Harvard Catalyst Profiles

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Andrew Michael Leader, M.D.,Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Grout JA, Sirven P, Leader AM, Maskey S, Hector E, Puisieux I, Steffan F, Cheng E, Tung N, Maurin M, Vaineau R, Karpf L, Plaud M, Begue AL, Ganesh K, Mesple J, Casanova-Acebes M, Tabachnikova A, Keerthivasan S, Lansky A, Berichel JL, Walker L, Rahman AH, Gnjatic S, Girard N, Lefevre M, Damotte D, Adam J, Martin JC, Wolf A, Flores RM, Beasley MB, Pradhan R, Muller S, Marron TU, Turley SJ, Merad M, Kenigsberg E, Salmon H. Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors. Cancer Discov. 2022 Nov 02; 12(11):2606-2625. PMID: 36027053; PMCID: PMC9633420.
    Citations:    Fields:    
  2. Leader AM, Grout JA, Maier BB, Nabet BY, Park MD, Tabachnikova A, Chang C, Walker L, Lansky A, Le Berichel J, Troncoso L, Malissen N, Davila M, Martin JC, Magri G, Tuballes K, Zhao Z, Petralia F, Samstein R, D'Amore NR, Thurston G, Kamphorst AO, Wolf A, Flores R, Wang P, Müller S, Mellman I, Beasley MB, Salmon H, Rahman AH, Marron TU, Kenigsberg E, Merad M. Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification. Cancer Cell. 2021 12 13; 39(12):1594-1609.e12. PMID: 34767762; PMCID: PMC8728963.
    Citations: 25     Fields:    Translation:Humans
  3. Casanova-Acebes M, Dalla E, Leader AM, LeBerichel J, Nikolic J, Morales BM, Brown M, Chang C, Troncoso L, Chen ST, Sastre-Perona A, Park MD, Tabachnikova A, Dhainaut M, Hamon P, Maier B, Sawai CM, Agulló-Pascual E, Schober M, Brown BD, Reizis B, Marron T, Kenigsberg E, Moussion C, Benaroch P, Aguirre-Ghiso JA, Merad M. Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells. Nature. 2021 07; 595(7868):578-584. PMID: 34135508; PMCID: PMC8923521.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  4. Hegde S, Leader AM, Merad M. MDSC: Markers, development, states, and unaddressed complexity. Immunity. 2021 05 11; 54(5):875-884. PMID: 33979585; PMCID: PMC8709560.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  5. Brown BD, Leader AM, Vilcek J, Merad M. "America First" Will Destroy U.S. Science. Cell. 2020 11 12; 183(4):841-844. PMID: 32949492; PMCID: PMC7500439.
    Citations: 1     Fields:    Translation:HumansCells
  6. Oh SA, Wu DC, Cheung J, Navarro A, Xiong H, Cubas R, Totpal K, Chiu H, Wu Y, Comps-Agrar L, Leader AM, Merad M, Roose-Germa M, Warming S, Yan M, Kim JM, Rutz S, Mellman I. PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer. Nat Cancer. 2020 07; 1(7):681-691. PMID: 35122038.
    Citations: 36     Translation:HumansCells
  7. Maier B, Leader AM, Chen ST, Tung N, Chang C, LeBerichel J, Chudnovskiy A, Maskey S, Walker L, Finnigan JP, Kirkling ME, Reizis B, Ghosh S, D'Amore NR, Bhardwaj N, Rothlin CV, Wolf A, Flores R, Marron T, Rahman AH, Kenigsberg E, Brown BD, Merad M. Author Correction: A conserved dendritic-cell regulatory program limits antitumour immunity. Nature. 2020 Jun; 582(7813):E17. PMID: 32499658.
