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Hongmei Mou, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. Research Grant (Hongmei Mou) Jan 1, 2020 - Dec 30, 2021
    Job Research Foundation
    Impaired Epithelial Differentiation and Host Defense as A Mechanism for Pulmonary Complications in Job Syndrome Patients
  2. MOU19G0 (Hongmei Mou) May 1, 2019 - Apr 30, 2021
    the Cystic Fibrosis Foundation
  3. SG-0120-19-00 (Hongmei Mou) Apr 1, 2019 - May 31, 2021
    Harvard Stem Cell Institute (HSCI)
    Advance Regenerative Capacity of Human iPSC-Derived Airway Basal Cells
  4. Child Health Research Award (Hongmei Mou) Jan 1, 2019 - Dec 31, 2020
    Charles H. Hood Foundation
    Genetic Etiology Study of Neuroendocrine Cell Hyperplasia of Infancy (NEHI) on Dish
  5. MOU16G0 (Hongmei Mou) Nov 1, 2016 - Oct 30, 2018
    Cystic Fibrosis Foundation
    Parallel analysis of CFTR function in matched airway epithelium

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhang Y, Black KE, Phung TN, Thundivalappil SR, Lin T, Wang W, Xu J, Zhang C, Hariri LP, Lapey A, Li H, Lerou PH, Ai X, Que J, Park JA, Hurley BP, Mou H. Human Airway Basal Cells Undergo Reversible Squamous Differentiation and Reshape Innate Immunity. Am J Respir Cell Mol Biol. 2023 Feb 08. PMID: 36753317.
    Citations:    Fields:    
  2. Zhang Y, Lin T, Leung HM, Zhang C, Wilson-Mifsud B, Feldman MB, Puel A, Lanternier F, Couderc LJ, Danion F, Catherinot E, Salvator H, Tcherkian C, Givel C, Xu J, Tearney GJ, Vyas JM, Li H, Hurley BP, Mou H. STAT3 mutation-associated airway epithelial defects in Job syndrome. J Allergy Clin Immunol. 2023 Jan 10. PMID: 36638921.
    Citations:    Fields:    
  3. Huang H, Fang Y, Jiang M, Zhang Y, Biermann J, Melms JC, Danielsson JA, Yang Y, Qiang L, Liu J, Zhou Y, Wang M, Hu Z, Wang TC, Saqi A, Sun J, Matsumoto I, Cardoso WV, Emala CW, Zhu J, Izar B, Mou H, Que J. Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells. Elife. 2022 09 21; 11. PMID: 36129169; PMCID: PMC9553211.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Hirai H, Liang X, Sun Y, Zhang Y, Zhang J, Chen YE, Mou H, Zhao Y, Xu J. The sodium/glucose cotransporters as potential therapeutic targets for CF lung diseases revealed by human lung organoid swelling assay. Mol Ther Methods Clin Dev. 2022 Mar 10; 24:11-19. PMID: 34977268; PMCID: PMC8666609.
    Citations: 3     
  5. Mou H. Induced Pluripotent Stem Cell-derived Alveolar Type II Heterogeneity: Revealed by SFTPC Expression. Am J Respir Cell Mol Biol. 2021 10; 65(4):345-346. PMID: 34153206.
    Citations: 2     Fields:    Translation:Cells
  6. Mou H, Yang Y, Riehs MA, Barrios J, Shivaraju M, Haber AL, Montoro DT, Gilmore K, Haas EA, Paunovic B, Rajagopal J, Vargas SO, Haynes RL, Fine A, Cardoso WV, Ai X. Airway basal stem cells generate distinct subpopulations of PNECs. Cell Rep. 2021 04 20; 35(3):109011. PMID: 33882306; PMCID: PMC8140387.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Yonker LM, Barrios J, Mou H, Hurley BP. Untapped Potential: Therapeutically Targeting Eicosanoids and Endocannabinoids in the Lung. Clin Pharmacol Ther. 2021 07; 110(1):69-81. PMID: 33423293.
