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Raj Kumar, Ph.D.

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Biography
Jawaharlal Nehru University, New Delhi, IndiaPh.D.2007Molecular Biology and Genetic Engineering
Jawaharlal Nehru University, New Delhi, IndiaM.Sc.2000Biochem-Biotechnology
Maharshi Dayanand University, Rohtak, Haryana, IndiaB.Sc.1998Life Sciences
2008 - 2009
Best Poster Presentation Travel Award
2003 - 2006
Senior Research Fellowship
2001 - 2003
Junior Research Fellowship
2001
National Eligibility Test for Lectureship
1998 - 2000
National Scholarship Master programs
1998
National President Scout Award
1998
1st Prize, Senior State level on the Spot painting contest
1990
1st Prize, Junior State level on the Spot painting contest

Overview
My fundamental research interests and expertise revolve around identifying and characterizing new molecular targets with novel approaches, particularly to treat NRAS mutant and drug-resistant melanoma. I have created an NRAS responsive and vemurafenib resistant A375 melanoma cell line to screen novel NRAS pathway inhibitor(s).

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kumar RS, Almansour AI, Arumugam N, Mohammad F, Kotresha D, Menéndez JC. Spirooxindole-pyrrolidine heterocyclic hybrids promotes apoptosis through activation of caspase-3. Bioorg Med Chem. 2019 06 15; 27(12):2487-2498. PMID: 30853330.
    Citations: 1     Fields:    Translation:HumansCells
  2. Raj Kumar, Njauw, C J., Reddy B. Y., Ji Z., Rajadurai A., Klebanov N., Tsao H. Growth Suppression by Dual BRAF(V600E) and NRAS(Q61) Oncogene Expression is Mediated by SPRY4 in Melanoma. Oncogene. 2018; (Doi):18.
  3. Eliades P, Abraham BJ, Ji Z, Miller DM, Christensen CL, Kwiatkowski N, Kumar R, Njauw CN, Taylor M, Miao B, Zhang T, Wong KK, Gray NS, Young RA, Tsao H. High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma. J Invest Dermatol. 2018 07; 138(7):1582-1590. PMID: 29408204.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  4. Artomov M, Stratigos AJ, Kim I, Kumar R, Lauss M, Reddy BY, Miao B, Daniela Robles-Espinoza C, Sankar A, Njauw CN, Shannon K, Gragoudas ES, Marie Lane A, Iyer V, Newton-Bishop JA, Timothy Bishop D, Holland EA, Mann GJ, Singh T, Daly MJ, Tsao H. Rare Variant, Gene-Based Association Study of Hereditary Melanoma Using Whole-Exome Sequencing. J Natl Cancer Inst. 2017 12 01; 109(12). PMID: 29522175.
    Citations: 9     Fields:    Translation:Humans
  5. Roh MR, Kumar R, Rajadurai A, Njauw C, Ryoo UH, Chung KY, Tsao H. Beta-catenin causes fibrotic changes in the extracellular matrix via upregulation of collagen I transcription. Br J Dermatol. 2017 07; 177(1):312-315. PMID: 27639179.
    Citations: 3     Fields:    Translation:HumansCells
  6. Eliades P, Miller DM, Miao B, Kumar R, Taylor M, Buch S, Srinivasa SP, Flaherty KT, Tsao H. A novel multi-CDK inhibitor P1446A-05 restricts melanoma growth and produces synergistic effects in combination with MAPK pathway inhibitors. . 2016 07 02; 17(7):778-84. PMID: 26810603.
    Citations: 1     Translation:HumansCells
  7. Ji Z, Erin Chen Y, Kumar R, Taylor M, Jenny Njauw CN, Miao B, Frederick DT, Wargo JA, Flaherty KT, Jönsson G, Tsao H. MITF Modulates Therapeutic Resistance through EGFR Signaling. J Invest Dermatol. 2015 Jul; 135(7):1863-1872. PMID: 25789707.
    Citations: 30     Fields:    Translation:HumansCells
  8. Miao B, Ji Z, Tan L, Taylor M, Zhang J, Choi HG, Frederick DT, Kumar R, Wargo JA, Flaherty KT, Gray NS, Tsao H. EPHA2 is a mediator of vemurafenib resistance and a novel therapeutic target in melanoma. Cancer Discov. 2015 Mar; 5(3):274-87. PMID: 25542448.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  9. Kumar R, Taylor M, Miao B, Ji Z, Njauw JC, Jönsson G, Frederick DT, Tsao H. BAP1 has a survival role in cutaneous melanoma. J Invest Dermatol. 2015 Apr; 135(4):1089-1097. PMID: 25521456.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  10. Sadasivam M, Avci P, Gupta GK, Lakshmanan S, Chandran R, Huang YY, Kumar R, Hamblin MR. Self-assembled liposomal nanoparticles in photodynamic therapy. Eur J Nanomed. 2013 Jul; 5(3). PMID: 24348377.
    Citations: 11     
  11. Ji Z, Kumar R, Taylor M, Rajadurai A, Marzuka-Alcalá A, Chen YE, Njauw CN, Flaherty K, Jönsson G, Tsao H. Vemurafenib synergizes with nutlin-3 to deplete survivin and suppresses melanoma viability and tumor growth. Clin Cancer Res. 2013 Aug 15; 19(16):4383-91. PMID: 23812671.
    Citations: 17     Fields:    Translation:HumansAnimals
  12. Avci P, Sadasivam M, Gupta A, De Melo WC, Huang YY, Yin R, Chandran R, Kumar R, Otufowora A, Nyame T, Hamblin MR. Animal models of skin disease for drug discovery. Expert Opin Drug Discov. 2013 Mar; 8(3):331-55. PMID: 23293893.
    Citations: 17     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.