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Karen Marie Cichowski, PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01CA202943 (CICHOWSKI, KAREN M) Jun 1, 2016 - May 31, 2020
    NIH/NCI
    Developing a translational pipeline for NF1-mutant malignancies
    Role: Principal Investigator
  2. R01CA198097 (CICHOWSKI, KAREN M) Apr 1, 2016 - Mar 31, 2021
    NIH/NCI
    Co-targeting oncogenic pathways in advanced prostate cancer
    Role: Principal Investigator
  3. R01CA188659 (CICHOWSKI, KAREN M) Sep 18, 2014 - Aug 31, 2019
    NIH/NCI
    Elucidating the role of new RasGAP tumor suppressors in cancer
    Role: Principal Investigator
  4. R13CA177059 (CICHOWSKI, KAREN M) Jun 6, 2013 - May 31, 2014
    NIH/NCI
    FASEB SRC on Regulation and Function of Small GTPases
    Role: Principal Investigator
  5. R01CA129814 (CICHOWSKI, KAREN M) Jul 1, 2007 - Apr 30, 2013
    NIH/NCI
    Elucidating the role of the mTOR pathway in NF1-related tumorigenesis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Haigis KM, Cichowski K, Elledge SJ. Tissue-specificity in cancer: The rule, not the exception. Science. 2019 Mar 15; 363(6432):1150-1151. PMID: 30872507.
    Citations:    
  2. Maertens O, Kuzmickas R, Manchester HE, Emerson CE, Gavin AG, Guild CJ, Wong TC, De Raedt T, Bowman-Colin C, Hatchi E, Garraway LA, Flaherty KT, Pathania S, Elledge SJ, Cichowski K. MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas. Cancer Discov. 2019 Apr; 9(4):526-545. PMID: 30709805.
    Citations:    Fields:    
  3. Liao S, Maertens O, Cichowski K, Elledge SJ. Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is. Genes Dev. 2018 09 01; 32(17-18):1188-1200. PMID: 30135075.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS. Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance. Cancer Cell. 2018 06 11; 33(6):985-1003.e7. PMID: 29805077.
    Citations: 1     Fields:    
  5. Singleton KR, Crawford L, Tsui E, Manchester HE, Maertens O, Liu X, Liberti MV, Magpusao AN, Stein EM, Tingley JP, Frederick DT, Boland GM, Flaherty KT, McCall SJ, Krepler C, Sproesser K, Herlyn M, Adams DJ, Locasale JW, Cichowski K, Mukherjee S, Wood KC. Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence. Cell Rep. 2017 Dec 05; 21(10):2796-2812. PMID: 29212027.
    Citations: 1     Fields:    Translation:HumansCells
  6. Maertens O, McCurrach ME, Braun BS, De Raedt T, Epstein I, Huang TQ, Lauchle JO, Lee H, Wu J, Cripe TP, Clapp DW, Ratner N, Shannon K, Cichowski K. A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies. Cancer Res. 2017 11 01; 77(21):5706-5711. PMID: 28993414.
    Citations: 1     Fields:    Translation:HumansAnimals
  7. Malone CF, Emerson C, Ingraham R, Barbosa W, Guerra S, Yoon H, Liu LL, Michor F, Haigis M, Macleod KF, Maertens O, Cichowski K. mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors. Cancer Discov. 2017 12; 7(12):1450-1463. PMID: 28963352.
    Citations: 1     Fields:    Translation:HumansCells
  8. Olsen SN, Wronski A, Castaño Z, Dake B, Malone C, De Raedt T, Enos M, DeRose YS, Zhou W, Guerra S, Loda M, Welm A, Partridge AH, McAllister SS, Kuperwasser C, Cichowski K. Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers. Cancer Discov. 2017 02; 7(2):202-217. PMID: 27974415.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  9. Zhang H, Qi J, Reyes JM, Li L, Rao PK, Li F, Lin CY, Perry JA, Lawlor MA, Federation A, De Raedt T, Li YY, Liu Y, Duarte MA, Zhang Y, Herter-Sprie GS, Kikuchi E, Carretero J, Perou CM, Reibel JB, Paulk J, Bronson RT, Watanabe H, Brainson CF, Kim CF, Hammerman PS, Brown M, Cichowski K, Long H, Bradner JE, Wong KK. Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer. Cancer Discov. 2016 09; 6(9):1006-21. PMID: 27312177.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  10. Lock R, Ingraham R, Maertens O, Miller AL, Weledji N, Legius E, Konicek BM, Yan SC, Graff JR, Cichowski K. Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers. J Clin Invest. 2016 06 01; 126(6):2181-90. PMID: 27159396.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  11. Lock R, Cichowski K. Loss of negative regulators amplifies RAS signaling. Nat Genet. 2015 May; 47(5):426-7. PMID: 25916896.
