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Muthiah Vaduganathan, M.D.

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Overview
Muthiah Vaduganathan, MD MPH is a cardiologist at Brigham and Women's Hospital and Harvard Medical School (Boston, MA).

He entered the medical field as a part of Northwestern University's Honors Program in Medical Education (HPME). Through this 7-year longitudinal program, he received a bachelor's degree in biological sciences (2008) and a medical doctorate (2012). During his time at Northwestern University (Chicago, IL), he also earned a Master of Public Health degree (2012) and was inducted into the Alpha Omega Alpha Honor Medical Society. He subsequently completed his residency training in Internal Medicine at Massachusetts General Hospital (Boston, MA), and served as a Chief Medical Resident at Newton-Wellesley Hospital (Newton, MA).

He is interested in drug development and clinical trials of cardiometabolic therapies. He has authored or co-authored more than 300 peer-reviewed publications. Dr. Vaduganathan serves on the editorial boards of the European Journal of Heart Failure, JACC Heart Failure (Social Media / CME Editor), and JACC (FIT / Early Career Section Editor). He is involved in a FDA Think Tank on improving future clinical trials in HF. He participates as a Clinical Endpoints Committee member for ongoing advanced-phase trials in HF / post-MI LV dysfunction and as a site investigator for DELIVER (dapagliflozin in HFpEF) and SELECT (semaglutide in obese/overweight) at Brigham and Women’s Hospital.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Docherty KF, Vaduganathan M, Solomon SD, McMurray JJV. Sacubitril/Valsartan: Neprilysin Inhibition 5 Years After PARADIGM-HF. JACC Heart Fail. 2020 Oct; 8(10):800-810. PMID: 33004114.
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  2. Rangaswami J, Bhalla V, de Boer IH, Staruschenko A, Sharp JA, Singh RR, Lo KB, Tuttle K, Vaduganathan M, Ventura H, McCullough PA. Cardiorenal Protection With the Newer Antidiabetic Agents in Patients With Diabetes and Chronic Kidney Disease: A Scientific Statement From the American Heart Association. Circulation. 2020 Sep 28; CIR0000000000000920. PMID: 32981345.
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  3. Khan MS, Fonarow GC, McGuire DK, Hernandez AF, Vaduganathan M, Rosenstock J, Handelsman Y, Verma S, Anker SD, McMurray JJV, Kosiborod MN, Butler J. Glucagon-Like Peptide 1 Receptor Agonists and Heart Failure: The Need for Further Evidence Generation and Practice Guidelines Optimization. Circulation. 2020 Sep 22; 142(12):1205-1218. PMID: 32955939.
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  4. Rohde LE, Chatterjee NA, Vaduganathan M, Claggett B, Packer M, Desai AS, Zile M, Rouleau J, Swedberg K, Lefkowitz M, Shi V, McMurray JJV, Solomon SD. Sacubitril/Valsartan and Sudden Cardiac Death According to Implantable Cardioverter-Defibrillator Use and Heart Failure Cause: A PARADIGM-HF Analysis. JACC Heart Fail. 2020 Oct; 8(10):844-855. PMID: 32919916.
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  5. Sumarsono A, Lalani HS, Vaduganathan M, Navar AM, Fonarow GC, Das SR, Pandey A. Trends in Utilization and Cost of Low-Density Lipoprotein Cholesterol-Lowering Therapies Among Medicare Beneficiaries: An Analysis From the Medicare Part D Database. JAMA Cardiol. 2020 Sep 09. PMID: 32902560.
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  6. Cunningham JW, Vaduganathan M, Claggett BL, Jering KS, Bhatt AS, Rosenthal N, Solomon SD. Clinical Outcomes in Young US Adults Hospitalized With COVID-19. JAMA Intern Med. 2020 Sep 09. PMID: 32902580.
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  7. Cohen AJ, DiFrancesco MF, Solomon SD, Vaduganathan M. Angioedema in COVID-19. Eur Heart J. 2020 09 07; 41(34):3283-3284. PMID: 32441750.
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  8. Sumarsono A, Buckley LF, Machado SR, Wadhera RK, Warraich HJ, Desai RJ, Everett BM, McGuire DK, Fonarow GC, Butler J, Pandey A, Vaduganathan M. Medicaid Expansion and Utilization of Antihyperglycemic Therapies. Diabetes Care. 2020 Sep 04. PMID: 32887711.
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  9. Hamid A, Vaduganathan M, Oshunbade AA, Ayyalasomayajula KK, Kalogeropoulos AP, Lien LF, Shafi T, Hall ME, Butler J. Antihyperglycemic Therapies With Expansions of US Food and Drug Administration Indications to Reduce Cardiovascular Events: Prescribing Patterns Within an Academic Medical Center. J Cardiovasc Pharmacol. 2020 Sep; 76(3):313-320. PMID: 32569016.
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  10. Patel KV, Vaduganathan M. Targeting multiple domains of residual cardiovascular disease risk in patients with diabetes. Curr Opin Cardiol. 2020 Sep; 35(5):517-523. PMID: 32649348.
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  11. Frary JMC, Pareek M, Byrne C, Vaduganathan M, Biering-Sørensen T, Rujic D, Kragholm KH, Olesen TB, Olsen MH, Bhatt DL. Intensive blood pressure control appears to be effective and safe in patients with peripheral artery disease: The Systolic Blood Pressure Intervention Trial (SPRINT). Eur Heart J Cardiovasc Pharmacother. 2020 Aug 27. PMID: 32853332.
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  12. Dani SS, Ganatra S, Vaduganathan M. Angioedema with sacubitril/valsartan: Trial-level meta-analysis of over 14,000 patients and real-world evidence to date. Int J Cardiol. 2020 Aug 22. PMID: 32841619.
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  13. Luc JGY, Vervoort D, Percy E, Hirji S, Mann GK, Phan K, Dibas M, Vaduganathan M, Preventza O, Antonoff MB. Trends in Female Authorship: A Bibliometric Analysis of the Annals of Thoracic Surgery. Ann Thorac Surg. 2020 Aug 19. PMID: 32827552.
