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Christopher D Barrett, M.D.

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Biography
United States Army, Ft. Bragg, NCAirborne Infantry, 2002-2005
University of Minnesota Duluth, Duluth, MNBachelor of Science (B.S.)07/2009Biomedical Sciences
Washington University in St. Louis School of Medicine, St. Louis, MODoctor of Medicine (M.D.)05/2012Medicine
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MAResident in General Surgery, 06/2012-present
Massachusetts Institute of Technology, Cambridge, MAPostdoctoral Fellow, Coagulation and Inflammation in Major Traumatic Injury, 06/2014-present
2003
Parachutist's Badge
2003
Combat Infantryman's Badge
2004
Army Commendation Medal
2006
President's Scholarship
2007 - 2008
Swenson Family Foundation Scholarship
2013
American Board of Surgery In-Training Exam Best Score Award
2012
Outstanding Resident Teaching Award (quarterly award for fall 2012)
2013
Outstanding Resident Teaching Award (for academic year 2012-2013)
2016 - 2018
Ruth L. Kirschstein National Research Service Award (F32)
2016 - 2018
L30 Grant

Overview
I am a General Surgery Resident at BIDMC (Harvard Medical School) (6/2012-present) with a personal focus/interest on trauma surgery and surgical critical care, and am a Postdoctoral Fellow in the lab of Michael B. Yaffe, M.D., Ph.D., FACS, COL (USAR), Massachusetts Institute of Technology (July 2014 – present). My research focuses on investigating the cellular and molecular relationships of traumatic coagulopathy, complement activity, fibrinolysis and inflammation in human traumatic injury and murine models as a co-investigator on the NIH/DoD Trans-Agency Consortium for Trauma Induced Coagulopathy (TACTIC). I am specifically interested in uncovering key molecular mechanisms that offer therapeutic targets to improve outcomes and survival after major traumatic injury to include those suffered on the battlefield.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F32HL134244 (BARRETT, CHRISTOPHER DAVID) Sep 12, 2016 - Sep 11, 2018
    NIH/NHLBI
    The Coagulopathy-Inflammation Interface: Integration of Coagulopathy and Complement Activation as a Mechanism for Neutrophil Priming and Tissue Damage
    Role: Principal Investigator
  2. L30GM120751 (BARRETT, CHRISTOPHER DAVID) Jul 1, 2016 - Jun 30, 2018
    NIH
    Neutrophil priming, reactive oxygen species, and complement in trauma-induced coagulopathy, endothelial injury and end-organ damage.
    Role: Principle Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Barrett CD, Yaffe MB. COVID-19: All the wrong moves in all the wrong places. Sci Signal. 2020 09 15; 13(649). PMID: 32934074.
    Citations:    
  2. Barrett CD, Moore HB, Vigneshwar N, Dhara S, Chandler J, Chapman MP, Sauaia A, Moore EE, Yaffe MB. Plasmin TEG Rapidly Identifies Trauma Patients at Risk for Massive Transfusion, Mortality and Hyperfibrinolysis: A Diagnostic Tool to Resolve an International Debate on TXA? J Trauma Acute Care Surg. 2020 Sep 09. PMID: 32925578.
    Citations:    
  3. Barrett CD, Oren-Grinberg A, Chao E, Moraco AH, Martin MJ, Reddy SH, Ilg AM, Jhunjhunwala R, Uribe M, Moore HB, Moore EE, Baedorf-Kassis EN, Krajewski ML, Talmor DS, Shaefi S, Yaffe MB. Rescue therapy for severe COVID-19-associated acute respiratory distress syndrome with tissue plasminogen activator: A case series. J Trauma Acute Care Surg. 2020 09; 89(3):453-457. PMID: 32427773.
    Citations:    
  4. Barrett CD, Vigneshwar N, Moore HB, Ghasabyan A, Chandler J, Moore EE, Yaffe MB. Tranexamic acid is associated with reduced complement activation in trauma patients with hemorrhagic shock and hyperfibrinolysis on thromboelastography. Blood Coagul Fibrinolysis. 2020 Jul 27. PMID: 32732500.
    Citations:    
  5. Proctor EA, Dineen SM, Van Nostrand SC, Kuhn MK, Barrett CD, Brubaker DK, Yaffe MB, Lauffenburger DA, Leon LR. Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model. J Thromb Haemost. 2020 Aug; 18(8):1900-1910. PMID: 32367690.
