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Ellen Tunney Roche, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21EB028414 (ROCHE, ELLEN T.) Sep 17, 2020 - Sep 16, 2023
    Mechanical Augmentation of the Diaphragm for End-Stage Respiratory Failure
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hu L, Bonnemain J, Saeed MY, Singh M, Quevedo Moreno D, Vasilyev NV, Roche ET. An implantable soft robotic ventilator augments inspiration in a pig model of respiratory insufficiency. Nat Biomed Eng. 2022 Dec 12. PMID: 36509912.
    Citations:    Fields:    
  2. Ozturk C, Schmid Daners M, Zhao X, Roche ET, Nguyen CT. Editorial: Cardiovascular engineering. Front Cardiovasc Med. 2022; 9:1089794. PMID: 36479566; PMCID: PMC9720374.
  3. Rosalia L, Ozturk C, Coll-Font J, Fan Y, Nagata Y, Singh M, Goswami D, Mauskapf A, Chen S, Eder RA, Goffer EM, Kim JH, Yurista S, Bonner BP, Foster AN, Levine RA, Edelman ER, Panagia M, Guerrero JL, Roche ET, Nguyen CT. A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis. Nat Biomed Eng. 2022 10; 6(10):1134-1147. PMID: 36163494; PMCID: PMC9588718.
    Citations:    Fields:    Translation:Animals
  4. Whyte W, Goswami D, Wang SX, Fan Y, Ward NA, Levey RE, Beatty R, Robinson ST, Sheppard D, O'Connor R, Monahan DS, Trask L, Mendez KL, Varela CE, Horvath MA, Wylie R, O'Dwyer J, Domingo-Lopez DA, Rothman AS, Duffy GP, Dolan EB, Roche ET. Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform. Nat Commun. 2022 08 03; 13(1):4496. PMID: 35922421.
    Citations: 1     Fields:    Translation:Humans
  5. Bonnemain J, Del Nido PJ, Roche ET. Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function. Annu Rev Biomed Eng. 2022 06 06; 24:137-156. PMID: 35395165.
    Citations:    Fields:    Translation:Humans
  6. Ozturk C, Rosalia L, Roche ET. A Multi-Domain Simulation Study of a Pulsatile-Flow Pump Device for Heart Failure With Preserved Ejection Fraction. Front Physiol. 2022; 13:815787. PMID: 35145432; PMCID: PMC8822361.
  7. Singh M, Park C, Roche ET. Decellularization Following Fixation of Explanted Aortic Valves as a Strategy for Preserving Native Mechanical Properties and Function. Front Bioeng Biotechnol. 2021; 9:803183. PMID: 35071211; PMCID: PMC8770733.
  8. Dillon T, Ozturk C, Mendez K, Rosalia L, Gollob SD, Kempf K, Roche ET. Computational Modeling of a Low-Cost Fluidic Oscillator for Use in an Educational Respiratory Simulator. Adv Nanobiomed Res. 2021 Dec; 1(12):2000112. PMID: 33786536; PMCID: PMC7995041.
  9. Rosalia L, Lamberti KK, Landry MK, Leclerc CM, Shuler FD, Hanumara NC, Roche ET. A Soft Robotic Sleeve for Compression Therapy of the Lower Limb. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:1280-1283. PMID: 34891519.
    Citations:    Fields:    Translation:Humans
  10. Mendoza MJ, Gollob SD, Lavado D, Koo BHB, Cruz S, Roche ET, Vela EA. A Vacuum-Powered Artificial Muscle Designed for Infant Rehabilitation. Micromachines (Basel). 2021 Aug 16; 12(8). PMID: 34442593.
  11. Fan Y, Coll-Font J, van den Boomen M, Kim JH, Chen S, Eder RA, Roche ET, Nguyen CT. Characterization of Exercise-Induced Myocardium Growth Using Finite Element Modeling and Bayesian Optimization. Front Physiol. 2021; 12:694940. PMID: 34434115; PMCID: PMC8381603.