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  14. Pedersen LR, Kristensen AMD, Petersen SS, Vaduganathan M, Bhatt DL, Juel J, Byrne C, Leósdóttir M, Olsen MH, Pareek M. Prognostic implications of left ventricular hypertrophy diagnosed on electrocardiogram vs echocardiography. J Clin Hypertens (Greenwich). 2020 Aug 19. PMID: 32813895.
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  15. Stienen S, Bhatt A, Ferreira JP, Vaduganathan M, Januzzi J, Adams K, Tardif JC, Rossignol P, Zannad F. Bias in natriuretic peptide-guided heart failure trials: time to improve guideline adherence using alternative approaches. Heart Fail Rev. 2020 Aug 12. PMID: 32783110.
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  16. Merz LE, Sinnenberg L, Gerhard-Herman MD, Vaduganathan M. Extensive Arterial Thrombosis in Covid-19. Am J Cardiol. 2020 Aug 07. PMID: 32861422.
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  17. Reza N, Tahhan AS, Mahmud N, DeFilippis EM, Alrohaibani A, Vaduganathan M, Greene SJ, Ho AH, Fonarow GC, Butler J, O'Connor C, Fiuzat M, Vardeny O, Piña IL, Lindenfeld J, Jessup M. Representation of Women Authors in International Heart Failure Guidelines and Contemporary Clinical Trials. Circ Heart Fail. 2020 Aug; 13(8):e006605. PMID: 32757645.
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  18. Vaduganathan M, McMurray JJV, Solomon SD. Angiotensin receptor-neprilysin inhibition in heart failure with preserved ejection fraction: lessons from PARAGON-HF. Eur J Heart Fail. 2020 Aug 02. PMID: 32741093.
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  19. Cunningham JW, Vaduganathan M, Claggett BL, McMurray JJV, Solomon SD. Reply: The PARAGON-HF Trial: Toward Extension to Patients With HF Middle Range Ejection Fraction. JACC Heart Fail. 2020 Aug; 8(8):698-699. PMID: 32731952.
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  20. Krogager ML, Pareek M, Kragholm KH, Byrne C, Vaduganathan M, Biering-Sørensen T, Rujic D, Olesen TB, Olsen MH, Bhatt DL. Intensive versus standard blood pressure control and vascular procedures: Insights from the Systolic Blood Pressure Intervention Trial (SPRINT). Eur Heart J Cardiovasc Pharmacother. 2020 Jul 28. PMID: 32722801.
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  21. Bhatia K, Uberoi G, Bajaj NS, Jain V, Arora S, Tafur A, Bangalore S, Olin JW, Piazza G, Goldhaber SZ, Vaduganathan M, Qamar A. Meta-Analysis Comparing Direct Oral Anticoagulants to Low Molecular Weight Heparin for Treatment of Venous Thromboembolism in Patients With Cancer. Am J Cardiol. 2020 Oct 15; 133:175-178. PMID: 32807386.
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  22. Yong CM, Han JJ, Vaduganathan M. Picking Up the Torch: Our Mission as the New FIT & EC Section Editors. J Am Coll Cardiol. 2020 Jul 14; 76(2):221-222. PMID: 32646572.
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  23. Cunningham JW, Vaduganathan M, Claggett BL, McMurray JJV, Solomon SD. Reply: NT-proBNP in Heart Failure With Preserved Ejection Fraction: Quest for a Marker Reflecting the Truth. JACC Heart Fail. 2020 Jul; 8(7):597-598. PMID: 32616172.
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  24. Vaduganathan M, Jhund PS, Claggett BL, Packer M, Widimský J, Seferovic P, Rizkala A, Lefkowitz M, Shi V, McMurray JJV, Solomon SD. A putative placebo analysis of the effects of sacubitril/valsartan in heart failure across the full range of ejection fraction. Eur Heart J. 2020 Jul 01; 41(25):2356-2362. PMID: 32221596.
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  25. Vaduganathan M, van Meijgaard J, Mehra MR, Joseph J, O'Donnell CJ, Warraich HJ. Prescription Fill Patterns for Commonly Used Drugs During the COVID-19 Pandemic in the United States. JAMA. 2020 06 23; 323(24):2524-2526. PMID: 32463459.
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  26. Khan MS, Vaduganathan M, Butler J. Orphan Drug Development in Cardiovascular Medicine. Circ Cardiovasc Qual Outcomes. 2020 Jul; 13(7):e006509. PMID: 32552063.
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  27. Leiva O, Bhatt AS, Vaduganathan M. Innovation in Ambulatory Care of Heart Failure in the Era of Coronavirus Disease 2019. Heart Fail Clin. 2020 Oct; 16(4):433-440. PMID: 32888638.
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  28. Honigberg MC, Chang LS, McGuire DK, Plutzky J, Aroda VR, Vaduganathan M. Use of Glucagon-Like Peptide-1 Receptor Agonists in Patients With Type 2 Diabetes and Cardiovascular Disease: A Review. JAMA Cardiol. 2020 Jun 17. PMID: 32584928.
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  29. Segar MW, Patel KV, Vaduganathan M, Caughey MC, Butler J, Fonarow GC, Grodin JL, McGuire DK, Pandey A. Association of Long-term Change and Variability in Glycemia With Risk of Incident Heart Failure Among Patients With Type 2 Diabetes: A Secondary Analysis of the ACCORD Trial. Diabetes Care. 2020 Aug; 43(8):1920-1928. PMID: 32540922.
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  30. Luc JGY, Percy E, Hirji S, Vervoort D, Mann GK, Phan K, Dibas M, Vaduganathan M, Preventza O, Antonoff MB. Predictors of High-Impact Articles in The Annals of Thoracic Surgery. Ann Thorac Surg. 2020 Jun 12. PMID: 32540436.
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  31. Selvaraj S, Myhre PL, Vaduganathan M, Claggett BL, Matsushita K, Kitzman DW, Borlaug BA, Shah AM, Solomon SD. Application of Diagnostic Algorithms for Heart Failure With Preserved Ejection Fraction to the Community. JACC Heart Fail. 2020 Aug; 8(8):640-653. PMID: 32535127.
