Harvard Catalyst Profiles

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Kai Bao, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bao K, Tully M, Cardenas K, Wang H, Srinivas S, Rho J, Jeon OH, Dinh J, Yokomizo S, McDonnell R, Yamashita A, Kashiwagi S, Kang H, Kim HK, Choi HS. Ultralow Background Near-infrared Fluorophores with Dual-Channel Intraoperative Imaging Capability. Adv Healthc Mater. 2023 Jan 14; e2203134. PMID: 36640372.
    Citations:    Fields:    
  2. Yokomizo S, Henary M, Buabeng ER, Fukuda T, Monaco H, Baek Y, Manganiello S, Wang H, Kubota J, Ulumben AD, Lv X, Wang C, Inoue K, Fukushi M, Kang H, Bao K, Kashiwagi S, Choi HS. Topical pH Sensing NIR Fluorophores for Intraoperative Imaging and Surgery of Disseminated Ovarian Cancer. Adv Sci (Weinh). 2022 07; 9(20):e2201416. PMID: 35567348; PMCID: PMC9286000.
    Citations: 1     Fields:    Translation:HumansAnimals
  3. Fukuda T, Yokomizo S, Casa S, Monaco H, Manganiello S, Wang H, Lv X, Ulumben AD, Yang C, Kang MW, Inoue K, Fukushi M, Sumi T, Wang C, Kang H, Bao K, Henary M, Kashiwagi S, Soo Choi H. Fast and Durable Intraoperative Near-infrared Imaging of Ovarian Cancer Using Ultrabright Squaraine Fluorophores. Angew Chem Int Ed Engl. 2022 04 19; 61(17):e202117330. PMID: 35150468; PMCID: PMC9007913.
    Citations: 2     Fields:    Translation:HumansAnimals
  4. Yang C, Wang H, Yokomizo S, Hickey M, Chang H, Kang H, Fukuda T, Song MY, Lee SY, Park JW, Bao K, Choi HS. ZW800-PEG: A Renal Clearable Zwitterionic Near-Infrared Fluorophore for Potential Clinical Translation. Angew Chem Int Ed Engl. 2021 06 14; 60(25):13847-13852. PMID: 33857346.
    Citations: 7     Fields:    Translation:Humans
  5. Park GK, Lee JH, Soriano E, Choi M, Bao K, Katagiri W, Kim DY, Paik JH, Yun SH, Frangioni JV, Clancy TE, Kashiwagi S, Henary M, Choi HS. Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors. iScience. 2020 Apr 24; 23(4):101006. PMID: 32268281.
    Citations: 2     
  6. Kang H, Stiles WR, Baek Y, Nomura S, Bao K, Hu S, Park GK, Jo MJ, I H, Coll JL, Rubin BP, Choi HS. Renal Clearable Theranostic Nanoplatforms for Gastrointestinal Stromal Tumors. Adv Mater. 2020 Feb; 32(6):e1905899. PMID: 31854033.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Lee JH, Jung SY, Park GK, Bao K, Hyun H, El Fakhri G, Choi HS. Fluorometric Imaging for Early Diagnosis and Prognosis of Rheumatoid Arthritis. Adv Sci (Weinh). 2020 Jan; 7(1):1902267. PMID: 31921569; PMCID: PMC6947695.
    Citations: 1     Fields:    
  8. Guan Q, Cong L, Wang Q, Yu C, Bao K, Zhou K, Wu L, Zhang W. Activated carbon/Br√łnsted acid-promoted aerobic benzylic oxidation under "on-water" condition: Green and efficient synthesis of 3-benzoylquinoxalinones as potent tubulin inhibitors. Eur J Med Chem. 2020 Jan 15; 186:111894. PMID: 31787361.
    Citations: 1     Fields:    Translation:HumansCells
  9. Huang L, Liu M, Man S, Ma D, Feng D, Sun Z, Guan Q, Zuo D, Wu Y, Zhang W, Bao K. Design, synthesis and bio-evaluation of novel 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazoles as the tubulin polymerization inhibitors. Eur J Med Chem. 2020 Jan 15; 186:111846. PMID: 31740055.
    Citations: 1     Fields:    Translation:HumansCells
  10. Hwang DW, Jo MJ, Lee JH, Kang H, Bao K, Hu S, Baek Y, Moon HG, Lee DS, Kashiwagi S, Henary M, Choi HS. Chemical Modulation of Bioengineered Exosomes for Tissue-Specific Biodistribution. Adv Ther (Weinh). 2019 Nov; 2(11). PMID: 32318623; PMCID: PMC7172497.
