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profilePaola Arlotta, Ph.D.

TitleProfessor of Stem Cell and Regenerative Biology
InstitutionFaculty of Arts & Sciences
DepartmentStem Cell and Regenerative Biology
AddressArlotta Lab, 3rd Floor
Sherman Fairchild Biochemistry Bldg
7 Divinity Ave
Cambridge MA 02138
Phone617/496-9810
Fax617/724-2662
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01MH102416     (ARLOTTA, PAOLA)Jan 1, 2014 - Dec 31, 2018
NIH/NIMH
Functional Roles of Long Noncoding RNAs During Neuronal Development
Role: Principal Investigator

R01MH101268     (ARLOTTA, PAOLA)Jul 1, 2013 - Jun 30, 2018
NIH/NIMH
Genetic targeting of cortical pyramidal neuron subtypes
Role: Principal Investigator

R01NS078164     (ARLOTTA, PAOLA)Jul 1, 2013 - Jun 30, 2018
NIH/NINDS
Projection neuron control over interneuron positioning into neocortical circuitry
Role: Principal Investigator

R01NS073124     (ARLOTTA, PAOLA)Sep 27, 2010 - May 31, 2015
NIH/NINDS
Genome-wide Light-inducible Tuning of Transcriptional Network Dynamic
Role: Principal Investigator

R01NS062849     (ARLOTTA, PAOLA)Mar 1, 2009 - Feb 28, 2014
NIH/NINDS
Fate specification of corticospinal neurons by cell autonomous signaling
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Amamoto R, Huerta VG, Takahashi E, Dai G, Grant AK, Fu Z, Arlotta P. Adult axolotls can regenerate original neuronal diversity in response to brain injury. Elife. 2016; 5. PMID: 27156560.
    View in: PubMed
  2. Quadrato G, Zhang AC, Arlotta P. Stressed out? Healing Tips for Newly Reprogrammed Neurons. Cell Stem Cell. 2016 Mar 3; 18(3):297-9. PMID: 26942845.
    View in: PubMed
  3. Chen HH, Arlotta P. Seq-ing the cortex one neuron at a time. Nat Neurosci. 2016 Feb; 19(2):179-81. PMID: 26814585.
    View in: PubMed
  4. Arlotta P, Hobert O. Homeotic Transformations of Neuronal Cell Identities. Trends Neurosci. 2015 Dec; 38(12):751-62. PMID: 26596501.
    View in: PubMed
  5. Ye Z, Mostajo-Radji MA, Brown JR, Rouaux C, Tomassy GS, Hensch TK, Arlotta P. Instructing Perisomatic Inhibition by Direct Lineage Reprogramming of Neocortical Projection Neurons. Neuron. 2015 Nov 4; 88(3):475-83. PMID: 26539889.
    View in: PubMed
  6. Tomassy GS, Dershowitz LB, Arlotta P. Diversity Matters: A Revised Guide to Myelination. Trends Cell Biol. 2016 Feb; 26(2):135-47. PMID: 26442841.
    View in: PubMed
  7. Lodato S, Arlotta P. Generating neuronal diversity in the mammalian cerebral cortex. Annu Rev Cell Dev Biol. 2015; 31:699-720. PMID: 26359774.
    View in: PubMed
  8. Goff LA, Groff AF, Sauvageau M, Trayes-Gibson Z, Sanchez-Gomez DB, Morse M, Martin RD, Elcavage LE, Liapis SC, Gonzalez-Celeiro M, Plana O, Li E, Gerhardinger C, Tomassy GS, Arlotta P, Rinn JL. Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain. Proc Natl Acad Sci U S A. 2015 Jun 2; 112(22):6855-62. PMID: 26034286; PMCID: PMC4460505.
  9. Harris J, Tomassy GS, Arlotta P. Building blocks of the cerebral cortex: from development to the dish. Wiley Interdiscip Rev Dev Biol. 2015 Sep-Oct; 4(5):529-44. PMID: 25926310; PMCID: PMC4529802 [Available on 09/01/16].
  10. Smith KA, Arlotta P, Watt FM, Solomon SL. Seven actionable strategies for advancing women in science, engineering, and medicine. Cell Stem Cell. 2015 Mar 5; 16(3):221-4. PMID: 25748929; PMCID: PMC4476252.
  11. Molyneaux BJ, Goff LA, Brettler AC, Chen HH, Brown JR, Hrvatin S, Rinn JL, Arlotta P. DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Neuron. 2015 Jan 21; 85(2):275-88. PMID: 25556833; PMCID: PMC4430475 [Available on 01/21/16].
  12. Lodato S, Shetty AS, Arlotta P. Cerebral cortex assembly: generating and reprogramming projection neuron diversity. Trends Neurosci. 2015 Feb; 38(2):117-25. PMID: 25529141; PMCID: PMC4334136 [Available on 02/01/16].