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  32. Pandey A, Vaduganathan M, Arora S, Qamar A, Mentz RJ, Shah SJ, Chang PP, Russell SD, Rosamond WD, Caughey MC. Temporal Trends in Prevalence and Prognostic Implications of Comorbidities Among Patients With Acute Decompensated Heart Failure: The ARIC Study Community Surveillance. Circulation. 2020 Jul 21; 142(3):230-243. PMID: 32486833.
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  33. Tahhan AS, Vaduganathan M, Greene SJ, Alrohaibani A, Raad M, Gafeer M, Mehran R, Fonarow GC, Douglas PS, Bhatt DL, Butler J. Enrollment of Older Patients, Women, and Racial/Ethnic Minority Groups in Contemporary Acute Coronary Syndrome Clinical Trials: A Systematic Review. JAMA Cardiol. 2020 Jun 01; 5(6):714-722. PMID: 32211813.
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  34. Bajaj NS, Vaduganathan M. Using antimatter to uncover what matters: metformin effects on myocardial efficiency in heart failure. Eur J Heart Fail. 2020 May 28. PMID: 32463971.
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  35. Bhatt AS, Moscone A, McElrath EE, Varshney AS, Claggett BL, Bhatt DL, Januzzi JL, Butler J, Adler DS, Solomon SD, Vaduganathan M. Fewer Hospitalizations for Acute Cardiovascular Conditions During the COVID-19 Pandemic. J Am Coll Cardiol. 2020 Jul 21; 76(3):280-288. PMID: 32470516.
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  36. Vaduganathan M, Claggett BL, Jhund PS, Cunningham JW, Pedro Ferreira J, Zannad F, Packer M, Fonarow GC, McMurray JJV, Solomon SD. Estimating lifetime benefits of comprehensive disease-modifying pharmacological therapies in patients with heart failure with reduced ejection fraction: a comparative analysis of three randomised controlled trials. Lancet. 2020 07 11; 396(10244):121-128. PMID: 32446323.
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  37. Vaduganathan M, Solomon SD. Renin-Angiotensin-Aldosterone System Inhibitors in Covid-19. Reply. N Engl J Med. 2020 06 11; 382(24):e92. PMID: 32427431.
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  38. Umarje S, Vaduganathan M, Levin R, Desai RJ. Medication Burden in Older Patients With Heart Failure: A Cohort Study of Medicare Beneficiaries. J Card Fail. 2020 Aug; 26(8):742-744. PMID: 32433932.
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  39. Hirji SA, Zogg CK, Vaduganathan M, Kiehm S, Percy ED, Yazdchi F, Pelletier M, Shah PB, Bhatt DL, O'Gara P, Kaneko T. Quantifying the Impact of Care Fragmentation on Outcomes After Transcatheter Aortic Valve Implantation. Am J Cardiol. 2020 08 01; 128:113-119. PMID: 32650903.
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  40. Hall ME, Vaduganathan M, Khan MS, Papadimitriou L, Long RC, Hernandez GA, Moore CK, Lennep BW, McMullan MR, Butler J. Reductions in Heart Failure Hospitalizations During the COVID-19 Pandemic. J Card Fail. 2020 06; 26(6):462-463. PMID: 32405232.
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  41. McCarthy CP, Murphy S, Rehman S, Jones-O'Connor M, Olshan DS, Cohen JA, Cui J, Singh A, Vaduganathan M, Januzzi JL, Wasfy JH. Home-Time After Discharge Among Patients With Type 2 Myocardial Infarction. J Am Heart Assoc. 2020 May 18; 9(10):e015978. PMID: 32384008.
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  42. Vaduganathan M, Fonarow GC, Greene SJ, DeVore AD, Kavati A, Sikirica S, Albert NM, Duffy CI, Hill CL, Patterson JH, Spertus JA, Thomas LE, Williams FB, Hernandez AF, Butler J. Contemporary Treatment Patterns and Clinical Outcomes of Comorbid Diabetes Mellitus and HFrEF: The CHAMP-HF Registry. JACC Heart Fail. 2020 06; 8(6):469-480. PMID: 32387066.
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  43. Cunningham JW, Vaduganathan M, Claggett BL, John JE, Desai AS, Lewis EF, Zile MR, Carson P, Jhund PS, Kober L, Pitt B, Shah SJ, Swedberg K, Anand IS, Yusuf S, McMurray JJV, Pfeffer MA, Solomon SD. Myocardial Infarction in Heart Failure With Preserved Ejection Fraction: Pooled Analysis of 3 Clinical Trials. JACC Heart Fail. 2020 Aug; 8(8):618-626. PMID: 32387067.
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  44. Redouane B, Greene SJ, Fudim M, Vaduganathan M, Ambrosy AP, Sun JL, DeVore AD, McNulty SE, Mentz RJ, Hernandez AF, Felker GM, Cooper LB, Borlaug BA, Velazquez EJ, Margulies KB, Sharma A. Effects of Liraglutide on Worsening Renal Function Among Patients With Heart Failure With Reduced Ejection Fraction: Insights From the FIGHT Trial. Circ Heart Fail. 2020 May; 13(5):e006758. PMID: 32362166.
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  45. Wadhera RK, Vaduganathan M, Jiang GY, Song Y, Xu J, Shen C, Bhatt DL, Yeh RW, Fonarow GC. Performance in Federal Value-Based Programs of Hospitals Recognized by the American Heart Association and American College of Cardiology for High-Quality Heart Failure and Acute Myocardial Infarction Care. JAMA Cardiol. 2020 May 01; 5(5):515-521. PMID: 32074242.
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  46. Vaduganathan M, Claggett BL, Juraschek SP, Solomon SD. Assessment of Long-term Benefit of Intensive Blood Pressure Control on Residual Life Span: Secondary Analysis of the Systolic Blood Pressure Intervention Trial (SPRINT). JAMA Cardiol. 2020 May 01; 5(5):576-581. PMID: 32101262.
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  47. Khan MS, Samman Tahhan A, Vaduganathan M, Greene SJ, Alrohaibani A, Anker SD, Vardeny O, Fonarow GC, Butler J. Trends in prevalence of comorbidities in heart failure clinical trials. Eur J Heart Fail. 2020 Jun; 22(6):1032-1042. PMID: 32293090.
