Shirong Liu, Ph.D., B.M.D.
Instructor in Neurology
Brigham and Women's Hospital
Harvard Institutes of Medicine
Center for Neurologic Diseases, HIM-720
77 Avenue Louis Pasteur
Boston MA 02115
Available: 09/24/18, Expires: 06/01/21
We recently found that Akkermansia muciniphila (Akkermansia) of the gut microbiome was altered in untreated multiple sclerosis(MS) patient. Using an acute MS mouse model, we have found that Akkermansia muciniphila could change the disease. Currently, approach for the treatment of progressive MS is very limited. We ask whether Akkermansia could change the pathogenesis of progressive MS.
The student will profile the microbiome of progressive MS patients to find how Akkermansia changes during progressive MS. He/She will induce progressive Experimental autoimmune encephalomyelitis (EAE), an animal model of progressive MS, using NOD/ShiltJ mice, and treat them with Akkermansia. He/She will evaluate the pathology of the spinal cord, immune responses of the treated mice. The outcome is He/She might find a novel strategy for the treatment of progressive MS. He/She will also be author on relevant papers according to his/her contribution. He/She may participate in other undergoing projects in the lab, which include manipulating gut microbiome for the treatment of MS, Alzheimer's disease, diabetes and colitis.
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