Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Amin Iskandar Kassis, Ph.D.

Co-Author

This page shows the publications co-authored by Amin Kassis and James Adelstein.
Connection Strength

8.248
  1. Novel prodrugs for targeting diagnostic and therapeutic radionuclides to solid tumors. Molecules. 2008 Feb 18; 13(2):391-404.
    View in: PubMed
    Score: 0.374
  2. Radiobiologic principles in radionuclide therapy. J Nucl Med. 2005 Jan; 46 Suppl 1:4S-12S.
    View in: PubMed
    Score: 0.301
  3. Therapeutic potential of 5-[125I]iodo-2'-deoxyuridine and methotrexate in the treatment of advanced neoplastic meningitis. Int J Radiat Biol. 2004 Nov-Dec; 80(11-12):941-6.
    View in: PubMed
    Score: 0.298
  4. Double-strand break yield following 125I decay--effects of DNA conformation. Acta Oncol. 2000; 39(6):721-6.
    View in: PubMed
    Score: 0.213
  5. In vivo therapy of neoplastic meningitis with methotrexate and 5. Acta Oncol. 2000; 39(6):731-7.
    View in: PubMed
    Score: 0.213
  6. Strand breaks in plasmid DNA after positional changes of Auger electron-emitting iodine-125: direct compared to indirect effects. Radiat Res. 1999 Nov; 152(5):530-8.
    View in: PubMed
    Score: 0.211
  7. Comparison of strand breaks in plasmid DNA after positional changes of Auger electron-emitting iodine-125. Radiat Res. 1999 Feb; 151(2):167-76.
    View in: PubMed
    Score: 0.200
  8. 5-[125I]iodo-2'-deoxyuridine in the radiotherapy of brain tumors in rats. J Nucl Med. 1998 Jul; 39(7):1148-54.
    View in: PubMed
    Score: 0.192
  9. Preclinical animal studies with radioiododeoxyuridine. J Nucl Med. 1996 Apr; 37(4 Suppl):10S-12S.
    View in: PubMed
    Score: 0.164
  10. Intratumoral administration of 5-[123I]iodo-2'-deoxyuridine in a patient with a brain tumor. J Nucl Med. 1996 Apr; 37(4 Suppl):19S-22S.
    View in: PubMed
    Score: 0.164
  11. Antibody-dependent signal amplification in tumor xenografts after pretreatment with biotinylated monoclonal antibody and avidin or streptavidin. J Nucl Med. 1996 Feb; 37(2):343-52.
    View in: PubMed
    Score: 0.162
  12. Strand breaks in plasmid DNA following positional changes of Auger-electron-emitting radionuclides. Acta Oncol. 1996; 35(7):797-801.
    View in: PubMed
    Score: 0.161
  13. 5-[125]iodo-2'-deoxyuridine in the radiotherapy of solid CNS tumors in rats. Acta Oncol. 1996; 35(7):935-9.
    View in: PubMed
    Score: 0.161
  14. Effect of distance between decaying (125)I and DNA on Auger-electron induced double-strand break yield. Int J Radiat Biol. 2012 Dec; 88(12):998-1008.
    View in: PubMed
    Score: 0.127
  15. Bystander effect in tumor cells produced by Iodine-125 labeled human lymphocytes. Int J Radiat Biol. 2012 Dec; 88(12):1019-27.
    View in: PubMed
    Score: 0.127
  16. Does nonuniformity of dose have implications for radiation protection? J Nucl Med. 1992 Mar; 33(3):384-7.
    View in: PubMed
    Score: 0.124
  17. Target discovery from data mining approaches. Drug Discov Today. 2012 Feb; 17 Suppl:S16-23.
    View in: PubMed
    Score: 0.122
  18. Human placental alkaline phosphatase-mediated hydrolysis correlates tightly with the electrostatic contribution from tail group. Chem Biol Drug Des. 2011 Dec; 78(6):923-31.
    View in: PubMed
    Score: 0.121
  19. Radiotoxicity of 5-[125I]iodo-2'-deoxyuridine in mammalian cells following treatment with 5-fluoro-2'-deoxyuridine. J Nucl Biol Med. 1991 Jul-Sep; 35(3):167-73.
    View in: PubMed
    Score: 0.118
  20. Novel method for quantifying radiation-induced single-strand-break yields in plasmid DNA highlights 10-fold discrepancy. Anal Biochem. 2011 Oct 15; 417(2):242-6.
    View in: PubMed
    Score: 0.118
  21. General approach to identifying potential targets for cancer imaging by integrated bioinformatics analysis of publicly available genomic profiles. Mol Imaging. 2011 Apr; 10(2):123-34.