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  48. Mahabir CA, DeFilippis EM, Aggarwal S, Bath A, Qamar A, Patel NK, Goldsweig AM, Vaduganathan M. The First 4 Years of Postmarketing Safety Surveillance Related to the MitraClip Device: A United States Food and Drug Administration MAUDE Experience. J Invasive Cardiol. 2020 May; 32(5):E130-E132. PMID: 32269176.
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  49. Vaduganathan M, Mehra MR. Reappraisal of the safety and effectiveness of Impella pumps. Nat Rev Cardiol. 2020 04; 17(4):203-204. PMID: 31937914.
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  50. Khan MS, Ochani RK, Shaikh A, Vaduganathan M, Khan SU, Fatima K, Yamani N, Mandrola J, Doukky R, Krasuski RA. Assessing the quality of reporting of harms in randomized controlled trials published in high impact cardiovascular journals. Eur Heart J Qual Care Clin Outcomes. 2020 04 01; 6(2):177-179. PMID: 31504381.
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  51. Vaduganathan M, Vardeny O, Michel T, McMurray JJV, Pfeffer MA, Solomon SD. Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19. N Engl J Med. 2020 04 23; 382(17):1653-1659. PMID: 32227760.
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  52. Cunningham JW, Vaduganathan M, Claggett BL, Zile MR, Anand IS, Packer M, Zannad F, Lam CSP, Janssens S, Jhund PS, Kober L, Rouleau J, Shah SJ, Chopra VK, Shi VC, Lefkowitz MP, Prescott MF, Pfeffer MA, McMurray JJV, Solomon SD. Effects of Sacubitril/Valsartan on N-Terminal Pro-B-Type Natriuretic Peptide in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2020 05; 8(5):372-381. PMID: 32241619.
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  53. Yadgir S, Johnson CO, Aboyans V, Adebayo OM, Adedoyin RA, Afarideh M, Alahdab F, Alashi A, Alipour V, Arabloo J, Azari S, Barthelemy CM, Benziger CP, Berman AE, Bijani A, Carrero JJ, Carvalho F, Daryani A, Durães AR, Esteghamati A, Farid TA, Farzadfar F, Fernandes E, Filip I, Gad MM, Hamidi S, Hay SI, Ilesanmi OS, Naghibi Irvani SS, Jürisson M, Kasaeian A, Kengne AP, Khan AR, Kisa A, Kisa S, Kolte D, Manafi N, Manafi A, Mensah GA, Mirrakhimov EM, Mohammad Y, Mokdad AH, Negoi RI, Thi Nguyen HL, Nguyen TH, Nixon MR, Otto CM, Patel S, Pilgrim T, Radfar A, Rawaf DL, Rawaf S, Rawasia WF, Rezapour A, Roever L, Saad AM, Saadatagah S, Senthilkumaran S, Sliwa K, Tesfay BE, Tran BX, Ullah I, Vaduganathan M, Vasankari TJ, Wolfe CDA, Yonemoto N, Roth GA. Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990-2017. Circulation. 2020 May 26; 141(21):1670-1680. PMID: 32223336.
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  54. Patel N, Chakraborty S, Bandyopadhyay D, Amgai B, Hajra A, Atti V, Das A, Ghosh RK, Deedwania PC, Aronow WS, Lavie CJ, Di Tullio MR, Vaduganathan M, Fonarow GC. Association between depression and readmission of heart failure: A national representative database study. Prog Cardiovasc Dis. 2020 Mar 26. PMID: 32224112.
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  55. McCarthy CP, Chang LS, Vaduganathan M. Training the Next Generation of Cardiometabolic Specialists. J Am Coll Cardiol. 2020 Mar 17; 75(10):1233-1237. PMID: 32164896.
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  56. Selvaraj S, Claggett BL, Böhm M, Anker SD, Vaduganathan M, Zannad F, Pieske B, Lam CSP, Anand IS, Shi VC, Lefkowitz MP, McMurray JJV, Solomon SD. Systolic Blood Pressure in Heart Failure With Preserved Ejection Fraction Treated With Sacubitril/Valsartan. J Am Coll Cardiol. 2020 Apr 14; 75(14):1644-1656. PMID: 32192799.
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  57. Ibrahim NE, Burnett JC, Butler J, Camacho A, Felker GM, Fiuzat M, O'Connor C, Solomon SD, Vaduganathan M, Zile MR, Januzzi JL. Natriuretic Peptides as Inclusion Criteria in Clinical Trials: A JACC: Heart Failure Position Paper. JACC Heart Fail. 2020 May; 8(5):347-358. PMID: 32171762.
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  58. Vaduganathan M, Singh A, Sharma A, Januzzi JL, Scirica BM, Butler J, Zannad F, McGuire DK, Cannon CP, Bhatt DL. Contemporary Trends in Prescription of Dipeptidyl Peptidase-4 Inhibitors in the Context of US Food and Drug Administration Warnings of Heart Failure Risk. Am J Cardiol. 2020 05 15; 125(10):1577-1581. PMID: 32245636.
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  59. Chandra A, Vaduganathan M, Lewis EF, Claggett B, McMurray JJV, Solomon SD. Reply: Health-Related Quality of Life in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2020 03; 8(3):245-246. PMID: 32131029.
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  60. Sumarsono A, Vaduganathan M, Ajufo E, Navar AM, Fonarow GC, Das SR, Pandey A. Contemporary Patterns of Medicare and Medicaid Utilization and Associated Spending on Sacubitril/Valsartan and Ivabradine in Heart Failure. JAMA Cardiol. 2020 Mar 01; 5(3):336-339. PMID: 31738371.
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  61. Honigberg MC, Vardeny O, Vaduganathan M. Practical Considerations for the Use of Sodium-Glucose Co-Transporter 2 Inhibitors in Heart Failure. Circ Heart Fail. 2020 02; 13(2):e006623. PMID: 32059632.
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  62. Sumarsono A, Sumarsono N, Das SR, Vaduganathan M, Agrawal D, Pandey A. Economic Burden Associated With Extended-Release vs Immediate-Release Drug Formulations Among Medicare Part D and Medicaid Beneficiaries. JAMA Netw Open. 2020 02 05; 3(2):e200181. PMID: 32108893.
