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Mark Robert Zielinski, Ph.D.

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Mentoring
Available: 10/02/17, Expires: 06/30/21

Investigate molecular and immunological mechanisms that regulate sleep responses to sleep loss and pathogens. The candidate will used molecular, immunological, and neuroscience techniques including real-time polymerase chain reaction, western blot analysis, immunohistochemistry, and polysomnogray using models which target particular inflammatory genes. A basic understanding of immunology and neuroscience is required.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. IK2BX002823 (ZIELINSKI, MARK ROBERT) Jul 1, 2016 - Jun 30, 2021
    VA
    Sleep Loss and Inflammation in the Neurovascular Unit
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gerashchenko D, Schmidt MA, Zielinski MR, Moore ME, Wisor JP. Sleep State Dependence of Optogenetically evoked Responses in Neuronal Nitric Oxide Synthase-positive Cells of the Cerebral Cortex. Neuroscience. 2018 05 21; 379:189-201. PMID: 29438803.
    Citations:    Fields:    
  2. Zielinski MR, Gerashchenko D. Sleep-inducing effect of substance P-cholera toxin A subunit in mice. Neurosci Lett. 2017 10 17; 659:44-47. PMID: 28866052.
    Citations:    Fields:    Translation:Animals
  3. Davis CJ, Zielinski MR, Dunbrasky D, Taishi P, Dinarello CA, Krueger JM. Interleukin 37 expression in mice alters sleep responses to inflammatory agents and influenza virus infection. Neurobiology of Sleep and Circadian Rhythms. 2017; 3:1-9. View Publication.
  4. Zielinski MR, Gerashchenko D, Karpova SA, Konanki V, McCarley RW, Sutterwala FS, Strecker RE, Basheer R. The NLRP3 inflammasome modulates sleep and NREM sleep delta power induced by spontaneous wakefulness, sleep deprivation and lipopolysaccharide. Brain Behav Immun. 2017 May; 62:137-150. PMID: 28109896.
    Citations: 2     Fields:    Translation:AnimalsCells
  5. Davis CJ, Zielinski MR, Dunbrasky D, Taishi P, Dinarello CA, Krueger JM. Interleukin 37 expression in mice alters sleep responses to inflammatory agents and influenza virus infection. Neurobiol Sleep Circadian Rhythms. 2017 Jun; 3:1-9. PMID: 28070566.
    Citations: 2     
  6. Zielinski MR, McKenna JT, McCarley RW. Functions and Mechanisms of Sleep. AIMS Neurosci. 2016; 3(1):67-104. PMID: 28413828.
    Citations: 2     
  7. Zielinski MR, McKenna JT, McCarley RW. Functions and Mechanisms of Sleep. AIMS Neuroscience. 2016; 3(1):67-104. View Publication.
  8. Youngstedt SD, Kline CE, Elliott JA, Zielinski MR, Devlin TM, Moore TA. Circadian Phase-Shifting Effects of Bright Light, Exercise, and Bright Light + Exercise. J Circadian Rhythms. 2016 Feb 26; 14:2. PMID: 27103935; PMCID: PMC4834751.
    Citations: 4     
  9. Zielinski MR, Gerashchenko D. Diet and Exercise in Cognitive Function and Neurological Diseases. Role of Sleep in Cognition, Immunity, and Disease and Its Interaction with Exercise. 2015; 225-240.
  10. Zielinski MR, Karpova SA, Yang X, Gerashchenko D. Substance P and the neurokinin-1 receptor regulate electroencephalogram non-rapid eye movement sleep slow-wave activity locally. Neuroscience. 2015 Jan 22; 284:260-72. PMID: 25301750; PMCID: PMC4268367.
    Citations: 3     Fields:    Translation:Animals
  11. Zielinski MR, Kim Y, Karpova SA, McCarley RW, Strecker RE, Gerashchenko D. Chronic sleep restriction elevates brain interleukin-1 beta and tumor necrosis factor-alpha and attenuates brain-derived neurotrophic factor expression. Neurosci Lett. 2014 Sep 19; 580:27-31. PMID: 25093703; PMCID: PMC4162816.
