Harvard Catalyst Profiles

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Roger D'Avesne Spealman, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DA047575 (BERGMAN, JACK) Jul 1, 2019 - Apr 30, 2024
    NIH/NIDA
    Neural, Cognitive and Abuse-Related Consequences of Chronic THC Exposure during Adolescence in Nonhuman Primates
    Role: Co-Principal Investigator
  2. R01DA035857 (BERGMAN, JACK) Mar 1, 2014 - Feb 28, 2019
    NIH/NIDA
    Pharmacologic Approaches to Prescription Opioid Addiction and Relapse Prevention
    Role: Co-Principal Investigator
  3. R01DA031299 (BERGMAN, JACK) Jul 1, 2011 - Oct 31, 2016
    NIH/NIDA
    Alpha Adrenergic Pharmacotherapy for Polydrug (Stimulant/Opiate) Abuse
    Role: Co-Principal Investigator
  4. R01DA017700 (SPEALMAN, ROGER D) Aug 1, 2004 - Jul 31, 2010
    NIH/NIDA
    mGluR5 Mechanisms in Primate Models of Cocaine Abuse
    Role: Principal Investigator
  5. R21AA013850 (SPEALMAN, ROGER D) Mar 1, 2003 - Feb 28, 2007
    NIH/NIAAA
    GABA A/alpha5 Ligands in Primate Models of Alcohol Abuse
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gauthier JM, Lin A, Nic Dhonnchadha BÁ, Spealman RD, Man HY, Kantak KM. Environmental enrichment facilitates cocaine-cue extinction, deters reacquisition of cocaine self-administration and alters AMPAR GluA1 expression and phosphorylation. Addict Biol. 2017 Jan; 22(1):152-162. PMID: 26384129.
    Citations:    Fields:    Translation:AnimalsCells
  2. Rüedi-Bettschen D, Spealman RD, Platt DM. Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys by direct and indirect activation of 5-HT2C receptors. Psychopharmacology (Berl). 2015 Aug; 232(16):2959-68. PMID: 25877746.
    Citations: 7     Fields:    Translation:Animals
  3. Hallett PJ, Deleidi M, Astradsson A, Smith GA, Cooper O, Osborn TM, Sundberg M, Moore MA, Perez-Torres E, Brownell AL, Schumacher JM, Spealman RD, Isacson O. Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell. 2015 Mar 05; 16(3):269-74. PMID: 25732245.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  4. Sundberg M, Bogetofte H, Lawson T, Jansson J, Smith G, Astradsson A, Moore M, Osborn T, Cooper O, Spealman R, Hallett P, Isacson O. Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells. 2013 Aug; 31(8):1548-62. PMID: 23666606.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  5. Achat-Mendes C, Nic Dhonnchadha BÁ, Platt DM, Kantak KM, Spealman RD. Glycine transporter-1 inhibition preceding extinction training inhibits reacquisition of cocaine seeking. Neuropsychopharmacology. 2012 Dec; 37(13):2837-45. PMID: 22948980.
    Citations: 6     Fields:    Translation:Animals
  6. Achat-Mendes C, Platt DM, Spealman RD. Antagonism of metabotropic glutamate 1 receptors attenuates behavioral effects of cocaine and methamphetamine in squirrel monkeys. J Pharmacol Exp Ther. 2012 Oct; 343(1):214-24. PMID: 22815535.
    Citations: 19     Fields:    Translation:Animals
  7. Platt DM, Carey G, Spealman RD. Models of neurological disease (substance abuse): self-administration in monkeys. Curr Protoc Pharmacol. 2011 Dec; Chapter 10:Unit10.5. PMID: 22382996.
    Citations: 7     Fields:    Translation:Animals
  8. Nic Dhonnchadha BÁ, Pinard E, Alberati D, Wettstein JG, Spealman RD, Kantak KM. Inhibiting glycine transporter-1 facilitates cocaine-cue extinction and attenuates reacquisition of cocaine-seeking behavior. Drug Alcohol Depend. 2012 Apr 01; 122(1-2):119-26. PMID: 21992874.
    Citations: 6     Fields:    Translation:Animals
  9. Xu TX, Ma Q, Spealman RD, Yao WD. Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant. J Neurochem. 2010 Dec; 115(6):1643-54. PMID: 20969573.
    Citations: 6     Fields:    Translation:Animals
  10. Achat-Mendes C, Grundt P, Cao J, Platt DM, Newman AH, Spealman RD. Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys. J Pharmacol Exp Ther. 2010 Aug; 334(2):556-65. PMID: 20494958.
    Citations: 29     Fields:    Translation:Animals
  11. Nic Dhonnchadha BA, Szalay JJ, Achat-Mendes C, Platt DM, Otto MW, Spealman RD, Kantak KM. D-cycloserine deters reacquisition of cocaine self-administration by augmenting extinction learning. Neuropsychopharmacology. 2010 Jan; 35(2):357-67. PMID: 19741593.
    Citations: 45     Fields:    Translation:Animals
  12. Platt DM, Rowlett JK, Spealman RD. Asymmetric generalization and interaction profiles in rhesus monkeys discriminating intravenous cocaine or intravenous heroin from vehicle. J Pharmacol Exp Ther. 2010 Mar; 332(3):985-95. PMID: 19965959.
    Citations:    Fields:    Translation:Animals
  13. Xu TX, Sotnikova TD, Liang C, Zhang J, Jung JU, Spealman RD, Gainetdinov RR, Yao WD. Hyperdopaminergic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate. J Neurosci. 2009 Nov 11; 29(45):14086-99. PMID: 19906957.