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  63. Pandey A, Keshvani N, Khera R, Lu D, Vaduganathan M, Joynt Maddox KE, Das SR, Kumbhani DJ, Goyal A, Girotra S, Chan P, Fonarow GC, Matsouaka R, Wang TY, de Lemos JA. Temporal Trends in Racial Differences in 30-Day Readmission and Mortality Rates After Acute Myocardial Infarction Among Medicare Beneficiaries. JAMA Cardiol. 2020 Feb 01; 5(2):136-145. PMID: 31913411.
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  64. Segar MW, Vaduganathan M, McGuire DK, Basit M, Pandey A. Response to Comment on Segar et al. Machine Learning to Predict the Risk of Incident Heart Failure Hospitalization Among Patients With Diabetes: The WATCH-DM Risk Score. Diabetes Care 2019;42:2298-2306. Diabetes Care. 2020 02; 43(2):e26-e27. PMID: 31959648.
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  65. DeFilippis EM, Bajaj NS, Singh A, Malloy R, Givertz MM, Blankstein R, Bhatt DL, Vaduganathan M. Marijuana Use in Patients With Cardiovascular Disease: JACC Review Topic of the Week. J Am Coll Cardiol. 2020 01 28; 75(3):320-332. PMID: 31976871.
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  66. McCarthy CP, Vaduganathan M, Solomon E, Sakhuja R, Piazza G, Bhatt DL, Connors JM, Patel NK. Running thin: implications of a heparin shortage. Lancet. 2020 02 15; 395(10223):534-536. PMID: 31982034.
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  67. Hirji SA, Percy ED, Zogg CK, Vaduganathan M, Kiehm S, Pelletier M, Kaneko T. Thirty-Day Nonindex Readmissions and Clinical Outcomes After Cardiac Surgery. Ann Thorac Surg. 2020 08; 110(2):484-491. PMID: 31972128.
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  68. Myhre PL, Vaduganathan M, O'Meara E, Claggett BL, de Denus S, Jarolim P, Anand IS, Pitt B, Rouleau JL, Solomon SD, Pfeffer MA, Desai AS. Mechanistic Effects of Spironolactone on Cardiovascular and Renal Biomarkers in Heart Failure With Preserved Ejection Fraction: A TOPCAT Biorepository Study. Circ Heart Fail. 2020 01; 13(1):e006638. PMID: 31957468.
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  69. Bhatt AS, Vaduganathan M, Butler J. Growing Mismatch Between Evidence Generation and Implementation in Heart Failure. Am J Med. 2020 05; 133(5):525-527. PMID: 31958429.
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  70. Khan MS, Memon MM, Murad MH, Vaduganathan M, Greene SJ, Hall M, Triposkiadis F, Lam CSP, Shah AM, Butler J, Shah SJ. Left atrial function in heart failure with preserved ejection fraction: a systematic review and meta-analysis. Eur J Heart Fail. 2020 Mar; 22(3):472-485. PMID: 31919960.
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  71. Sharma A, Vaduganathan M, Ferreira JP, Liu Y, Bakris GL, Cannon CP, White WB, Zannad F. Clinical and Biomarker Predictors of Expanded Heart Failure Outcomes in Patients With Type 2 Diabetes Mellitus After a Recent Acute Coronary Syndrome: Insights From the EXAMINE Trial. J Am Heart Assoc. 2020 01 07; 9(1):e012797. PMID: 31902327.
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  72. Desai RJ, Wang SV, Vaduganathan M, Evers T, Schneeweiss S. Comparison of Machine Learning Methods With Traditional Models for Use of Administrative Claims With Electronic Medical Records to Predict Heart Failure Outcomes. JAMA Netw Open. 2020 01 03; 3(1):e1918962. PMID: 31922560.
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  73. Vaduganathan M, Claggett BL, Solomon SD. How Do SGLT-2 Inhibitors Work to Prevent Heart Failure? JACC Heart Fail. 2020 01; 8(1):67-69. PMID: 31896418.
    Citations:    
  74. Vaduganathan M, McCarthy CP, Ayers C, Bhatt DL, Kumbhani DJ, de Lemos JA, Fonarow GC, Pandey A. Longitudinal trajectories of hospital performance across targeted cardiovascular conditions in the USA. Eur Heart J Qual Care Clin Outcomes. 2020 01 01; 6(1):62-71. PMID: 31124567.
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  75. Buckley LF, Vaduganathan M, Lauffenburger JC, Machado SR, Fanikos J. Unintended Impact of US Food and Drug Administration Recalls on the Use of Contaminated and Non-Contaminated Angiotensin Receptor Blockers Among Medicaid Beneficiaries. Ann Pharmacother. 2020 Jun; 54(6):615-616. PMID: 31876432.
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  76. Myhre PL, Vaduganathan M, Greene SJ. Diagnosing heart failure with preserved ejection fraction in 2019: the search for a gold standard. Eur J Heart Fail. 2020 Mar; 22(3):422-424. PMID: 31863672.
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  77. Raber I, McCarthy CP, Al Rifai M, Vaduganathan M, Michos ED, Wood MJ, Smyth YM, Ibrahim NE, DeFaria Yeh D, Asnani A, Mehran R, McEvoy JW. Gender differences in industry payments among cardiologists. Am Heart J. 2020 05; 223:123-131. PMID: 31926591.
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  78. Patel RB, Alenezi F, Sun JL, Alhanti B, Vaduganathan M, Oh JK, Redfield MM, Butler J, Hernandez AF, Velazquez EJ, Shah SJ. Biomarker Profile of Left Atrial Myopathy in Heart Failure With Preserved Ejection Fraction: Insights From the RELAX Trial. J Card Fail. 2020 Mar; 26(3):270-275. PMID: 31857197.
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  79. Butler J, Packer M, Greene SJ, Fiuzat M, Anker SD, Anstrom KJ, Carson PE, Cooper LB, Fonarow GC, Hernandez AF, Januzzi JL, Jessup M, Kalyani RR, Kaul S, Kosiborod M, Lindenfeld J, McGuire DK, Sabatine MS, Solomon SD, Teerlink JR, Vaduganathan M, Yancy CW, Stockbridge N, O'Connor CM. Heart Failure End Points in Cardiovascular Outcome Trials of Sodium Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes Mellitus: A Critical Evaluation of Clinical and Regulatory Issues. Circulation. 2019 12 17; 140(25):2108-2118. PMID: 31841369.