    Citations: 14     Fields:    Translation:Animals
  12. Zielinski MR, Souza G, Taishi P, Bohnet SG, Krueger JM. Olfactory bulb and hypothalamic acute-phase responses to influenza virus: effects of immunization. Neuroimmunomodulation. 2013; 20(6):323-33. PMID: 23948712; PMCID: PMC3874867.
    Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
  13. Zielinski MR, Dunbrasky DL, Taishi P, Souza G, Krueger JM. Vagotomy attenuates brain cytokines and sleep induced by peripherally administered tumor necrosis factor-a and lipopolysaccharide in mice. Sleep. 2013 Aug 01; 36(8):1227-38, 1238A. PMID: 23904683; PMCID: PMC3700720.
    Citations: 16     Fields:    Translation:Animals
  14. Zielinski MR, Kim Y, Karpova SA, Winston S, McCarley RW, Strecker RE, Gerashchenko D. Sleep active cortical neurons expressing neuronal nitric oxide synthase are active after both acute sleep deprivation and chronic sleep restriction. Neuroscience. 2013 Sep 05; 247:35-42. PMID: 23685166; PMCID: PMC3801181.
    Citations: 2     Fields:    Translation:AnimalsCells
  15. Zielinski MR, Davis JM, Fadel JR, Youngstedt SD. Influence of chronic moderate sleep restriction and exercise training on anxiety, spatial memory, and associated neurobiological measures in mice. Behav Brain Res. 2013 Aug 01; 250:74-80. PMID: 23644185; PMCID: PMC3801204.
    Citations: 4     Fields:    Translation:Animals
  16. Zielinski MR, Gerashchenko L, Karpova SA, Gerashchenko D. A novel telemetric system to measure polysomnographic biopotentials in freely moving animals. J Neurosci Methods. 2013 Jun 15; 216(2):79-86. PMID: 23563323; PMCID: PMC3679249.
    Citations: 4     Fields:    Translation:Animals
  17. Zielinski MR, Taishi P, Clinton JM, Krueger JM. 5'-Ectonucleotidase-knockout mice lack non-REM sleep responses to sleep deprivation. Eur J Neurosci. 2012 Jun; 35(11):1789-98. PMID: 22540145; PMCID: PMC3370120.
    Citations: 17     Fields:    Translation:Animals
  18. Zielinski MR, Davis JM, Fadel JR, Youngstedt SD. Influence of chronic moderate sleep restriction and exercise on inflammation and carcinogenesis in mice. Brain Behav Immun. 2012 May; 26(4):672-9. PMID: 22433899; PMCID: PMC3645371.
    Citations: 8     Fields:    Translation:Animals
  19. Zielinski MR, Krueger JM. Therapy in sleep medicine. Barkoukis TJ, Matheson JK, Ferber R, Doghramji K, eds. Sleep and Inflammation. 2012; 607-616.
  20. Taishi P, Davis CJ, Bayomy O, Zielinski MR, Liao F, Clinton JM, Smith DE, Krueger JM. Brain-specific interleukin-1 receptor accessory protein in sleep regulation. J Appl Physiol (1985). 2012 Mar; 112(6):1015-22. PMID: 22174404; PMCID: PMC3311656.
    Citations: 11     Fields:    Translation:AnimalsCells
  21. Davis CJ, Clinton JM, Jewett KA, Zielinski MR, Krueger JM. Delta wave power: an independent sleep phenotype or epiphenomenon? J Clin Sleep Med. 2011 Oct 15; 7(5 Suppl):S16-8. PMID: 22003323; PMCID: PMC3190419.
    Citations: 32     Fields:    Translation:HumansAnimals
  22. Clinton JM, Davis CJ, Zielinski MR, Jewett KA, Krueger JM. Biochemical regulation of sleep and sleep biomarkers. J Clin Sleep Med. 2011 Oct 15; 7(5 Suppl):S38-42. PMID: 22003330; PMCID: PMC3190410.
