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Dong Wang, M.D., Sc.D.

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Biography
Harvard T.H. Chan School of Public Health, Boston, MAPostdoctoral Fellowship08/2020Human Microbiome and Computational Biology
Harvard T.H. Chan School of Public Health, Boston, MAPostdoctoral Fellowship08/2018Metabolomics
Harvard T.H. Chan School of Public Health, Boston, MAScD05/2016Nutrition and Epidemiology
National Institute for Nutrition and Health, Beijing, ChinaMS06/2007Nutrition
Anhui Medical University, Hefei, ChinaMD06/2004Preventive Medicine

Overview
My research is situated where nutrition, the human microbiome, and chronic disease epidemiology intersect. My program has two key objectives: understanding the functional role of the human microbiome in aging-related chronic diseases and developing personalized dietary approaches for more effective prevention of cardiometabolic disease and Alzheimer's dementia.

Currently, I am PI of an R01 project (R01NR019992), which aims to identify gut microbial features and fecal and plasma metabolites that explain interindividual variations in cardiometabolic risk changes following dietary interventions in two randomized controlled trials. This project also investigates the combined effects of Mediterranean diet interventions and autologous fecal microbiota transplantation. Furthermore, I serve as PI of an R00 project (R00DK119412) that examines the associations between the Mediterranean diet, the gut microbiome, and type 2 diabetes. In this R00 project, we found, for the first time, that the associations of a Mediterranean dietary pattern with cardiometabolic risk varied in individuals with different gut microbial profiles (Wang et al. Nature Medicine. 2021). Building on this, I established the MicroCardio Consortium, expanding my research from two cohorts to include 14 population-based studies across ten countries. Through this consortium, we recently identified strain-specific microbial signatures and functional genes underlying the pathogenesis of type 2 diabetes (Mei and Wang et al. Nature Medicine. 2024).

Additionally, I serve as PI of two ongoing projects (R01AG077489 and RF1AG083764) funded by the National Institute on Aging (NIA). These projects investigate the interactions between dietary intake and the gut microbiome and aim to enhance dietary prevention strategies for Alzheimer's dementia. These studies involve multiple observational cohort studies and randomized controlled trials. In these NIA-funded projects, we have identified dysbiosis-related markers, including Veillonella spp. and the opportunistic pathogen Erysipelatoclostridium ramosum, as indicators of cognitive decline (Ma et al. Neurology. 2023).

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. RF1AG083764 (WANG, DONG) May 15, 2024 - Apr 30, 2027
    NIH
    The Microbiome-Gut-Brain Axis and Personalized Mediterranean Diet Interventions for Alzheimer's Dementia Prevention
    Role: Principal Investigator
  2. R01AG077489 (WANG, DONG) Jun 1, 2022 - Mar 31, 2027
    NIH
    Towards Precision Nutrition for Alzheimer's Dementia Prevention: A Prospective Study of Dietary Patterns, the Gut Microbiome and Cognitive Function
    Role: Principal Investigator
  3. R01NR019992 (WANG, DONG) Sep 23, 2021 - Jun 30, 2026
    NIH
    The Gut Microbiome and Personalized Mediterranean Diet Interventions for Cardiometabolic Disease Prevention
    Role: Principal Investigator
  4. R00DK119412 (WANG, DONG) Sep 1, 2020 - Aug 31, 2023
    NIH
    Mediterranean Diet, Polyphenol-Rich Foods, Gut Microbiota and Type 2 Diabetes
    Role: Principal Investigator
  5. K99DK119412 (WANG, DONG) Sep 6, 2018 - Aug 31, 2020
    NIH
    Mediterranean Diet, Polyphenol-Rich Foods, Gut Microbiota and Type 2 Diabetes
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.