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  80. Bhatt AS, Vaduganathan M, Butler J. Angiotensin-neprilysin inhibition in de novo heart failure - starting off strong. Eur J Heart Fail. 2020 Feb; 22(2):313-314. PMID: 31840351.
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  81. Vaduganathan M, Januzzi JL. Preventing and Treating Heart Failure with Sodium-Glucose Co-Transporter 2 Inhibitors. Am J Cardiol. 2019 12 15; 124 Suppl 1:S20-S27. PMID: 31741436.
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  82. Chang LS, Vaduganathan M, Plutzky J, Aroda VR. Bridging the Gap for Patients with Diabetes and Cardiovascular Disease Through Cardiometabolic Collaboration. Curr Diab Rep. 2019 12 04; 19(12):157. PMID: 31802265.
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  83. Bhatt AS, Vaduganathan M, Patel RB, Fonarow GC, Subacius HP, Konstam MA, Zannad F, Butler J, Greene SJ. Post-discharge haemodilution, congestion, and clinical outcomes among patients hospitalized for heart failure with reduced ejection fraction: results from the EVEREST trial. Eur J Heart Fail. 2020 01; 22(1):164-167. PMID: 31797490.
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  84. Vardeny O, Claggett B, Vaduganathan M, Beldhuis I, Rouleau J, O'Meara E, Anand IS, Shah SJ, Sweitzer NK, Fang JC, Desai AS, Lewis EF, Pitt B, Pfeffer MA, Solomon SD. Influence of Age on Efficacy and Safety of Spironolactone in Heart Failure. JACC Heart Fail. 2019 12; 7(12):1022-1028. PMID: 31779923.
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  85. Mehra MR, Vaduganathan M, Fu M, Ferreira JP, Anker SD, Cleland JGF, Lam CSP, van Veldhuisen DJ, Byra WM, Spiro TE, Deng H, Zannad F, Greenberg B. A comprehensive analysis of the effects of rivaroxaban on stroke or transient ischaemic attack in patients with heart failure, coronary artery disease, and sinus rhythm: the COMMANDER HF trial. Eur Heart J. 2019 11 21; 40(44):3593-3602. PMID: 31461239.
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  86. Solomon SD, Vaduganathan M, L Claggett B, Packer M, Zile M, Swedberg K, Rouleau J, A Pfeffer M, Desai A, Lund LH, Kober L, Anand I, Sweitzer N, Linssen G, Merkely B, Luis Arango J, Vinereanu D, Chen CH, Senni M, Sibulo A, Boytsov S, Shi V, Rizkala A, Lefkowitz M, McMurray JJV. Sacubitril/Valsartan Across the Spectrum of Ejection Fraction in Heart Failure. Circulation. 2020 02 04; 141(5):352-361. PMID: 31736342.
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  87. Khan MS, Irfan S, Khan SU, Mehra MR, Vaduganathan M. Transforming the interpretation of significance in heart failure trials. Eur J Heart Fail. 2020 Feb; 22(2):177-180. PMID: 31729133.
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  88. Vaduganathan M, Claggett BL, Desai AS, Anker SD, Perrone SV, Janssens S, Milicic D, Arango JL, Packer M, Shi VC, Lefkowitz MP, McMurray JJV, Solomon SD. Prior Heart Failure Hospitalization, Clinical Outcomes, and Response to Sacubitril/Valsartan Compared With Valsartan in HFpEF. J Am Coll Cardiol. 2020 01 28; 75(3):245-254. PMID: 31726194.
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  89. Vaduganathan M, Fonarow GC, Greene SJ, DeVore AD, Albert NM, Duffy CI, Hill CL, Spertus JA, Thomas LE, Butler J. Health-Related Quality of Life in Comorbid Heart Failure With Reduced Ejection Fraction and Diabetes Mellitus. J Am Coll Cardiol. 2019 12 24; 74(25):3176-3178. PMID: 31727426.
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  90. Pandey A, Patel KV, Vongpatanasin W, Ayers C, Berry JD, Mentz RJ, Blaha MJ, McEvoy JW, Muntner P, Vaduganathan M, Correa A, Butler J, Shimbo D, Nambi V, deFilippi C, Seliger SL, Ballantyne CM, Selvin E, de Lemos JA, Joshi PH. Incorporation of Biomarkers Into Risk Assessment for Allocation of Antihypertensive Medication According to the 2017 ACC/AHA High Blood Pressure Guideline: A Pooled Cohort Analysis. Circulation. 2019 12 17; 140(25):2076-2088. PMID: 31707797.
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  91. Murphy SP, McCarthy CP, Cohen JA, Rehman S, Jones-O'Connor M, Olshan DS, Singh A, Vaduganathan M, Cui J, Januzzi JL, Wasfy JH. Application of the GRACE, TIMI, and TARRACO Risk Scores in Type 2 Myocardial Infarction. J Am Coll Cardiol. 2020 01 28; 75(3):344-345. PMID: 31726195.
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  92. Patel RB, Al Rifai M, McEvoy JW, Vaduganathan M. Implications of Specialist Density for Diabetes Care in the United States. JAMA Cardiol. 2019 11 01; 4(11):1174-1175. PMID: 31642870.
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  93. Vaduganathan M, Butler J. SGLT-2 inhibitors in heart failure: a new therapeutic avenue. Nat Med. 2019 11; 25(11):1653-1654. PMID: 31700170.
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  94. Greene SJ, DeVore AD, Sheng S, Fonarow GC, Butler J, Califf RM, Hernandez AF, Matsouaka RA, Samman Tahhan A, Thomas KL, Vaduganathan M, Yancy CW, Peterson ED, O'Connor CM, Mentz RJ. Representativeness of a Heart Failure Trial by Race and Sex: Results From ASCEND-HF and GWTG-HF. JACC Heart Fail. 2019 11; 7(11):980-992. PMID: 31606362.
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  95. Arora S, Qamar A, Gupta P, Vaduganathan M, Chauhan I, Tripathi AK, Sharma VY, Bansal A, Fatima A, Jain G, Batra V, Tyagi S, Khandelwal L, Kaul P, Rao SV, Girish MP, Bhatt DL, Gupta MD. Design and rationale of the North Indian ST-Segment Elevation Myocardial Infarction Registry: A prospective cohort study. Clin Cardiol. 2019 Dec; 42(12):1140-1146. PMID: 31593344.
