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Aaron Dominic Aguirre, M.D.,Ph.D.

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  1. F31EB005978 (AGUIRRE, AARON D) Jan 16, 2006 - Jan 15, 2009
    NIH/NIBIB
    Optical Coherence Microscopy for Endoscopic Diagnostics
    Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Aguirre AD, Apiou-Sbirlea G, Roblyer D, Tromberg BJ. Special Section Guest Editorial: Translational Biophotonics. J Biomed Opt. 2017 Dec; 22(12):1-2. PMID: 29282907.
    View in: PubMed
  2. King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R. IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nat Med. 2017 Dec; 23(12):1481-1487. PMID: 29106401.
    View in: PubMed
  3. Yamamoto E, Xing L, Higuma T, Minami Y, Bryniarski K, Zanchin T, Wang Z, Aguirre AD, Lee H, Jang IK. Dynamic neointimal pattern after drug-eluting stent implantation defined by optical coherence tomography. Coron Artery Dis. 2017 Nov; 28(7):557-563. PMID: 28704243.
    View in: PubMed
  4. Minami Y, Wang Z, Aguirre AD, Ong DS, Kim CJ, Uemura S, Soeda T, Lee H, Fujimoto J, Jang IK. Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study. J Am Heart Assoc. 2017 Nov 01; 6(11). PMID: 29092845.
    View in: PubMed
  5. Xing L, Higuma T, Wang Z, Aguirre AD, Mizuno K, Takano M, Dauerman HL, Park SJ, Jang Y, Kim CJ, Kim SJ, Choi SY, Itoh T, Uemura S, Lowe H, Walters DL, Barlis P, Lee S, Lerman A, Toma C, Tan JWC, Yamamoto E, Bryniarski K, Dai J, Zanchin T, Zhang S, Yu B, Lee H, Fujimoto J, Fuster V, Jang IK. Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography: A 4-Year Follow-Up Study. J Am Coll Cardiol. 2017 May 23; 69(20):2502-2513. PMID: 28521888.
    View in: PubMed
  6. Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M. Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017 04 20; 169(3):510-522.e20. PMID: 28431249.
    View in: PubMed
  7. Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M. Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease. Nat Commun. 2017 01 16; 8:14064. PMID: 28091604.
    View in: PubMed
  8. Vergallo R, Uemura S, Soeda T, Minami Y, Cho JM, Ong DS, Aguirre AD, Gao L, Biasucci LM, Crea F, Yu B, Lee H, Kim CJ, Jang IK. Prevalence and Predictors of Multiple Coronary Plaque Ruptures: In Vivo 3-Vessel Optical Coherence Tomography Imaging Study. Arterioscler Thromb Vasc Biol. 2016 11; 36(11):2229-2238. PMID: 27634834.
    View in: PubMed
  9. Wang Z, Cho YS, Soeda T, Minami Y, Xing L, Jia H, Aguirre A, Vergallo R, Lee H, Fujimoto JG, Yu B, Jang IK. Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy: a serial optical coherence tomography study. Coron Artery Dis. 2016 Aug; 27(5):350-6. PMID: 27105047; PMCID: PMC4912393 [Available on 08/01/17].
  10. Minami Y, Wang Z, Aguirre AD, Lee S, Uemura S, Soeda T, Vergallo R, Raffel OC, Barlis P, Itoh T, Lee H, Fujimoto J, Jang IK. Quantitative analysis of the side-branch orifice after bifurcation stenting using en-face processing of OCT images: a comparison between Xience V and Resolute Integrity stents. Coron Artery Dis. 2016 Jan; 27(1):19-28. PMID: 26554662.
    View in: PubMed
  11. Vinegoni C, Aguirre AD, Lee S, Weissleder R. Imaging the beating heart in the mouse using intravital microscopy techniques. Nat Protoc. 2015 Nov; 10(11):1802-19. PMID: 26492138.