    Citations: 2     Fields:    Translation:Animals
  12. Montero J, Sarosiek KA, DeAngelo JD, Maertens O, Ryan J, Ercan D, Piao H, Horowitz NS, Berkowitz RS, Matulonis U, Jänne PA, Amrein PC, Cichowski K, Drapkin R, Letai A. Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy. Cell. 2015 Feb 26; 160(5):977-989. PMID: 25723171.
    Citations: 64     Fields:    Translation:HumansCells
  13. De Raedt T, Beert E, Pasmant E, Luscan A, Brems H, Ortonne N, Helin K, Hornick JL, Mautner V, Kehrer-Sawatzki H, Clapp W, Bradner J, Vidaud M, Upadhyaya M, Legius E, Cichowski K. PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature. 2014 Oct 09; 514(7521):247-51. PMID: 25119042.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  14. Malone CF, Fromm JA, Maertens O, DeRaedt T, Ingraham R, Cichowski K. Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers. Cancer Discov. 2014 Sep; 4(9):1062-73. PMID: 24913553.
    Citations: 16     Fields:    Translation:HumansCells
  15. Maertens O, Cichowski K. Paths of resistance to EGFR inhibitors: is NF enough? Cancer Discov. 2014 May; 4(5):519-21. PMID: 24795011.
    Citations: 1     Fields:    Translation:Humans
  16. Maertens O, Cichowski K. An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer. Adv Biol Regul. 2014 May; 55:1-14. PMID: 24814062.
    Citations: 30     Fields:    Translation:Humans
  17. Widemann BC, Acosta MT, Ammoun S, Belzberg AJ, Bernards A, Blakeley J, Bretscher A, Cichowski K, Clapp DW, Dombi E, Evans GD, Ferner R, Fernandez-Valle C, Fisher MJ, Giovannini M, Gutmann DH, Hanemann CO, Hennigan R, Huson S, Ingram D, Kissil J, Korf BR, Legius E, Packer RJ, McClatchey AI, McCormick F, North K, Pehrsson M, Plotkin SR, Ramesh V, Ratner N, Schirmer S, Sherman L, Schorry E, Stevenson D, Stewart DR, Ullrich N, Bakker AC, Morrison H. CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies. Am J Med Genet A. 2014 Mar; 164A(3):563-78. PMID: 24443315.
    Citations: 5     Fields:    Translation:Humans
  18. McLaughlin SK, Olsen SN, Dake B, De Raedt T, Lim E, Bronson RT, Beroukhim R, Polyak K, Brown M, Kuperwasser C, Cichowski K. The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. Cancer Cell. 2013 Sep 09; 24(3):365-78. PMID: 24029233.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  19. Hollstein PE, Cichowski K. Identifying the Ubiquitin Ligase complex that regulates the NF1 tumor suppressor and Ras. Cancer Discov. 2013 Aug; 3(8):880-93. PMID: 23661552.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  20. Maertens O, Johnson B, Hollstein P, Frederick DT, Cooper ZA, Messiaen L, Bronson RT, McMahon M, Granter S, Flaherty K, Wargo JA, Marais R, Cichowski K. Elucidating distinct roles for NF1 in melanomagenesis. Cancer Discov. 2013 Mar; 3(3):338-49. PMID: 23171796.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  21. McClatchey AI, Cichowski K. SPRED proteins provide a NF-ty link to Ras suppression. Genes Dev. 2012 Jul 15; 26(14):1515-9. PMID: 22802525.
    Citations: 3     Fields:    Translation:HumansAnimals
  22. Kalamarides M, Acosta MT, Babovic-Vuksanovic D, Carpen O, Cichowski K, Evans DG, Giancotti F, Hanemann CO, Ingram D, Lloyd AC, Mayes DA, Messiaen L, Morrison H, North K, Packer R, Pan D, Stemmer-Rachamimov A, Upadhyaya M, Viskochil D, Wallace MR, Hunter-Schaedle K, Ratner N. Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting. Acta Neuropathol. 2012 Mar; 123(3):369-80. PMID: 22083253.
    Citations: 7     Fields:    Translation:Humans
  23. De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, Macleod KF, Cichowski K. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell. 2011 Sep 13; 20(3):400-13. PMID: 21907929.