    Citations:    Fields:    Translation:HumansAnimals
  8. Xu J, Livraghi-Butrico A, Hou X, Rajagopalan C, Zhang J, Song J, Jiang H, Wei HG, Wang H, Bouhamdan M, Ruan J, Yang D, Qiu Y, Xie Y, Barrett R, McClellan S, Mou H, Wu Q, Chen X, Rogers TD, Wilkinson KJ, Gilmore RC, Esther CR, Zaman K, Liang X, Sobolic M, Hazlett L, Zhang K, Frizzell RA, Gentzsch M, O'Neal WK, Grubb BR, Chen YE, Boucher RC, Sun F. Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene. JCI Insight. 2021 01 11; 6(1). PMID: 33232302.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  9. Hao Y, Bates S, Mou H, Yun JH, Pham B, Liu J, Qiu W, Guo F, Morrow JD, Hersh CP, Benway CJ, Gong L, Zhang Y, Rosas IO, Cho MH, Park JA, Castaldi PJ, Du F, Zhou X. Genome-Wide Association Study: Functional Variant rs2076295 Regulates Desmoplakin Expression in Airway Epithelial Cells. Am J Respir Crit Care Med. 2020 11 01; 202(9):1225-1236. PMID: 32551799; PMCID: PMC7605184.
    Citations: 7     Fields:    Translation:HumansCells
  10. Mou H. Culture nTAD: A New Avenue for Research in Late-stage Human Lung Development and Perinatal Lung Disease. J Cell Immunol. 2020; 2(5):232 - 236. View Publication.
  11. Lu J, Zhu X, Shui JE, Xiong L, Gierahn T, Zhang C, Wood M, Hally S, Love JC, Li H, Crawford BC, Mou H, Lerou PH. Rho/SMAD/mTOR triple inhibition enables long-term expansion of human neonatal tracheal aspirate-derived airway basal cell-like cells. Pediatr Res. 2021 02; 89(3):502-509. PMID: 32365352.
    Citations: 7     Fields:    Translation:HumansCells
  12. Wiesner DL, Merkhofer RM, Ober C, Kujoth GC, Niu M, Keller NP, Gern JE, Brockman-Schneider RA, Evans MD, Jackson DJ, Warner T, Jarjour NN, Esnault SJ, Feldman MB, Freeman M, Mou H, Vyas JM, Klein BS. Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation. Cell Host Microbe. 2020 04 08; 27(4):614-628.e6. PMID: 32130954; PMCID: PMC7305569.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  13. Feldman MB, Dutko RA, Wood MA, Ward RA, Leung HM, Snow RF, De La Flor DJ, Yonker LM, Reedy JL, Tearney GJ, Mou H, Hurley BP, Vyas JM. Aspergillus fumigatus Cell Wall Promotes Apical Airway Epithelial Recruitment of Human Neutrophils. Infect Immun. 2020 01 22; 88(2). PMID: 31767773; PMCID: PMC6977131.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  14. Long SR, Lanter BB, Pazos MA, Mou H, Barrios J, Su CW, Wang ZQ, Walker WA, Hurley BP, Shi HN. Intestinal helminth infection enhances bacteria-induced recruitment of neutrophils to the airspace. Sci Rep. 2019 10 31; 9(1):15703. PMID: 31673002.
    Citations: 6     Fields:    Translation:AnimalsCells
  15. Hurley BP, Jugo RH, Snow RF, Samuels TL, Yonker LM, Mou H, Johnston N, Rosen R. Pepsin Triggers Neutrophil Migration Across Acid Damaged Lung Epithelium. Sci Rep. 2019 09 24; 9(1):13778. PMID: 31551494.
    Citations: 5     Fields:    Translation:HumansCells
  16. Feldman MB, Wood M, Lapey A, Mou H. SMAD Signaling Restricts Mucous Cell Differentiation in Human Airway Epithelium. Am J Respir Cell Mol Biol. 2019 09; 61(3):322-331. PMID: 30848657; PMCID: PMC6839926.