    Citations: 1     
  12. Yuk H, Wu J, Sarrafian TL, Mao X, Varela CE, Roche ET, Griffiths LG, Nabzdyk CS, Zhao X. Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue. Nat Biomed Eng. 2021 10; 5(10):1131-1142. PMID: 34373600; PMCID: PMC9254891.
    Citations: 8     Fields:    Translation:Animals
  13. Rosalia L, Ozturk C, Shoar S, Fan Y, Malone G, Cheema FH, Conway C, Byrne RA, Duffy GP, Malone A, Roche ET, Hameed A. Device-Based Solutions to Improve Cardiac Physiology and Hemodynamics in Heart Failure With Preserved Ejection Fraction. JACC Basic Transl Sci. 2021 Sep-Oct; 6(9-10):772-795. PMID: 34754993.
    Citations: 3     
  14. Goswami D, Domingo-Lopez DA, Ward NA, Millman JR, Duffy GP, Dolan EB, Roche ET. Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes. Adv Sci (Weinh). 2021 08; 8(16):e2100820. PMID: 34155834; PMCID: PMC8373111.
    Citations: 5     Fields:    Translation:AnimalsCells
  15. Byrne O, Coulter F, Roche ET, O'Cearbhaill ED. In silico design of additively manufacturable composite synthetic vascular conduits and grafts with tuneable compliance. Biomater Sci. 2021 Jun 15; 9(12):4343-4355. PMID: 33724267.
    Citations: 3     Fields:    
  16. Hu L, Gau D, Nixon J, Klein M, Fan Y, Menary G, Roche ET. Precurved, Fiber-Reinforced Actuators Enable Pneumatically Efficient Replication of Complex Biological Motions. Soft Robot. 2022 04; 9(2):293-308. PMID: 34000210; PMCID: PMC9639240.
    Citations:    Fields:    Translation:Humans
  17. Singh M, Varela CE, Whyte W, Horvath MA, Tan NCS, Ong CB, Liang P, Schermerhorn ML, Roche ET, Steele TWJ. Minimally invasive electroceutical catheter for endoluminal defect sealing. Sci Adv. 2021 04; 7(14). PMID: 33811080.
    Citations: 3     Fields:    
  18. Gollob SD, Park C, Koo BHB, Roche ET. A Modular Geometrical Framework for Modelling the Force-Contraction Profile of Vacuum-Powered Soft Actuators. Front Robot AI. 2021; 8:606938. PMID: 33763454.
    Citations: 2     
  19. Rosalia L, Ozturk C, Roche ET. Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction. J Vis Exp. 2021 02 13; (168). PMID: 33645575.
    Citations: 2     Fields:    Translation:Humans
  20. Roche ET. Catheters gain arrays of sensors and actuators. Nat Biomed Eng. 2020 10; 4(10):939-940. PMID: 33093667.
    Citations:    Fields:    
  21. Deng J, Yuk H, Wu J, Varela CE, Chen X, Roche ET, Guo CF, Zhao X. Electrical bioadhesive interface for bioelectronics. Nat Mater. 2021 02; 20(2):229-236. PMID: 32989277.
    Citations: 18     Fields:    Translation:Animals
  22. Roche ET. Minimally Invasive Delivery of Tissue Engineered Heart Valves to the Pulmonary Annulus. JACC Basic Transl Sci. 2020 Aug; 5(8):829-830. PMID: 32876644; PMCID: PMC7452324.
  23. Horvath MA, Hu L, Mueller T, Hochstein J, Rosalia L, Hibbert KA, Hardin CC, Roche ET. An organosynthetic soft robotic respiratory simulator. APL Bioeng. 2020 Jun; 4(2):026108. PMID: 32566890; PMCID: PMC7286700.
    Citations: 3     
  24. Duffy GP, Robinson ST, O'Connor R, Wylie R, Mauerhofer C, Bellavia G, Straino S, Cianfarani F, Mendez K, Beatty R, Levey R, O'Sullivan J, McDonough L, Kelly H, Roche ET, Dolan EB. Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models. Adv Healthc Mater. 2020 06; 9(11):e2000305. PMID: 32339411.
