Harvard Catalyst Profiles

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Rafael Machado Rezende, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Moreira TG, Mangani D, Cox LM, Leibowitz J, Lobo ELC, Oliveira MA, Gauthier CD, Nakagaki BN, Willocq V, Song A, Guo L, Lima DCA, Murugaiyan G, Butovsky O, Gabriely G, Anderson AC, Rezende RM, Faria AMC, Weiner HL. PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis. Nat Commun. 2021 08 13; 12(1):4907. PMID: 34389726.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Moreira TG, Matos KTF, De Paula GS, Santana TMM, Da Mata RG, Pansera FC, Cortina AS, Spinola MG, Keppeke GD, Jacob J, Palejwala V, Chen K, Izzy S, Healey BC, Rezende RM, Dedivitis RA, Shailubhai K, Weiner HL. Nasal Administration of Anti-CD3 Monoclonal Antibody (Foralumab) Reduces Lung Inflammation and Blood Inflammatory Biomarkers in Mild to Moderate COVID-19 Patients: A Pilot Study. Front Immunol. 2021; 12:709861. PMID: 34475873.
    Citations:    Fields:    
  3. Antunes MM, Diniz AB, Castro-Oliveira HM, Mendes GAM, Freitas-Lopes MA, de Oliveira Costa KM, Bicalho KM, Nakagaki BNL, Mattos MS, de Miranda CDM, Lopes ME, Melão ACR, Carvalho-Gontijo R, Radhakrishnnan S, Ricci M, Rezende RM, Menezes GB. Chronic ingestion of Primex-Z, compared with other common fat sources, drives worse liver injury and enhanced susceptibility to bacterial infections. Nutrition. 2021 01; 81:110938. PMID: 32739658.
    Citations: 1     Fields:    Translation:Animals
  4. Mattos MS, Lopes ME, de Araujo AM, Alvarenga DM, Nakagaki BN, Mafra K, de Miranda CDM, Diniz AB, Antunes MM, Lopes MAF, Rezende RM, Menezes GB. Prolonged neutrophil survival at necrotic sites is a fundamental feature for tissue recovery and resolution of hepatic inflammation. J Leukoc Biol. 2020 10; 108(4):1199-1213. PMID: 32422690.
    Citations:    Fields:    Translation:AnimalsCells
  5. Diniz AB, Antunes MM, Lacerda VAS, Nakagaki BN, Freitas Lopes MA, Castro-Oliveira HM, Mattos MS, Mafra K, de Miranda CDM, de Oliveira Costa KM, Lopes ME, Alvarenga DM, Carvalho-Gontijo R, Marchesi SC, Lacerda DR, de Araújo AM, de Carvalho É, David BA, Santos MM, Lima CX, Silva Gomes JA, Minto Fontes Cal TC, de Souza BR, Couto CA, Faria LC, Teixeira Vidigal PV, Matos Ferreira AV, Radhakrishnnan S, Ricci M, Oliveira AG, Rezende RM, Menezes GB. Imaging and immunometabolic phenotyping uncover changes in the hepatic immune response in the early phases of NAFLD. JHEP Rep. 2020 Aug; 2(4):100117. PMID: 32695965.
  6. Cramer A, de Lima Oliveira BC, Leite PG, Rodrigues DH, Brant F, Esper L, Pimentel PMO, Rezende RM, Rachid MA, Teixeira AL, Faria AMC, Teixeira MM, Machado FS. Role of SOCS2 in the Regulation of Immune Response and Development of the Experimental Autoimmune Encephalomyelitis. Mediators Inflamm. 2019; 2019:1872593. PMID: 31949423.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Liu S, Rezende RM, Moreira TG, Tankou SK, Cox LM, Wu M, Song A, Dhang FH, Wei Z, Costamagna G, Weiner HL. Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila. Cell Host Microbe. 2019 12 11; 26(6):779-794.e8. PMID: 31784260.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  8. Rezende RM, Nakagaki BN, Moreira TG, Lopes JR, Kuhn C, Tatematsu BK, Boulenouar S, Maghzi AH, Rubino S, Menezes GB, Chitnis T, Weiner HL. ?d T Cell-Secreted XCL1 Mediates Anti-CD3-Induced Oral Tolerance. J Immunol. 2019 11 15; 203(10):2621-2629. PMID: 31578268.
