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Sophia Koo, M.D.

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Biography
2006
ASM Student and Post Doctoral Fellow Travel Grant Award
2008
Fellow Teaching Award in Infectious Diseases
2013
Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Program Committee Award
2014
First Prize, MassBio/Massachusetts Life Sciences Innovation (MALSI) Day
2015
CID Top Article Award
2015
Chair’s Research Award
2016
Fellow, Infectious Diseases Society of America
2017
Thomas J. Walsh Award Young Investigator Award
2017
Semifinalist, Antimicrobial Resistance Diagnostic Challenge

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI138999 (KOO, SOPHIA) Jun 20, 2018 - May 31, 2023
    NIH/NIAID
    Rapid, Breath Volatile Metabolite-Based Diagnostic for In Vivo Identification and Antibiotic Resistance Profiling of Bacterial Pathogens in Ventilator-Associated Pneumonia
    Role: Principal Investigator
  2. R21AI133330 (KOO, SOPHIA) Aug 1, 2017 - Jul 31, 2019
    NIH/NIAID
    Rapid Breath-Based Diagnosis of Histoplasmosis
    Role: Principal Investigator
  3. R21AI130669 (KOO, SOPHIA) Mar 1, 2017 - Mar 1, 2019
    NIH/NIAID
    Aspergillus fumigatus volatile secondary metabolite dynamics for the identification of azole-resistant aspergillosis
    Role: Principal Investigator
  4. R21AI130669 (KOO, SOPHIA) Mar 1, 2017 - Feb 28, 2019
    NIH/NIAID
    Aspergillus fumigatus Volatile Secondary Metabolite Dynamics for the Identification of Azole-resistant Aspergillosis
    Role: Principal Investigator
  5. R21AI119692 (KOO, SOPHIA) Jul 1, 2015 - Jun 30, 2017
    NIH/NIAID
    Volatile Metabolite-Based Detection of Clostridium difficile Infection
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Fung M, Jacobsen E, Freedman A, Prestes D, Farmakiotis D, Gu X, Nguyen PL, Koo S. Increased Risk of Infectious Complications in Older Patients With Indolent Non-Hodgkin Lymphoma Exposed to Bendamustine. Clin Infect Dis. 2019 Jan 07; 68(2):247-255. PMID: 29800121.
    Citations: 1     Fields:    
  2. Baek MS, Lee SM, Chung CR, Cho WH, Cho YJ, Park S, Koo SM, Jung JS, Park SY, Chang Y, Kang BJ, Kim JH, Oh JY, Park SH, Yoo JW, Sim YS, Hong SB. Improvement in the survival rates of extracorporeal membrane oxygenation-supported respiratory failure patients: a multicenter retrospective study in Korean patients. Crit Care. 2019 01 03; 23(1):1. PMID: 30606235.
    Citations:    Fields:    
  3. Farmakiotis D, Le A, Weiss Z, Ismail N, Kubiak DW, Koo S. False positive bronchoalveolar lavage galactomannan: Effect of host and cut-off value. Mycoses. 2019 Mar; 62(3):204-213. PMID: 30387195.
    Citations:    Fields:    
  4. Knoll BM, Peixoto D, Koo S, Hammond SP, Ho VT, Antin JH, Soiffer RJ, Cutler C, Marty FM. Cytomegalovirus Infection Among Cord Blood Allogeneic Transplantation Recipients: Low Incidence of Cytomegalovirus Events without High-Dose Valacyclovir Prophylaxis. Biol Blood Marrow Transplant. 2018 10; 24(10):2164-2165. PMID: 29969749.
    Citations:    Fields:    
  5. Solomon IH, Spera KM, Ryan SL, Helgager J, Andrici J, Zaki SR, Vaitkevicius H, Leon KE, Wilson MR, DeRisi JL, Koo S, Smirnakis SM, De Girolami U. Fatal Powassan Encephalitis (Deer Tick Virus, Lineage II) in a Patient With Fever and Orchitis Receiving Rituximab. JAMA Neurol. 2018 Jun 01; 75(6):746-750. PMID: 29554185.
