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Maria Catarina Lima da Silva, Ph.D.

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University of Lisbon Faculty of Sciences, Lisbon, PortugalB.Sc./M.Sc.2005Biochemistry
Northwestern University and University of Lisbon, IL USA, Lisbon PortugalPhD2012Biochemistry and Molecular Biology


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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Silva MC, Nandi G, Haggarty SJ. Differentiation of Human Induced Pluripotent Stem Cells into Cortical Neurons to Advance Precision Medicine. Methods Mol Biol. 2022; 2429:143-174. PMID: 35507160.
    Citations:    Fields:    Translation:HumansCells
  2. Cheng C, Reis SA, Adams ET, Fass DM, Angus SP, Stuhlmiller TJ, Richardson J, Olafson H, Wang ET, Patnaik D, Beauchamp RL, Feldman DA, Silva MC, Sur M, Johnson GL, Ramesh V, Miller BL, Temple S, Kosik KS, Dickerson BC, Haggarty SJ. High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy. Sci Rep. 2021 08 23; 11(1):17029. PMID: 34426604.
    Citations: 2     Fields:    Translation:HumansCells
  3. Bowles KR, Silva MC, Whitney K, Bertucci T, Berlind JE, Lai JD, Garza JC, Boles NC, Mahali S, Strang KH, Marsh JA, Chen C, Pugh DA, Liu Y, Gordon RE, Goderie SK, Chowdhury R, Lotz S, Lane K, Crary JF, Haggarty SJ, Karch CM, Ichida JK, Goate AM, Temple S. ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids. Cell. 2021 08 19; 184(17):4547-4563.e17. PMID: 34314701; PMCID: PMC8635409.
    Citations: 11     Fields:    Translation:HumansCells
  4. Patnaik D, Pao PC, Zhao WN, Silva MC, Hylton NK, Chindavong PS, Pan L, Tsai LH, Haggarty SJ. Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration. ACS Chem Neurosci. 2021 01 20; 12(2):271-284. PMID: 33417763.
    Citations: 3     Fields:    Translation:HumansCells
  5. Silva MC, Haggarty SJ. Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies. Int J Mol Sci. 2020 Nov 25; 21(23). PMID: 33255694.
    Citations: 13     Fields:    Translation:HumansCells
  6. Silva MC, Nandi GA, Tentarelli S, Gurrell IK, Jamier T, Lucente D, Dickerson BC, Brown DG, Brandon NJ, Haggarty SJ. Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons. Nat Commun. 2020 06 26; 11(1):3258. PMID: 32591533; PMCID: PMC7320012.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  7. Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, Theofilas P, Grinberg LT, Moreno F, McIlroy K, Boeve BF, Cairns NJ, Crary JF, Haggarty SJ, Ichida JK, Kosik KS, Miller BL, Gan L, Goate AM, Temple S. A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies. Stem Cell Reports. 2019 11 12; 13(5):939-955. PMID: 31631020.
    Citations: 16     Fields:    Translation:HumansCells
  8. Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ. Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 2019 03 25; 8. PMID: 30907729.
    Citations: 60     Fields:    Translation:HumansCells
  9. Silva MC, Haggarty SJ. Human pluripotent stem cell-derived models and drug screening in CNS precision medicine. Ann N Y Acad Sci. 2020 07; 1471(1):18-56. PMID: 30875083.
    Citations: 25     Fields:    Translation:HumansCells
  10. Boselli M, Lee BH, Robert J, Prado MA, Min SW, Cheng C, Silva MC, Seong C, Elsasser S, Hatle KM, Gahman TC, Gygi SP, Haggarty SJ, Gan L, King RW, Finley D. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem. 2017 11 24; 292(47):19209-19225. PMID: 28972160; PMCID: PMC5702663.
    Citations: 52     Fields:    Translation:AnimalsCells
  11. Seo J, Kritskiy O, Watson LA, Barker SJ, Dey D, Raja WK, Lin YT, Ko T, Cho S, Penney J, Silva MC, Sheridan SD, Lucente D, Gusella JF, Dickerson BC, Haggarty SJ, Tsai LH. Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia. J Neurosci. 2017 10 11; 37(41):9917-9924. PMID: 28912154; PMCID: PMC5637118.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  12. Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MHU, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ. Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability. Stem Cell Reports. 2016 09 13; 7(3):325-340. PMID: 27594585.
    Citations: 39     Fields:    Translation:HumansCells
  13. Haggarty SJ, Silva MC, Cross A, Brandon NJ, Perlis RH. Advancing drug discovery for neuropsychiatric disorders using patient-specific stem cell models. Mol Cell Neurosci. 2016 06; 73:104-15. PMID: 26826498; PMCID: PMC5292010.
    Citations: 26     Fields:    Translation:HumansCells
  14. Silva MC, Amaral MD, Morimoto RI. Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response. PLoS Genet. 2013 Aug; 9(8):e1003711. PMID: 24009518.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  15. Beam M, Silva MC, Morimoto RI. Dynamic imaging by fluorescence correlation spectroscopy identifies diverse populations of polyglutamine oligomers formed in vivo. J Biol Chem. 2012 Jul 27; 287(31):26136-45. PMID: 22669943.
    Citations: 15     Fields:    Translation:AnimalsCells
  16. Silva MC, Fox S, Beam M, Thakkar H, Amaral MD, Morimoto RI. A genetic screening strategy identifies novel regulators of the proteostasis network. PLoS Genet. 2011 Dec; 7(12):e1002438. PMID: 22242008.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  17. Garcia SM, Casanueva MO, Silva MC, Amaral MD, Morimoto RI. Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells. Genes Dev. 2007 Nov 15; 21(22):3006-16. PMID: 18006691.
    Citations: 52     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.