    Citations: 6     
  11. Ji Y, Wang Z, Bao K, Park GK, Kang H, Hu S, McDonald E, Kim MS, Kashiwagi S, Choi HS. Targeted molecular imaging of TLR4 in hepatocellular carcinoma using zwitterionic near-infrared fluorophores. Quant Imaging Med Surg. 2019 Sep; 9(9):1548-1555. PMID: 31667140; PMCID: PMC6785503.
    Citations: 8     
  12. Ahn CB, Kim JH, Park GK, Park KY, Bao K, Lee JW, Choi HS, Son KH. Prognostic imaging of iatrogenic and traumatic ureteral injury by near-infrared fluorescence. Quant Imaging Med Surg. 2019 Jun; 9(6):1056-1065. PMID: 31367559; PMCID: PMC6629557.
    Citations: 3     
  13. Hong Y, Zhao Y, Yang L, Gao M, Li L, Man S, Wang Z, Guan Q, Bao K, Zuo D, Wu Y, Zhang W. Design, synthesis and biological evaluation of 3,4-diaryl-1,2,5-oxadiazole-2/5-oxides as highly potent inhibitors of tubulin polymerization. Eur J Med Chem. 2019 Sep 15; 178:287-296. PMID: 31195170.
    Citations: 1     Fields:    Translation:HumansCells
  14. Zhang L, Wang S, Yang M, Shi A, Wang H, Guan Q, Bao K, Zhang W. Design, synthesis and bioevaluation of 3-oxo-6-aryl-2,3-dihydropyridazine-4-carbohydrazide derivatives as novel xanthine oxidase inhibitors. Bioorg Med Chem. 2019 05 01; 27(9):1818-1823. PMID: 30885567.
    Citations: 1     Fields:    Translation:AnimalsCells
  15. Wang C, Yang S, Du J, Ni J, Wu Y, Wang J, Guan Q, Zuo D, Bao K, Wu Y, Zhang W. Synthesis and bioevaluation of diarylpyrazoles as antiproliferative agents. Eur J Med Chem. 2019 Jun 01; 171:1-10. PMID: 30901597.
    Citations:    Fields:    Translation:HumansCells
  16. Zhai M, Liu S, Gao M, Wang L, Sun J, Du J, Guan Q, Bao K, Zuo D, Wu Y, Zhang W. 3,5-Diaryl-1H-pyrazolo[3,4-b]pyridines as potent tubulin polymerization inhibitors: Rational design, synthesis and biological evaluation. Eur J Med Chem. 2019 Apr 15; 168:426-435. PMID: 30831410.
    Citations: 6     Fields:    Translation:HumansCells
  17. Wu Y, Guan Q, Zheng D, Yan P, Feng D, Du J, Zhang J, Zuo D, Bao K, Zhang W. Conformation impacts on the bioactivities of SMART analogues. Eur J Med Chem. 2018 Oct 05; 158:733-742. PMID: 30245397.
    Citations:    Fields:    Translation:HumansAnimalsCells
  18. Shi A, Zhang L, Wang H, Wang S, Yang M, Guan Q, Bao K, Zhang W. Design, synthesis and bioevaluation of 2-mercapto-6-phenylpyrimidine-4-carboxylic acid derivatives as potent xanthine oxidase inhibitors. Eur J Med Chem. 2018 Jul 15; 155:590-595. PMID: 29920453.
    Citations:    Fields:    Translation:HumansCells
  19. Zhai M, Wang L, Liu S, Wang L, Yan P, Wang J, Zhang J, Guo H, Guan Q, Bao K, Wu Y, Zhang W. Synthesis and biological evaluation of (1-aryl-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanone derivatives as tubulin inhibitors. Eur J Med Chem. 2018 Aug 05; 156:137-147. PMID: 30006160.
    Citations: 1     Fields:    Translation:HumansCells
  20. Wada H, Hyun H, Bao K, Lee JH, El Fakhri G, Choi Y, Choi HS. Multivalent Mannose-Decorated NIR Nanoprobes for Targeting Pan Lymph Nodes. Chem Eng J. 2018 May 15; 340:51-57. PMID: 29962899; PMCID: PMC6022841.
    Citations: 8     
  21. Wu Y, Feng D, Gao M, Wang Z, Yan P, Gu Z, Guan Q, Zuo D, Bao K, Sun J, Wu Y, Zhang W. Design and synthesis of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2H-1,2,3-triazole derivatives as colchicine binding site inhibitors. Sci Rep. 2017 12 07; 7(1):17120. PMID: 29215079.