    Citations: 3     Fields:    
  8. Maier B, Leader AM, Chen ST, Tung N, Chang C, LeBerichel J, Chudnovskiy A, Maskey S, Walker L, Finnigan JP, Kirkling ME, Reizis B, Ghosh S, D'Amore NR, Bhardwaj N, Rothlin CV, Wolf A, Flores R, Marron T, Rahman AH, Kenigsberg E, Brown BD, Merad M. A conserved dendritic-cell regulatory program limits antitumour immunity. Nature. 2020 04; 580(7802):257-262. PMID: 32269339.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  9. Maniar YM, Bahethi RR, Naert M, Leader AM, Thomas DC, Meah Y. An Innovative Consulting Group for Sharing Expertise on Launching and Sustaining Student-Run Free Clinics: A Model for Building Student-Run Endeavors. Med Sci Educ. 2020 Mar; 30(1):555-560. PMID: 34457700.
    Citations:    
  10. Martin JC, Chang C, Boschetti G, Ungaro R, Giri M, Grout JA, Gettler K, Chuang LS, Nayar S, Greenstein AJ, Dubinsky M, Walker L, Leader A, Fine JS, Whitehurst CE, Mbow ML, Kugathasan S, Denson LA, Hyams JS, Friedman JR, Desai PT, Ko HM, Laface I, Akturk G, Schadt EE, Salmon H, Gnjatic S, Rahman AH, Merad M, Cho JH, Kenigsberg E. Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy. Cell. 2019 09 05; 178(6):1493-1508.e20. PMID: 31474370; PMCID: PMC7060942.
    Citations: 190     Fields:    Translation:HumansCells
  11. Kana V, Desland FA, Casanova-Acebes M, Ayata P, Badimon A, Nabel E, Yamamuro K, Sneeboer M, Tan IL, Flanigan ME, Rose SA, Chang C, Leader A, Le Bourhis H, Sweet ES, Tung N, Wroblewska A, Lavin Y, See P, Baccarini A, Ginhoux F, Chitu V, Stanley ER, Russo SJ, Yue Z, Brown BD, Joyner AL, De Witte LD, Morishita H, Schaefer A, Merad M. CSF-1 controls cerebellar microglia and is required for motor function and social interaction. J Exp Med. 2019 10 07; 216(10):2265-2281. PMID: 31350310; PMCID: PMC6781012.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  12. Langer AL, Leader A, Kim-Schulze S, Ginzburg Y, Merad M, Glassberg J. Inhaled steroids associated with decreased macrophage markers in nonasthmatic individuals with sickle cell disease in a randomized trial. Ann Hematol. 2019 Apr; 98(4):841-849. PMID: 30783732.
    Citations: 4     Fields:    Translation:HumansCells
  13. Arao RK, O'Connor MY, Barrett T, Chockalingam L, Khan F, Kumar A, Leader A, Leven E, Power JR, Shuham B, Rifkin R, Thomas D, Meah Y, Shah BJ. Strengthening value-based medication management in a free clinic for the uninsured: Quality interventions aimed at reducing costs and enhancing adherence. BMJ Open Qual. 2017; 6(2):e000069. PMID: 29450274; PMCID: PMC5699148.
    Citations: 1     Fields:    
  14. Rahman AH, Lavin Y, Kobayashi S, Leader A, Merad M. High-dimensional single cell mapping of cerium distribution in the lung immune microenvironment of an active smoker. Cytometry B Clin Cytom. 2018 11; 94(6):941-945. PMID: 28734132; PMCID: PMC6289862.
    Citations: 5     Fields:    Translation:Humans
  15. Lavin Y, Kobayashi S, Leader A, Amir ED, Elefant N, Bigenwald C, Remark R, Sweeney R, Becker CD, Levine JH, Meinhof K, Chow A, Kim-Shulze S, Wolf A, Medaglia C, Li H, Rytlewski JA, Emerson RO, Solovyov A, Greenbaum BD, Sanders C, Vignali M, Beasley MB, Flores R, Gnjatic S, Pe'er D, Rahman A, Amit I, Merad M. Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses. Cell. 2017 05 04; 169(4):750-765.e17. PMID: 28475900; PMCID: PMC5737939.
    Citations: 491     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.