    Citations: 5     Fields:    Translation:AnimalsCells
  9. Rezende RM, Lopes ME, Menezes GB, Weiner HL. Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy. J Vis Exp. 2019 08 09; (150). PMID: 31449231.
    Citations: 1     Fields:    Translation:Animals
  10. Mafra K, Nakagaki BN, Castro Oliveira HM, Rezende RM, Antunes MM, Menezes GB. The liver as a nursery for leukocytes. J Leukoc Biol. 2019 09; 106(3):687-693. PMID: 31107980.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Brito LC, Peçanha T, Fecchio RY, Rezende RA, Sousa P, DA Silva-Júnior N, Abreu A, Silva G, Mion-Junior D, Halliwill JR, Forjaz CLM. Morning versus Evening Aerobic Training Effects on Blood Pressure in Treated Hypertension. Med Sci Sports Exerc. 2019 04; 51(4):653-662. PMID: 30489494.
    Citations: 9     Fields:    Translation:Humans
  12. Alvarenga DM, Mattos MS, Lopes ME, Marchesi SC, Araújo AM, Nakagaki BN, Santos MM, David BA, De Souza VA, Carvalho É, Sousa Pereira RV, Marques PE, Mafra K, de Castro Oliveira HM, de Miranda CDM, Diniz AB, de Oliveira THC, Teixeira MM, Rezende RM, Antunes MM, Menezes GB. Paradoxical Role of Matrix Metalloproteinases in Liver Injury and Regeneration after Sterile Acute Hepatic Failure. Cells. 2018 Dec 06; 7(12). PMID: 30563238.
    Citations: 5     Fields:    
  13. Rubino SJ, Mayo L, Wimmer I, Siedler V, Brunner F, Hametner S, Madi A, Lanser A, Moreira T, Donnelly D, Cox L, Rezende RM, Butovsky O, Lassmann H, Weiner HL. Acute microglia ablation induces neurodegeneration in the somatosensory system. Nat Commun. 2018 11 01; 9(1):4578. PMID: 30385785.
    Citations: 16     Fields:    Translation:AnimalsCells
  14. Moreira TG, Horta LS, Gomes-Santos AC, Oliveira RP, Queiroz NMGP, Mangani D, Daniel B, Vieira AT, Liu S, Rodrigues AM, Gomes DA, Gabriely G, Ferreira E, Weiner HL, Rezende RM, Nagy L, Faria AMC. CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-ß-producing macrophages and T cells. Mucosal Immunol. 2019 01; 12(1):188-199. PMID: 30279515.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  15. Nakagaki BN, Mafra K, de Carvalho É, Lopes ME, Carvalho-Gontijo R, de Castro-Oliveira HM, Campolina-Silva GH, de Miranda CDM, Antunes MM, Silva ACC, Diniz AB, Alvarenga DM, Lopes MAF, de Souza Lacerda VA, Mattos MS, Araújo AM, Vidigal PVT, Lima CX, Mahecha GAB, Madeira MFM, Fernandes GR, Nogueira RF, Moreira TG, David BA, Rezende RM, Menezes GB. Immune and metabolic shifts during neonatal development reprogram liver identity and function. J Hepatol. 2018 12; 69(6):1294-1307. PMID: 30171870.
    Citations: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  16. Rezende RM, Lanser AJ, Rubino S, Kuhn C, Skillin N, Moreira TG, Liu S, Gabriely G, David BA, Menezes GB, Weiner HL. ?d T cells control humoral immune response by inducing T follicular helper cell differentiation. Nat Commun. 2018 08 08; 9(1):3151. PMID: 30089795.
    Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
  17. Araujo AM, Antunes MM, Mattos MS, Diniz AB, Alvarenga DM, Nakagaki BN, Carvalho É, Lacerda VAS, Carvalho-Gontijo R, Goulart J, Mafra K, Freitas-Lopes MA, Oliveira HMC, Dutra CM, David BA, Mendes Silva A, Quesniaux V, Ryffel B, Oliveira SC, Barber GN, Mansur DS, Cunha TM, Rezende RM, Oliveira AG, Menezes GB. Liver Immune Cells Release Type 1 Interferon Due to DNA Sensing and Amplify Liver Injury from Acetaminophen Overdose. Cells. 2018 Jul 27; 7(8). PMID: 30060463.