  13. Lodato S, Molyneaux BJ, Zuccaro E, Goff LA, Chen HH, Yuan W, Meleski A, Takahashi E, Mahony S, Rinn JL, Gifford DK, Arlotta P. Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014 Aug; 17(8):1046-54. PMID: 24997765; PMCID: PMC4188416.
  14. Arlotta P, Berninger B. Brains in metamorphosis: reprogramming cell identity within the central nervous system. Curr Opin Neurobiol. 2014 Aug; 27:208-14. PMID: 24800935; PMCID: PMC4122594.
  15. Tomassy GS, Berger DR, Chen HH, Kasthuri N, Hayworth KJ, Vercelli A, Seung HS, Lichtman JW, Arlotta P. Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex. Science. 2014 Apr 18; 344(6181):319-24. PMID: 24744380; PMCID: PMC4122120.
  16. Amamoto R, Arlotta P. Development-inspired reprogramming of the mammalian central nervous system. Science. 2014 Jan 31; 343(6170):1239882. PMID: 24482482; PMCID: PMC4122114.
  17. Sauvageau M, Goff LA, Lodato S, Bonev B, Groff AF, Gerhardinger C, Sanchez-Gomez DB, Hacisuleyman E, Li E, Spence M, Liapis SC, Mallard W, Morse M, Swerdel MR, D'Ecclessis MF, Moore JC, Lai V, Gong G, Yancopoulos GD, Frendewey D, Kellis M, Hart RP, Valenzuela DM, Arlotta P, Rinn JL. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Elife. 2013; 2:e01749. PMID: 24381249; PMCID: PMC3874104.
  18. Amamoto R, Arlotta P. Reshaping the brain: direct lineage conversion in the nervous system. F1000Prime Rep. 2013; 5:33. PMID: 24049637; PMCID: PMC3768326.
  19. Zuccaro E, Arlotta P. The quest for myelin in the adult brain. Nat Cell Biol. 2013 Jun; 15(6):572-5. PMID: 23644465.
    View in: PubMed
  20. Rouaux C, Arlotta P. Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo. Nat Cell Biol. 2013 Feb; 15(2):214-21. PMID: 23334497; PMCID: PMC4118591.
  21. Tomassy GS, Lodato S, Arlotta P. A sip of GABA for the cerebral cortex. Neuron. 2013 Jan 9; 77(1):1-3. PMID: 23312509.
    View in: PubMed
  22. Rouaux C, Bhai S, Arlotta P. Programming and reprogramming neuronal subtypes in the central nervous system. Dev Neurobiol. 2012 Jul; 72(7):1085-98. PMID: 22378700; PMCID: PMC4123849.
  23. Cappello S, Böhringer CR, Bergami M, Conzelmann KK, Ghanem A, Tomassy GS, Arlotta P, Mainardi M, Allegra M, Caleo M, van Hengel J, Brakebusch C, Götz M. A radial glia-specific role of RhoA in double cortex formation. Neuron. 2012 Mar 8; 73(5):911-24. PMID: 22405202.
    View in: PubMed
  24. Sohur US, Arlotta P, Macklis JD. Developmental Controls are Re-Expressed during Induction of Neurogenesis in the Neocortex of Young Adult Mice. Front Neurosci. 2012; 6:12. PMID: 22347158; PMCID: PMC3272649.
  25. López-Bendito G, Arlotta P. Cell replacement therapies for nervous system regeneration. Dev Neurobiol. 2012 Feb; 72(2):145-52. PMID: 21557508; PMCID: PMC4226408.
  26. Lodato S, Tomassy GS, De Leonibus E, Uzcategui YG, Andolfi G, Armentano M, Touzot A, Gaztelu JM, Arlotta P, Menendez de la Prida L, Studer M. Loss of COUP-TFI alters the balance between caudal ganglionic eminence- and medial ganglionic eminence-derived cortical interneurons and results in resistance to epilepsy. J Neurosci. 2011 Mar 23; 31(12):4650-62. PMID: 21430164.
    View in: PubMed
  27. Lodato S, Rouaux C, Quast KB, Jantrachotechatchawan C, Studer M, Hensch TK, Arlotta P. Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex. Neuron. 2011 Feb 24; 69(4):763-79. PMID: 21338885; PMCID: PMC3061282.
  28. Zhang F, Cong L, Lodato S, Kosuri S, Church GM, Arlotta P. Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol. 2011 Feb; 29(2):149-53. PMID: 21248753; PMCID: PMC3084533.
  29. Rouaux C, Arlotta P. Fezf2 directs the differentiation of corticofugal neurons from striatal progenitors in vivo. Nat Neurosci. 2010 Nov; 13(11):1345-7. PMID: 20953195; PMCID: PMC4207442.
