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Hsiao-Ying Wey, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R21MH138923 (WEY, HSIAO-YING) Feb 19, 2025 - Jan 31, 2027
    NIH
    Measure striatal adenosine-dopamine receptors interactions: from molecule to behaviors
    Role: Principal Investigator
  2. R21AG086721 (YEN, YI-FEN) May 15, 2024 - Apr 30, 2026
    NIH
    Hyperpolarized MR-PET for evaluating mitochondrial function and availability in an Alzheimers Disease Model
    Role: Co-Principal Investigator
  3. UH3AR076741 (WEY, HSIAO-YING) Sep 26, 2019 - Aug 31, 2024
    NIH
    Imaging Epigenetic Dysregulation in Patients with Low Back Pain
    Role: Principal Investigator
  4. UH2AR076741 (WEY, HSIAO-YING) Sep 26, 2019 - Aug 31, 2021
    NIH
    Imaging Epigenetic Dysregulation in Patients with Low Back Pain
    Role: Principal Investigator
  5. R33DA048485 (WEY, HSIAO-YING) Jul 1, 2019 - Jun 30, 2025
    NIH
    Neuroepigenetic mechanisms of chronic low back pain using histone deacetylases PET imaging
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 73 total Publications Show all
  1. Chen JE, Lewis L, Coursey S, Catana C, Polimeni J, Fan J, Dropppa K, Patel R, Wey HY, Chang C, Manoach D, Price J, Sander C, Rosen BR. Simultaneous EEG-PET-MRI identifies temporally coupled, spatially structured hemodynamic and metabolic dynamics across wakefulness and NREM sleep. bioRxiv. 2025 Jan 18. PMID: 39868228; PMCID: PMC11761522.
    Citations:
  2. Xu Y, Xu Y, Bagdasarian FA, Dagnew TM, Cheng H, Wang Y, Wang Y, Kang L, Wey HY, Zhang C, Zhang S, Wang C. Characterization of a novel PET radioligand for mitochondrial complex I in nonhuman primate. Nucl Med Biol. 2025 Jan 10; 142-143:108993. PMID: 39824008.
    Citations:
    Fields: BioBiologyNucNuclear Medicine
  3. Lee SJ, Pearson TD, Dhaynaut M, MacDonagh AC, Wey HY, Wilks MQ, Roth BL, Hooker JM, Normandin MD. Selective Mu-Opioid Receptor Imaging Using 18F-Labeled Carfentanils. J Med Chem. 2025 Jan 23; 68(2):1632-1644. PMID: 39772615.
    Citations:
    Fields: CheChemistry
  4. Bagdasarian FA, Larsen K, Deng HP, Fisher PM, Mandeville JB, Sander CY, Wey HY, Hansen HD. Neurochemical characterization of 5-HT2AR partial agonists with simultaneous PET-MRI. J Cereb Blood Flow Metab. 2024 Nov 29; 271678X241302937. PMID: 39610321; PMCID: PMC11605697.
    Citations:
    Fields: BraBrainMetMetabolismVasVascular Diseases
  5. Cazuza RA, Zagrai SM, Grieco AR, Avery TD, Abell AD, Wey HY, Loggia ML, Grace PM. 18 kDa Translocator protein (TSPO) is upregulated in rat brain after peripheral nerve injury and downregulated by diroximel fumarate. Brain Behav Immun. 2025 Jan; 123:11-27. PMID: 39218234; PMCID: PMC11624078.
    Citations: 1
    Fields: AllAllergy and ImmunologyBraBrainPsyPsychophysiologyTranslation:AnimalsCells
  6. Bagdasarian FA, Hansen HD, Chen J, Yoo CH, Placzek MS, Hooker JM, Wey HY. Acute Effects of Hallucinogens on Functional Connectivity: Psilocybin and Salvinorin-A. ACS Chem Neurosci. 2024 Jul 17; 15(14):2654-2661. PMID: 38916752.
    Citations:
    Fields: NeuNeurologyTranslation:Animals
  7. Bai P, Lan Y, Liu Y, Mondal P, Gomm A, Xu Y, Wang Y, Wang Y, Kang L, Pan L, Bagdasarian FA, Hallisey M, Lobo F, Varela B, Choi SH, Gomperts SN, Wey HY, Shen S, Tanzi RE, Wang C, Zhang C. Development of a New Positron Emission Tomography Imaging Radioligand Targeting RIPK1 in the Brain and Characterization in Alzheimer's Disease. Adv Sci (Weinh). 2024 Aug; 11(32):e2309021. PMID: 38923244; PMCID: PMC11348174.
    Citations: 2
    Fields: BioBiomedical EngineeringTranslation:HumansAnimals
  8. Zürcher NR, Chen JE, Wey HY. PET-MRI Applications and Future Prospects in Psychiatry. J Magn Reson Imaging. 2025 Feb; 61(2):568-578. PMID: 38838352; PMCID: PMC11617601.