    View in: PubMed
    Score: 0.116
  22. Integrated bioinformatics analysis for cancer target identification. Methods Mol Biol. 2011; 719:527-45.
    View in: PubMed
    Score: 0.114
  23. Specific uptake of the auger electron-emitting thymidine analogue 5-[123I/125I]iodo-2'-deoxyuridine in rat brain tumors: diagnostic and therapeutic implications in humans. Cancer Res. 1990 Aug 15; 50(16):5199-203.
    View in: PubMed
    Score: 0.111
  24. Putative molecular signatures for the imaging of prostate cancer. Expert Rev Mol Diagn. 2010 Jan; 10(1):65-74.
    View in: PubMed
    Score: 0.106
  25. Radiotoxicity of an 125I-labeled DNA intercalator in mammalian cells. Radiat Res. 1989 May; 118(2):283-94.
    View in: PubMed
    Score: 0.102
  26. Target discovery from data mining approaches. Drug Discov Today. 2009 Feb; 14(3-4):147-54.
    View in: PubMed
    Score: 0.100
  27. Meeting overview. Int J Radiat Biol. 2008 Dec; 84(12):957-8.
    View in: PubMed
    Score: 0.099
  28. DNA double-strand breaks induced by decay of (123)I-labeled Hoechst 33342: role of DNA topology. Int J Radiat Biol. 2008 Dec; 84(12):976-83.
    View in: PubMed
    Score: 0.099
  29. Synthesis and application of molecular probe for detection of hydroxyl radicals produced by Na(125)I and gamma-rays in aqueous solution. Int J Radiat Biol. 2008 Dec; 84(12):1001-10.
    View in: PubMed
    Score: 0.099
  30. Integrative genomic data mining for discovery of potential blood-borne biomarkers for early diagnosis of cancer. PLoS One. 2008; 3(11):e3661.
    View in: PubMed
    Score: 0.098
  31. Method to eliminate linear DNA from mixture containing nicked circular, supercoiled, and linear plasmid DNA. Anal Biochem. 2008 Oct 01; 381(1):172-4.
    View in: PubMed
    Score: 0.096
  32. Auger electron-induced double-strand breaks depend on DNA topology. Radiat Res. 2008 Jul; 170(1):70-82.
    View in: PubMed
    Score: 0.096
  33. DMSO increases radioiodination yield of radiopharmaceuticals. Appl Radiat Isot. 2008 Jan; 66(1):50-9.
    View in: PubMed
    Score: 0.090
  34. Radiotoxicity of 125I in mammalian cells. Radiat Res. 1987 Aug; 111(2):305-18.
    View in: PubMed
    Score: 0.090
  35. Synthesis of coumarin-polyamine-based molecular probe for the detection of hydroxyl radicals generated by gamma radiation. Radiat Res. 2007 Aug; 168(2):233-42.
    View in: PubMed
    Score: 0.090
  36. Evaluation of chemical, physical, and biologic properties of tumor-targeting radioiodinated quinazolinone derivative. Bioconjug Chem. 2007 May-Jun; 18(3):754-64.
    View in: PubMed
    Score: 0.088
  37. Computational modeling and experimental evaluation of a novel prodrug for targeting the extracellular space of prostate tumors. Cancer Res. 2007 Mar 01; 67(5):2197-205.
    View in: PubMed
    Score: 0.087
  38. Molecular-docking-guided design, synthesis, and biologic evaluation of radioiodinated quinazolinone prodrugs. J Med Chem. 2007 Feb 22; 50(4):663-73.
    View in: PubMed
    Score: 0.087
  39. Kinetics of uptake, retention, and radiotoxicity of 125IUdR in mammalian cells: implications of localized energy deposition by Auger processes. Radiat Res. 1987 Jan; 109(1):78-89.
    View in: PubMed
    Score: 0.086
  40. Radiobiologic implications of the microscopic distribution of energy from radionuclides. Int J Rad Appl Instrum B. 1987; 14(3):165-9.
    View in: PubMed
    Score: 0.086
  41. In silico design, synthesis, and biological evaluation of radioiodinated quinazolinone derivatives for alkaline phosphatase-mediated cancer diagnosis and therapy. Mol Cancer Ther. 2006 Dec; 5(12):3001-13.
    View in: PubMed
    Score: 0.086
  42. Induction of apoptosis in human tumor cells after exposure to Auger electrons: comparison with gamma-ray exposure. Nucl Med Biol. 2006 Nov; 33(8):1055-63.