    Citations: 2     Fields:    
  22. Kim KS, Kim YS, Bao K, Wada H, Choi HS, Hahn SK. Bioimaging of botulinum toxin and hyaluronate hydrogels using zwitterionic near-infrared fluorophores. Biomater Res. 2017; 21:15. PMID: 29046820; PMCID: PMC5633902.
    Citations: 5     
  23. Xu Q, Bao K, Sun M, Xu J, Wang Y, Tian H, Zuo D, Guan Q, Wu Y, Zhang W. Design, synthesis and structure-activity relationship of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as novel tubulin inhibitors. Sci Rep. 2017 09 20; 7(1):11997. PMID: 28931885.
    Citations: 6     Fields:    Translation:HumansCells
  24. Xu Q, Sun M, Bai Z, Wang Y, Wu Y, Tian H, Zuo D, Guan Q, Bao K, Wu Y, Zhang W. Design, synthesis and bioevaluation of antitubulin agents carrying diaryl-5,5-fused-heterocycle scaffold. Eur J Med Chem. 2017 Oct 20; 139:242-249. PMID: 28802124.
    Citations: 3     Fields:    Translation:HumansCells
  25. Sun M, Xu Q, Xu J, Wu Y, Wang Y, Zuo D, Guan Q, Bao K, Wang J, Wu Y, Zhang W. Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity. PLoS One. 2017; 12(3):e0174006. PMID: 28333984.
    Citations: 5     Fields:    Translation:HumansCells
  26. Bao K, Lee JH, Kang H, Park GK, El Fakhri G, Choi HS. PSMA-targeted contrast agents for intraoperative imaging of prostate cancer. Chem Commun (Camb). 2017 Feb 04; 53(10):1611-1614. PMID: 28085163; PMCID: PMC5728657.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  27. Xu Q, Wang Y, Xu J, Sun M, Tian H, Zuo D, Guan Q, Bao K, Wu Y, Zhang W. Synthesis and Bioevaluation of 3,6-Diaryl-[1,2,4]triazolo[4,3-b] Pyridazines as Antitubulin Agents. ACS Med Chem Lett. 2016 Dec 08; 7(12):1202-1206. PMID: 27994764; PMCID: PMC5150690.
    Citations: 3     
  28. Koo H, Lee JH, Bao K, Wu Y, El Fakhri G, Henary M, Yun SH, Choi HS. Site-Specific In Vivo Bioorthogonal Ligation via Chemical Modulation. Adv Healthc Mater. 2016 10; 5(19):2510-2516. PMID: 27568818.
    Citations: 6     Fields:    Translation:AnimalsCells
  29. Wu L, Bao K, Song R, Wang D, Zhang L, Wang W, Zhang W, Bin W. Development of Novel Erythromycin Derivatives with Inhibitory Activity against Proliferation of Tumor Cells. PLoS One. 2016; 11(7):e0159503. PMID: 27447724.
    Citations:    Fields:    Translation:HumansCells
  30. Kang H, Gravier J, Bao K, Wada H, Lee JH, Baek Y, El Fakhri G, Gioux S, Rubin BP, Coll JL, Choi HS. Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery. Adv Mater. 2016 Oct; 28(37):8162-8168. PMID: 27414255; PMCID: PMC5155334.
    Citations: 37     Fields:    
  31. Wang Z, Qi H, Shen Q, Lu G, Li M, Bao K, Wu Y, Zhang W. 4,5-Diaryl-3H-1,2-dithiole-3-thiones and related compounds as combretastatin A-4/oltipraz hybrids: Synthesis, molecular modelling and evaluation as antiproliferative agents and inhibitors of tubulin. Eur J Med Chem. 2016 Oct 21; 122:520-529. PMID: 27428395.
    Citations: 6     Fields:    Translation:HumansCells
  32. Wen Z, Li X, Zuo D, Lang B, Wu Y, Jiang M, Ma H, Bao K, Wu Y, Zhang W. Ultrasound-promoted two-step synthesis of 3-arylselenylindoles and 3-arylthioindoles as novel combretastatin A-4 analogues. Sci Rep. 2016 Apr 05; 6:23986. PMID: 27045272.
    Citations: 3     Fields:    Translation:HumansCells
  33. Bao K, Belibasakis GN, Selevsek N, Grossmann J, Bostanci N. Proteomic profiling of host-biofilm interactions in an oral infection model resembling the periodontal pocket. Sci Rep. 2015 Nov 03; 5:15999. PMID: 26525412.