    Citations: 25     Fields:    Translation:AnimalsCells
  14. Rüedi-Bettschen D, Rowlett JK, Spealman RD, Platt DM. Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms. Psychopharmacology (Berl). 2010 Jun; 210(2):169-77. PMID: 19859697.
    Citations: 13     Fields:    Translation:Animals
  15. Achat-Mendes C, Platt DM, Newman AH, Spealman RD. The dopamine D3 receptor partial agonist CJB 090 inhibits the discriminative stimulus but not the reinforcing or priming effects of cocaine in squirrel monkeys. Psychopharmacology (Berl). 2009 Sep; 206(1):73-84. PMID: 19513698.
    Citations: 13     Fields:    Translation:Animals
  16. Astradsson A, Jenkins BG, Choi JK, Hallett PJ, Levesque MA, McDowell JS, Brownell AL, Spealman RD, Isacson O. The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies. Neurobiol Dis. 2009 Sep; 35(3):348-51. PMID: 19501164.
    Citations: 13     Fields:    Translation:Animals
  17. Achat-Mendes C, Valdez GR, Platt DM, Rowlett JK, Spealman RD. Intravenous self-administration of etonitazene alone and combined with cocaine in rhesus monkeys: comparison with heroin and antagonism by naltrexone and naloxonazine. Psychopharmacology (Berl). 2009 Jun; 204(3):489-98. PMID: 19225763.
    Citations:    Fields:    Translation:Animals
  18. Platt DM, Rowlett JK, Spealman RD. Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine. Psychopharmacology (Berl). 2008 Oct; 200(2):167-76. PMID: 18509621.
    Citations: 34     Fields:    Translation:Animals
  19. Haney M, Spealman R. Controversies in translational research: drug self-administration. Psychopharmacology (Berl). 2008 Aug; 199(3):403-19. PMID: 18283437.
    Citations: 115     Fields:    Translation:HumansAnimals
  20. Yao WD, Spealman RD, Zhang J. Dopaminergic signaling in dendritic spines. Biochem Pharmacol. 2008 Jun 01; 75(11):2055-69. PMID: 18353279.
    Citations: 41     Fields:    Translation:AnimalsCells
  21. Valdez GR, Platt DM, Rowlett JK, Rüedi-Bettschen D, Spealman RD. Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms. J Pharmacol Exp Ther. 2007 Nov; 323(2):525-33. PMID: 17702903.
    Citations: 52     Fields:    Translation:Animals
  22. Platt DM, Rowlett JK, Spealman RD. Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys. J Pharmacol Exp Ther. 2007 Aug; 322(2):894-902. PMID: 17505018.
    Citations: 23     Fields:    Translation:Animals
  23. Rowlett JK, Platt DM, Yao WD, Spealman RD. Modulation of heroin and cocaine self-administration by dopamine D1- and D2-like receptor agonists in rhesus monkeys. J Pharmacol Exp Ther. 2007 Jun; 321(3):1135-43. PMID: 17351103.
    Citations: 14     Fields:    Translation:Animals
  24. Adewale AS, Platt DM, Spealman RD. Pharmacological stimulation of group ii metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeys. J Pharmacol Exp Ther. 2006 Aug; 318(2):922-31. PMID: 16675638.
    Citations: 43     Fields:    Translation:AnimalsPHPublic Health
  25. Platt DM, Carey G, Spealman RD. Intravenous self-administration techniques in monkeys. Curr Protoc Neurosci. 2005 Aug; Chapter 9:Unit 9.21. PMID: 18428630.
    Citations: 2     Fields:    Translation:Animals
  26. Platt DM, Duggan A, Spealman RD, Cook JM, Li X, Yin W, Rowlett JK. Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys. J Pharmacol Exp Ther. 2005 May; 313(2):658-67. PMID: 15650112.
    Citations: 12     Fields:    Translation:Animals
  27. Rowlett JK, Rodefer JS, Spealman RD. Self-Administration of cocaine-opioid combinations by rhesus monkeys: evaluation of the role of mu receptor efficacy using labor supply analysis. J Pharmacol Exp Ther. 2005 Mar; 312(3):1289-97. PMID: 15550572.
    Citations: 8     Fields:    Translation:Animals
  28. Lee B, Platt DM, Rowlett JK, Adewale AS, Spealman RD. Attenuation of behavioral effects of cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine. J Pharmacol Exp Ther. 2005 Mar; 312(3):1232-40. PMID: 15550570.
    Citations: 56     Fields:    Translation:Animals
  29. Lee B, Tiefenbacher S, Platt DM, Spealman RD. Pharmacological blockade of alpha2-adrenoceptors induces reinstatement of cocaine-seeking behavior in squirrel monkeys. Neuropsychopharmacology. 2004 Apr; 29(4):686-93. PMID: 14872205.
    Citations: 86     Fields:    Translation:Animals
  30. Rowlett JK, Platt DM, Spealman RD. Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors. J Pharmacol Exp Ther. 2004 Jul; 310(1):342-8. PMID: 14985417.
    Citations: 7     Fields:    Translation:Animals
  31. Spealman RD, Lee B, Tiefenbacher S, Platt DM, Rowlett JK, Khroyan TV. Triggers of relapse: nonhuman primate models of reinstated cocaine seeking. Nebr Symp Motiv. 2004; 50:57-84. PMID: 15160638.