    Citations: 1
    Fields: DiaDiagnostic ImagingTranslation:Humans
  9. Dagnew TM, Tseng CJ, Yoo CH, Makary MM, Goodheart AE, Striar R, Meyer TN, Rattray AK, Kang L, Wolf KA, Fiedler SA, Tocci D, Shapiro H, Provost S, Sultana E, Liu Y, Ding W, Chen P, Kubicki M, Shen S, Catana C, Zürcher NR, Wey HY, Hooker JM, Weiss RD, Wang C. Toward AI-driven neuroepigenetic imaging biomarker for alcohol use disorder: A proof-of-concept study. iScience. 2024 Jul 19; 27(7):110159. PMID: 39021792; PMCID: PMC11253155.
    Citations:
  10. Yoo CH, Rani N, Shen S, Loggia ML, Gaynor K, Moore KE, Bagdasarian FA, Lin YS, Edwards RR, Price JC, Hooker JM, Wey HY. Investigating neuroepigenetic alterations in chronic low back pain with positron emission tomography. Pain. 2024 Nov 01; 165(11):2586-2594. PMID: 38776171; PMCID: PMC11511648.
    Citations:
    Fields: NeuNeurologyPsyPsychophysiologyTranslation:Humans
  11. Placzek MS, Wilton DK, Weïwer M, Manter MA, Reid SE, Meyer CJ, Campbell AJ, Bajrami B, Bigot A, Bricault S, Fayet A, Frouin A, Gergits F, Gupta M, Jiang W, Melanson M, Romano CD, Riley MM, Wang JM, Wey HY, Wagner FF, Stevens B, Hooker JM. A Fast-Binding, Functionally Reversible, COX-2 Radiotracer for CNS PET Imaging. ACS Cent Sci. 2024 May 22; 10(5):1105-1114. PMID: 38799654; PMCID: PMC11117721.
    Citations:
  12. Bai P, Bagdasarian FA, Xu Y, Wang Y, Wang Y, Gomm A, Zhou Y, Wu R, Wey HY, Tanzi RE, Zhang C, Lan Y, Wang C. Molecular Imaging of Alzheimer's Disease-Related Sigma-1 Receptor in the Brain via a Novel Ru-Mediated Aromatic 18F-deoxyfluorination Probe. J Med Chem. 2024 Apr 25; 67(8):6207-6217. PMID: 38607332.
    Citations:
    Fields: CheChemistryTranslation:HumansAnimalsCells
  13. Luo T, Sang N, Liu Y, Zhou Y, Wu R, Bagdasarian FA, Wey HY, Lang J, Wang C, Bai P. Synthesis and preclinical evaluation of 11C-labeled 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine radioligands for RIPK1 positron emission tomography imaging. Bioorg Chem. 2024 May; 146:107279. PMID: 38513325.
    Citations:
    Fields: BioBiochemistryCheChemistryTranslation:Animals
  14. Xu Y, Xu Y, Biby S, Kaur B, Liu Y, Bagdasarian FA, Wey HY, Tanzi R, Zhang C, Wang C, Zhang S. Design and Discovery of Novel NLRP3 Inhibitors and PET Imaging Radiotracers Based on a 1,2,3-Triazole-Bearing Scaffold. J Med Chem. 2024 01 11; 67(1):555-571. PMID: 38150705; PMCID: PMC11002996.
    Citations: 1
    Fields: CheChemistryTranslation:HumansAnimals
  15. Yoo CH, DuBois JM, Wang L, Tang Y, Hou L, Xu H, Chen J, Liang SH, Izquierdo-Garcia D, Wey HY. Preliminary Exploration of Pseudo-CT-Based Attenuation Correction for Simultaneous PET/MRI Brain Imaging in Nonhuman Primates. ACS Omega. 2023 Dec 05; 8(48):45438-45446. PMID: 38075761; PMCID: PMC10702200.
    Citations:
  16. Mandeville JB, Weigand-Whittier J, Wey HY, Chen YI. Amphetamine pretreatment blunts dopamine-induced D2/D3-receptor occupancy by an arrestin-mediated mechanism: A PET study in internalization compromised mice. Neuroimage. 2023 Dec 01; 283:120416. PMID: 37866759; PMCID: PMC10841768.
    Citations: 1
    Fields: DiaDiagnostic ImagingTranslation:Animals
  17. Mauck MC, Lotz J, Psioda MA, Carey TS, Clauw DJ, Majumdar S, Marras WS, Vo N, Aylward A, Hoffmeyer A, Zheng P, Ivanova A, McCumber M, Carson C, Anstrom KJ, Bowden AE, Dalton D, Derr L, Dufour J, Fields AJ, Fritz J, Hassett AL, Harte SE, Hue TF, Krug R, Loggia ML, Mageswaran P, McLean SA, Mitchell UH, O'Neill C, Pedoia V, Quirk DA, Rhon DI, Rieke V, Shah L, Sowa G, Spiegel B, Wasan AD, Wey HM, LaVange L. The Back Pain Consortium (BACPAC) Research Program: Structure, Research Priorities, and Methods. Pain Med. 2023 08 04; 24(Suppl 1):S3-S12. PMID: 36622041; PMCID: PMC10403298.