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  96. Sumarsono A, Everett BM, McGuire DK, Fonarow GC, Butler J, Pandey A, Vaduganathan M. Trends in Aggregate Use and Associated Expenditures of Antihyperglycemic Therapies Among US Medicare Beneficiaries Between 2012 and 2017. JAMA Intern Med. 2019 Sep 30. PMID: 31566649.
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  97. Almarzooq ZI, Varshney AS, Vaduganathan M, Pareek M, Stewart GC, Estep JD, Mehra MR. Expanding the Scope of Multimodality Imaging in Durable Mechanical Circulatory Support. JACC Cardiovasc Imaging. 2020 Apr; 13(4):1069-1081. PMID: 31542528.
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  98. Byrne C, Pareek M, Vaduganathan M, Biering-Sørensen T, Qamar A, Pandey A, Olesen TB, Olsen MH, Bhatt DL. Intensive blood pressure lowering in different age categories: insights from the Systolic Blood Pressure Intervention Trial. Eur Heart J Cardiovasc Pharmacother. 2019 Sep 14. PMID: 31529024.
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  99. Segar MW, Vaduganathan M, Patel KV, McGuire DK, Butler J, Fonarow GC, Basit M, Kannan V, Grodin JL, Everett B, Willett D, Berry J, Pandey A. Machine Learning to Predict the Risk of Incident Heart Failure Hospitalization Among Patients With Diabetes: The WATCH-DM Risk Score. Diabetes Care. 2019 12; 42(12):2298-2306. PMID: 31519694.
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  100. Selvaraj S, Claggett B, Pozzi A, McMurray JJV, Jhund PS, Packer M, Desai AS, Lewis EF, Vaduganathan M, Lefkowitz MP, Rouleau JL, Shi VC, Zile MR, Swedberg K, Solomon SD. Prognostic Implications of Congestion on Physical Examination Among Contemporary Patients With Heart Failure and Reduced Ejection Fraction: PARADIGM-HF. Circulation. 2019 10 22; 140(17):1369-1379. PMID: 31510768.
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  101. Myhre PL, Januzzi JL, Butler J, Vaduganathan M. De novo heart failure: where the journey begins. Eur J Heart Fail. 2019 10; 21(10):1245-1247. PMID: 31496006.
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  102. Patel RB, Nohria A, Butler J, Vaduganathan M. Dying is not what it used to be! Impact of evolving epidemiology and treatment on mode of death in heart failure. Eur J Heart Fail. 2019 10; 21(10):1267-1269. PMID: 31410990.
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  103. Machado SR, Vaduganathan M, Mehra MR. Adoption of hepatitis C virus-infected donor hearts: A "middle child" no more. J Heart Lung Transplant. 2019 09; 38(9):918-919. PMID: 31420158.
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  104. Myhre PL, Vaduganathan M, Claggett BL, Lam CSP, Desai AS, Anand IS, Sweitzer NK, Fang JC, O'Meara E, Shah SJ, Shah AM, Lewis EF, Rouleau J, Pitt B, Solomon SD. Application of the H2 FPEF score to a global clinical trial of patients with heart failure with preserved ejection fraction: the TOPCAT trial. Eur J Heart Fail. 2019 10; 21(10):1288-1291. PMID: 31332920.
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  105. Gupta K, Prejean SP, Vaduganathan M, Golwala H, Watts TE, Aryal SR, von Mering G, Booker OJ, Ahmed MI, Bajaj NS. Does dual vs. triple antithrombotic therapy after percutaneous coronary intervention in patients with atrial fibrillation lower the risk of bleeding at the cost of increased risk of ischemic events? Int J Cardiol Heart Vasc. 2019 Sep; 24:100404. PMID: 31763435.
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  106. Chandra A, Vaduganathan M, Lewis EF, Claggett BL, Rizkala AR, Wang W, Lefkowitz MP, Shi VC, Anand IS, Ge J, Lam CSP, Maggioni AP, Martinez F, Packer M, Pfeffer MA, Pieske B, Redfield MM, Rouleau JL, Van Veldhuisen DJ, Zannad F, Zile MR, McMurray JJV, Solomon SD. Health-Related Quality of Life in Heart Failure With Preserved Ejection Fraction: The PARAGON-HF Trial. JACC Heart Fail. 2019 10; 7(10):862-874. PMID: 31302043.
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  107. Myhre PL, Vaduganathan M, Solomon SD. Reply: Searching for Optimal Prognostic Marker of Heart Failure Progression in the Era of ARNI. J Am Coll Cardiol. 2019 07 09; 74(1):165-166. PMID: 31272546.
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  108. McCarthy CP, Murphy S, Cohen JA, Rehman S, Jones-O'Connor M, Olshan DS, Singh A, Vaduganathan M, Januzzi JL, Wasfy JH. Sex Differences in Patient Characteristics, Treatment Strategies, and Outcomes for Type 2 Myocardial Infarction. J Am Coll Cardiol. 2019 06 25; 73(24):3230-3232. PMID: 31221266.
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  109. Selvaraj S, Claggett B, Shah SJ, Anand IS, Rouleau JL, Desai AS, Lewis EF, Vaduganathan M, Wang SY, Pitt B, Sweitzer NK, Pfeffer MA, Solomon SD. Utility of the Cardiovascular Physical Examination and Impact of Spironolactone in Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2019 07; 12(7):e006125. PMID: 31220936.
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  110. Raber I, McCarthy CP, Vaduganathan M, Bhatt DL, Wood DA, Cleland JGF, Blumenthal RS, McEvoy JW. The rise and fall of aspirin in the primary prevention of cardiovascular disease. Lancet. 2019 05 25; 393(10186):2155-2167. PMID: 31226053.
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  111. Arora S, Shemisa K, Vaduganathan M, Qamar A, Gupta A, Garg SK, Kumbhani DJ, Mayo H, Khalili H, Pandey A, Das SR. Premature Ticagrelor Discontinuation in Secondary Prevention of Atherosclerotic CVD: JACC Review Topic of the Week. J Am Coll Cardiol. 2019 05 21; 73(19):2454-2464. PMID: 31097167.