    Citations: 5     Fields:    Translation:Animals
  32. Platt DM, Rowlett JK, Izenwasser S, Spealman RD. Opioid partial agonist effects of 3-O-methylnaltrexone in rhesus monkeys. J Pharmacol Exp Ther. 2004 Mar; 308(3):1030-9. PMID: 14634035.
    Citations:    Fields:    Translation:Animals
  33. Madras BK, Fahey MA, Miller GM, De La Garza R, Goulet M, Spealman RD, Meltzer PC, George SR, O'Dowd BF, Bonab AA, Livni E, Fischman AJ. Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors. Eur J Pharmacol. 2003 Oct 31; 479(1-3):41-51. PMID: 14612136.
    Citations: 4     Fields:    Translation:Animals
  34. Tiefenbacher S, Lee B, Meyer JS, Spealman RD. Noninvasive technique for the repeated sampling of salivary free cortisol in awake, unrestrained squirrel monkeys. Am J Primatol. 2003 Jun; 60(2):69-75. PMID: 12784287.
    Citations: 4     Fields:    Translation:Animals
  35. Lee B, Tiefenbacher S, Platt DM, Spealman RD. Role of the hypothalamic-pituitary-adrenal axis in reinstatement of cocaine-seeking behavior in squirrel monkeys. Psychopharmacology (Berl). 2003 Jul; 168(1-2):177-183. PMID: 12652344.
    Citations: 12     Fields:    Translation:Animals
  36. Khroyan TV, Platt DM, Rowlett JK, Spealman RD. Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates. Psychopharmacology (Berl). 2003 Jul; 168(1-2):124-131. PMID: 12607074.
    Citations: 11     Fields:    Translation:AnimalsPHPublic Health
  37. Platt DM, Rodefer JS, Rowlett JK, Spealman RD. Suppression of cocaine- and food-maintained behavior by the D2-like receptor partial agonist terguride in squirrel monkeys. Psychopharmacology (Berl). 2003 Mar; 166(3):298-305. PMID: 12589523.
    Citations: 9     Fields:    Translation:Animals
  38. Rowlett JK, Spealman RD, Lelas S, Cook JM, Yin W. Discriminative stimulus effects of zolpidem in squirrel monkeys: role of GABA(A)/alpha1 receptors. Psychopharmacology (Berl). 2003 Jan; 165(3):209-15. PMID: 12420154.
    Citations: 13     Fields:    Translation:Animals
  39. Rowlett JK, Rodefer JS, Spealman RD. Self-administration of cocaine, alfentanil, and nalbuphine under progressive-ratio schedules: consumer demand and labor supply analyses of relative reinforcing effectiveness. Exp Clin Psychopharmacol. 2002 Nov; 10(4):367-75. PMID: 12498333.
    Citations: 7     Fields:    Translation:Animals
  40. Platt DM, Rowlett JK, Spealman RD, Cook J, Ma C. Selective antagonism of the ataxic effects of zolpidem and triazolam by the GABAA/alpha1-preferring antagonist beta-CCt in squirrel monkeys. Psychopharmacology (Berl). 2002 Nov; 164(2):151-9. PMID: 12404077.
    Citations: 14     Fields:    Translation:Animals
  41. Platt DM, Rowlett JK, Spealman RD. Behavioral effects of cocaine and dopaminergic strategies for preclinical medication development. Psychopharmacology (Berl). 2002 Oct; 163(3-4):265-82. PMID: 12373428.
    Citations: 50     Fields:    Translation:Animals
  42. Park WK, Bari AA, Jey AR, Anderson SM, Spealman RD, Rowlett JK, Pierce RC. Cocaine administered into the medial prefrontal cortex reinstates cocaine-seeking behavior by increasing AMPA receptor-mediated glutamate transmission in the nucleus accumbens. J Neurosci. 2002 Apr 01; 22(7):2916-25. PMID: 11923456.
    Citations: 120     Fields:    Translation:AnimalsCells
  43. Lelas S, Rowlett JK, Spealman RD, Cook JM, Ma C, Li X, Yin W. Role of GABAA/benzodiazepine receptors containing alpha 1 and alpha 5 subunits in the discriminative stimulus effects of triazolam in squirrel monkeys. Psychopharmacology (Berl). 2002 May; 161(2):180-8. PMID: 11981598.
    Citations: 7     Fields:    Translation:Animals
  44. Lelas S, Rowlett JK, Spealman RD. Isobolographic analysis of chlordiazepoxide and triazolam combinations in squirrel monkeys discriminating triazolam. Psychopharmacology (Berl). 2001 Nov; 158(2):181-9. PMID: 11702092.
    Citations: 6     Fields:    Translation:Animals
  45. Platt DM, Rowlett JK, Spealman RD. Discriminative stimulus effects of intravenous heroin and its metabolites in rhesus monkeys: opioid and dopaminergic mechanisms. J Pharmacol Exp Ther. 2001 Nov; 299(2):760-7. PMID: 11602692.
    Citations: 4     Fields:    Translation:Animals
  46. Rowlett JK, Spealman RD, Platt DM. Similar enhancement of the discriminative stimulus effects of cocaine and GBR 12909 by heroin in squirrel monkeys. Psychopharmacology (Berl). 2001 Sep; 157(3):313-9. PMID: 11605088.
    Citations: 1     Fields:    Translation:Animals
  47. Platt DM, Rowlett JK, Spealman RD. Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys. Psychopharmacology (Berl). 2001 Sep; 157(2):208-16. PMID: 11594448.