    Citations:    Fields:    
  6. Fung M, Jacobsen E, Freedman A, Prestes D, Farmakiotis D, Gu X, Nguyen PL, Koo S. Increased risk of infectious complications in older patients with indolent non-Hodgkin lymphoma exposed to bendamustine. Clin Infect Dis. 2018; in press.
  7. Acharige MJT, Koshy S, Ismail N, Aloum O, Jazaerly M, Astudillo CL, Koo S. Breath-based diagnosis of fungal infections. J Breath Res. 2018 02 06; 12(2):027108. PMID: 29109305.
    Citations: 1     Fields:    
  8. Prestes DP, Arbona E, Nevett-Fernandez A, Woolley AE, Ho VT, Koo S, Baden LR, Koreth J, Hammond SP, Issa NC, Marty FM. Dasatinib Use and Risk of Cytomegalovirus Reactivation After Allogeneic Hematopoietic-Cell Transplantation. Clin Infect Dis. 2017 Aug 01; 65(3):510-513. PMID: 28419210.
    Citations: 2     Fields:    Translation:HumansCells
  9. Moniodis A, Townsend K, Rabin A, Aloum O, Stempel J, Burkett P, Camp P, Divo M, El-Chemaly S, Mallidi H, Rosas I, Fuhlbrigge A, Koo S, Goldberg HJ. Comparison of extracorporeal photopheresis and alemtuzumab for the treatment of chronic lung allograft dysfunction. J Heart Lung Transplant. 2018 Mar; 37(3):340-348. PMID: 28431983.
    Citations:    Fields:    
  10. Krasnow RE, Mossanen M, Koo S, Kubiak DW, Preston MA, Chung BI, Kibel AS, Chang SL. Prophylactic Antibiotics and Postoperative Complications of Radical Cystectomy: A Population Based Analysis in the United States. J Urol. 2017 08; 198(2):297-304. PMID: 28267603.
    Citations:    Fields:    
  11. Smith RM, Muehlenbachs A, Schaenmann J, Baxi S, Koo S, Blau D, Chin-Hong P, Thorner AR, Kuehnert MJ, Wheeler K, Liakos A, Jackson JW, Benedict T, da Silva AJ, Ritter JM, Rollin D, Metcalfe M, Goldsmith CS, Visvesvara GS, Basavaraju SV, Zaki S. Three Cases of Neurologic Syndrome Caused by Donor-Derived Microsporidiosis. Emerg Infect Dis. 2017 03; 23(3):387-395. PMID: 28220747.
    Citations: 1     Fields:    Translation:HumansAnimals
  12. Furtek KJ, Kubiak DW, Barra M, Varughese CA, Ashbaugh CD, Koo S. High incidence of neutropenia in patients with prolonged ceftaroline exposure. J Antimicrob Chemother. 2016 07; 71(7):2010-3. PMID: 27076105.
    Citations: 6     Fields:    Translation:Humans
  13. Kubiak DW, Farmakiotis D, Arons V, Hollins RM, Rostas SE, Weiser LM, Baden LR, Marty FM, Koo S. Utility of in-house fluconazole disk diffusion susceptibility testing in the treatment of candidemia. Diagn Microbiol Infect Dis. 2016 Mar; 84(3):223-6. PMID: 26763713.
    Citations:    Fields:    Translation:Humans
  14. Fung M, Kim J, Marty FM, Schwarzinger M, Koo S. Meta-Analysis and Cost Comparison of Empirical versus Pre-Emptive Antifungal Strategies in Hematologic Malignancy Patients with High-Risk Febrile Neutropenia. PLoS One. 2015; 10(11):e0140930. PMID: 26554923.
    Citations: 3     Fields:    Translation:Humans
  15. Koo S, Thomas HR, Daniels SD, Lynch RC, Fortier SM, Shea MM, Rearden P, Comolli JC, Baden LR, Marty FM. A breath fungal secondary metabolite signature to diagnose invasive aspergillosis. Clin Infect Dis. 2014 Dec 15; 59(12):1733-40. PMID: 25342502.