    Citations: 4     Fields:    
  18. Moreira TG, Gomes-Santos AC, Horta LS, Goncalves MC, Santiago AF, Lauar JG, Dos Reis DS, Castro-Junior AB, Lemos L, Guimarães M, Aguilar EC, Pap A, Amaral JF, Alvarez-Leite JI, Cara DC, Rezende RM, Nagy L, Faria AMC, Maioli TU. Consumption of conjugated linoleic acid (CLA)-supplemented diet during colitis development ameliorates gut inflammation without causing steatosis in mice. J Nutr Biochem. 2018 07; 57:238-245. PMID: 29800810.
    Citations:    Fields:    Translation:Animals
  19. Nakagaki BN, Vieira AT, Rezende RM, David BA, Menezes GB. Tissue macrophages as mediators of a healthy relationship with gut commensal microbiota. Cell Immunol. 2018 08; 330:16-26. PMID: 29422270.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  20. Rezende RM, Weiner HL. Cellular Components and Mechanisms of Oral Tolerance Induction. Crit Rev Immunol. 2018; 38(3):207-231. PMID: 30004858.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  21. Nakagaki BN, Freitas-Lopes MA, Carvalho É, Carvalho-Gontijo R, Castro-Oliveira HM, Rezende RM, Cara DC, Santos MM, Lopes RP, David BA, Menezes GB. Generation of a triple-fluorescent mouse strain allows a dynamic and spatial visualization of different liver phagocytes in vivo. An Acad Bras Cienc. 2019; 91(suppl 1):e20170317. PMID: 29044327.
    Citations:    Fields:    Translation:AnimalsCells
  22. Antunes MM, Araújo AM, Diniz AB, Pereira RVS, Alvarenga DM, David BA, Rocha RM, Lopes MAF, Marchesi SC, Nakagaki BN, Carvalho É, Marques PE, Ryffel B, Quesniaux V, Guabiraba Brito R, Filho JCA, Cara DC, Rezende RM, Menezes GB. IL-33 signalling in liver immune cells enhances drug-induced liver injury and inflammation. Inflamm Res. 2018 Jan; 67(1):77-88. PMID: 29032512.
    Citations: 6     Fields:    Translation:AnimalsCells
  23. Lanser AJ, Rezende RM, Rubino S, Lorello PJ, Donnelly DJ, Xu H, Lau LA, Dulla CG, Caldarone BJ, Robson SC, Weiner HL. Disruption of the ATP/adenosine balance in CD39-/- mice is associated with handling-induced seizures. Immunology. 2017 12; 152(4):589-601. PMID: 28742222.
    Citations: 11     Fields:    Translation:Animals
  24. Rezende RM, Weiner HL. History and mechanisms of oral tolerance. Semin Immunol. 2017 04; 30:3-11. PMID: 28774470.
    Citations: 13     Fields:    Translation:HumansAnimals
  25. Gabriely G, da Cunha AP, Rezende RM, Kenyon B, Madi A, Vandeventer T, Skillin N, Rubino S, Garo L, Mazzola MA, Kolypetri P, Lanser AJ, Moreira T, Faria AMC, Lassmann H, Kuchroo V, Murugaiyan G, Weiner HL. Targeting latency-associated peptide promotes antitumor immunity. Sci Immunol. 2017 May 19; 2(11). PMID: 28763794.
    Citations: 17     Fields:    
  26. David BA, Rubino S, Moreira TG, Freitas-Lopes MA, Araújo AM, Paul NE, Rezende RM, Menezes GB. Isolation and high-dimensional phenotyping of gastrointestinal immune cells. Immunology. 2017 05; 151(1):56-70. PMID: 28039862.
    Citations: 8     Fields:    Translation:AnimalsCells
  27. Gomes-Santos AC, de Oliveira RP, Moreira TG, Castro-Junior AB, Horta BC, Lemos L, de Almeida LA, Rezende RM, Cara DC, Oliveira SC, Azevedo VA, Miyoshi A, Faria AM. Hsp65-Producing Lactococcus lactis Prevents Inflammatory Intestinal Disease in Mice by IL-10- and TLR2-Dependent Pathways. Front Immunol. 2017; 8:30. PMID: 28194152.
