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Kai Bao, Ph.D.

Concepts

This page shows the publications Kai Bao has written about Structure-Activity Relationship.
Connection Strength

0.713
  1. Design, synthesis and bio-evaluation of novel 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazoles as the tubulin polymerization inhibitors. Eur J Med Chem. 2020 Jan 15; 186:111846.
    View in: PubMed
    Score: 0.126
  2. Design, synthesis and structure-activity relationship of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as novel tubulin inhibitors. Sci Rep. 2017 09 20; 7(1):11997.
    View in: PubMed
    Score: 0.109
  3. Design and synthesis of biphenyl derivatives as mushroom tyrosinase inhibitors. Bioorg Med Chem. 2010 Sep 15; 18(18):6708-14.
    View in: PubMed
    Score: 0.066
  4. Activated carbon/Br√łnsted acid-promoted aerobic benzylic oxidation under "on-water" condition: Green and efficient synthesis of 3-benzoylquinoxalinones as potent tubulin inhibitors. Eur J Med Chem. 2020 Jan 15; 186:111894.
    View in: PubMed
    Score: 0.032
  5. Design, synthesis and biological evaluation of 3,4-diaryl-1,2,5-oxadiazole-2/5-oxides as highly potent inhibitors of tubulin polymerization. Eur J Med Chem. 2019 Sep 15; 178:287-296.
    View in: PubMed
    Score: 0.030
  6. Design, synthesis and bioevaluation of 3-oxo-6-aryl-2,3-dihydropyridazine-4-carbohydrazide derivatives as novel xanthine oxidase inhibitors. Bioorg Med Chem. 2019 05 01; 27(9):1818-1823.
    View in: PubMed
    Score: 0.030
  7. Synthesis and bioevaluation of diarylpyrazoles as antiproliferative agents. Eur J Med Chem. 2019 Jun 01; 171:1-10.
    View in: PubMed
    Score: 0.030
  8. 3,5-Diaryl-1H-pyrazolo[3,4-b]pyridines as potent tubulin polymerization inhibitors: Rational design, synthesis and biological evaluation. Eur J Med Chem. 2019 Apr 15; 168:426-435.
    View in: PubMed
    Score: 0.030
  9. Design, synthesis and bioevaluation of 2-mercapto-6-phenylpyrimidine-4-carboxylic acid derivatives as potent xanthine oxidase inhibitors. Eur J Med Chem. 2018 Jul 15; 155:590-595.
    View in: PubMed
    Score: 0.029
  10. Synthesis and biological evaluation of (1-aryl-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanone derivatives as tubulin inhibitors. Eur J Med Chem. 2018 Aug 05; 156:137-147.
    View in: PubMed
    Score: 0.029
  11. Design, synthesis and bioevaluation of antitubulin agents carrying diaryl-5,5-fused-heterocycle scaffold. Eur J Med Chem. 2017 Oct 20; 139:242-249.
    View in: PubMed
    Score: 0.027
  12. 4,5-Diaryl-3H-1,2-dithiole-3-thiones and related compounds as combretastatin A-4/oltipraz hybrids: Synthesis, molecular modelling and evaluation as antiproliferative agents and inhibitors of tubulin. Eur J Med Chem. 2016 Oct 21; 122:520-529.
    View in: PubMed
    Score: 0.025
  13. Ultrasound-promoted two-step synthesis of 3-arylselenylindoles and 3-arylthioindoles as novel combretastatin A-4 analogues. Sci Rep. 2016 Apr 05; 6:23986.
    View in: PubMed
    Score: 0.025
  14. Synthesis and Biological Evaluations of 1,2-Diaryl Pyrroles as Analogues of Combretastatin A-4. Chem Biol Drug Des. 2015 Dec; 86(6):1541-7.
    View in: PubMed
    Score: 0.024
  15. Microwave-assisted synthesis and biological evaluation of 3,4-diaryl maleic anhydride/N-substituted maleimide derivatives as combretastatin A-4 analogues. Bioorg Med Chem Lett. 2015 Feb 01; 25(3):631-4.
    View in: PubMed
    Score: 0.022
  16. 3-(3,4,5-Trimethoxyphenylselenyl)-1H-indoles and their selenoxides as combretastatin A-4 analogs: microwave-assisted synthesis and biological evaluation. Eur J Med Chem. 2015 Jan 27; 90:184-94.
    View in: PubMed
    Score: 0.022
  17. Synthesis and biological evaluation of novel 3,4-diaryl-1,2,5-selenadiazol analogues of combretastatin A-4. Eur J Med Chem. 2014 Nov 24; 87:1-9.
    View in: PubMed
    Score: 0.022
  18. Synthesis and bioevaluation of 2-phenyl-4-methyl-1,3-selenazole-5-carboxylic acids as potent xanthine oxidase inhibitors. Eur J Med Chem. 2014 Oct 06; 85:508-16.
    View in: PubMed
    Score: 0.022
  19. Synthesis and antiproliferative in-vitro activity of natural flavans and related compounds. Arch Pharm (Weinheim). 2007 Dec; 340(12):650-5.
    View in: PubMed
    Score: 0.014
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.