    Citations: 7
    Fields: NeuNeurologyPalPalliative CarePsyPsychophysiologyTranslation:Humans
  18. Yoo CH, Chen Z, Rani N, Chen J, Rong J, Chen L, Zhang L, Liang SH, Wey HY. Evaluation of [18F]PF-06455943 as a Potential LRRK2 PET Imaging Agent in the Brain of Nonhuman Primates. ACS Chem Neurosci. 2023 02 01; 14(3):370-377. PMID: 36630128.
    Citations: 1
    Fields: NeuNeurologyTranslation:HumansAnimals
  19. Chen Z, Chen J, Chen L, Yoo CH, Rong J, Fu H, Shao T, Coffman K, Steyn SJ, Davenport AT, Daunais JB, Haider A, Collier L, Josephson L, Wey HY, Zhang L, Liang SH. Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography Ligand. J Med Chem. 2023 02 09; 66(3):1712-1724. PMID: 36256881.
    Citations: 4
    Fields: CheChemistry
  20. Pascoal TA, Chamoun M, Lax E, Wey HY, Shin M, Ng KP, Kang MS, Mathotaarachchi S, Benedet AL, Therriault J, Lussier FZ, Schroeder FA, DuBois JM, Hightower BG, Gilbert TM, Zürcher NR, Wang C, Hopewell R, Chakravarty M, Savard M, Thomas E, Mohaddes S, Farzin S, Salaciak A, Tullo S, Cuello AC, Soucy JP, Massarweh G, Hwang H, Kobayashi E, Hyman BT, Dickerson BC, Guiot MC, Szyf M, Gauthier S, Hooker JM, Rosa-Neto P. Author Correction: [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease. Nat Commun. 2022 Oct 03; 13(1):5833. PMID: 36192402; PMCID: PMC9529935.
    Citations:
    Fields: BioBiologySciScience
  21. Bai P, Yan L, Bagdasarian FA, Wilks MQ, Wey HY, Wang C. A positron emission tomography imaging probe selectively targeting the BD1 bromodomain and extra-terminal domain. Chem Commun (Camb). 2022 Aug 25; 58(69):9654-9657. PMID: 35943085; PMCID: PMC9618257.
    Citations: 2
    Fields: CheChemistryTranslation:AnimalsCells
  22. Pascoal TA, Chamoun M, Lax E, Wey HY, Shin M, Ng KP, Kang MS, Mathotaarachchi S, Benedet AL, Therriault J, Lussier FZ, Schroeder FA, DuBois JM, Hightower BG, Gilbert TM, Zürcher NR, Wang C, Hopewell R, Chakravarty M, Savard M, Thomas E, Mohaddes S, Farzin S, Salaciak A, Tullo S, Cuello AC, Soucy JP, Massarweh G, Hwang H, Kobayashi E, Hyman BT, Dickerson BC, Guiot MC, Szyf M, Gauthier S, Hooker JM, Rosa-Neto P. [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease. Nat Commun. 2022 07 19; 13(1):4171. PMID: 35853847; PMCID: PMC9296476.
    Citations: 12
    Fields: BioBiologySciScienceTranslation:HumansAnimals
  23. Bai P, Mondal P, Bagdasarian FA, Rani N, Liu Y, Gomm A, Tocci DR, Choi SH, Wey HY, Tanzi RE, Zhang C, Wang C. Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease. Acta Pharm Sin B. 2022 Oct; 12(10):3891-3904. PMID: 36213537; PMCID: PMC9532562.
    Citations: 12
  24. Xu Y, Chen Z, Wey HY, Liang Y, Tanzi RE, Zhang C, Wang C. Molecular imaging of NAD+ -dependent deacetylase SIRT1 in the brain. Alzheimers Dement. 2021 12; 17(12):1988-1997. PMID: 33860595.
    Citations: 1
    Fields: NeuNeurologyPsyPsychiatryTranslation:Animals
  25. Xu Y, Wang C, Wey HY, Liang Y, Chen Z, Choi SH, Ran C, Rynearson KD, Bernales DR, Koegel RE, Fiedler SA, Striar R, Wagner SL, Tanzi RE, Zhang C. Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates. J Exp Med. 2020 12 07; 217(12). PMID: 32936886.
    Citations: 19
    Fields: AllAllergy and ImmunologyMedMedicine (General)Translation:HumansAnimals
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© 2025 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.