    Citations: 14     Fields:    
  28. Kuhn C, Rezende RM, M'Hamdi H, da Cunha AP, Weiner HL. IL-6 Inhibits Upregulation of Membrane-Bound TGF-ß 1 on CD4+ T Cells and Blocking IL-6 Enhances Oral Tolerance. J Immunol. 2017 02 01; 198(3):1202-1209. PMID: 28039301.
    Citations: 4     Fields:    Translation:AnimalsCells
  29. Kuhn C, Rezende RM, da Cunha AP, Valette F, Quintana FJ, Chatenoud L, Weiner HL. Mucosal administration of CD3-specific monoclonal antibody inhibits diabetes in NOD mice and in a preclinical mouse model transgenic for the CD3 epsilon chain. J Autoimmun. 2017 01; 76:115-122. PMID: 27745778.
    Citations: 4     Fields:    Translation:AnimalsCells
  30. David BA, Rezende RM, Antunes MM, Santos MM, Freitas Lopes MA, Diniz AB, Sousa Pereira RV, Marchesi SC, Alvarenga DM, Nakagaki BN, Araújo AM, Dos Reis DS, Rocha RM, Marques PE, Lee WY, Deniset J, Liew PX, Rubino S, Cox L, Pinho V, Cunha TM, Fernandes GR, Oliveira AG, Teixeira MM, Kubes P, Menezes GB. Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice. Gastroenterology. 2016 12; 151(6):1176-1191. PMID: 27569723.
    Citations: 51     Fields:    Translation:AnimalsCells
  31. Pereira TB, Setotaw TA, Santos DN, Mendes AN, Salgado SM, Carvalho GR, Rezende RM. Identification of microsatellite markers in coffee associated with resistance to Meloidogyne exigua. Genet Mol Res. 2016 Jul 29; 15(3). PMID: 27525876.
    Citations:    Fields:    Translation:AnimalsCells
  32. Rezende RM, Weiner HL. Inducing tolerance one antigen at a time. Nat Biotechnol. 2016 05 06; 34(5):515-7. PMID: 27153283.
    Citations:    Fields:    Translation:Humans
  33. Liu S, da Cunha AP, Rezende RM, Cialic R, Wei Z, Bry L, Comstock LE, Gandhi R, Weiner HL. The Host Shapes the Gut Microbiota via Fecal MicroRNA. . 2016 Jan 13; 19(1):32-43. PMID: 26764595.
    Citations: 187     Translation:HumansAnimalsCells
  34. Takenaka MC, Araujo LP, Maricato JT, Nascimento VM, Guereschi MG, Rezende RM, Quintana FJ, Basso AS. Norepinephrine Controls Effector T Cell Differentiation through ß2-Adrenergic Receptor-Mediated Inhibition of NF-?B and AP-1 in Dendritic Cells. J Immunol. 2016 Jan 15; 196(2):637-44. PMID: 26663782.
    Citations: 22     Fields:    Translation:AnimalsCells
  35. Rezende RM, da Cunha AP, Kuhn C, Rubino S, M'Hamdi H, Gabriely G, Vandeventer T, Liu S, Cialic R, Pinheiro-Rosa N, Oliveira RP, Gaublomme JT, Obholzer N, Kozubek J, Pochet N, Faria AMC, Weiner HL. Identification and characterization of latency-associated peptide-expressing ?d T cells. Nat Commun. 2015 Dec 08; 6:8726. PMID: 26644347.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  36. da Cunha AP, Wu HY, Rezende RM, Vandeventer T, Weiner HL. In vivo anti-LAP mAb enhances IL-17/IFN-? responses and abrogates anti-CD3-induced oral tolerance. Int Immunol. 2015 Feb; 27(2):73-82. PMID: 25194146.
    Citations: 9     Fields:    Translation:AnimalsCells
  37. Novaes RD, Gonçalves RV, Cupertino MC, Araújo BM, Rezende RM, Santos EC, Leite JP, Matta SL. The energy density of laser light differentially modulates the skin morphological reorganization in a murine model of healing by secondary intention. Int J Exp Pathol. 2014 Apr; 95(2):138-46. PMID: 24354418.