    Citations: 5     Fields:    Translation:HumansAnimals
  25. Park C, Fan Y, Hager G, Yuk H, Singh M, Rojas A, Hameed A, Saeed M, Vasilyev NV, Steele TWJ, Zhao X, Nguyen CT, Roche ET. An organosynthetic dynamic heart model with enhanced biomimicry guided by cardiac diffusion tensor imaging. Sci Robot. 2020 01 29; 5(38). PMID: 33022595.
    Citations: 4     Fields:    Translation:HumansAnimals
  26. Yuk H, Varela CE, Nabzdyk CS, Mao X, Padera RF, Roche ET, Zhao X. Dry double-sided tape for adhesion of wet tissues and devices. Nature. 2019 11; 575(7781):169-174. PMID: 31666696.
    Citations: 66     Fields:    Translation:AnimalsCells
  27. Fan Y, Ronan W, Teh I, Schneider JE, Varela CE, Whyte W, McHugh P, Leen S, Roche E. A comparison of two quasi-static computational models for assessment of intra-myocardial injection as a therapeutic strategy for heart failure. Int J Numer Method Biomed Eng. 2019 09; 35(9):e3213. PMID: 31062508.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  28. Shirazi RN, Islam S, Weafer FM, Whyte W, Varela CE, Villanyi A, Ronan W, McHugh P, Roche ET. Multiscale Experimental and Computational Modeling Approaches to Characterize Therapy Delivery to the Heart from an Implantable Epicardial Biomaterial Reservoir. Adv Healthc Mater. 2019 08; 8(16):e1900228. PMID: 31322319.
    Citations: 3     Fields:    
  29. Weafer FM, Duffy S, Machado I, Gunning G, Mordasini P, Roche E, McHugh PE, Gilvarry M. Characterization of strut indentation during mechanical thrombectomy in acute ischemic stroke clot analogs. J Neurointerv Surg. 2019 Sep; 11(9):891-897. PMID: 30661030.
    Citations: 16     Fields:    Translation:AnimalsCells
  30. Varela CE, Fan Y, Roche ET. Optimizing Epicardial Restraint and Reinforcement Following Myocardial Infarction: Moving Towards Localized, Biomimetic, and Multitherapeutic Options. Biomimetics (Basel). 2019 Jan 17; 4(1). PMID: 31105193; PMCID: PMC6477619.
  31. Roche ET. Implanted device enables responsive bladder control. Nature. 2019 01; 565(7739):298-300. PMID: 30643302.
    Citations: 1     Fields:    
  32. Whyte W, Roche ET, Varela CE, Mendez K, Islam S, O'Neill H, Weafer F, Shirazi RN, Weaver JC, Vasilyev NV, McHugh PE, Murphy B, Duffy GP, Walsh CJ, Mooney DJ. Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir. Nat Biomed Eng. 2018 06; 2(6):416-428. PMID: 31011199.
    Citations: 20     Fields:    Translation:AnimalsCells
  33. Horvath MA, Varela CE, Dolan EB, Whyte W, Monahan DS, Payne CJ, Wamala IA, Vasilyev NV, Pigula FA, Mooney DJ, Walsh CJ, Duffy GP, Roche ET. Towards Alternative Approaches for Coupling of a Soft Robotic Sleeve to the Heart. Ann Biomed Eng. 2018 Oct; 46(10):1534-1547. PMID: 29766347.
    Citations: 2     Fields:    Translation:Animals
  34. Wamala I, Roche ET, Pigula FA. The use of soft robotics in cardiovascular therapy. Expert Rev Cardiovasc Ther. 2017 Oct; 15(10):767-774. PMID: 28817983.