    Citations: 12     Fields:    Translation:HumansCells
  17. Ruan J, Hirai H, Yang D, Ma L, Hou X, Jiang H, Wei H, Rajagopalan C, Mou H, Wang G, Zhang J, Li K, Chen YE, Sun F, Xu J. Efficient Gene Editing at Major CFTR Mutation Loci. Mol Ther Nucleic Acids. 2019 Jun 07; 16:73-81. PMID: 30852378; PMCID: PMC6409404.
    Citations: 24     
  18. Montoro DT, Haber AL, Biton M, Vinarsky V, Lin B, Birket SE, Yuan F, Chen S, Leung HM, Villoria J, Rogel N, Burgin G, Tsankov AM, Waghray A, Slyper M, Waldman J, Nguyen L, Dionne D, Rozenblatt-Rosen O, Tata PR, Mou H, Shivaraju M, Bihler H, Mense M, Tearney GJ, Rowe SM, Engelhardt JF, Regev A, Rajagopal J. A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Nature. 2018 08; 560(7718):319-324. PMID: 30069044; PMCID: PMC6295155.
    Citations: 343     Fields:    Translation:HumansAnimalsCells
  19. Levardon H, Yonker LM, Hurley BP, Mou H. Expansion of Airway Basal Cells and Generation of Polarized Epithelium. Bio Protoc. 2018 Jun 05; 8(11). PMID: 30009215; PMCID: PMC6040659.
    Citations: 15     
  20. Lynch TJ, Anderson PJ, Rotti PG, Tyler SR, Crooke AK, Choi SH, Montoro DT, Silverman CL, Shahin W, Zhao R, Jensen-Cody CW, Adamcakova-Dodd A, Evans TIA, Xie W, Zhang Y, Mou H, Herring BP, Thorne PS, Rajagopal J, Yeaman C, Parekh KR, Engelhardt JF. Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell. 2018 05 03; 22(5):779. PMID: 29727685; PMCID: PMC5940330.
    Citations: 15     Fields:    
  21. Tata PR, Chow RD, Saladi SV, Tata A, Konkimalla A, Bara A, Montoro D, Hariri LP, Shih AR, Mino-Kenudson M, Mou H, Kimura S, Ellisen LW, Rajagopal J. Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. Dev Cell. 2018 03 26; 44(6):679-693.e5. PMID: 29587142; PMCID: PMC5875457.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  22. Mou H. Quality before Quantity: Inspecting CFTR. Dev Cell. 2018 03 26; 44(6):655-656. PMID: 29587139.
    Citations:    Fields:    Translation:HumansCells
  23. Yonker LM, Pazos MA, Lanter BB, Mou H, Chu KK, Eaton AD, Bonventre JV, Tearney GJ, Rajagopal J, Hurley BP. Neutrophil-Derived Cytosolic PLA2a Contributes to Bacterial-Induced Neutrophil Transepithelial Migration. J Immunol. 2017 10 15; 199(8):2873-2884. PMID: 28887431; PMCID: PMC5636676.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  24. Yonker LM*, Mou H*, Chu KK, Pazos MA, Leung H, Cui D, Ryu J, Hibbler RM, Eaton AD, Ford TN, Falck JR, Kinane TB, Tearney GJ, Rajagopal J, Hurley BP. (*: equal contribution authors). Development of a Primary Human Co-Culture Model of Inflamed Airway Mucosa. scientific reports. 2017; 1(7):8182.
  25. Saladi SV, Ross K, Karaayvaz M, Tata PR, Mou H, Rajagopal J, Ramaswamy S, Ellisen LW. ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. Cancer Cell. 2017 01 09; 31(1):35-49. PMID: 28041841; PMCID: PMC5225026.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  26. Gou CQ, Gao J, Wu CX, Bai DX, Mou HY, Hou XL, Zhao X. Moxibustion for Primary Dysmenorrhea at Different Interventional Times: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2016; 2016:6706901. PMID: 28115970; PMCID: PMC5225331.
    Citations: 4     
  27. Mou H, Vinarsky V, Tata PR, Brazauskas K, Choi SH, Crooke AK, Zhang B, Solomon GM, Turner B, Bihler H, Harrington J, Lapey A, Channick C, Keyes C, Freund A, Artandi S, Mense M, Rowe S, Engelhardt JF, Hsu YC, Rajagopal J. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell. 2016 08 04; 19(2):217-231. PMID: 27320041.