    Citations:    
  6. Barrett CD, Moore HB, Yaffe MB, Moore EE. ISTH interim guidance on recognition and management of coagulopathy in COVID-19: A comment. J Thromb Haemost. 2020 08; 18(8):2060-2063. PMID: 32302462.
    Citations:    
  7. Barrett CD, Moore HB, Moore EE, McIntyre RC, Moore PK, Burke J, Hua F, Apgar J, Talmor DS, Sauaia A, Liptzin DR, Veress LA, Yaffe MB. Fibrinolytic therapy for refractory COVID-19 acute respiratory distress syndrome: Scientific rationale and review. Res Pract Thromb Haemost. 2020 May; 4(4):524-531. PMID: 32542213.
    Citations:    
  8. Moore HB, Barrett CD, Moore EE, McIntyre RC, Moore PK, Talmor DS, Moore FA, Yaffe MB. Is there a role for tissue plasminogen activator as a novel treatment for refractory COVID-19 associated acute respiratory distress syndrome? J Trauma Acute Care Surg. 2020 06; 88(6):713-714. PMID: 32281766.
    Citations:    
  9. Moore HB, Barrett CD, Moore EE, Jhunjhnuwala R, McIntyre RC, Moore PK, Wang J, Hajizadeh N, Talmor DS, Sauaia A, Yaffe MB. STudy of Alteplase for Respiratory failure in SARS-Cov2/COVID-19: Study Design of the Phase IIa STARS Trial. Res Pract Thromb Haemost. 2020 May 21. PMID: 32838109.
    Citations:    
  10. Wang J, Hajizadeh N, Moore EE, McIntyre RC, Moore PK, Veress LA, Yaffe MB, Moore HB, Barrett CD. Tissue plasminogen activator (tPA) treatment for COVID-19 associated acute respiratory distress syndrome (ARDS): A case series. J Thromb Haemost. 2020 07; 18(7):1752-1755. PMID: 32267998.
    Citations:    
  11. Choudhury R, Barrett CD, Moore HB, Moore EE, McIntyre RC, Moore PK, Talmor DS, Nydam TL, Yaffe MB. Salvage use of tissue plasminogen activator (tPA) in the setting of acute respiratory distress syndrome (ARDS) due to COVID-19 in the USA: a Markov decision analysis. World J Emerg Surg. 2020 04 20; 15(1):29. PMID: 32312290.
    Citations:    
  12. Barrett CD, Yaffe MB. Influence of tranexamic acid on the complement system in trauma. ANZ J Surg. 2020 04; 90(4):418-420. PMID: 32339419.
    Citations:    
  13. Barrett CD, Kong YW, Yaffe MB. Influence of Tranexamic Acid on Inflammatory Signaling in Trauma. Semin Thromb Hemost. 2020 Mar; 46(2):183-188. PMID: 32160643.
    Citations:    
  14. Moore HB, Gando S, Iba T, Kim PY, Yeh CH, Brohi K, Hunt BJ, Levy JH, Draxler DF, Stanworth S, Görlinger K, Neal MD, Schreiber MA, Barrett CD, Medcalf RL, Moore EE, Mutch NJ, Thachil J, Urano T, Thomas S, Scarlatescu E, Walsh M. Defining trauma-induced coagulopathy with respect to future implications for patient management: Communication from the SSC of the ISTH. J Thromb Haemost. 2020 03; 18(3):740-747. PMID: 32112533.
    Citations:    
  15. Dhara S, Moore EE, Yaffe MB, Moore HB, Barrett CD. Modern Management of Bleeding, Clotting, and Coagulopathy in Trauma Patients: What Is the Role of Viscoelastic Assays? Curr Trauma Rep. 2020 Mar; 6(1):69-81. PMID: 32864298.
    Citations:    
  16. Walker CB, Moore EE, Kam A, Dexter-Meldrum J, Nydam TL, Chapman MP, Chandler J, Sauaia A, Barrett CD, Yaffe MB, Moore HB. Clot activators do not expedite the time to predict massive transfusion in trauma patients analyzed with tissue plasminogen activator thrombelastography. Surgery. 2019 09; 166(3):408-415. PMID: 31230841.
    Citations:    
  17. Han TS, Gulli G, Affley B, Fluck D, Fry CH, Barrett C, Kakar P, Sharma S, Sharma P. New evidence-based A1, A2, A3 alarm time zones for transferring thrombolysed patients to hyper-acute stroke units: faster is better. Neurol Sci. 2019 Aug; 40(8):1659-1665. PMID: 31030369.