    Citations: 16     Fields:    Translation:HumansCells
  34. Sun J, Chen L, Liu C, Wang Z, Zuo D, Pan J, Qi H, Bao K, Wu Y, Zhang W. Synthesis and Biological Evaluations of 1,2-Diaryl Pyrroles as Analogues of Combretastatin A-4. Chem Biol Drug Des. 2015 Dec; 86(6):1541-7. PMID: 26202587.
    Citations: 6     Fields:    Translation:HumansCells
  35. Bao K, Li F, Liu H, Wang Z, Shen Q, Wang J, Zhang W. Activated carbon for aerobic oxidation: Benign approach toward 2-benzoylbenzimidazoles and 2-benzoylbenzoxazoles synthesis. Sci Rep. 2015 Jun 04; 5:10360. PMID: 26041483.
    Citations: 3     Fields:    
  36. Bordo MW, Oketokoun R, Cross CJ, Bao K, Lee JH, Feygin I, Chang AB, Frangioni JV, Choi HS. High-Throughput Sorting and Placement of One-Bead-One-Compound (OBOC) Libraries from Bulk to Single Wells in Organic Solvent. ACS Comb Sci. 2015 May 11; 17(5):303-9. PMID: 25879633.
    Citations: 1     Fields:    
  37. Bao K, Nasr KA, Hyun H, Lee JH, Gravier J, Gibbs SL, Choi HS. Charge and hydrophobicity effects of NIR fluorophores on bone-specific imaging. Theranostics. 2015; 5(6):609-17. PMID: 25825600.
    Citations: 21     Fields:    Translation:Animals
  38. Lee JH, Bao K, Frangioni JV, Choi HS. Screening of Small Molecule Microarrays for Ligands Targeted to the Extracellular Epitopes of Living Cells. Microarrays (Basel). 2015; 4(1):53-63. PMID: 26435848; PMCID: PMC4589137.
    Citations: 2     
  39. Guan Q, Zuo D, Jiang N, Qi H, Zhai Y, Bai Z, Feng D, Yang L, Jiang M, Bao K, Li C, Wu Y, Zhang W. Microwave-assisted synthesis and biological evaluation of 3,4-diaryl maleic anhydride/N-substituted maleimide derivatives as combretastatin A-4 analogues. Bioorg Med Chem Lett. 2015 Feb 01; 25(3):631-4. PMID: 25529737.
    Citations: 3     Fields:    Translation:HumansCells
  40. Wen Z, Xu J, Wang Z, Qi H, Xu Q, Bai Z, Zhang Q, Bao K, Wu Y, Zhang W. 3-(3,4,5-Trimethoxyphenylselenyl)-1H-indoles and their selenoxides as combretastatin A-4 analogs: microwave-assisted synthesis and biological evaluation. Eur J Med Chem. 2015 Jan 27; 90:184-94. PMID: 25461319.
    Citations: 13     Fields:    Translation:HumansCells
  41. Guan Q, Han C, Zuo D, Zhai M, Li Z, Zhang Q, Zhai Y, Jiang X, Bao K, Wu Y, Zhang W. Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities. Eur J Med Chem. 2014 Nov 24; 87:306-15. PMID: 25262051.
    Citations: 12     Fields:    Translation:HumansCells
  42. Guan Q, Yang F, Guo D, Xu J, Jiang M, Liu C, Bao K, Wu Y, Zhang W. Synthesis and biological evaluation of novel 3,4-diaryl-1,2,5-selenadiazol analogues of combretastatin A-4. Eur J Med Chem. 2014 Nov 24; 87:1-9. PMID: 25233100.
    Citations: 11     Fields:    Translation:HumansCells
  43. Hyun H, Wada H, Bao K, Gravier J, Yadav Y, Laramie M, Henary M, Frangioni JV, Choi HS. Phosphonated near-infrared fluorophores for biomedical imaging of bone. Angew Chem Int Ed Engl. 2014 Sep 26; 53(40):10668-72. PMID: 25139079.
    Citations: 38     Fields:    Translation:Animals
  44. Guan Q, Cheng Z, Ma X, Wang L, Feng D, Cui Y, Bao K, Wu L, Zhang W. Synthesis and bioevaluation of 2-phenyl-4-methyl-1,3-selenazole-5-carboxylic acids as potent xanthine oxidase inhibitors. Eur J Med Chem. 2014 Oct 06; 85:508-16. PMID: 25113879.