    Citations: 12     Fields:    Translation:Animals
  48. Lelas S, Rowlett JK, Spealman RD. Triazolam discrimination in squirrel monkeys distinguishes high-efficacy agonists from other benzodiazepines and non-benzodiazepine drugs. Psychopharmacology (Berl). 2001 Feb; 154(1):96-104. PMID: 11292012.
    Citations: 4     Fields:    Translation:Animals
  49. Rowlett JK, Lelas S, Spealman RD. Transduction of the discriminative stimulus effects of zolpidem by GABA(A)/alpha1 receptors. Eur J Pharmacol. 2000 Oct 06; 406(1):R9-R10. PMID: 11011051.
    Citations: 6     Fields:    Translation:Animals
  50. Lelas S, Spealman RD, Rowlett JK. Using behavior to elucidate receptor mechanisms: a review of the discriminative stimulus effects of benzodiazepines. Exp Clin Psychopharmacol. 2000 Aug; 8(3):294-311. PMID: 10975618.
    Citations: 14     Fields:    Translation:HumansAnimals
  51. Khroyan TV, Barrett-Larimore RL, Rowlett JK, Spealman RD. Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists. J Pharmacol Exp Ther. 2000 Aug; 294(2):680-7. PMID: 10900248.
    Citations: 70     Fields:    Translation:Animals
  52. Rowlett JK, Spealman RD, Platt DM. Cocaine-like discriminative stimulus effects of heroin in squirrel monkeys: role of active metabolites and opioid receptor mechanisms. Psychopharmacology (Berl). 2000 Jun; 150(2):191-9. PMID: 10907672.
    Citations: 1     Fields:    Translation:Animals
  53. Platt DM, Rowlett JK, Spealman RD. Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434. J Pharmacol Exp Ther. 2000 Jun; 293(3):1017-26. PMID: 10869406.
    Citations: 12     Fields:    Translation:Animals
  54. Spealman RD, Khroyan TV, Barrett-Larimore RL, Rowlett JK, Platt DM. Dopaminergic mechanisms in relapse to cocaine-seeking behavior. Implications for medications development. Ann N Y Acad Sci. 2000; 909:273-4. PMID: 10911940.
    Citations:    Fields:    Translation:HumansAnimals
  55. Kantak KM, Riberdy A, Spealman RD. Cocaine-opioid interactions in groups of rats trained to discriminate different doses of cocaine. Psychopharmacology (Berl). 1999 Dec; 147(3):257-65. PMID: 10639683.
    Citations: 7     Fields:    Translation:Animals
  56. Rowlett JK, Spealman RD, Lelas S. Discriminative stimulus effects of zolpidem in squirrel monkeys: comparison with conventional benzodiazepines and sedative-hypnotics. J Pharmacol Exp Ther. 1999 Dec; 291(3):1233-41. PMID: 10565847.
    Citations: 6     Fields:    Translation:Animals
  57. Spealman RD, Barrett-Larimore RL, Rowlett JK, Platt DM, Khroyan TV. Pharmacological and environmental determinants of relapse to cocaine-seeking behavior. Pharmacol Biochem Behav. 1999 Oct; 64(2):327-36. PMID: 10515309.
    Citations: 63     Fields:    Translation:HumansAnimals
  58. Platt DM, Grech DM, Rowlett JK, Spealman RD. Discriminative stimulus effects of morphine in squirrel monkeys: stimulants, opioids, and stimulant-opioid combinations. J Pharmacol Exp Ther. 1999 Sep; 290(3):1092-100. PMID: 10454482.
    Citations: 5     Fields:    Translation:Animals
  59. Brownell AL, Jenkins BG, Elmaleh DR, Deacon TW, Spealman RD, Isacson O. Combined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease. Nat Med. 1998 Nov; 4(11):1308-12. PMID: 9809556.
    Citations: 16     Fields:    Translation:AnimalsCells
  60. Rowlett JK, Spealman RD. Opioid enhancement of the discriminative stimulus effects of cocaine: evidence for involvement of mu and delta opioid receptors. Psychopharmacology (Berl). 1998 Nov; 140(2):217-24. PMID: 9860113.
    Citations: 6     Fields:    Translation:Animals
  61. Spealman RD, Bergman J, Rosenzweig-Lipson S. Differential modulation of behavioral effects of cocaine by low- and high-efficacy D1 agonists. Psychopharmacology (Berl). 1997 Oct; 133(3):283-92. PMID: 9361335.
    Citations: 6     Fields:    Translation:Animals
  62. Howell LL, Coffin VL, Spealman RD. Behavioral and physiological effects of xanthines in nonhuman primates. Psychopharmacology (Berl). 1997 Jan; 129(1):1-14. PMID: 9122357.
    Citations: 9     Fields:    Translation:Animals
  63. Spealman RD. Dopamine D3 receptor agonists partially reproduce the discriminative stimulus effects of cocaine in squirrel monkeys. J Pharmacol Exp Ther. 1996 Sep; 278(3):1128-37. PMID: 8819495.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  64. Grech DM, Spealman RD, Bergman J. Self-administration of D1 receptor agonists by squirrel monkeys. Psychopharmacology (Berl). 1996 May; 125(2):97-104. PMID: 8783382.
    Citations: 18     Fields:    Translation:Animals
  65. Bergman J, Spealman RD, Madras BK, Rosenzweig-Lipson S. Agonist efficacy and the behavioral effects of dopamine D1 receptor ligands: drug interaction studies in squirrel monkeys. J Pharmacol Exp Ther. 1996 Mar; 276(3):942-50. PMID: 8786574.
