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Shirong Liu, Ph.D., B.M.D.

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Available: 09/24/18, Expires: 06/01/20

We recently found that Akkermansia muciniphila (Akkermansia) of the gut microbiome was altered in untreated multiple sclerosis(MS) patient. Using an acute MS mouse model, we have found that Akkermansia muciniphila could change the disease. Currently, approach for the treatment of progressive MS is very limited. We ask whether Akkermansia could change the pathogenesis of progressive MS.

The student will profile the microbiome of progressive MS patients to find how Akkermansia changes during progressive MS. He/She will induce progressive Experimental autoimmune encephalomyelitis (EAE), an animal model of progressive MS, using NOD/ShiltJ mice, and treat them with Akkermansia. He/She will evaluate the pathology of the spinal cord, immune responses of the treated mice. The outcome is He/She might find a novel strategy for the treatment of progressive MS. He/She will also be author on relevant papers according to his/her contribution. He/She may participate in other undergoing projects in the lab, which include manipulating gut microbiome for the treatment of MS, Alzheimer's disease, diabetes and colitis.


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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Moreira TG, Horta LS, Gomes-Santos AC, Oliveira RP, Queiroz NMGP, Mangani D, Daniel B, Vieira AT, Liu S, Rodrigues AM, Gomes DA, Gabriely G, Ferreira E, Weiner HL, Rezende RM, Nagy L, Faria AMC. CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-ß-producing macrophages and T cells. Mucosal Immunol. 2019 01; 12(1):188-199. PMID: 30279515.
    Citations:    Fields:    
  2. Rezende RM, Lanser AJ, Rubino S, Kuhn C, Skillin N, Moreira TG, Liu S, Gabriely G, David BA, Menezes GB, Weiner HL. ?d T cells control humoral immune response by inducing T follicular helper cell differentiation. Nat Commun. 2018 08 08; 9(1):3151. PMID: 30089795.
    Citations:    
  3. Liu S. The Development of Our Organ of Other Kinds-The Gut Microbiota. Front Microbiol. 2016; 7:2107. PMID: 28066404.
    Citations:    
  4. Jangi S, Gandhi R, Cox LM, Li N, von Glehn F, Yan R, Patel B, Mazzola MA, Liu S, Glanz BL, Cook S, Tankou S, Stuart F, Melo K, Nejad P, Smith K, Topçuolu BD, Holden J, Kivisäkk P, Chitnis T, De Jager PL, Quintana FJ, Gerber GK, Bry L, Weiner HL. Alterations of the human gut microbiome in multiple sclerosis. Nat Commun. 2016 06 28; 7:12015. PMID: 27352007.
    Citations: 78     Fields:    Translation:HumansCells
  5. Liu S, Weiner HL. Control of the gut microbiome by fecal microRNA. Microb Cell. 2016 Mar 09; 3(4):176-177. PMID: 28357349.
    Citations: 3     
  6. Liu S, da Cunha AP, Rezende RM, Cialic R, Wei Z, Bry L, Comstock LE, Gandhi R, Weiner HL. The Host Shapes the Gut Microbiota via Fecal MicroRNA. Cell Host Microbe. 2016 Jan 13; 19(1):32-43. PMID: 26764595.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  7. Schnöder L, Hao W, Qin Y, Liu S, Tomic I, Liu X, Fassbender K, Liu Y. Deficiency of Neuronal p38a MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1. J Biol Chem. 2016 Jan 29; 291(5):2067-79. PMID: 26663083.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  8. Rezende RM, da Cunha AP, Kuhn C, Rubino S, M'Hamdi H, Gabriely G, Vandeventer T, Liu S, Cialic R, Pinheiro-Rosa N, Oliveira RP, Gaublomme JT, Obholzer N, Kozubek J, Pochet N, Faria AMC, Weiner HL. Identification and characterization of latency-associated peptide-expressing ?d T cells. Nat Commun. 2015 Dec 08; 6:8726. PMID: 26644347.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  9. Liu S, Liu Y, Hao W, Wolf L, Kiliaan AJ, Penke B, Rübe CE, Walter J, Heneka MT, Hartmann T, Menger MD, Fassbender K. TLR2 is a primary receptor for Alzheimer's amyloid ß peptide to trigger neuroinflammatory activation. J Immunol. 2012 Feb 01; 188(3):1098-107. PMID: 22198949.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  10. Hao W, Liu Y, Liu S, Walter S, Grimm MO, Kiliaan AJ, Penke B, Hartmann T, Rübe CE, Menger MD, Fassbender K. Myeloid differentiation factor 88-deficient bone marrow cells improve Alzheimer's disease-related symptoms and pathology. Brain. 2011 Jan; 134(Pt 1):278-92. PMID: 21115468.
    Citations: 19     Fields:    Translation:AnimalsCells
  11. Liu Y, Hao W, Dawson A, Liu S, Fassbender K. Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2. J Biol Chem. 2009 Feb 06; 284(6):3691-9. PMID: 19091752.
    Citations: 37     Fields:    Translation:HumansCells
  12. Kang N, Chen D, Wang L, Duan L, Liu S, Tang L, Liu Q, Cui L, He W. Rwdd1, a thymus aging related molecule, is a new member of the intrinsically unstructured protein family. Cell Mol Immunol. 2008 Oct; 5(5):333-9. PMID: 18954556.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Kang N, Duan L, Tang L, Liu S, Li C, Li Y, Liu Q, Hu Y, Cui L, He W. Identification and characterization of a novel thymus aging related protein Rwdd1. Cell Mol Immunol. 2008 Aug; 5(4):279-85. PMID: 18761815.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.