    Citations: 6     Fields:    Translation:Animals
  38. Paiva-Lima P, Rezende RM, Leite R, Duarte ID, Bakhle Y, Francischi JN. Crucial involvement of actin filaments in celecoxib and morphine analgesia in a model of inflammatory pain. J Pain Res. 2012; 5:535-45. PMID: 23166451.
    Citations: 1     
  39. Rezende RM, Oliveira RP, Medeiros SR, Gomes-Santos AC, Alves AC, Loli FG, Guimarães MA, Amaral SS, da Cunha AP, Weiner HL, Azevedo V, Miyoshi A, Faria AM. Hsp65-producing Lactococcus lactis prevents experimental autoimmune encephalomyelitis in mice by inducing CD4+LAP+ regulatory T cells. J Autoimmun. 2013 Feb; 40:45-57. PMID: 22939403.
    Citations: 33     Fields:    Translation:AnimalsCells
  40. Saito VM, Rezende RM, Teixeira AL. Cannabinoid modulation of neuroinflammatory disorders. Curr Neuropharmacol. 2012 Jun; 10(2):159-66. PMID: 23204985.
    Citations: 13     Fields:    
  41. Rezende RM, Paiva-Lima P, Dos Reis WG, Camêlo VM, Faraco A, Bakhle YS, Francischi JN. Endogenous opioid and cannabinoid mechanisms are involved in the analgesic effects of celecoxib in the central nervous system. Pharmacology. 2012; 89(3-4):127-36. PMID: 22415159.
    Citations: 6     Fields:    Translation:Animals
  42. Rezende RM, Paiva-Lima P, Dos Reis WG, Camêlo VM, Bakhle YS, de Francischi JN. Celecoxib induces tolerance in a model of peripheral inflammatory pain in rats. Neuropharmacology. 2010 Nov; 59(6):551-7. PMID: 20691196.
    Citations: 6     Fields:    Translation:Animals
  43. Gassani BC, Rezende RM, Paiva-Lima P, Ferreira-Alves DL, dos Reis WG, Bakhle YS, de Francischi JN. Is the sulphonamide radical in the celecoxib molecule essential for its analgesic activity? Pharmacol Res. 2010 Nov; 62(5):439-43. PMID: 20600917.
    Citations: 1     Fields:    Translation:Animals
  44. Correa JD, Paiva-Lima P, Rezende RM, Dos Reis WG, Ferreira-Alves DL, Bakhle YS, Francischi JN. Peripheral mu-, kappa- and delta-opioid receptors mediate the hypoalgesic effect of celecoxib in a rat model of thermal hyperalgesia. Life Sci. 2010 Jun 19; 86(25-26):951-6. PMID: 20451533.
    Citations: 5     Fields:    Translation:Animals
  45. Rezende RM, Dos Reis WG, Duarte ID, Lima PP, Bakhle YS, de Francischi JN. The analgesic actions of centrally administered celecoxib are mediated by endogenous opioids. Pain. 2009 Mar; 142(1-2):94-100. PMID: 19186002.
    Citations: 6     Fields:    Translation:Animals
  46. Menezes GB, Rezende RM, Pereira-Silva PE, Klein A, Cara DC, Francischi JN. Differential involvement of cyclooxygenase isoforms in neutrophil migration in vivo and in vitro. Eur J Pharmacol. 2008 Nov 19; 598(1-3):118-22. PMID: 18823975.
    Citations: 14     Fields:    Translation:AnimalsCells
  47. Rezende RM, França DS, Menezes GB, dos Reis WG, Bakhle YS, Francischi JN. Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain. Br J Pharmacol. 2008 Feb; 153(4):760-8. PMID: 18157167.
    Citations: 8     Fields:    Translation:Animals
  48. França DS, Ferreira-Alves DL, Duarte ID, Ribeiro MC, Rezende RM, Bakhle YS, Francischi JN. Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan. Neuropharmacology. 2006 Jul; 51(1):37-43. PMID: 16620880.
    Citations: 6     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.