    Citations: 3     Fields:    Translation:AnimalsCells
  66. Spealman RD. Noradrenergic involvement in the discriminative stimulus effects of cocaine in squirrel monkeys. J Pharmacol Exp Ther. 1995 Oct; 275(1):53-62. PMID: 7562595.
    Citations: 26     Fields:    Translation:Animals
  67. Spealman RD. Discriminative stimulus effects of cocaine in squirrel monkeys: lack of antagonism by the dopamine D2 partial agonists terguride, SDZ 208-911, and SDZ 208-912. Pharmacol Biochem Behav. 1995 Aug; 51(4):661-5. PMID: 7675840.
    Citations: 2     Fields:    Translation:Animals
  68. Kantak KM, Edwards MA, Spealman RD. Effects of N-methyl-D-aspartate antagonists in rats discriminating different doses of cocaine: comparison with direct and indirect dopamine agonists. J Pharmacol Exp Ther. 1995 Aug; 274(2):657-65. PMID: 7636725.
    Citations: 4     Fields:    Translation:Animals
  69. Bergman J, Rosenzweig-Lipson S, Spealman RD. Differential effects of dopamine D1 and D2 receptor agonists on schedule-controlled behavior of squirrel monkeys. J Pharmacol Exp Ther. 1995 Apr; 273(1):40-8. PMID: 7714795.
    Citations: 5     Fields:    Translation:Animals
  70. Wüllner U, Pakzaban P, Brownell AL, Hantraye P, Burns L, Shoup T, Elmaleh D, Petto AJ, Spealman RD, Brownell GL, et al. Dopamine terminal loss and onset of motor symptoms in MPTP-treated monkeys: a positron emission tomography study with 11C-CFT. Exp Neurol. 1994 Apr; 126(2):305-9. PMID: 7925829.
    Citations: 7     Fields:    
  71. Spealman RD, Bergman J. Opioid modulation of the discriminative stimulus effects of cocaine: comparison of µ, kappa and delta agonists in squirrel monkeys discriminating low doses of cocaine. Behav Pharmacol. 1994 Feb; 5(1):21-31. PMID: 11224248.
    Citations: 7     Fields:    
  72. Spealman RD. Modification of behavioral effects of cocaine by selective serotonin and dopamine uptake inhibitors in squirrel monkeys. Psychopharmacology (Berl). 1993; 112(1):93-9. PMID: 7871015.
    Citations: 25     Fields:    Translation:Animals
  73. Spealman RD. Failure of cholecystokinin antagonists to modify the discriminative stimulus effects of cocaine. Pharmacol Biochem Behav. 1992 Oct; 43(2):613-6. PMID: 1438498.
    Citations: 2     Fields:    Translation:Animals
  74. Spealman RD, Bergman J. Modulation of the discriminative stimulus effects of cocaine by mu and kappa opioids. J Pharmacol Exp Ther. 1992 May; 261(2):607-15. PMID: 1315861.
    Citations: 15     Fields:    Translation:Animals
  75. Hantraye P, Brownell AL, Elmaleh D, Spealman RD, Wüllner U, Brownell GL, Madras BK, Isacson O. Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism. Neuroreport. 1992 Mar; 3(3):265-8. PMID: 1515582.
    Citations: 13     Fields:    Translation:AnimalsCells
  76. Spealman RD, Bergman J, Madras BK, Kamien JB, Melia KF. Role of D1 and D2 dopamine receptors in the behavioral effects of cocaine. Neurochem Int. 1992 Mar; 20 Suppl:147S-152S. PMID: 1365414.
    Citations: 8     Fields:    Translation:HumansAnimals
  77. Rosenzweig-Lipson S, Bergman J, Spealman RD, Madras BK. Stereoselective behavioral effects of Lu 19-005 in monkeys: relation to binding at cocaine recognition sites. Psychopharmacology (Berl). 1992; 107(2-3):186-94. PMID: 1377395.
    Citations: 1     Fields:    Translation:AnimalsCells
  78. Spealman RD. Use of cocaine-discrimination techniques for preclinical evaluation of candidate therapeutics for cocaine dependence. NIDA Res Monogr. 1992; 119:175-9. PMID: 1435975.
    Citations: 1     Fields:    Translation:HumansAnimals
  79. Kamien JB, Spealman RD. Modulation of the discriminative-stimulus effects of cocaine by buprenorphine. Behav Pharmacol. 1991 Dec; 2(6):517-520. PMID: 11224094.
    Citations: 2     Fields:    
  80. Kaufman MJ, Spealman RD, Madras BK. Distribution of cocaine recognition sites in monkey brain: I. In vitro autoradiography with [3H]CFT. Synapse. 1991 Nov; 9(3):177-87. PMID: 1776130.
    Citations: 8     Fields:    Translation:AnimalsCells
  81. Spealman RD, Bergman J, Madras BK, Melia KF. Discriminative stimulus effects of cocaine in squirrel monkeys: involvement of dopamine receptor subtypes. J Pharmacol Exp Ther. 1991 Sep; 258(3):945-53. PMID: 1679852.
    Citations: 27     Fields:    Translation:Animals
  82. Bergman J, Madras BK, Spealman RD. Behavioral effects of D1 and D2 dopamine receptor antagonists in squirrel monkeys. J Pharmacol Exp Ther. 1991 Sep; 258(3):910-7. PMID: 1890625.
    Citations: 10     Fields:    Translation:Animals
  83. Spealman RD, Bergman J, Madras BK. Self-administration of the high-affinity cocaine analog 2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane. Pharmacol Biochem Behav. 1991 Aug; 39(4):1011-3. PMID: 1763097.