    Citations: 17     Fields:    Translation:HumansAnimals
  16. Rabin AS, Givertz MM, Couper GS, Shea MM, Peixoto D, Yokoe DS, Baden LR, Marty FM, Koo S. Risk factors for invasive fungal disease in heart transplant recipients. J Heart Lung Transplant. 2015 Feb; 34(2):227-32. PMID: 25455750.
    Citations: 1     Fields:    Translation:Humans
  17. Peixoto D, Hammond SP, Issa NC, Madan R, Gill RR, Milner DA, Colson YL, Koo S, Baden LR, Marty FM. Green herring syndrome: bacterial infection in patients with mucormycosis cavitary lung disease. Open Forum Infect Dis. 2014 Mar; 1(1):ofu014. PMID: 25734087.
    Citations: 1     
  18. Kubiak DW, Gilmore ET, Buckley MW, Lynch R, Marty FM, Koo S. Adjunctive management of central line-associated bloodstream infections with 70% ethanol-lock therapy. J Antimicrob Chemother. 2014 Jun; 69(6):1665-8. PMID: 24526514.
    Citations: 1     Fields:    Translation:Humans
  19. Hammond SP, Buckley MW, Petruzziello G, Koo S, Marty FM, Baden LR. Clinical characteristics and outcomes of clostridial bacteremia in cancer patients. Clin Microbiol Infect. 2013.
  20. Koo S, Gagne LS, Lee P, Pratibhu PP, James LM, Givertz MM, Marty FM. Incidence and risk factors for herpes zoster following heart transplantation. Transpl Infect Dis. 2014 Feb; 16(1):17-25. PMID: 24147978.
    Citations: 4     Fields:    Translation:Humans
  21. Aizer AA, Chen MH, McCarthy EP, Mendu ML, Koo S, Wilhite TJ, Graham PL, Choueiri TK, Hoffman KE, Martin NE, Hu JC, Nguyen PL. Marital status and survival in patients with cancer. J Clin Oncol. 2013 Nov 01; 31(31):3869-76. PMID: 24062405.
    Citations: 138     Fields:    Translation:Humans
  22. Awosika OO, Lyons JL, Ciarlini P, Phillips RE, Alfson ED, Johnson EL, Koo S, Marty F, Drew C, Zaki S, Folkerth RD, Klein JP. Fatal adenovirus encephalomyeloradiculitis in an umbilical cord stem cell transplant recipient. Neurology. 2013 Apr 30; 80(18):1715-7. PMID: 23596062.
    Citations: 1     Fields:    Translation:Humans
  23. Knoll BM, Hammond SP, Koo S, Issa NC, Tullius SG, Baden LR, Pomahac B, Marty FM. Infections following facial composite tissue allotransplantation--single center experience and review of the literature. Am J Transplant. 2013 Mar; 13(3):770-9. PMID: 23279299.
    Citations: 3     Fields:    Translation:HumansCells
  24. Koo S, Kubiak DW, Issa NC, Dietzek A, Boukedes S, Camp PC, Goldberg HJ, Baden LR, Fuhlbrigge AL, Marty FM. A targeted peritransplant antifungal strategy for the prevention of invasive fungal disease after lung transplantation: a sequential cohort analysis. Transplantation. 2012 Aug 15; 94(3):281-6. PMID: 22790447.
    Citations: 6     Fields:    Translation:Humans
  25. Ng R, Koo S, Johnston R. Multicenter evaluation of bacterial contamination of glucose test strips. Clin Chim Acta. 2012 Oct 09; 413(19-20):1485-7. PMID: 22728213.
    Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
  26. Hill JA, Koo S, Guzman Suarez BB, Ho VT, Cutler C, Koreth J, Armand P, Alyea EP, Baden LR, Antin JH, Soiffer RJ, Marty FM. Cord-blood hematopoietic stem cell transplant confers an increased risk for human herpesvirus-6-associated acute limbic encephalitis: a cohort analysis. Biol Blood Marrow Transplant. 2012 Nov; 18(11):1638-48. PMID: 22564265.