    Citations: 88     Fields:    Translation:AnimalsCells
  24. Beert E, Brems H, Daniëls B, De Wever I, Van Calenbergh F, Schoenaers J, Debiec-Rychter M, Gevaert O, De Raedt T, Van Den Bruel A, de Ravel T, Cichowski K, Kluwe L, Mautner V, Sciot R, Legius E. Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors. Genes Chromosomes Cancer. 2011 Dec; 50(12):1021-32. PMID: 21987445.
    Citations: 40     Fields:    Translation:HumansCells
  25. Huson SM, Acosta MT, Belzberg AJ, Bernards A, Chernoff J, Cichowski K, Gareth Evans D, Ferner RE, Giovannini M, Korf BR, Listernick R, North KN, Packer RJ, Parada LF, Peltonen J, Ramesh V, Reilly KM, Risner JW, Schorry EK, Upadhyaya M, Viskochil DH, Zhu Y, Hunter-Schaedle K, Giancotti FG. Back to the future: proceedings from the 2010 NF Conference. Am J Med Genet A. 2011 Feb; 155A(2):307-21. PMID: 21271647.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  26. Cichowski K, Jänne PA. Drug discovery: inhibitors that activate. Nature. 2010 Mar 18; 464(7287):358-9. PMID: 20237552.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  27. Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T, Guney I, Strochlic DE, Macconaill LE, Beroukhim R, Bronson RT, Ryeom S, Hahn WC, Loda M, Cichowski K. An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nat Med. 2010 Mar; 16(3):286-94. PMID: 20154697.
    Citations: 154     Fields:    Translation:HumansAnimalsCells
  28. McGillicuddy LT, Fromm JA, Hollstein PE, Kubek S, Beroukhim R, De Raedt T, Johnson BW, Williams SM, Nghiemphu P, Liau LM, Cloughesy TF, Mischel PS, Parret A, Seiler J, Moldenhauer G, Scheffzek K, Stemmer-Rachamimov AO, Sawyers CL, Brennan C, Messiaen L, Mellinghoff IK, Cichowski K. Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis. Cancer Cell. 2009 Jul 07; 16(1):44-54. PMID: 19573811.
    Citations: 59     Fields:    Translation:AnimalsCells
  29. Cichowski K, Hahn WC. Unexpected pieces to the senescence puzzle. Cell. 2008 Jun 13; 133(6):958-61. PMID: 18555773.
    Citations: 22     Fields:    Translation:HumansAnimals
  30. Courtois-Cox S, Jones SL, Cichowski K. Many roads lead to oncogene-induced senescence. Oncogene. 2008 May 01; 27(20):2801-9. PMID: 18193093.
    Citations: 123     Fields:    Translation:HumansAnimals
  31. Johannessen CM, Johnson BW, Williams SM, Chan AW, Reczek EE, Lynch RC, Rioth MJ, McClatchey A, Ryeom S, Cichowski K. TORC1 is essential for NF1-associated malignancies. Curr Biol. 2008 Jan 08; 18(1):56-62. PMID: 18164202.
    Citations: 77     Fields:    Translation:AnimalsCells
  32. Courtois-Cox S, Genther Williams SM, Reczek EE, Johnson BW, McGillicuddy LT, Johannessen CM, Hollstein PE, MacCollin M, Cichowski K. A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell. 2006 Dec; 10(6):459-72. PMID: 17157787.
    Citations: 204     Fields:    Translation:HumansAnimalsCells
  33. Johannessen CM, Reczek EE, James MF, Brems H, Legius E, Cichowski K. The NF1 tumor suppressor critically regulates TSC2 and mTOR. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8573-8. PMID: 15937108.
    Citations: 173     Fields:    Translation:AnimalsCells
  34. Engelman JA, Jänne PA, Mermel C, Pearlberg J, Mukohara T, Fleet C, Cichowski K, Johnson BE, Cantley LC. ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3788-93. PMID: 15731348.
    Citations: 164     Fields:    Translation:HumansAnimalsCells
  35. Stemmer-Rachamimov AO, Louis DN, Nielsen GP, Antonescu CR, Borowsky AD, Bronson RT, Burns DK, Cervera P, McLaughlin ME, Reifenberger G, Schmale MC, MacCollin M, Chao RC, Cichowski K, Kalamarides M, Messerli SM, McClatchey AI, Niwa-Kawakita M, Ratner N, Reilly KM, Zhu Y, Giovannini M. Comparative pathology of nerve sheath tumors in mouse models and humans. Cancer Res. 2004 May 15; 64(10):3718-24. PMID: 15150133.