    Citations: 139     Fields:    Translation:HumansAnimalsCells
  28. Mou H, Brazauskas K, Rajagopal J. Personalized medicine for cystic fibrosis: establishing human model systems. Pediatr Pulmonol. 2015 Oct; 50 Suppl 40:S14-23. PMID: 26335952.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  29. Dowdall JR, Sadow PM, Hartnick C, Vinarsky V, Mou H, Zhao R, Song PC, Franco RA, Rajagopal J. Identification of distinct layers within the stratified squamous epithelium of the adult human true vocal fold. Laryngoscope. 2015 Sep; 125(9):E313-9. PMID: 25988619.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  30. Pardo-Saganta A, Law BM, Tata PR, Villoria J, Saez B, Mou H, Zhao R, Rajagopal J. Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations. Cell Stem Cell. 2015 Feb 05; 16(2):184-97. PMID: 25658372.
    Citations: 81     Fields:    Translation:AnimalsCells
  31. Gilpin SE, Ren X, Okamoto T, Guyette JP, Mou H, Rajagopal J, Mathisen DJ, Vacanti JP, Ott HC. Enhanced lung epithelial specification of human induced pluripotent stem cells on decellularized lung matrix. Ann Thorac Surg. 2014 Nov; 98(5):1721-9; discussion 1729. PMID: 25149047; PMCID: PMC4252658.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  32. Zhao R, Fallon TR, Saladi SV, Pardo-Saganta A, Villoria J, Mou H, Vinarsky V, Gonzalez-Celeiro M, Nunna N, Hariri LP, Camargo F, Ellisen LW, Rajagopal J. Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells. Dev Cell. 2014 Jul 28; 30(2):151-65. PMID: 25043474; PMCID: PMC4130488.
    Citations: 94     Fields:    Translation:AnimalsCells
  33. Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature. 2013 Nov 14; 503(7475):218-23. PMID: 24196716.
    Citations: 286     Fields:    Translation:AnimalsCells
  34. Mou H, Zhao R, Sherwood R, Ahfeldt T, Lapey A, Wain J, Sicilian L, Izvolsky K, Musunuru K, Cowan C, Rajagopal J. Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell. 2012 Apr 06; 10(4):385-97. PMID: 22482504.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  35. Longmire TA, Ikonomou L, Hawkins F, Christodoulou C, Cao Y, Jean JC, Kwok LW, Mou H, Rajagopal J, Shen SS, Dowton AA, Serra M, Weiss DJ, Green MD, Snoeck HW, Ramirez MI, Kotton DN. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell. 2012 Apr 06; 10(4):398-411. PMID: 22482505.
    Citations: 173     Fields:    Translation:AnimalsCells
  36. Lee Y, Miron A, Drapkin R, Nucci MR, Medeiros F, Saleemuddin A, Garber J, Birch C, Mou H, Gordon RW, Cramer DW, McKeon FD, Crum CP. A candidate precursor to serous carcinoma that originates in the distal fallopian tube. J Pathol. 2007 Jan; 211(1):26-35. PMID: 17117391.
    Citations: 332     Fields:    Translation:Humans
  37. Paglia MJ, Mou H, Cote RH. Regulation of photoreceptor phosphodiesterase (PDE6) by phosphorylation of its inhibitory gamma subunit re-evaluated. J Biol Chem. 2002 Feb 15; 277(7):5017-23. PMID: 11741972.
    Citations: 9     Fields:    Translation:AnimalsCells
  38. Mou H, Cote RH. The catalytic and GAF domains of the rod cGMP phosphodiesterase (PDE6) heterodimer are regulated by distinct regions of its inhibitory gamma subunit. J Biol Chem. 2001 Jul 20; 276(29):27527-34. PMID: 11375400.
    Citations: 44     Fields:    Translation:AnimalsCells
  39. Mou H, Grazio HJ, Cook TA, Beavo JA, Cote RH. cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits. J Biol Chem. 1999 Jun 25; 274(26):18813-20. PMID: 10373499.
    Citations: 23     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.