    Citations: 3     Fields:    Translation:Animals
  84. Melia KF, Spealman RD. Pharmacological characterization of the discriminative-stimulus effects of GBR 12909. J Pharmacol Exp Ther. 1991 Aug; 258(2):626-32. PMID: 1678014.
    Citations: 13     Fields:    Translation:Animals
  85. Howell LL, Morse WH, Spealman RD. Respiratory effects of xanthines and adenosine analogs in rhesus monkeys. J Pharmacol Exp Ther. 1990 Sep; 254(3):786-91. PMID: 2395111.
    Citations: 1     Fields:    Translation:Animals
  86. Madras BK, Kamien JB, Fahey MA, Canfield DR, Milius RA, Saha JK, Neumeyer JL, Spealman RD. N-modified fluorophenyltropane analogs of cocaine with high affinity for cocaine receptors. Pharmacol Biochem Behav. 1990 Apr; 35(4):949-53. PMID: 2345768.
    Citations: 1     Fields:    Translation:Animals
  87. Bergman J, Kamien JB, Spealman RD. Antagonism of cocaine self-administration by selective dopamine D(1) and D(2) antagonists. Behav Pharmacol. 1990; 1(4):355-363. PMID: 11175420.
    Citations: 46     Fields:    
  88. Canfield DR, Spealman RD, Kaufman MJ, Madras BK. Autoradiographic localization of cocaine binding sites by [3H]CFT ([3H]WIN 35,428) in the monkey brain. Synapse. 1990; 6(2):189-95. PMID: 2237780.
    Citations: 9     Fields:    Translation:AnimalsCells
  89. Spealman RD. Antagonism of behavioral effects of cocaine by selective dopamine receptor blockers. Psychopharmacology (Berl). 1990; 101(1):142-5. PMID: 1971446.
    Citations: 5     Fields:    Translation:Animals
  90. Coffin VL, Spealman RD. Psychomotor-stimulant effects of 3-isobutyl-1-methylxanthine: comparison with caffeine and 7-(2-chloroethyl) theophylline. Eur J Pharmacol. 1989 Oct 24; 170(1-2):35-40. PMID: 2482186.
    Citations: 4     Fields:    Translation:Animals
  91. Spealman RD, Madras BK, Bergman J. Effects of cocaine and related drugs in nonhuman primates. II. Stimulant effects on schedule-controlled behavior. J Pharmacol Exp Ther. 1989 Oct; 251(1):142-9. PMID: 2795456.
    Citations: 25     Fields:    Translation:AnimalsCells
  92. Madras BK, Fahey MA, Bergman J, Canfield DR, Spealman RD. Effects of cocaine and related drugs in nonhuman primates. I. [3H]cocaine binding sites in caudate-putamen. J Pharmacol Exp Ther. 1989 Oct; 251(1):131-41. PMID: 2529364.
    Citations: 42     Fields:    Translation:AnimalsCells
  93. Madras BK, Spealman RD, Fahey MA, Neumeyer JL, Saha JK, Milius RA. Cocaine receptors labeled by [3H]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane. Mol Pharmacol. 1989 Oct; 36(4):518-24. PMID: 2811854.
    Citations: 31     Fields:    Translation:AnimalsCells
  94. Bergman J, Madras BK, Johnson SE, Spealman RD. Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys. J Pharmacol Exp Ther. 1989 Oct; 251(1):150-5. PMID: 2529365.
    Citations: 85     Fields:    Translation:Animals
  95. Madras BK, Fahey MA, Canfield DR, Spealman RD. D1 and D2 dopamine receptors in caudate-putamen of nonhuman primates (Macaca fascicularis). J Neurochem. 1988 Sep; 51(3):934-43. PMID: 2970527.
    Citations: 18     Fields:    Translation:Animals
  96. Spealman RD, Coffin VL. Discriminative-stimulus effects of adenosine analogs: mediation by adenosine A2 receptors. J Pharmacol Exp Ther. 1988 Aug; 246(2):610-8. PMID: 3404449.
    Citations:    Fields:    Translation:Animals
  97. Bergman J, Spealman RD. Behavioral effects of histamine H1 antagonists: comparison with other drugs and modification by haloperidol. J Pharmacol Exp Ther. 1988 May; 245(2):471-8. PMID: 2896793.
    Citations: 14     Fields:    Translation:Animals
  98. Wettstein JG, Spealman RD. Distinctive behavioral effects of the pyrazoloquinoline CGS 8216 in squirrel monkeys. Pharmacol Biochem Behav. 1988 Apr; 29(4):741-5. PMID: 3137587.
    Citations:    Fields:    Translation:Animals
  99. Spealman RD. Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism. Psychopharmacology (Berl). 1988; 95(1):19-24. PMID: 3133696.
    Citations: 9     Fields:    Translation:Animals
  100. Wettstein JG, Spealman RD. GABA-related drugs modulate the behavioral effects of lorazepam. Psychopharmacology (Berl). 1988; 95(1):38-42. PMID: 2838859.
    Citations: 1     Fields:    Translation:Animals
  101. Kirby DA, Spealman RD. Attenuation by naloxone of the pressor effects of angiotensin II in conscious cynomolgus monkeys. Life Sci. 1988; 43(5):453-8. PMID: 3398708.
    Citations:    Fields:    Translation:Animals
  102. Coffin VL, Spealman RD. Behavioral and cardiovascular effects of analogs of adenosine in cynomolgus monkeys. J Pharmacol Exp Ther. 1987 Apr; 241(1):76-83. PMID: 3572798.