    Citations: 26     Fields:    Translation:HumansAnimals
  23. Youngstedt SD, Kline CE, Ginsberg JP, Zielinski MR, Hardin JW. Bright light treatment for high-anxious young adults: a randomized controlled pilot study. Depress Anxiety. 2011 Apr; 28(4):324-32. PMID: 21254315.
    Citations: 2     Fields:    Translation:Humans
  24. Zielinski MR, Krueger JM. Sleep and innate immunity. Front Biosci (Schol Ed). 2011 Jan 01; 3:632-42. PMID: 21196401.
    Citations: 28     Fields:    Translation:HumansCells
  25. Krueger JM, Clinton JM, Winters BD, Zielinski MR, Taishi P, Jewett KA, Davis CJ. Involvement of cytokines in slow wave sleep. Prog Brain Res. 2011; 193:39-47. PMID: 21854954; PMCID: PMC3645329.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  26. Krueger JM, Taishi P, De A, Davis CJ, Winters BD, Clinton J, Szentirmai E, Zielinski MR. ATP and the purine type 2 X7 receptor affect sleep. J Appl Physiol (1985). 2010 Nov; 109(5):1318-27. PMID: 20829501; PMCID: PMC2980381.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  27. Youngstedt SD, Kripke DF, Kline CE, Zielinski MR, Bogan RK. Lack of impairment in glucose tolerance: support for further investigation of sleep restriction in older long sleepers. J Sleep Res. 2010 Mar; 19(1 Pt 1):116-7. PMID: 20470263.
    Citations: 3     Fields:    Translation:Humans
  28. Kline CE, Zielinski, MR, Devlin TM, Kripke DF, Bogan RK, Youngstedt SD. . Self-reported long sleep in older adults is closely related to objective time in bed. Sleep and Biological Rhythms. 2010; (8):42-51.
  29. Kline CE, Zielinski MR, Devlin TM, Kripke DF, Bogan RK, Youngstedt SD. Self-reported long sleep in older adults is closely related to objective time in bed. Sleep Biol Rhythms. 2010 Jan; 8(1):42-51. PMID: 25210491.
    Citations: 7     
  30. Youngstedt SD, Kline CE, Zielinski MR, Kripke DF, Devlin TM, Bogan RK, Wilcox S, Hardin JW. Tolerance of chronic 90-minute time-in-bed restriction in older long sleepers. Sleep. 2009 Nov; 32(11):1467-79. PMID: 19928386; PMCID: PMC2768953.
    Citations: 8     Fields:    Translation:Humans
  31. Zielinski MR, Kline CE, Kripke DF, Bogan RK, Youngstedt SD. No effect of 8-week time in bed restriction on glucose tolerance in older long sleepers. J Sleep Res. 2008 Dec; 17(4):412-9. PMID: 18691360; PMCID: PMC3244074.
    Citations: 16     Fields:    Translation:HumansPHPublic Health
  32. Davis JM, Murphy EA, Carmichael MD, Zielinski MR, Groschwitz CM, Brown AS, Gangemi JD, Ghaffar A, Mayer EP. Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. Am J Physiol Regul Integr Comp Physiol. 2007 Jun; 292(6):R2168-73. PMID: 17332159.
    Citations: 36     Fields:    Translation:Animals
  33. Kline CE, Durstine JL, Davis JM, Moore TA, Devlin TM, Zielinski MR, Youngstedt SD. Circadian variation in swim performance. J Appl Physiol (1985). 2007 Feb; 102(2):641-9. PMID: 17095634.
    Citations: 16     Fields:    Translation:Humans
  34. Youngstedt S, Kline C, Zielinski M, Devlin T, Lee A, Kripke D. Proceedings of the Interim Congress of the World Federation of Sleep Research and Sleep medicine Society: Clinical and Neurophysiological Aspects of Sleep. Kumar VM, Mallick HN, eds. Moderate sleep restriction in older long sleepers. 2005; 161-166.
  35. Zielinski MR, Muenchow M, Wallig MA, Horn PL, Woods JA. Exercise delays allogeneic tumor growth and reduces intratumoral inflammation and vascularization. J Appl Physiol (1985). 2004 Jun; 96(6):2249-56. PMID: 15020578; PMCID: PMC3645346.
    Citations: 13     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.