    Citations:    
  18. Barrett CD, Moore HB, Kong YW, Chapman MP, Sriram G, Lim D, Moore EE, Yaffe MB. Tranexamic acid mediates proinflammatory and anti-inflammatory signaling via complement C5a regulation in a plasminogen activator-dependent manner. J Trauma Acute Care Surg. 2019 01; 86(1):101-107. PMID: 30575685.
    Citations:    Fields:    
  19. Barrett CD, Hsu AT, Ellson CD, Y Miyazawa B, Kong YW, Greenwood JD, Dhara S, Neal MD, Sperry JL, Park MS, Cohen MJ, Zuckerbraun BS, Yaffe MB. Blood clotting and traumatic injury with shock mediates complement-dependent neutrophil priming for extracellular ROS, ROS-dependent organ injury and coagulopathy. Clin Exp Immunol. 2018 10; 194(1):103-117. PMID: 30260475.
    Citations:    Fields:    
  20. Barrett CD, Moore HB, Banerjee A, Silliman CC, Moore EE, Yaffe MB. Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin. J Trauma Acute Care Surg. 2017 12; 83(6):1053-1061. PMID: 28837538.
    Citations:    Fields:    Translation:HumansCells
  21. Barrett CD & Yaffe MB. Trauma Induced Coagulopathy. Gonzalez E, Moore HB, & Moore EE, editors. “Neutrophils, Inflammation and Innate Immunity in Trauma-Induced Coagulopathy.”. 2016; 149-165.
  22. Barrett CD, Celestin A, Fish E, Glass CC, Eskander MF, Murillo R, Gospodinov G, Gupta A, Hauser CJ. Surgical wound assessment by sonography in the prediction of surgical wound infections. J Trauma Acute Care Surg. 2016 Feb; 80(2):229-36. PMID: 26502211.
    Citations:    Fields:    Translation:Humans
  23. Hsu AT, Barrett CD, DeBusk GM, Ellson CD, Gautam S, Talmor DS, Gallagher DC, Yaffe MB. Kinetics and Role of Plasma Matrix Metalloproteinase-9 Expression in Acute Lung Injury and the Acute Respiratory Distress Syndrome. Shock. 2015 Aug; 44(2):128-36. PMID: 26009816.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  24. Cavallo JA, Ousley J, Barrett CD, Baalman S, Ward K, Borchardt M, Thomas JR, Perotti G, Frisella MM, Matthews BD. A material cost-minimization analysis for hernia repairs and minor procedures during a surgical mission in the Dominican Republic. Surg Endosc. 2014 Mar; 28(3):747-66. PMID: 24162140.
    Citations: 1     Fields:    Translation:Humans
  25. Nemykin VN, Rohde GT, Barrett CD, Hadt RG, Sabin JR, Reina G, Galloni P, Floris B. Long-range electronic communication in free-base meso-poly(ferrocenyl)-containing porphyrins. Inorg Chem. 2010 Aug 16; 49(16):7497-509. PMID: 20690759.
    Citations:    Fields:    
  26. Nemykin VN, Rohde GT, Barrett CD, Hadt RG, Bizzarri C, Galloni P, Floris B, Nowik I, Herber RH, Marrani AG, Zanoni R, Loim NM. Electron-transfer processes in metal-free tetraferrocenylporphyrin. Understanding internal interactions to access mixed-valence States potentially useful for quantum cellular automata. J Am Chem Soc. 2009 Oct 21; 131(41):14969-78. PMID: 19772340.
    Citations: 1     Fields:    
  27. Nemykin VN, Galloni P, Floris B, Barrett CD, Hadt RG, Subbotin RI, Marrani AG, Zanoni R, Loim NM. Metal-free and transition-metal tetraferrocenylporphyrins part 1: synthesis, characterization, electronic structure, and conformational flexibility of neutral compounds. Dalton Trans. 2008 Aug 28; (32):4233-46. PMID: 18682862.
    Citations: 2     Fields:    
  28. Nemykin VN, Barrett CD, Hadt RG, Subbotin RI, Maximov AY, Polshin EV, Koposov AY. Mixed-valence states formation in conformationally flexible metal-free 5,10,15,20-tetraferrocenylporphyrin and 5,10-bisferrocenyl-15,20-bisphenylporphyrin. Dalton Trans. 2007 Aug 21; (31):3378-89. PMID: 17664974.
    Citations: 1     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.