    Citations: 21     Fields:    Translation:HumansCells
  27. Kubiak DW, Koo S, Hammond SP, Armand P, Baden LR, Antin JH, Marty FM. Safety of posaconazole and sirolimus coadministration in allogeneic hematopoietic stem cell transplants. Biol Blood Marrow Transplant. 2012 Sep; 18(9):1462-5. PMID: 22564264.
    Citations: 3     Fields:    Translation:Humans
  28. Koo S, Baden LR, Marty FM. Post-diagnostic kinetics of the (1 ? 3)-ß-D-glucan assay in invasive aspergillosis, invasive candidiasis and Pneumocystis jirovecii pneumonia. Clin Microbiol Infect. 2012 May; 18(5):E122-7. PMID: 22404638.
    Citations: 13     Fields:    Translation:HumansAnimals
  29. Guzmán-Suarez BB, Buckley MW, Gilmore ET, Vocca E, Moss R, Marty FM, Sanders R, Baden LR, Wurtman D, Issa NC, Fang F, Koo S. Clinical potential of DAS181 for treatment of parainfluenza-3 infections in transplant recipients. Transpl Infect Dis. 2012 Aug; 14(4):427-33. PMID: 22340538.
    Citations: 15     Fields:    Translation:HumansCells
  30. Koo S, Sutton DA, Yeh WW, Thompson EH, Sigler L, Shearer JF, Hofstra DE, Wickes BL, Marty FM. Invasive Mycoleptodiscus fungal cellulitis and myositis. Med Mycol. 2012 Oct; 50(7):740-5. PMID: 22332907.
    Citations: 1     Fields:    Translation:HumansAnimals
  31. Issa NC, Koo S, Lynch RC, Gay C, Hammond SP, Baden LR, Ghobrial IM, Finkelman MA, Marty FM. Serum galactomannan and (1->3)-ß-D-glucan assays for patients with multiple myeloma and Waldenstrom's macroglobulinemia. J Clin Microbiol. 2012 Mar; 50(3):1054-6. PMID: 22170932.
    Citations: 1     Fields:    Translation:Humans
  32. Lee AI, Koo S, Vaidya A, Katz JT, Loscalzo J. Clinical problem-solving. A bird's-eye view of fever. N Engl J Med. 2011 Nov 03; 365(18):1727-32. PMID: 22047564.
    Citations:    Fields:    Translation:HumansAnimals
  33. Ross JJ, Koo S, Lee AI, Mushlin SB, Milner DA. Interactive medical case. A bird's-eye view of fever. N Engl J Med. 2011 Oct 13; 365(15):e33. PMID: 21995411.
    Citations:    Fields:    Translation:HumansAnimals
  34. Koo S, Marty FM, Baden LR. Infectious complications associated with immunomodulating biologic agents. Hematol Oncol Clin North Am. 2011 Feb; 25(1):117-38. PMID: 21236394.
    Citations: 3     Fields:    
  35. Issa NC, Marty FM, Gagne LS, Koo S, Verrill KA, Alyea EP, Cutler CS, Koreth J, Armand P, Ho VT, Antin JH, Soiffer RJ, Baden LR. Seroprotective titers against 2009 H1N1 influenza A virus after vaccination in allogeneic hematopoietic stem cell transplantation recipients. Biol Blood Marrow Transplant. 2011 Mar; 17(3):434-8. PMID: 20950701.
    Citations: 11     Fields:    Translation:HumansCells
  36. Koo S, Klompas M, Marty FM. Fonsecaea monophora cerebral phaeohyphomycosis: case report of successful surgical excision and voriconazole treatment and review. Med Mycol. 2010 Aug; 48(5):769-74. PMID: 20100141.
    Citations: 13     Fields:    Translation:HumansAnimals
  37. Koo S, Marty FM, Baden LR. Infectious complications associated with immunomodulating biologic agents. Infect Dis Clin North Am. 2010 Jun; 24(2):285-306. PMID: 20466271.
    Citations: 8     Fields:    Translation:Humans
  38. Koo S, Bryar JM, Baden LR, Marty FM. Prognostic features of galactomannan antigenemia in galactomannan-positive invasive aspergillosis. J Clin Microbiol. 2010 Apr; 48(4):1255-60. PMID: 20147646.