    Citations: 33     Fields:    Translation:HumansAnimals
  36. Cichowski K, Santiago S, Jardim M, Johnson BW, Jacks T. Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor. Genes Dev. 2003 Feb 15; 17(4):449-54. PMID: 12600938.
    Citations: 44     Fields:    Translation:AnimalsCells
  37. Cichowski K, Jacks T. NF1 tumor suppressor gene function: narrowing the GAP. Cell. 2001 Feb 23; 104(4):593-604. PMID: 11239415.
    Citations: 174     Fields:    Translation:HumansAnimalsCells
  38. McClatchey AI, Cichowski K. Mouse models of neurofibromatosis. Biochim Biophys Acta. 2001; 1471(2):M73-80. PMID: 11342186.
    Citations: 1     Fields:    Translation:HumansAnimals
  39. Cichowski K, Shih TS, Schmitt E, Santiago S, Reilly K, McLaughlin ME, Bronson RT, Jacks T. Mouse models of tumor development in neurofibromatosis type 1. Science. 1999 Dec 10; 286(5447):2172-6. PMID: 10591652.
    Citations: 129     Fields:    Translation:HumansAnimalsCells
  40. Halper AS, Cherney LR, Cichowski K, Zhang M. Dysphagia after head trauma: the effect of cognitive-communicative impairments on functional outcomes. J Head Trauma Rehabil. 1999 Oct; 14(5):486-96. PMID: 10653944.
    Citations: 8     Fields:    Translation:Humans
  41. Cichowski K, Orsini MJ, Brass LF. PAR1 activation initiates integrin engagement and outside-in signalling in megakaryoblastic CHRF-288 cells. Biochim Biophys Acta. 1999 Jul 08; 1450(3):265-76. PMID: 10395938.
    Citations: 3     Fields:    Translation:HumansCells
  42. Johnson L, Greenbaum D, Cichowski K, Mercer K, Murphy E, Schmitt E, Bronson RT, Umanoff H, Edelmann W, Kucherlapati R, Jacks T. K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev. 1997 Oct 01; 11(19):2468-81. PMID: 9334313.
    Citations: 140     Fields:    Translation:AnimalsCells
  43. Brass LF, Manning DR, Cichowski K, Abrams CS. Signaling through G proteins in platelets: to the integrins and beyond. Thromb Haemost. 1997 Jul; 78(1):581-9. PMID: 9198220.
    Citations: 25     Fields:    Translation:HumansCells
  44. Cichowski K, Shih TS, Jacks T. Nf1 gene targeting: toward models and mechanisms. Semin Cancer Biol. 1996 Oct; 7(5):291-8. PMID: 9110406.
    Citations: 5     Fields:    Translation:HumansAnimals
  45. Cichowski K, Brugge JS, Brass LF. Thrombin receptor activation and integrin engagement stimulate tyrosine phosphorylation of the proto-oncogene product, p95vav, in platelets. J Biol Chem. 1996 Mar 29; 271(13):7544-50. PMID: 8631786.
    Citations: 19     Fields:    Translation:HumansCells
  46. Brass LF, Vassallo RR, Belmonte E, Ahuja M, Cichowski K, Hoxie JA. Structure and function of the human platelet thrombin receptor. Studies using monoclonal antibodies directed against a defined domain within the receptor N terminus. J Biol Chem. 1992 Jul 15; 267(20):13795-8. PMID: 1321125.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  47. Vassallo RR, Kieber-Emmons T, Cichowski K, Brass LF. Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J Biol Chem. 1992 Mar 25; 267(9):6081-5. PMID: 1313429.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  48. Cichowski K, McCormick F, Brugge JS. p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets. J Biol Chem. 1992 Mar 15; 267(8):5025-8. PMID: 1544885.
    Citations: 18     Fields:    Translation:HumansCells
  49. Corvera S, Bartels JL, Capocasale RJ, Cichowski K, Moore JS. Increased assembly of clathrin occurs in response to mitogenic activation of murine lymphocytes. J Biol Chem. 1989 Jul 25; 264(21):12568-72. PMID: 2663860.
    Citations: 1     Fields:    Translation:AnimalsCells
  50. Heinemann AW, Roth EJ, Cichowski K, Betts HB. Multivariate analysis of improvement and outcome following stroke rehabilitation. Arch Neurol. 1987 Nov; 44(11):1167-72. PMID: 3675249.
    Citations: 10     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.