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Paul James Hoover, M.D.,Ph.D.

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Biography
Broad Institute, Cambridge, MaPost-doctoral Fellow, Hacohen Lab
Brigham & Women's Hospital, Boston, Ma2018Rheumatology Fellowship
Brigham & Women's Hospital, Boston, Ma2014Internal Medicine Residency
Stanford School of Medicine, Stanford, CaMD, PhD2012Molec. & Cell Phys.
NIH, Bethesda, MD2003Fellow
Univ. of Arizona, Tucson, AzBS2002Molec. & Cell Bio.
2019
Investigator Award, Rheumatology Research Foundation
2018
Master Class in Lupus Basic and Clinical Sciences
2017 - 2019
Career Development Award, Lupus Foundation of America
2015
Clinical Fellow Teaching Award, Brigham and Women's Hospital
2003 - 2012
Medical Scientist Training Program Fellowship, Stanford School of Medicine
2002
Phi Beta Kappa, Univ. of Az
1998 - 2002
Student Achievement Award, undergraduate tuition scholarship

Overview
My efforts as a physician-scientist are focused on understanding how infiltrating immune cells drive tissue damage in autoimmune kidney disease with a focus on lupus nephritis. As a post-doctoral fellow at Broad Institute in the Hacohen laboratory, I develop and apply cutting edge technologies to profile autoimmune human kidney tissue to identify cell-types and cell networks associated with distinct tissue lesions for follow-up mechanistic studies. At Brigham and Women's Hospital and Harvard Medical School, I see rheumatology patients one half day per week, and provide inpatient service 2 weeks per year; I also teach the pathophysiology of systemic lupus erythematosus to medical students.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. Aug 1, 2017 - Aug 1, 2019
    NIH/NIDDK
    Kidney Precision Medicine through Interrogation of RNA in the Kidney
    Role Description: Develop and apply parallel, complimentary approaches to define human kidney cell type, disease state specific transcriptomic profiles with 2D & 3D tissue spatial characterization.
    Role: Co-investigator
  2. Jun 30, 2017 - Jul 1, 2019
    Lupus Foundation of America
    Mapping disease-specific immune cells in lupus nephritis tissue
    Role Description: This project leverages signatures generated from single cell RNA sequencing of lupus nephritis biopsies to map the myeloid cell compartment across tissue from clinical samples. The goal is to define the organizational landscape between myeloid cells, their cellular neighborhood, and histopathologic lesions in order to identify myeloid cell types and immune cell networks associated with tissue damage.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Reyes M, Vickers D, Billman K, Eisenhaure T, Hoover P, Browne EP, Rao DA, Hacohen N, Blainey PC. Multiplexed enrichment and genomic profiling of peripheral blood cells reveal subset-specific immune signatures. Sci Adv. 2019 Jan; 5(1):eaau9223. PMID: 30746468.
    Citations:    
  2. Sade-Feldman M, Yizhak K, Bjorgaard SL, Ray JP, de Boer CG, Jenkins RW, Lieb DJ, Chen JH, Frederick DT, Barzily-Rokni M, Freeman SS, Reuben A, Hoover PJ, Villani AC, Ivanova E, Portell A, Lizotte PH, Aref AR, Eliane JP, Hammond MR, Vitzthum H, Blackmon SM, Li B, Gopalakrishnan V, Reddy SM, Cooper ZA, Paweletz CP, Barbie DA, Stemmer-Rachamimov A, Flaherty KT, Wargo JA, Boland GM, Sullivan RJ, Getz G, Hacohen N. Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma. Cell. 2019 Jan 10; 176(1-2):404. PMID: 30633907.
    Citations:    Fields:    
  3. Sade-Feldman M, Yizhak K, Bjorgaard SL, Ray JP, de Boer CG, Jenkins RW, Lieb DJ, Chen JH, Frederick DT, Barzily-Rokni M, Freeman SS, Reuben A, Hoover PJ, Villani AC, Ivanova E, Portell A, Lizotte PH, Aref AR, Eliane JP, Hammond MR, Vitzthum H, Blackmon SM, Li B, Gopalakrishnan V, Reddy SM, Cooper ZA, Paweletz CP, Barbie DA, Stemmer-Rachamimov A, Flaherty KT, Wargo JA, Boland GM, Sullivan RJ, Getz G, Hacohen N. Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma. Cell. 2018 Nov 01; 175(4):998-1013.e20. PMID: 30388456.
    Citations:    Fields:    
  4. Gillies CE, Putler R, Menon R, Otto E, Yasutake K, Nair V, Hoover P, Lieb D, Li S, Eddy S, Fermin D, McNulty MT, Hacohen N, Kiryluk K, Kretzler M, Wen X, Sampson MG. An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome. Am J Hum Genet. 2018 08 02; 103(2):232-244. PMID: 30057032.
    Citations: 1     Fields:    
  5. Hoover PJ, Costenbader KH. Insights into the epidemiology and management of lupus nephritis from the US rheumatologist's perspective. Kidney Int. 2016 09; 90(3):487-92. PMID: 27344205.
    Citations: 3     Fields:    Translation:Humans
  6. Hoover PJ, Lewis RS. Stoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A. 2011 Aug 09; 108(32):13299-304. PMID: 21788510.
    Citations: 59     Fields:    Translation:HumansCells
  7. Park CY*, Hoover PJ*, Mullins FM, Bachhawat P, Covington ED, Raunser S, Walz T, Garcia KC, Dolmetsch RE, Lewis RS. *Co-first author. STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell. 2009; 5(136):876-90.
  8. Reed C, Sturbaum GD, Hoover PJ, Sterling CR. Cryptosporidium parvum mixed genotypes detected by PCR-restriction fragment length polymorphism analysis. Appl Environ Microbiol. 2002 Jan; 68(1):427-9. PMID: 11772657.
    Citations: 14     Fields:    Translation:Animals
  9. Sturbaum GD, Reed C, Hoover PJ, Jost BH, Marshall MM, Sterling CR. Species-specific, nested PCR-restriction fragment length polymorphism detection of single Cryptosporidium parvum oocysts. Appl Environ Microbiol. 2001 Jun; 67(6):2665-8. PMID: 11375178.
    Citations: 19     Fields:    Translation:Animals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.