    Citations: 7     Fields:    Translation:AnimalsCells
  103. Wettstein JG, Spealman RD. Behavioral effects of the beta-carboline derivatives ZK 93423 and ZK 91296 in squirrel monkeys: comparison with lorazepam and suriclone. J Pharmacol Exp Ther. 1987 Feb; 240(2):471-5. PMID: 2879907.
    Citations: 1     Fields:    Translation:Animals
  104. Wettstein JG, Spealman RD. Behavioral effects of the pyrazoloquinoline CGS 9896: agonist and antagonist actions in squirrel monkeys. J Pharmacol Exp Ther. 1987 Jan; 240(1):82-7. PMID: 3100774.
    Citations: 1     Fields:    Translation:Animals
  105. Bergman J, Spealman RD. Some behavioral effects of histamine H1 antagonists in squirrel monkeys. J Pharmacol Exp Ther. 1986 Oct; 239(1):104-10. PMID: 2876090.
    Citations: 13     Fields:    Translation:Animals
  106. Wettstein JG, Spealman RD. Behavioral effects of zopiclone, CL 218,872 and diazepam in squirrel monkeys: antagonism by Ro 15-1788 and CGS 8216. J Pharmacol Exp Ther. 1986 Aug; 238(2):522-8. PMID: 2874212.
    Citations: 3     Fields:    Translation:Animals
  107. Spealman RD, Coffin VL. Behavioral effects of adenosine analogs in squirrel monkeys: relation to adenosine A2 receptors. Psychopharmacology (Berl). 1986; 90(3):419-21. PMID: 3097732.
    Citations: 7     Fields:    Translation:Animals
  108. Spealman RD. Disruption of schedule-controlled behavior by Ro 15-1788 one day after acute treatment with benzodiazepines. Psychopharmacology (Berl). 1986; 88(3):398-400. PMID: 2870534.
    Citations: 5     Fields:    Translation:Animals
  109. Coffin VL, Spealman RD. Modulation of the behavioral effects of chlordiazepoxide by methylxanthines and analogs of adenosine in squirrel monkeys. J Pharmacol Exp Ther. 1985 Dec; 235(3):724-8. PMID: 2416907.
    Citations: 5     Fields:    Translation:Animals
  110. Spealman RD. Discriminative-stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by Ro 15-1788. J Pharmacol Exp Ther. 1985 Nov; 235(2):456-62. PMID: 2932547.
    Citations: 18     Fields:    Translation:Animals
  111. Katz JL, Spealman RD, Clark RD. Stereoselective behavioral effects of N-allylnormetazocine in pigeons and squirrel monkeys. J Pharmacol Exp Ther. 1985 Feb; 232(2):452-61. PMID: 3968644.
    Citations: 7     Fields:    Translation:Animals
  112. Spealman RD. Effects of some dibenzo-azepines on suppressed and nonsuppressed behavior of squirrel monkeys. Psychopharmacology (Berl). 1985; 85(2):129-32. PMID: 2861615.
    Citations:    Fields:    Translation:Animals
  113. Glowa JR, Spealman RD. Behavioral effects of caffeine, N6-(L-phenylisopropyl) adenosine and their combination in the squirrel monkey. J Pharmacol Exp Ther. 1984 Dec; 231(3):665-70. PMID: 6502521.
    Citations: 4     Fields:    Translation:Animals
  114. Goldberg SR, Spealman RD, Risner ME, Henningfield JE. Control of behavior by intravenous nicotine injections in laboratory animals. Pharmacol Biochem Behav. 1983 Dec; 19(6):1011-20. PMID: 6657719.
    Citations: 26     Fields:    Translation:Animals
  115. Spealman RD. Maintenance of behavior by postponement of scheduled injections of nicotine in squirrel monkeys. J Pharmacol Exp Ther. 1983 Oct; 227(1):154-9. PMID: 6684684.
    Citations: 8     Fields:    Translation:HumansAnimals
  116. Spealman RD, Kelleher RT, Goldberg SR. Stereoselective behavioral effects of cocaine and a phenyltropane analog. J Pharmacol Exp Ther. 1983 Jun; 225(3):509-14. PMID: 6864516.
    Citations: 7     Fields:    Translation:Animals
  117. Goldberg SR, Spealman RD. Suppression of behavior by intravenous injections of nicotine or by electric shocks in squirrel monkeys: effects of chlordiazepoxide and mecamylamine. J Pharmacol Exp Ther. 1983 Feb; 224(2):334-40. PMID: 6822959.
    Citations: 23     Fields:    Translation:Animals
  118. Spealman RD, Kelleher RT, Goldberg SR, DeWeese J, Goldberg DM. Behavioral effects of clozapine: comparison with thioridazine, chlorpromazine, haloperidol and chlordiazepoxide in squirrel monkeys. J Pharmacol Exp Ther. 1983 Jan; 224(1):127-34. PMID: 6848739.
    Citations: 7     Fields:    Translation:Animals
  119. Spealman RD, Goldberg SR. Maintenance of schedule-controlled behavior by intravenous injections of nicotine in squirrel monkeys. J Pharmacol Exp Ther. 1982 Nov; 223(2):402-8. PMID: 7131295.
    Citations: 29     Fields:    Translation:Animals
  120. Goldberg SR, Spealman RD. Maintenance and suppression of behavior by intravenous nicotine injections in squirrel monkeys. Fed Proc. 1982 Feb; 41(2):216-20. PMID: 7060749.
