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Matthew David Lynes, Ph.D.

Title
Institution
Department
Address
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Biography
Colby College, Waterville, MEB.A.Biology
Boston University, Boston, MAPh.D.Cell and Molecular Biology
Joslin Diabetes Center, Boston, MAPostdoctoral FellowshipIntegrative Physiology and Metabolism

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K01DK111714 (LYNES, MATTHEW) Aug 1, 2017 - Jul 31, 2022
    NIH
    The Lipidomics of Adipose Tissue Thermogenesis
    Role: Principal Investigator
  2. F32DK102320 (LYNES, MATTHEW) Jun 1, 2014 - May 31, 2015
    NIH
    Telomerase as a Marker of Brown and White Adipose Tissue Stem Cells
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Lynes MD, Shamsi F, Sustarsic EG, Leiria LO, Wang CH, Su SC, Huang TL, Gao F, Narain NR, Chen EY, Cypess AM, Schulz TJ, Gerhart-Hines Z, Kiebish MA, Tseng YH. Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism. Cell Rep. 2018 Jul 17; 24(3):781-790. PMID: 30021173.
    View in: PubMed
  2. Sustarsic EG, Ma T, Lynes MD, Larsen M, Karavaeva I, Havelund JF, Nielsen CH, Jedrychowski MP, Moreno-Torres M, Lundh M, Plucinska K, Jespersen NZ, Grevengoed TJ, Kramar B, Peics J, Hansen JB, Shamsi F, Forss I, Neess D, Keipert S, Wang J, Stohlmann K, Brandslund I, Christensen C, Jørgensen ME, Linneberg A, Pedersen O, Kiebish MA, Qvortrup K, Han X, Pedersen BK, Jastroch M, Mandrup S, Kjær A, Gygi SP, Hansen T, Gillum MP, Grarup N, Emanuelli B, Nielsen S, Scheele C, Tseng YH, Færgeman NJ, Gerhart-Hines Z. Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis. Cell Metab. 2018 Jul 03; 28(1):159-174.e11. PMID: 29861389.
    View in: PubMed
  3. Stanford KI, Lynes MD, Takahashi H, Baer LA, Arts PJ, May FJ, Lehnig AC, Middelbeek RJW, Richard JJ, So K, Chen EY, Gao F, Narain NR, Distefano G, Shettigar VK, Hirshman MF, Ziolo MT, Kiebish MA, Tseng YH, Coen PM, Goodyear LJ. 12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metab. 2018 May 01; 27(5):1111-1120.e3. PMID: 29719226.
    View in: PubMed
  4. Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS. Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nat Med. 2018 Mar; 24(3):292-303. PMID: 29400713.
    View in: PubMed
  5. Gao F, McDaniel J, Chen EY, Rockwell HE, Nguyen C, Lynes MD, Tseng YH, Sarangarajan R, Narain NR, Kiebish MA. Adapted MS/MSALL Shotgun Lipidomics Approach for Analysis of Cardiolipin Molecular Species. Lipids. 2018 Jan; 53(1):133-142. PMID: 29488636.
    View in: PubMed
  6. Ramirez AK, Lynes MD, Shamsi F, Xue R, Tseng YH, Kahn CR, Kasif S, Dreyfuss JM. Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes. Cell Rep. 2017 Dec 12; 21(11):3040-3048. PMID: 29241534.
    View in: PubMed
  7. Townsend KL, Madden CJ, Blaszkiewicz M, McDougall L, Tupone D, Lynes MD, Mishina Y, Yu P, Morrison SF, Tseng YH. Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A. Endocrinology. 2017 12 01; 158(12):4233-4245. PMID: 29040444.
    View in: PubMed
  8. Lynes MD, Tseng YH. Deciphering adipose tissue heterogeneity. Ann N Y Acad Sci. 2018 Jan; 1411(1):5-20. PMID: 28763833.
    View in: PubMed
  9. Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH. The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 2017 May; 23(5):631-637. PMID: 28346411.