  30. Shoemaker LD, Arlotta P. Untangling the cortex: Advances in understanding specification and differentiation of corticospinal motor neurons. Bioessays. 2010 Mar; 32(3):197-206. PMID: 20108227; PMCID: PMC4240621.
  31. Tomassy GS, Lodato S, Trayes-Gibson Z, Arlotta P. Development and regeneration of projection neuron subtypes of the cerebral cortex. Sci Prog. 2010; 93(Pt 2):151-69. PMID: 20681320; PMCID: PMC4226406.
  32. Molyneaux BJ, Arlotta P, Fame RM, MacDonald JL, MacQuarrie KL, Macklis JD. Novel subtype-specific genes identify distinct subpopulations of callosal projection neurons. J Neurosci. 2009 Sep 30; 29(39):12343-54. PMID: 19793993; PMCID: PMC2776075.
  33. Lai T, Jabaudon D, Molyneaux BJ, Azim E, Arlotta P, Menezes JR, Macklis JD. SOX5 controls the sequential generation of distinct corticofugal neuron subtypes. Neuron. 2008 Jan 24; 57(2):232-47. PMID: 18215621.
    View in: PubMed
  34. Arlotta P, Molyneaux BJ, Jabaudon D, Yoshida Y, Macklis JD. Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum. J Neurosci. 2008 Jan 16; 28(3):622-32. PMID: 18199763.
    View in: PubMed
  35. Gao X, Arlotta P, Macklis JD, Chen J. Conditional knock-out of beta-catenin in postnatal-born dentate gyrus granule neurons results in dendritic malformation. J Neurosci. 2007 Dec 26; 27(52):14317-25. PMID: 18160639.
    View in: PubMed
  36. Molyneaux BJ, Arlotta P, Menezes JR, Macklis JD. Neuronal subtype specification in the cerebral cortex. Nat Rev Neurosci. 2007 Jun; 8(6):427-37. PMID: 17514196.
    View in: PubMed
  37. Molyneaux BJ, Arlotta P, Macklis JD. Molecular development of corticospinal motor neuron circuitry. Novartis Found Symp. 2007; 288:3-15; discussion 15-20, 96-8. PMID: 18494249.
    View in: PubMed
  38. Molyneaux BJ, Arlotta P, Hirata T, Hibi M, Macklis JD. Fezl is required for the birth and specification of corticospinal motor neurons. Neuron. 2005 Sep 15; 47(6):817-31. PMID: 16157277.
    View in: PubMed
  39. Arlotta P, Macklis JD. Archeo-cell biology: carbon dating is not just for pots and dinosaurs. Cell. 2005 Jul 15; 122(1):4-6. PMID: 16009125.
    View in: PubMed
  40. Arlotta P, Molyneaux BJ, Chen J, Inoue J, Kominami R, Macklis JD. Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron. 2005 Jan 20; 45(2):207-21. PMID: 15664173.
    View in: PubMed
  41. Emsley JG, Mitchell BD, Magavi SS, Arlotta P, Macklis JD. The repair of complex neuronal circuitry by transplanted and endogenous precursors. NeuroRx. 2004 Oct; 1(4):452-71. PMID: 15717047; PMCID: PMC534952.
  42. Emsley JG, Arlotta P, Macklis JD. Star-cross'd neurons: astroglial effects on neural repair in the adult mammalian CNS. Trends Neurosci. 2004 May; 27(5):238-40. PMID: 15111002.
    View in: PubMed
  43. Catapano LA, Arlotta P, Cage TA, Macklis JD. Stage-specific and opposing roles of BDNF, NT-3 and bFGF in differentiation of purified callosal projection neurons toward cellular repair of complex circuitry. Eur J Neurosci. 2004 May; 19(9):2421-34. PMID: 15128396.
    View in: PubMed
  44. Mitchell BD, Emsley JG, Magavi SS, Arlotta P, Macklis JD. Constitutive and induced neurogenesis in the adult mammalian brain: manipulation of endogenous precursors toward CNS repair. Dev Neurosci. 2004 Mar-Aug; 26(2-4):101-17. PMID: 15711054.
    View in: PubMed
  45. Arlotta P, Magavi SS, Macklis JD. Induction of adult neurogenesis: molecular manipulation of neural precursors in situ. Ann N Y Acad Sci. 2003 Jun; 991:229-36. PMID: 12846990.
    View in: PubMed
  46. Arlotta P, Magavi SS, Macklis JD. Molecular manipulation of neural precursors in situ: induction of adult cortical neurogenesis. Exp Gerontol. 2003 Jan-Feb; 38(1-2):173-82. PMID: 12543275.