    Citations: 2     Fields:    Translation:AnimalsCells
  45. Hyun H, Owens EA, Narayana L, Wada H, Gravier J, Bao K, Frangioni JV, Choi HS, Henary M. Central C-C Bonding Increases Optical and Chemical Stability of NIR Fluorophores. RSC Adv. 2014 Jan 01; 4(102):58762-58768. PMID: 25530846; PMCID: PMC4267294.
    Citations: 22     
  46. Sun J, Fan S, Wang Z, Zhang G, Bao K, Zhang W. The total synthesis of D-chalcose and its C-3 epimer. Beilstein J Org Chem. 2013; 9:2620-4. PMID: 24367425.
  47. Trost BM, Breder A, Kai B. Atom-economical synthesis of functionalized cycloalkanes via catalytic redox cycloisomerization of propargyl alcohols. Org Lett. 2012 Apr 06; 14(7):1708-11. PMID: 22416797.
    Citations: 1     Fields:    Translation:Cells
  48. Bao KQ, Gao JQ, Wang ZB, Zhang RQ, Zhang ZY, Sugiura N. Enhanced removal of chemical oxygen demand, nitrogen and phosphorus using the ameliorative anoxic/anaerobic/oxic process and micro-electrolysis. Water Sci Technol. 2012; 66(4):850-7. PMID: 22766877.
    Citations: 1     Fields:    Translation:CellsPHPublic Health
  49. Bao K, Dai Y, Zhu ZB, Tu FJ, Zhang WG, Yao XS. Design and synthesis of biphenyl derivatives as mushroom tyrosinase inhibitors. Bioorg Med Chem. 2010 Sep 15; 18(18):6708-14. PMID: 20729091.
    Citations: 13     Fields:    Translation:Animals
  50. Bao K, Fan A, Dai Y, Zhang L, Zhang W, Cheng M, Yao X. Selective demethylation and debenzylation of aryl ethers by magnesium iodide under solvent-free conditions and its application to the total synthesis of natural products. Org Biomol Chem. 2009 Dec 21; 7(24):5084-90. PMID: 20024102.
    Citations: 5     Fields:    Translation:Cells
  51. Wu L, Lin JH, Bao K, Li PF, Zhang WG. In vitro effects of erythromycin on RANKL and nuclear factor-kappa B by human TNF-alpha stimulated Jurkat cells. Int Immunopharmacol. 2009 Aug; 9(9):1105-9. PMID: 19500694.
    Citations: 5     Fields:    Translation:HumansCells
  52. Lin J, Zhang W, Jiang N, Niu Z, Bao K, Zhang L, Liu D, Pan C, Yao X. Total synthesis of bulbophylol-B. J Nat Prod. 2008 Nov; 71(11):1938-41. PMID: 18959443.
    Citations: 6     Fields:    Translation:Cells
  53. Bao K, Zhang W, Bu X, Song Z, Zhang L, Cheng M. A novel type of N-formylation and related reactions of amines via cyanides and esters as formylating agents. Chem Commun (Camb). 2008 Nov 14; (42):5429-31. PMID: 18985233.
    Citations: 3     Fields:    Translation:Cells
  54. Zhang L, Zhang WG, Kang J, Bao K, Dai Y, Yao XS. Synthesis of (+/-) homoisoflavanone and corresponding homoisoflavane. J Asian Nat Prod Res. 2008 Sep-Oct; 10(9-10):909-13. PMID: 19003606.
    Citations: 3     Fields:    Translation:Cells
  55. Zhang L, Zhang WG, Ma EL, Wu L, Bao K, Wang XL, Wang YL, Song HR. Synthesis and antiproliferative in-vitro activity of natural flavans and related compounds. Arch Pharm (Weinheim). 2007 Dec; 340(12):650-5. PMID: 17994602.
    Citations:    Fields:    Translation:HumansCells
  56. Bao K, Zhang W, Zhang C, Qu Y, Tian L, Wu L, Zhao X, Cheng M. Synthesis of ring-contracted erythromycin A derivatives via microwave-assisted intramolecular transesterification. Molecules. 2007 Aug 30; 12(9):2123-9. PMID: 17962730.
    Citations: 1     Fields:    Translation:Cells
  57. Wu L, Zhang W, Tian L, Bao K, Li P, Lin J. Immunomodulatory effects of erythromycin and its derivatives on human T-lymphocyte in vitro. Immunopharmacol Immunotoxicol. 2007; 29(3-4):587-96. PMID: 18075867.
    Citations: 10     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.