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profileYvette Yee Yien, Ph.D.

TitleInstructor in Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women
Hematology/Karp Bldg, 5th Floor
75 Francis St
Boston MA 02115
Phone617/390-0255
Fax617/355-0993
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
K01DK106156     (YIEN, YVETTE Y)Aug 1, 2015 - Jun 30, 2020
NIH/NIDDK
Mechanism and Function of TMEM14 proteins in vertebrate heme synthesis
Role: Principal Investigator

F32DK098866     (YIEN, YVETTE Y)Jun 30, 2013 - Jun 29, 2015
NIH/NIDDK
Regulation of mitochondrial heme metabolism by Tmem14c
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Grillo AS, SantaMaria AM, Kafina MD, Cioffi AG, Huston NC, Han M, Seo YA, Yien YY, Nardone C, Menon AV, Fan J, Svoboda DC, Anderson JB, Hong JD, Nicolau BG, Subedi K, Gewirth AA, Wessling-Resnick M, Kim J, Paw BH, Burke MD. Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science. 2017 May 12; 356(6338):608-616. PMID: 28495746.
    View in: PubMed
  2. Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH. Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. J Biol Chem. 2017 Feb 10; 292(6):2556. PMID: 28188222.
    View in: PubMed
  3. Yien YY, Paw BH. A role for iron deficiency in dopaminergic neurodegeneration. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):3417-8. PMID: 26984501; PMCID: PMC4822629.
  4. Yien YY, Ringel AR, Paw BH. Mitochondrial transport of protoporphyrinogen IX in erythroid cells. Oncotarget. 2015 Aug 28; 6(25):20742-3. PMID: 26369700; PMCID: PMC4673221.
  5. Kardon JR, Yien YY, Huston NC, Branco DS, Hildick-Smith GJ, Rhee KY, Paw BH, Baker TA. Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis. Cell. 2015 May 07; 161(4):858-67. PMID: 25957689; PMCID: PMC4467794.
  6. Chung J, Bauer DE, Ghamari A, Nizzi CP, Deck KM, Kingsley PD, Yien YY, Huston NC, Chen C, Schultz IJ, Dalton AJ, Wittig JG, Palis J, Orkin SH, Lodish HF, Eisenstein RS, Cantor AB, Paw BH. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Sci Signal. 2015 Apr 14; 8(372):ra34. PMID: 25872869; PMCID: PMC4402725.
  7. Yien YY, Gnanapragasam MN, Gupta R, Rivella S, Bieker JJ. Alternative splicing of EKLF/KLF1 in murine primary erythroid tissues. Exp Hematol. 2015 Jan; 43(1):65-70. PMID: 25283745; PMCID: PMC4268327.
  8. Yien YY, Robledo RF, Schultz IJ, Takahashi-Makise N, Gwynn B, Bauer DE, Dass A, Yi G, Li L, Hildick-Smith GJ, Cooney JD, Pierce EL, Mohler K, Dailey TA, Miyata N, Kingsley PD, Garone C, Hattangadi SM, Huang H, Chen W, Keenan EM, Shah DI, Schlaeger TM, DiMauro S, Orkin SH, Cantor AB, Palis J, Koehler CM, Lodish HF, Kaplan J, Ward DM, Dailey HA, Phillips JD, Peters LL, Paw BH. TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest. 2014 Oct; 124(10):4294-304. PMID: 25157825; PMCID: PMC4191016.
  9. Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH. Characterization of genomic deletion efficiency mediated by clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. J Biol Chem. 2014 Aug 01; 289(31):21312-24. PMID: 24907273; PMCID: PMC4118095.
  10. Hildick-Smith GJ, Cooney JD, Garone C, Kremer LS, Haack TB, Thon JN, Miyata N, Lieber DS, Calvo SE, Akman HO, Yien YY, Huston NC, Branco DS, Shah DI, Freedman ML, Koehler CM, Italiano JE, Merkenschlager A, Beblo S, Strom TM, Meitinger T, Freisinger P, Donati MA, Prokisch H, Mootha VK, DiMauro S, Paw BH. Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4. Am J Hum Genet. 2013 Nov 07; 93(5):906-14. PMID: 24119684; PMCID: PMC3824126.
  11. Chen C, Garcia-Santos D, Ishikawa Y, Seguin A, Li L, Fegan KH, Hildick-Smith GJ, Shah DI, Cooney JD, Chen W, King MJ, Yien YY, Schultz IJ, Anderson H, Dalton AJ, Freedman ML, Kingsley PD, Palis J, Hattangadi SM, Lodish HF, Ward DM, Kaplan J, Maeda T, Ponka P, Paw BH. Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab. 2013 Mar 05; 17(3):343-52. PMID: 23416069; PMCID: PMC3595351.
  12. Yien YY, Bieker JJ. EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination. Mol Cell Biol. 2013 Jan; 33(1):4-13. PMID: 23090966; PMCID: PMC3536305.
  13. Yien YY, Bieker JJ. Functional interactions between erythroid Krüppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2Cß. J Biol Chem. 2012 May 04; 287(19):15193-204. PMID: 22393050; PMCID: PMC3346094.
  14. Tan TC, Yien YY, Patel BK, Mijts BN, Swaminathan K. Crystallization of a novel alpha-amylase, AmyB, from the thermophilic halophile Halothermothrix orenii. Acta Crystallogr D Biol Crystallogr. 2003 Dec; 59(Pt 12):2257-8. PMID: 14646087.
    View in: PubMed
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