    View in: PubMed
  47. Arlotta P, Miyazaki D, Copeland NG, Gilbert DJ, Jenkins NA, Ono SJ. Murine NFX.1: isolation and characterization of its messenger RNA, mapping of its chromosomal location and assessment of its developmental expression. Immunology. 2002 Jun; 106(2):173-81. PMID: 12047746; PMCID: PMC1782705.
  48. Liu F, Chau KY, Arlotta P, Ono SJ. The HMG I proteins: dynamic roles in gene activation, development, and tumorigenesis. Immunol Res. 2001; 24(1):13-29. PMID: 11485207.
    View in: PubMed
  49. Fedoseyeva EV, Boisgérault F, Anosova NG, Wollish WS, Arlotta P, Jensen PE, Ono SJ, Benichou G. CD4+ T cell responses to self- and mutated p53 determinants during tumorigenesis in mice. J Immunol. 2000 Jun 1; 164(11):5641-51. PMID: 10820239.
    View in: PubMed
  50. Arlotta P, Tai AK, Manfioletti G, Clifford C, Jay G, Ono SJ. Transgenic mice expressing a truncated form of the high mobility group I-C protein develop adiposity and an abnormally high prevalence of lipomas. J Biol Chem. 2000 May 12; 275(19):14394-400. PMID: 10747931.
    View in: PubMed
  51. Chau K, Arlotta P, Patel UA, Crane-Robinson C, Manfioletti G, Ono SJ. A novel downstream positive regulatory element mediating transcription of the human high mobility group (HMG) I-C gene. FEBS Lett. 1999 Sep 3; 457(3):429-36. PMID: 10471823.
    View in: PubMed
  52. Arlotta P, Rustighi A, Mantovani F, Manfioletti G, Giancotti V, Tell G, Damante G. High mobility group I proteins interfere with the homeodomains binding to DNA. J Biol Chem. 1997 Nov 21; 272(47):29904-10. PMID: 9368066.
    View in: PubMed
  53. Arlotta P, Curci G, Perazzoli CA, Santori L. [Reconstruction of severe loss of mandibular bone substance using metal prostheses]. Minerva Stomatol. 1980 Nov-Dec; 29(6):515-26. PMID: 6939966.
    View in: PubMed
  54. Arlotta P, Santori L, de Vecchi A. [A case of mixed tumor of the palate]. Acta Biol Med Ger. 1976 Jul-Sep; 2(3):34. PMID: 209648.
    View in: PubMed
  55. Arlotta P, Tassarotti B, Santori L. [Surgical therapy of submandibular sialolithiasis]. Odontostomatol Implantoprotesi. 1975 Jan-Mar; (1):78-81. PMID: 802397.
    View in: PubMed
  56. Arlotta P, Curci G, Morelli-Coghi A, Pizzoni D. [Treatment of fracture of the zygomatic arch by means of metallic osteosynthesis]. Rass Int Stomatol Prat. 1972 Nov-Dec; 23(6):189-203. PMID: 4515386.
    View in: PubMed
  57. Arlotta P, Silla M. [Solitary plasmacytoma of the mandible]. Rass Int Stomatol Prat. 1972 Sep-Oct; 23(5):153-61. PMID: 4515384.
    View in: PubMed
  58. Grampa G, Bestetti-Bosisio M, Bergamini F, Arlotta P. A case of Burkitt's tumor in Italy. Pathol Eur. 1970; 5(4):470-84. PMID: 5515049.
    View in: PubMed
  59. Arlotta P, Pizzoni D. Fractures of the zygomatic complex. Br J Oral Surg. 1967 Mar; 4(3):192-3. PMID: 5228979.
    View in: PubMed
  60. ARLOTTA P, TALAMAZZI F. [Clinico-statistical study of tumors of the upper jaw]. Riv Ital Stomatol. 1954 May; 9(5):539-50. PMID: 13195472.
    View in: PubMed
  61. ARLOTTA P. [Transalveolar route in novocaine analgesia with gelatin sponge in periodontitis]. Minerva Stomatol. 1953 May-Jun; 2(3):141-3. PMID: 13086831.
    View in: PubMed
  62. ARLOTTA P. [Xylocaine in use at the Milan Dental Clinic]. Riv Ital Stomatol. 1951 Nov; 6(11):1187-91. PMID: 14912893.
    View in: PubMed
  63. ARLOTTA P. [Trichloroethylene in dentin hyperesthesia]. Riv Ital Stomatol. 1951 Sep; 6(9):916-20. PMID: 14900859.
    View in: PubMed
  64. ARLOTTA P. [Gingival hyperplasia due to sodium diphenylhydantoinate]. Riv Ital Stomatol. 1951 Feb; 6(2):180-7. PMID: 14845570.
    View in: PubMed
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