    View in: PubMed
    Score: 0.085
  43. Mechanisms underlying production of double-strand breaks in plasmid DNA after decay of 125I-Hoechst. Radiat Res. 2006 Aug; 166(2):333-44.
    View in: PubMed
    Score: 0.084
  44. A combined approach to data mining of textual and structured data to identify cancer-related targets. BMC Bioinformatics. 2006 Jul 20; 7:354.
    View in: PubMed
    Score: 0.084
  45. Inhibitory and stimulatory bystander effects are differentially induced by Iodine-125 and Iodine-123. Radiat Res. 2006 Jun; 165(6):688-94.
    View in: PubMed
    Score: 0.083
  46. 5-[123I/125I]iodo-2'-deoxyuridine in metastatic lung cancer: radiopharmaceutical formulation affects targeting. J Nucl Med. 2005 May; 46(5):800-6.
    View in: PubMed
    Score: 0.077
  47. Chemotoxicity of indium-111 oxine in mammalian cells. J Nucl Med. 1985 Feb; 26(2):187-90.
    View in: PubMed
    Score: 0.076
  48. Intracellular distribution and radiotoxicity of chromium-51 in mammalian cells: Auger-electron dosimetry. J Nucl Med. 1985 Jan; 26(1):59-67.
    View in: PubMed
    Score: 0.075
  49. Activation of diverse pathways to apoptosis by (125)IdUrd and gamma-photon exposure. Int J Radiat Biol. 2004 Nov-Dec; 80(11-12):867-74.
    View in: PubMed
    Score: 0.074
  50. Molecular simulation of ligand-binding with DNA: implications for 125I-labeled pharmaceutical design. Int J Radiat Biol. 2004 Nov-Dec; 80(11-12):921-6.
    View in: PubMed
    Score: 0.074
  51. Radiotoxicity of iodine-125 and other auger-electron-emitting radionuclides: background to therapy. Cancer Biother Radiopharm. 2003 Jun; 18(3):301-16.
    View in: PubMed
    Score: 0.067
  52. Bystander effect produced by radiolabeled tumor cells in vivo. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13765-70.
    View in: PubMed
    Score: 0.064
  53. Synthesis and biologic evaluation of a radioiodinated quinazolinone derivative for enzyme-mediated insolubilization therapy. Bioconjug Chem. 2002 Mar-Apr; 13(2):357-64.
    View in: PubMed
    Score: 0.062
  54. Chemical modification of 5-[125I]iodo-2'-deoxyuridine toxicity in mammalian cells in vitro. Int J Radiat Biol. 2001 May; 77(5):625-30.
    View in: PubMed
    Score: 0.058
  55. Emerging roles for radiometabolic therapy of tumors based on auger electron emission. J Nucl Med. 2000 Sep; 41(9):1519-21.
    View in: PubMed
    Score: 0.056
  56. Morphological transformation of C3H 10T1/2 cells by 99mTc-cardiolite. J Nucl Med. 2000 Sep; 41(9):1545-51.
    View in: PubMed
    Score: 0.056
  57. A rapid and reproducible method for the separation of cells from radioactive media. J Nucl Med. 1980 Jan; 21(1):88-90.
    View in: PubMed
    Score: 0.053
  58. Cytotoxicity of [125I]iodoHoechst 33342: contribution of scavengeable effects. Int J Radiat Biol. 1999 Dec; 75(12):1579-87.
    View in: PubMed
    Score: 0.053
  59. Survival and DNA damage in Chinese hamster V79 cells exposed to alpha particles emitted by DNA-incorporated astatine-211. Radiat Res. 1998 Sep; 150(3):263-8.
    View in: PubMed
    Score: 0.049
  60. [125I/127I/131I]Iodorhodamine: synthesis, cellular localization, and biodistribution in athymic mice bearing human tumor xenografts and comparison with [99mTc]hexakis(2-methoxyisobutylisonitrile). J Med Chem. 1998 Jun 04; 41(12):2111-7.
    View in: PubMed
    Score: 0.048
  61. Lysine-directed conjugation of ethidium homodimer to B72.3 antibody: retention of immunoreactivity but altered tumor targeting. Nucl Med Biol. 1998 Apr; 25(3):267-78.
    View in: PubMed
    Score: 0.047
  62. Indirect mechanisms contribute to biological effects produced by decay of DNA-incorporated iodine-125 in mammalian cells in vitro: double-strand breaks. Radiat Res. 1998 Feb; 149(2):134-41.
    View in: PubMed
    Score: 0.047
  63. Indirect mechanisms contribute to biological effects produced by decay of DNA-incorporated iodine-125 in mammalian cells in vitro: clonogenic survival. Radiat Res. 1998 Feb; 149(2):142-6.
