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Paul James Hoover, M.D.,Ph.D.

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Broad Institute, Cambridge, MaPost-doctoral Fellow, Hacohen Lab
Brigham & Women's Hospital, Boston, Ma2018Rheumatology Fellowship
Brigham & Women's Hospital, Boston, Ma2014Internal Medicine Residency
Stanford School of Medicine, Stanford, CaMD, PhD2012Molec. & Cell Phys.
NIH, Bethesda, MD2003Fellow
Univ. of Arizona, Tucson, AzBS2002Molec. & Cell Bio.
Investigator Award, Rheumatology Research Foundation
Master Class in Lupus Basic and Clinical Sciences
2017 - 2019
Career Development Award, Lupus Foundation of America
Clinical Fellow Teaching Award, Brigham and Women's Hospital
2003 - 2012
Medical Scientist Training Program Fellowship, Stanford School of Medicine
Phi Beta Kappa, Univ. of Az
1998 - 2002
Student Achievement Award, undergraduate tuition scholarship

Dr. Paul Hoover is a physician-scientist in the Division of Rheumatology at the Brigham and Women’s Hospital with a clinical and research focus on lupus nephritis and related myeloid biology. As an Instructor he has worked at the Broad Institute in the Hacohen laboratory to develop a unique scientific program with the goal of understanding how myeloid cells drive tissue damage in lupus kidneys. His scientific program is composed of three major efforts: 1) identification of associations between novel myeloid states and gene programs with kidney lesions in clinical samples that can be experimentally tested; 2) utilization of lupus mouse models to test hypotheses from studying human samples; 3) identification of genetic drivers of myeloid differentiation, gene programs, and key functions in kidneys using CRISPR screens. Dr. Hoover earned his medical degree and doctorate in cellular physiology from Stanford University School of Medicine. He completed residency training and a fellowship in Rheumatology at Brigham and Women’s Hospital.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. Aug 1, 2017 - Aug 1, 2019
    Kidney Precision Medicine through Interrogation of RNA in the Kidney
    Role Description: Develop and apply parallel, complimentary approaches to define human kidney cell type, disease state specific transcriptomic profiles with 2D & 3D tissue spatial characterization.
    Role: Co-investigator
  2. Jun 30, 2017 - Jul 1, 2019
    Lupus Foundation of America
    Mapping disease-specific immune cells in lupus nephritis tissue
    Role Description: This project leverages signatures generated from single cell RNA sequencing of lupus nephritis biopsies to map the myeloid cell compartment across tissue from clinical samples. The goal is to define the organizational landscape between myeloid cells, their cellular neighborhood, and histopathologic lesions in order to identify myeloid cell types and immune cell networks associated with tissue damage.
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.