Paul James Hoover, M.D.,Ph.D.
Instructor in Medicine
Brigham and Women's Hospital
Brigham and Womens Hospital
75 Francis St
Boston MA 02115
|Broad Institute, Cambridge, Ma||Post-doctoral Fellow, Hacohen Lab|
|Brigham & Women's Hospital, Boston, Ma||2018||Rheumatology Fellowship|
|Brigham & Women's Hospital, Boston, Ma||2014||Internal Medicine Residency|
|Stanford School of Medicine, Stanford, Ca||MD, PhD||2012||Molec. & Cell Phys.|
|NIH, Bethesda, MD||2003||Fellow|
|Univ. of Arizona, Tucson, Az||BS||2002||Molec. & Cell Bio.|
Investigator Award, Rheumatology Research Foundation
Master Class in Lupus Basic and Clinical Sciences
2017 - 2019
Career Development Award, Lupus Foundation of America
Clinical Fellow Teaching Award, Brigham and Women's Hospital
2003 - 2012
Medical Scientist Training Program Fellowship, Stanford School of Medicine
Phi Beta Kappa, Univ. of Az
1998 - 2002
Student Achievement Award, undergraduate tuition scholarship
My efforts as a physician-scientist are focused on understanding how infiltrating immune cells drive tissue damage in autoimmune kidney disease with a focus on lupus nephritis. As a post-doctoral fellow at Broad Institute in the Hacohen laboratory, I develop and apply cutting edge technologies to profile autoimmune human kidney tissue to identify cell-types and cell networks associated with distinct tissue lesions for follow-up mechanistic studies. At Brigham and Women's Hospital and Harvard Medical School, I see rheumatology patients one half day per week, and provide inpatient service 2 weeks per year; I also teach the pathophysiology of systemic lupus erythematosus to medical students.
The research activities and funding listed below are automatically derived from
NIH ExPORTER and other sources, which might result in incorrect or missing items.
to make corrections and additions.
Aug 1, 2017 - Aug 1, 2019
Kidney Precision Medicine through Interrogation of RNA in the Kidney
Role Description: Develop and apply parallel, complimentary approaches to define human kidney cell type, disease state specific transcriptomic profiles with 2D & 3D tissue spatial characterization.
Jun 30, 2017 - Jul 1, 2019
Lupus Foundation of America
Mapping disease-specific immune cells in lupus nephritis tissue
Role Description: This project leverages signatures generated from single cell RNA sequencing of lupus nephritis biopsies to map the myeloid cell compartment across tissue from clinical samples. The goal is to define the organizational landscape between myeloid cells, their cellular neighborhood, and histopathologic lesions in order to identify myeloid cell types and immune cell networks associated with tissue damage.
Role: Principal Investigator
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