    View in: PubMed
    Score: 0.047
  64. Strand breaks after the decay of iodine-125 in proximity to plasmid pBR322 DNA. Radiat Res. 1997 Apr; 147(4):401-8.
    View in: PubMed
    Score: 0.044
  65. Intrathecal 5-[125I]iodo-2'-deoxyuridine in a rat model of leptomeningeal metastases. J Nucl Med. 1997 Mar; 38(3):386-90.
    View in: PubMed
    Score: 0.044
  66. [125I/127I]iodoHoechst 33342: synthesis, DNA binding, and biodistribution. J Med Chem. 1996 Nov 22; 39(24):4804-9.
    View in: PubMed
    Score: 0.043
  67. Radiolabeled nucleoside analogs in cancer diagnosis and therapy. Q J Nucl Med. 1996 Sep; 40(3):301-19.
    View in: PubMed
    Score: 0.042
  68. Tumor targeting by intra-arterial infusion of 5-[123I]iodo-2'-deoxyuridine in patients with liver metastases from colorectal cancer. J Nucl Med. 1996 Apr; 37(4 Suppl):22S-25S.
    View in: PubMed
    Score: 0.041
  69. Kit formulation for the preparation of radiolabeled iododeoxyuridine by demetallation. J Nucl Med. 1996 Apr; 37(4 Suppl):1S-3S.
    View in: PubMed
    Score: 0.041
  70. Tumor uptake and mitotic activity pattern of 5-[125I]iodo-2'- deoxyuridine after intravesical infusion in patients with bladder cancer. J Nucl Med. 1996 Apr; 37(4 Suppl):16S-19S.
    View in: PubMed
    Score: 0.041
  71. Tumor-targeting potential of radioiodinated iododeoxyuridine in bladder cancer. J Nucl Med. 1996 Feb; 37(2):315-20.
    View in: PubMed
    Score: 0.041
  72. Biochemical modulation by 5-fluorouracil and 1-folinic acid of tumor uptake of intra-arterial 5-[123I]iodo-2'deoxyuridine in patients with liver metastases from colorectal cancer. Acta Oncol. 1996; 35(7):941-5.
    View in: PubMed
    Score: 0.040
  73. Instantaneous preparation of radiolabeled 5-iodo-2'-deoxyuridine. Appl Radiat Isot. 1995 Oct; 46(10):1039-46.
    View in: PubMed
    Score: 0.040
  74. The effects of indium-111 decay on pBR322 DNA. Radiat Res. 1995 Feb; 141(2):193-8.
    View in: PubMed
    Score: 0.038
  75. DNA damage produced in V79 cells by DNA-incorporated iodine-123: a comparison with iodine-125. Radiat Res. 1992 Mar; 129(3):309-14.
    View in: PubMed
    Score: 0.031
  76. 5-[123I]iodo-2'-deoxyuridine in the radiotherapy of an early ascites tumor model. Int J Radiat Oncol Biol Phys. 1991 Nov; 21(6):1541-51.
    View in: PubMed
    Score: 0.030
  77. Capping and internalization of a monoclonal antibody-surface antigen complex: a possible mode of interaction of monoclonal antibodies and tumor cells. J Nucl Biol Med. 1991 Apr-Jun; 35(2):111-9.
    View in: PubMed
    Score: 0.029
  78. Antigen-binding site protection during radiolabeling leads to a higher immunoreactive fraction. J Nucl Med. 1991 Jan; 32(1):116-22.
    View in: PubMed
    Score: 0.029
  79. Potential for tumor therapy with iodine-125 labeled immunoglobulins. Int J Rad Appl Instrum B. 1991; 18(1):43-4.
    View in: PubMed
    Score: 0.029
  80. Cellular radiation dosimetry and its implications for estimation of radiation risks. Illustrative results with technetium 99m-labeled microspheres and macroaggregates. JAMA. 1990 Aug 01; 264(5):592-5.
    View in: PubMed
    Score: 0.028
  81. Inhomogeneous deposition of radiopharmaceuticals at the cellular level: experimental evidence and dosimetric implications. J Nucl Med. 1990 Aug; 31(8):1358-63.
    View in: PubMed
    Score: 0.028
  82. Preadsorption of radiolabeled monoclonal antibodies to liver and spleen tissues leads to higher tumor-to-normal-tissue ratios. J Nucl Med Allied Sci. 1990 Apr-Jun; 34(2):94-102.
    View in: PubMed
    Score: 0.027
  83. Synthesis and biological activity of the intercalating agent 3-acetamido-5-[123/125I]iodo-6-aminoacridine. Int J Rad Appl Instrum B. 1990; 17(3):341-6.
