    Citations: 8     Fields:    Translation:Humans
  28. Alexander BM, Trippa L, Gaffey S, Arrillaga-Romany IC, Lee EQ, Rinne ML, Ahluwalia MS, Colman H, Fell G, Galanis E, de Groot J, Drappatz J, Lassman AB, Meredith DM, Nabors LB, Santagata S, Schiff D, Welch MR, Ligon KL, Wen PY. Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT): A Bayesian Adaptive Platform Trial to Develop Precision Medicines for Patients With Glioblastoma. JCO Precis Oncol. 2019; 3. PMID: 32914038; PMCID: PMC7448806.
    Citations: 24     Fields:    
  29. LaVigne AW, Meredith DM, D'Adamo DR, Margalit DN. Treatment-refractory ALK-positive inflammatory myofibroblastic tumour of the oral cavity. BMJ Case Rep. 2018 Apr 11; 2018. PMID: 29643133; PMCID: PMC5898273.
    Citations: 1     Fields:    Translation:Humans
  30. Meredith DM, Fletcher CDM, Jo VY. Chondromyxoid Fibroma Arising in Craniofacial Sites: A Clinicopathologic Analysis of 25 Cases. Am J Surg Pathol. 2018 03; 42(3):392-400. PMID: 29324473.
    Citations: 7     Fields:    Translation:Humans
  31. Borromeo MD, Meredith DM, Castro DS, Chang JC, Tung KC, Guillemot F, Johnson JE. Correction: A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord. Development. 2017 07 01; 144(13):2539. PMID: 28676570.
    Citations: 1     Fields:    
  32. Levin SN, de Gusmao CM, Etherton MR, Will Rondeau M, Meredith DM, Folkerth RD, Klein JP, Nadeem O, Castillo JJ. "All the soarings of my mind begin in my blood:" central nervous system complication of Waldenström macroglobulinemia. Am J Hematol. 2016 Oct; 91(10):1057-60. PMID: 27414991.
    Citations:    Fields:    Translation:Humans
  33. Mona B, Avila JM, Meredith DM, Kollipara RK, Johnson JE. Regulating the dorsal neural tube expression of Ptf1a through a distal 3' enhancer. Dev Biol. 2016 10 01; 418(1):216-225. PMID: 27350561; PMCID: PMC5031539.
    Citations: 5     Fields:    Translation:AnimalsCells
  34. Ho GP, Brizzi KT, Meredith DM, Laws ER, Berkowitz AL. Clinical Reasoning: A 58-year-old woman with loss of vision in her left eye. Neurology. 2016 Mar 08; 86(10):e101-7. PMID: 26952304.
    Citations:    Fields:    Translation:Humans
  35. Chapuy B, Roemer MG, Stewart C, Tan Y, Abo RP, Zhang L, Dunford AJ, Meredith DM, Thorner AR, Jordanova ES, Liu G, Feuerhake F, Ducar MD, Illerhaus G, Gusenleitner D, Linden EA, Sun HH, Homer H, Aono M, Pinkus GS, Ligon AH, Ligon KL, Ferry JA, Freeman GJ, van Hummelen P, Golub TR, Getz G, Rodig SJ, de Jong D, Monti S, Shipp MA. Targetable genetic features of primary testicular and primary central nervous system lymphomas. Blood. 2016 Feb 18; 127(7):869-81. PMID: 26702065; PMCID: PMC4760091.
    Citations: 179     Fields:    Translation:Humans
  36. Borromeo MD, Meredith DM, Castro DS, Chang JC, Tung KC, Guillemot F, Johnson JE. A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord. Development. 2014 Aug; 141(15):3102. PMID: 25053438.
  37. Borromeo MD, Meredith DM, Castro DS, Chang JC, Tung KC, Guillemot F, Johnson JE. A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord. Development. 2014 Jul; 141(14):2803-12. PMID: 24924197; PMCID: PMC4197617.
    Citations: 55     Fields:    Translation:AnimalsCells
  38. Meredith DM, Borromeo MD, Deering TG, Casey BH, Savage TK, Mayer PR, Hoang C, Tung KC, Kumar M, Shen C, Swift GH, Macdonald RJ, Johnson JE. Program specificity for Ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility. Mol Cell Biol. 2013 Aug; 33(16):3166-79. PMID: 23754747.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  39. Chang JC, Meredith DM, Mayer PR, Borromeo MD, Lai HC, Ou YH, Johnson JE. Prdm13 mediates the balance of inhibitory and excitatory neurons in somatosensory circuits. Dev Cell. 2013 Apr 29; 25(2):182-95. PMID: 23639443.
    Citations: 38     Fields:    Translation:AnimalsCells
  40. Meredith DM, Masui T, Swift GH, MacDonald RJ, Johnson JE. Multiple transcriptional mechanisms control Ptf1a levels during neural development including autoregulation by the PTF1-J complex. J Neurosci. 2009 Sep 09; 29(36):11139-48. PMID: 19741120.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  41. Henke RM, Savage TK, Meredith DM, Glasgow SM, Hori K, Dumas J, MacDonald RJ, Johnson JE. Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord. Development. 2009 Sep; 136(17):2945-54. PMID: 19641016.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  42. Henke RM, Meredith DM, Borromeo MD, Savage TK, Johnson JE. Ascl1 and Neurog2 form novel complexes and regulate Delta-like3 (Dll3) expression in the neural tube. Dev Biol. 2009 Apr 15; 328(2):529-40. PMID: 19389376.
    Citations: 48     Fields:    Translation:AnimalsCells
  43. Masui T, Swift GH, Hale MA, Meredith DM, Johnson JE, Macdonald RJ. Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood. Mol Cell Biol. 2008 Sep; 28(17):5458-68. PMID: 18606784.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.