    Citations: 18     Fields:    Translation:Animals
  121. Goldberg SR, Spealman RD, Goldberg DM. Persistent behavior at high rates maintained by intravenous self-administration of nicotine. Science. 1981 Oct 30; 214(4520):573-5. PMID: 7291998.
    Citations: 105     Fields:    Translation:HumansAnimals
  122. Spealman RD, Kelleher RT. Self-administration of cocaine derivatives by squirrel monkeys. J Pharmacol Exp Ther. 1981 Mar; 216(3):532-6. PMID: 7205634.
    Citations: 4     Fields:    Translation:Animals
  123. Spealman RD, Goldberg SR, Gardner ML. Behavioral effects of nicotine: schedule-controlled responding by squirrel monkeys. J Pharmacol Exp Ther. 1981 Mar; 216(3):484-91. PMID: 7205628.
    Citations: 18     Fields:    Translation:Animals
  124. Spealman RD, Kelleher RT, Morse WH, Goldberg SR. Supersensitivity to the behavioral effects of opiate antagonists [proceedings]. Psychopharmacol Bull. 1981 Jan; 17(1):54-6. PMID: 7232659.
    Citations: 8     Fields:    Translation:Animals
  125. Spealman RD, Katz JL. Some effects of clozapine on punished responding by mice and squirrel monkeys. J Pharmacol Exp Ther. 1980 Mar; 212(3):435-40. PMID: 6767017.
    Citations: 7     Fields:    Translation:Animals
  126. Goldberg SR, Spealman RD, Kelleher RT. Enhancement of drug-seeking behavior by environmental stimuli associated with cocaine or morphine injections. Neuropharmacology. 1979 Dec; 18(12):1015-7. PMID: 119167.
    Citations: 17     Fields:    Translation:Animals
  127. Spealman RD, Kelleher RT. Behavioral effects of self-administered cocaine: responding maintained alternately by cocaine and electric shock in squirrel monkeys. J Pharmacol Exp Ther. 1979 Aug; 210(2):206-14. PMID: 110922.
    Citations: 11     Fields:    Translation:Animals
  128. Spealman RD, Goldberg SR, Kelleher RT, Morse WH, Goldberg DM, Hakansson CG, Nieforth KA, Lazer ES. Effects of norcocaine and some norcocaine derivatives on schedule-controlled behavior of pigeons and squirrel monkeys. J Pharmacol Exp Ther. 1979 Aug; 210(2):196-205. PMID: 110921.
    Citations: 4     Fields:    Translation:Animals
  129. Spealman RD. Behavior maintained by termination of a schedule of self-administered cocaine. Science. 1979 Jun 15; 204(4398):1231-3. PMID: 109920.
    Citations: 23     Fields:    Translation:HumansAnimals
  130. Spealman RD. Comparison of drug effects on responding punished by pressurized air or electric shock delivery in squirrel monkeys: pentobarbital, chlordiazepoxide, d-amphetamine and cocaine. J Pharmacol Exp Ther. 1979 May; 209(2):309-15. PMID: 108387.
    Citations: 17     Fields:    Translation:Animals
  131. Lazer ES, Aggarwal ND, Hite GJ, Nieforth KA, Kelleher RT, Spealman RD, Schuster CR, Wolverton W. Synthesis and biological activity of cocaine analogs I: N-alkylated norcocaine derivatives. J Pharm Sci. 1978 Dec; 67(12):1656-8. PMID: 102759.
    Citations: 2     Fields:    Translation:AnimalsCells
  132. Spealman RD. Interactions in multiple schedules: negative induction with squirrel monkeys. J Exp Anal Behav. 1978 Nov; 30(3):315-27. PMID: 16812112.
    Citations:    Fields:    
  133. Spealman RD, Katz JL, Witkin JM. Drug effects on responding maintained by stimulus-reinforcer and response-reinforcer contingencies. J Exp Anal Behav. 1978 Sep; 30(2):187-96. PMID: 702026.
    Citations: 5     Fields:    Translation:Animals
  134. Barrett JE, Spealman RD. Behavior simultaneously maintained by both presentation and termination of noxious stimuli. J Exp Anal Behav. 1978 May; 29(3):375-83. PMID: 16812064.
    Citations: 9     Fields:    
  135. Spealman RD. Pressurized air as a punisher. J Exp Anal Behav. 1978 Mar; 29(2):341-5. PMID: 16812061.
    Citations: 1     Fields:    
  136. Spealman RD, Goldberg SR. Drug self-administration by laboratory animals: control by schedules of reinforcement. Annu Rev Pharmacol Toxicol. 1978; 18:313-39. PMID: 348062.
    Citations: 39     Fields:    Translation:Animals
  137. Spealman RD, Goldberg SR, Kelleher RT, Goldberg DM, Charlton JP. Some effects of cocaine and two cocaine analogs on schedule-controlled behavior of squirrel monkeys. J Pharmacol Exp Ther. 1977 Sep; 202(3):500-9. PMID: 408481.
    Citations: 25     Fields:    Translation:Animals
  138. Spealman RD. Interactions in multiple schedules: the role of the stimulus-reinforcer contingency. J Exp Anal Behav. 1976 Jul; 26(1):79-93. PMID: 16811933.
    Citations: 20     Fields:    
  139. Spealman RD, Gollub LR. Behavioral interactions in multiple variable-interval schedules. J Exp Anal Behav. 1974 Nov; 22(3):471-81. PMID: 16811810.
    Citations: 28     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.