    View in: PubMed
    Score: 0.027
  84. 5-iodo-2'-deoxyuridine-protein conjugates: synthesis and enzymatic degradation. Sel Cancer Ther. 1990; 6(1):1-13.
    View in: PubMed
    Score: 0.027
  85. Auger electron emitters: insights gained from in vitro experiments. Radiat Environ Biophys. 1990; 29(2):75-91.
    View in: PubMed
    Score: 0.027
  86. Antibody internalization by tumor cells: implications for tumor diagnosis and therapy. J Nucl Med Allied Sci. 1990 Jan-Mar; 34(1):51-4.
    View in: PubMed
    Score: 0.027
  87. Absence of preferential uptake of [125I]iododihydrorhodamine 123 by four human tumor xenografts. Cancer Res. 1989 Nov 01; 49(21):5986-8.
    View in: PubMed
    Score: 0.026
  88. Limitations of conventional internal dosimetry at the cellular level. J Nucl Med. 1989 Nov; 30(11):1856-64.
    View in: PubMed
    Score: 0.026
  89. Radiotoxicity of 5-[123I]iodo-2'-deoxyuridine in V79 cells: a comparison with 5-[125I]iodo-2'-deoxyuridine. Radiat Res. 1989 Jun; 118(3):532-44.
    View in: PubMed
    Score: 0.026
  90. Monoclonal antibody internalization by tumor cells: an experimental model for potential radioimmunotherapy applications. Int J Rad Appl Instrum B. 1989; 16(2):147-50.
    View in: PubMed
    Score: 0.025
  91. First human treatment of resistant neoplastic meningitis by intrathecal administration of MTX plus (125)IUdR. Int J Radiat Biol. 2008 Dec; 84(12):1123-9.
    View in: PubMed
    Score: 0.025
  92. Does the in vitro testing of the immunoreactivity of an antibody reflect its in vivo behavior? J Nucl Med Allied Sci. 1988 Oct-Dec; 32(4):260-7.
    View in: PubMed
    Score: 0.024
  93. Synthesis and biological studies of iodinated (127/125I) derivatives of rhodamine 123. J Med Chem. 1987 Oct; 30(10):1757-61.
    View in: PubMed
    Score: 0.023
  94. HPLC analysis of the dissociation and recombination of rabbit immunoglobulin G. J Immunol Methods. 1987 Feb 11; 96(2):195-9.
    View in: PubMed
    Score: 0.022
  95. The in vitro radiobiology of astatine-211 decay. Radiat Res. 1986 Jan; 105(1):27-36.
    View in: PubMed
    Score: 0.020
  96. Biological studies of a new class of technetium complexes: the hexakis(alkylisonitrile)technetium(I) cations. Int J Nucl Med Biol. 1984; 11(3-4):225-34.
    View in: PubMed
    Score: 0.018
  97. Radionuclide therapy with iodine-125 and other auger-electron-emitting radionuclides: experimental models and clinical applications. Cancer Biother Radiopharm. 2003 Dec; 18(6):861-77.
    View in: PubMed
    Score: 0.017
  98. Thallium-201: an experimental and a theoretical radiobiological approach to dosimetry. J Nucl Med. 1983 Dec; 24(12):1164-75.
    View in: PubMed
    Score: 0.017
  99. Transient toxicity of 2-deoxy-2-[18F]fluoro-D-glucose in mammalian cells: concise communication. J Nucl Med. 1983 Nov; 24(11):1055-9.
    View in: PubMed
    Score: 0.017
  100. Lethality of Auger electrons from the decay of bromine-77 in the DNA of mammalian cells. Radiat Res. 1982 May; 90(2):362-73.
    View in: PubMed
    Score: 0.016
  101. Radiotoxicity of 75Se and 35S: theory and application to a cellular model. Radiat Res. 1980 Dec; 84(3):407-25.
    View in: PubMed
    Score: 0.014
  102. Radiotoxicity of platinum-195m-labeled trans-platinum (II) in mammalian cells. Radiat Res. 1994 Oct; 140(1):55-62.
    View in: PubMed
    Score: 0.009
  103. Mutation induction by 125iodoacetylproflavine, a DNA-intercalating agent, in human cells. Int J Radiat Biol. 1990 Jun; 57(6):1087-103.
    View in: PubMed
    Score: 0.007
  104. Radioimmunotherapy with alpha-particle-emitting immunoconjugates. Science. 1988 May 20; 240(4855):1024-6.
    View in: PubMed
    Score: 0.006
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.