    Citations: 2     Fields:    Translation:HumansAnimals
  35. Payne CJ, Wamala I, Abah C, Thalhofer T, Saeed M, Bautista-Salinas D, Horvath MA, Vasilyev NV, Roche ET, Pigula FA, Walsh CJ. An Implantable Extracardiac Soft Robotic Device for the Failing Heart: Mechanical Coupling and Synchronization. Soft Robot. 2017 Sep; 4(3):241-250. PMID: 29182083.
    Citations: 10     Fields:    Translation:HumansAnimals
  36. Horvath MA, Wamala I, Rytkin E, Doyle E, Payne CJ, Thalhofer T, Berra I, Solovyeva A, Saeed M, Hendren S, Roche ET, Del Nido PJ, Walsh CJ, Vasilyev NV. An Intracardiac Soft Robotic Device for Augmentation of Blood Ejection from the Failing Right Ventricle. Ann Biomed Eng. 2017 Sep; 45(9):2222-2233. PMID: 28512702; PMCID: PMC5937685.
    Citations: 6     Fields:    Translation:HumansAnimals
  37. Roche ET, Horvath MA, Wamala I, Alazmani A, Song SE, Whyte W, Machaidze Z, Payne CJ, Weaver JC, Fishbein G, Kuebler J, Vasilyev NV, Mooney DJ, Pigula FA, Walsh CJ. Soft robotic sleeve supports heart function. Sci Transl Med. 2017 01 18; 9(373). PMID: 28100834.
    Citations: 46     Fields:    Translation:HumansAnimals
  38. O'Neill HS, Gallagher LB, O'Sullivan J, Whyte W, Curley C, Dolan E, Hameed A, O'Dwyer J, Payne C, O'Reilly D, Ruiz-Hernandez E, Roche ET, O'Brien FJ, Cryan SA, Kelly H, Murphy B, Duffy GP. Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives. Adv Mater. 2016 Jul; 28(27):5648-61. PMID: 26840955.
    Citations: 22     Fields:    
  39. Cezar CA, Roche ET, Vandenburgh HH, Duda GN, Walsh CJ, Mooney DJ. Biologic-free mechanically induced muscle regeneration. Proc Natl Acad Sci U S A. 2016 Feb 09; 113(6):1534-9. PMID: 26811474; PMCID: PMC4760832.
    Citations: 45     Fields:    Translation:AnimalsCells
  40. Roche ET, Fabozzo A, Lee Y, Polygerinos P, Friehs I, Schuster L, Whyte W, Casar Berazaluce AM, Bueno A, Lang N, Pereira MJ, Feins E, Wasserman S, O'Cearbhaill ED, Vasilyev NV, Mooney DJ, Karp JM, Del Nido PJ, Walsh CJ. A light-reflecting balloon catheter for atraumatic tissue defect repair. Sci Transl Med. 2015 Sep 23; 7(306):306ra149. PMID: 26400910.
    Citations: 10     Fields:    Translation:Animals
  41. Hastings CL, Roche ET, Ruiz-Hernandez E, Schenke-Layland K, Walsh CJ, Duffy GP. Drug and cell delivery for cardiac regeneration. Adv Drug Deliv Rev. 2015 Apr; 84:85-106. PMID: 25172834.
    Citations: 58     Fields:    Translation:Humans
  42. Roche ET, Hastings CL, Lewin SA, Shvartsman D, Brudno Y, Vasilyev NV, O'Brien FJ, Walsh CJ, Duffy GP, Mooney DJ. Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart. Biomaterials. 2014 Aug; 35(25):6850-6858. PMID: 24862441.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  43. Roche ET, Wohlfarth R, Overvelde JT, Vasilyev NV, Pigula FA, Mooney DJ, Bertoldi K, Walsh CJ. A bioinspired soft actuated material. Adv Mater. 2014 Feb 26; 26(8):1200-6. PMID: 24227698.
    Citations: 26     Fields:    Translation:HumansCells
  44. O'Flynn PM, Roche ET, Pandit AS. Generating an ex vivo vascular model. ASAIO J. 2005 Jul-Aug; 51(4):426-33. PMID: 16156309.
    Citations: 4     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.