    Citations: 27     Fields:    Translation:Humans
  39. Koo S, Bryar JM, Page JH, Baden LR, Marty FM. Diagnostic performance of the (1-->3)-beta-D-glucan assay for invasive fungal disease. Clin Infect Dis. 2009 Dec 01; 49(11):1650-9. PMID: 19863452.
    Citations: 47     Fields:    Translation:Humans
  40. Marty FM, Koo S. Role of (1-->3)-beta-D-glucan in the diagnosis of invasive aspergillosis. Med Mycol. 2009; 47 Suppl 1:S233-40. PMID: 18720216.
    Citations: 23     Fields:    Translation:Humans
  41. Koo S, Baden LR. Infectious complications associated with immunomodulating monoclonal antibodies used in the treatment of hematologic malignancy. J Natl Compr Canc Netw. 2008 Feb; 6(2):202-13. PMID: 18319052.
    Citations: 3     Fields:    Translation:Humans
  42. Marty FM, Koo S, Bryar J, Baden LR. (1->3)beta-D-glucan assay positivity in patients with Pneumocystis (carinii) jiroveci pneumonia. Ann Intern Med. 2007 Jul 03; 147(1):70-2. PMID: 17606968.
    Citations: 18     Fields:    Translation:HumansAnimals
  43. Nguyen PL, Whittington R, Koo S, Schultz D, Cote KB, Loffredo M, McMahon E, Renshaw AA, Tomaszewski JE, D'Amico AV. The impact of a delay in initiating radiation therapy on prostate-specific antigen outcome for patients with clinically localized prostate carcinoma. Cancer. 2005 May 15; 103(10):2053-9. PMID: 15816048.
    Citations: 13     Fields:    Translation:Humans
  44. Kucher N, Koo S, Quiroz R, Cooper JM, Paterno MD, Soukonnikov B, Goldhaber SZ. Electronic alerts to prevent venous thromboembolism among hospitalized patients. N Engl J Med. 2005 Mar 10; 352(10):969-77. PMID: 15758007.
    Citations: 141     Fields:    Translation:HumansCTClinical Trials
  45. Fanikos J, Stapinski C, Koo S, Kucher N, Tsilimingras K, Goldhaber SZ. Medication errors associated with anticoagulant therapy in the hospital. Am J Cardiol. 2004 Aug 15; 94(4):532-5. PMID: 15325949.
    Citations: 7     Fields:    Translation:Humans
  46. Kucher N, Castellanos LR, Quiroz R, Koo S, Fanikos J, Goldhaber SZ. Time trends in warfarin-associated hemorrhage. Am J Cardiol. 2004 Aug 01; 94(3):403-6. PMID: 15276120.
    Citations: 7     Fields:    Translation:Humans
  47. Koo S, Kucher N, Nguyen PL, Fanikos J, Marks PW, Goldhaber SZ. The effect of excessive anticoagulation on mortality and morbidity in hospitalized patients with anticoagulant-related major hemorrhage. Arch Intern Med. 2004 Jul 26; 164(14):1557-60. PMID: 15277289.
    Citations: 7     Fields:    Translation:Humans
  48. Nguyen PL, Whittington R, Koo S, Schultz D, Cote KB, Loffredo M, Tempany CM, Titelbaum DS, Schnall MD, Renshaw AA, Tomaszewski JE, D'Amico AV. Quantifying the impact of seminal vesicle invasion identified using endorectal magnetic resonance imaging on PSA outcome after radiation therapy for patients with clinically localized prostate cancer. Int J Radiat Oncol Biol Phys. 2004 Jun 01; 59(2):400-5. PMID: 15145155.
    Citations: 8     Fields:    Translation:Humans
  49. Monterroso V, Zhou Y, Koo S, Glackin C, Bujan W, Medeiros LJ. Hodgkin's disease in Costa Rica: a report of 40 cases analyzed for Epstein-Barr virus. Am J Clin Pathol. 1998 May; 109(5):618-24. PMID: 9576582.
    Citations: 2     Fields:    Translation:HumansCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.