Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Nathanael Gray, Ph.D.

Co-Author

This page shows the publications co-authored by Nathanael Gray and Eric Fischer.
Connection Strength

4.834
  1. Exploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development. ACS Med Chem Lett. 2021 Aug 12; 12(8):1302-1307.
    View in: PubMed
    Score: 0.246
  2. Selective degradation-inducing probes for studying cereblon (CRBN) biology. RSC Med Chem. 2021 Aug 18; 12(8):1381-1390.
    View in: PubMed
    Score: 0.245
  3. Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2. Angew Chem Int Ed Engl. 2021 07 12; 60(29):15905-15911.
    View in: PubMed
    Score: 0.244
  4. Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol. 2021 06; 17(6):711-717.
    View in: PubMed
    Score: 0.243
  5. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 12 10; 183(6):1714-1731.e10.
    View in: PubMed
    Score: 0.236
  6. Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library. ACS Chem Biol. 2020 10 16; 15(10):2722-2730.
    View in: PubMed
    Score: 0.233
  7. Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations. Angew Chem Int Ed Engl. 2020 08 17; 59(34):14481-14489.
    View in: PubMed
    Score: 0.229
  8. Development of CDK2 and CDK5 Dual Degrader TMX-2172. Angew Chem Int Ed Engl. 2020 08 10; 59(33):13865-13870.
    View in: PubMed
    Score: 0.228
  9. Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface. ACS Med Chem Lett. 2020 Jun 11; 11(6):1269-1273.
    View in: PubMed
    Score: 0.225
  10. Exploring Targeted Degradation Strategy for Oncogenic KRASG12C. Cell Chem Biol. 2020 01 16; 27(1):19-31.e6.
    View in: PubMed
    Score: 0.221
  11. Development and Characterization of a Wee1 Kinase Degrader. Cell Chem Biol. 2020 01 16; 27(1):57-65.e9.
    View in: PubMed
    Score: 0.219
  12. Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat Chem Biol. 2020 01; 16(1):7-14.
    View in: PubMed
    Score: 0.219
  13. Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 05 06; 58(19):6321-6326.
    View in: PubMed
    Score: 0.210
  14. Bruton tyrosine kinase degradation as a therapeutic strategy for cancer. Blood. 2019 02 28; 133(9):952-961.
    View in: PubMed
    Score: 0.205
  15. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 07; 14(7):706-714.
    View in: PubMed
    Score: 0.198
  16. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK). J Med Chem. 2018 05 10; 61(9):4249-4255.
    View in: PubMed
    Score: 0.197
  17. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 02; 14(2):163-170.
    View in: PubMed
    Score: 0.192
  18. A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader. Cell Chem Biol. 2018 01 18; 25(1):88-99.e6.
    View in: PubMed
    Score: 0.191
  19. Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C. Cell Chem Biol. 2017 Aug 17; 24(8):1005-1016.e3.
    View in: PubMed
    Score: 0.187
  20. INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors. Cancer Discov. 2021 Sep 20.
    View in: PubMed
    Score: 0.062
  21. TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma. Cancer Cell. 2021 Sep 13; 39(9):1262-1278.e7.
    View in: PubMed
    Score: 0.062
  22. Targeting oncoproteins with a positive selection assay for protein degraders. Sci Adv. 2021 Feb; 7(6).
    View in: PubMed
    Score: 0.060
  23. Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins. Cell Rep. 2021 01 05; 34(1):108532.
    View in: PubMed
    Score: 0.059
  24. Tubulin Resists Degradation by Cereblon-Recruiting PROTACs. Cells. 2020 04 27; 9(5).
    View in: PubMed
    Score: 0.056
  25. Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2. Cell. 2020 04 30; 181(3):702-715.e20.
    View in: PubMed
    Score: 0.056
  26. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 01 16; 27(1):66-73.e7.
    View in: PubMed
    Score: 0.055
  27. Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations. Nat Commun. 2019 08 01; 10(1):3468.
    View in: PubMed
    Score: 0.054
  28. Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 2019 03 25; 8.
    View in: PubMed
    Score: 0.052
  29. Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML. Cell Chem Biol. 2019 02 21; 26(2):300-306.e9.
    View in: PubMed
    Score: 0.052
  30. Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. Cell. 2018 07 12; 174(2):300-311.e11.
    View in: PubMed
    Score: 0.050
  31. ER Stress Signaling Promotes the Survival of Cancer "Persister Cells" Tolerant to EGFR Tyrosine Kinase Inhibitors. Cancer Res. 2018 02 15; 78(4):1044-1057.
    View in: PubMed
    Score: 0.048
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.