    View in: PubMed
  10. Zhu Y, Gao Y, Tao C, Shao M, Zhao S, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland WL, Gupta RK, Spray DC, Tanowitz HB, Cao L, Lynes MD, Tseng YH, Elmquist JK, Williams KW, Lin HV, Scherer PE. Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Cell Metab. 2016 09 13; 24(3):420-433. PMID: 27626200.
    View in: PubMed
  11. Gao F, McDaniel J, Chen EY, Rockwell H, Lynes MD, Tseng YH, Sarangarajan R, Narain NR, Kiebish MA. Monoacylglycerol Analysis Using MS/MS(ALL) Quadruple Time of Flight Mass Spectrometry. Metabolites. 2016 Aug 17; 6(3). PMID: 27548241.
    View in: PubMed
  12. Schulz TJ, Graja A, Huang TL, Xue R, An D, Poehle-Kronawitter S, Lynes MD, Tolkachov A, O'Sullivan LE, Hirshman MF, Schupp M, Goodyear LJ, Mishina Y, Tseng YH. Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance. Diabetologia. 2016 08; 59(8):1769-77. PMID: 27209464; PMCID: PMC4930470.
  13. Zhang X, Tian Y, Zhang H, Kavishwar A, Lynes M, Brownell AL, Sun H, Tseng YH, Moore A, Ran C. Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning. Sci Rep. 2015 Aug 13; 5:13116. PMID: 26269357; PMCID: PMC4534785.
  14. Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM, Tseng YH. Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nat Med. 2015 Jul; 21(7):760-8. PMID: 26076036; PMCID: PMC4496292.
  15. Lynes MD, Tseng YH. The Thermogenic Circuit: Regulators of Thermogenic Competency and Differentiation. Genes Dis. 2015 Jun; 2(2):164-172. PMID: 26491708.
    View in: PubMed
  16. Lynes MD, Schulz TJ, Pan AJ, Tseng YH. Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat but normal muscle development. Endocrinology. 2015 May; 156(5):1637-47. PMID: 25625589; PMCID: PMC4398768.
  17. Lynes MD, Tseng YH. Unwiring the transcriptional heat circuit. Proc Natl Acad Sci U S A. 2014 Oct 07; 111(40):14318-9. PMID: 25261553; PMCID: PMC4209983.
  18. Castiglioni A, Hettmer S, Lynes MD, Rao TN, Tchessalova D, Sinha I, Lee BT, Tseng YH, Wagers AJ. Isolation of progenitors that exhibit myogenic/osteogenic bipotency in vitro by fluorescence-activated cell sorting from human fetal muscle. Stem Cell Reports. 2014 Jan 14; 2(1):92-106. PMID: 24678452; PMCID: PMC3966115.
  19. Townsend KL, An D, Lynes MD, Huang TL, Zhang H, Goodyear LJ, Tseng YH. Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake. Antioxid Redox Signal. 2013 Jul 20; 19(3):243-57. PMID: 22938691; PMCID: PMC3691916.
  20. Lynes M, Narisawa S, Millán JL, Widmaier EP. Interactions between CD36 and global intestinal alkaline phosphatase in mouse small intestine and effects of high-fat diet. Am J Physiol Regul Integr Comp Physiol. 2011 Dec; 301(6):R1738-47. PMID: 21900644; PMCID: PMC3233846.
  21. Lynes MD, Widmaier EP. Involvement of CD36 and intestinal alkaline phosphatases in fatty acid transport in enterocytes, and the response to a high-fat diet. Life Sci. 2011 Feb 28; 88(9-10):384-91. PMID: 21172358.
    View in: PubMed
  22. Gardner H, Shearstone JR, Bandaru R, Crowell T, Lynes M, Trojanowska M, Pannu J, Smith E, Jablonska S, Blaszczyk M, Tan FK, Mayes MD. Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts. Arthritis Rheum. 2006 Jun; 54(6):1961-73. PMID: 16736506.
    View in: PubMed
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