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  112. Patel KV, Li X, Kondamudi N, Vaduganathan M, Adams-Huet B, Fonarow GC, Vongpatanasin W, Pandey A. Prevalence of Apparent Treatment-Resistant Hypertension in the United States According to the 2017 High Blood Pressure Guideline. Mayo Clin Proc. 2019 05; 94(5):776-782. PMID: 31054605.
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  113. McCarthy C, Murphy S, Cohen JA, Rehman S, Jones-O'Connor M, Olshan DS, Singh A, Vaduganathan M, Januzzi JL, Wasfy JH. Misclassification of Myocardial Injury as Myocardial Infarction: Implications for Assessing Outcomes in Value-Based Programs. JAMA Cardiol. 2019 05 01; 4(5):460-464. PMID: 30879022.
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  114. Bajaj NS, Vaduganathan M, Qamar A, Gupta K, Gupta A, Golwala H, Butler J, Goldhaber SZ, Mehra MR. Extended prophylaxis for venous thromboembolism after hospitalization for medical illness: A trial sequential and cumulative meta-analysis. PLoS Med. 2019 04; 16(4):e1002797. PMID: 31034476.
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  115. Yin MY, Wever-Pinzon O, Mehra MR, Selzman CH, Toll AE, Cherikh WS, Nativi-Nicolau J, Fang JC, Kfoury AG, Gilbert EM, Kemeyou L, McKellar SH, Koliopoulou A, Vaduganathan M, Drakos SG, Stehlik J. Post-transplant outcome in patients bridged to transplant with temporary mechanical circulatory support devices. J Heart Lung Transplant. 2019 08; 38(8):858-869. PMID: 31072751.
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  116. Jha MK, Qamar A, Vaduganathan M, Charney DS, Murrough JW. Screening and Management of Depression in Patients With Cardiovascular Disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019 04 16; 73(14):1827-1845. PMID: 30975301.
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  117. Jogu HR, Arora S, Vaduganathan M, Qamar A, Pandey A, Chevli PA, Pansuriya TH, Ahmad MI, Dutta A, Sunkara PR, Qureshi W, Vasu S, Upadhya B, Bhatt DL, Januzzi JL, Herrington D. Wake Forest University long-term follow-up of type 2 myocardial infarction: The Wake-Up T2MI Registry. Clin Cardiol. 2019 Jun; 42(6):592-604. PMID: 30941774.
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  118. McCarthy CP, Vaduganathan M, Patel KV, Lalani HS, Ayers C, Bhatt DL, Januzzi JL, de Lemos JA, Yancy C, Fonarow GC, Pandey A. Association of the New Peer Group-Stratified Method With the Reclassification of Penalty Status in the Hospital Readmission Reduction Program. JAMA Netw Open. 2019 04 05; 2(4):e192987. PMID: 31026033.
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  119. Vaduganathan M, Patel RB, Singh A, McCarthy CP, Qamar A, Januzzi JL, Scirica BM, Butler J, Cannon CP, Bhatt DL. Prescription of Glucagon-Like Peptide-1 Receptor Agonists by Cardiologists. J Am Coll Cardiol. 2019 04 02; 73(12):1596-1598. PMID: 30922481.
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  120. Mosarla RC, Vaduganathan M, Qamar A, Moslehi J, Piazza G, Giugliano RP. Anticoagulation Strategies in Patients With Cancer: JACC Review Topic of the Week. J Am Coll Cardiol. 2019 03 26; 73(11):1336-1349. PMID: 30898209.
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  121. Almarzooq Z, Pareek M, Sinnenberg L, Vaduganathan M, Mehra MR. Nine contemporary therapeutic directions in heart failure. Heart Asia. 2019; 11(1):e011150. PMID: 31031834.
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  122. Patel RB, Vaduganathan M, Mosarla RC, Venkateswaran RV, Bhatt DL, Bonow RO. Open Access Publishing and Subsequent Citations Among Articles in Major Cardiovascular Journals. Am J Med. 2019 09; 132(9):1103-1105. PMID: 30851265.
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  123. McCarthy CP, Murphy S, Venkateswaran RV, Singh A, Chang LL, Joice MG, Rivero JM, Vaduganathan M, Januzzi JL, Bhatt DL. Left Ventricular Thrombus: Contemporary Etiologies, Treatment Strategies, and Outcomes. J Am Coll Cardiol. 2019 04 23; 73(15):2007-2009. PMID: 30846340.
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  124. Greene SJ, Fonarow GC, DeVore AD, Sharma PP, Vaduganathan M, Albert NM, Duffy CI, Hill CL, McCague K, Patterson JH, Spertus JA, Thomas L, Williams FB, Hernandez AF, Butler J. Titration of Medical Therapy for Heart Failure With Reduced Ejection Fraction. J Am Coll Cardiol. 2019 05 21; 73(19):2365-2383. PMID: 30844480.
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  125. McCarthy CP, Murphy S, Cohen JA, Rehman S, Jones-O'Connor M, Olshan DS, Singh A, Vaduganathan M, Januzzi JL, Wasfy JH. Underutilization of Cardiac Rehabilitation for Type 2 Myocardial Infarction. J Am Coll Cardiol. 2019 04 23; 73(15):2005-2007. PMID: 30846342.
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  126. Myhre PL, Vaduganathan M, Claggett B, Packer M, Desai AS, Rouleau JL, Zile MR, Swedberg K, Lefkowitz M, Shi V, McMurray JJV, Solomon SD. B-Type Natriuretic Peptide During Treatment With Sacubitril/Valsartan: The PARADIGM-HF Trial. J Am Coll Cardiol. 2019 03 26; 73(11):1264-1272. PMID: 30846338.
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  127. Vaduganathan M, Tahhan AS, Alrohaibani A, Greene SJ, Fonarow GC, Vardeny O, Lindenfeld J, Jessup M, Fiuzat M, O'Connor CM, Butler J. Do Women and Men Respond Similarly to Therapies in Contemporary Heart Failure Clinical Trials? JACC Heart Fail. 2019 03; 7(3):267-271. PMID: 30819383.
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  128. Patel RB, Vaduganathan