    View in: PubMed
  12. Vergallo R, Aguirre AD, Abtahian F, Minami Y, Soeda T, Chatzizisis YS, Croce K, Jang IK. Recurrent myocardial infarctions and premature coronary atherosclerosis in a 23-year-old man with antiphospholipid syndrome. Thromb Haemost. 2016 Jan; 115(2):237-9. PMID: 26423215.
    View in: PubMed
  13. Vinegoni C, Lee S, Aguirre AD, Weissleder R. New techniques for motion-artifact-free in vivo cardiac microscopy. Front Physiol. 2015; 6:147. PMID: 26029116; PMCID: PMC4428079.
  14. Minami Y, Ong DS, Uemura S, Wang Z, Aguirre AD, Mukhopadhyay S, Soeda T, Vergallo R, Jia H, Tian J, Hu S, Kim SJ, Park CB, Dauerman HL, Lee S, Jang IK. Impacts of lesion angle on incidence and distribution of acute vessel wall injuries and strut malapposition after drug-eluting stent implantation assessed by optical coherence tomography. Eur Heart J Cardiovasc Imaging. 2015 Dec; 16(12):1390-8. PMID: 25925215.
    View in: PubMed
  15. Aguirre AD, Vinegoni C, Sebas M, Weissleder R. Intravital imaging of cardiac function at the single-cell level. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):11257-62. PMID: 25053815; PMCID: PMC4128110.
  16. Wang Z, Jia H, Tian J, Soeda T, Vergallo R, Minami Y, Lee H, Aguirre A, Fujimoto JG, Jang IK. Computer-aided image analysis algorithm to enhance in vivo diagnosis of plaque erosion by intravascular optical coherence tomography. Circ Cardiovasc Imaging. 2014 Sep; 7(5):805-10. PMID: 25034595.
    View in: PubMed
  17. Hiremath P, Bauer M, Aguirre AD, Cheng HW, Unno K, Patel RB, Harvey BW, Chang WT, Groarke JD, Liao R, Cheng S. Identifying early changes in myocardial microstructure in hypertensive heart disease. PLoS One. 2014; 9(5):e97424. PMID: 24831515; PMCID: PMC4022613.
  18. Liong M, Im H, Majmudar MD, Aguirre AD, Sebas M, Lee H, Weissleder R. Magnetic ligation method for quantitative detection of microRNAs. Adv Healthc Mater. 2014 Jul; 3(7):1015-9. PMID: 24532323; PMCID: PMC4107040.
  19. Hu S, Yonetsu T, Jia H, Karanasos A, Aguirre AD, Tian J, Abtahian F, Vergallo R, Soeda T, Lee H, McNulty I, Kato K, Yu B, Mizuno K, Toutouzas K, Stefanadis C, Jang IK. Residual thrombus pattern in patients with ST-segment elevation myocardial infarction caused by plaque erosion versus plaque rupture after successful fibrinolysis: an optical coherence tomography study. J Am Coll Cardiol. 2014 Apr 08; 63(13):1336-1338. PMID: 24361315.
    View in: PubMed
  20. Vergallo R, Ren X, Yonetsu T, Kato K, Uemura S, Yu B, Jia H, Abtahian F, Aguirre AD, Tian J, Hu S, Soeda T, Lee H, McNulty I, Park SJ, Jang Y, Prasad A, Lee S, Zhang S, Porto I, Biasucci LM, Crea F, Jang IK. Pancoronary plaque vulnerability in patients with acute coronary syndrome and ruptured culprit plaque: a 3-vessel optical coherence tomography study. Am Heart J. 2014 Jan; 167(1):59-67. PMID: 24332143.
    View in: PubMed
  21. Lee HC, Liu JJ, Sheikine Y, Aguirre AD, Connolly JL, Fujimoto JG. Ultrahigh speed spectral-domain optical coherence microscopy. Biomed Opt Express. 2013; 4(8):1236-54. PMID: 24009989; PMCID: PMC3756571.
  22. Jia H, Abtahian F, Aguirre AD, Lee S, Chia S, Lowe H, Kato K, Yonetsu T, Vergallo R, Hu S, Tian J, Lee H, Park SJ, Jang YS, Raffel OC, Mizuno K, Uemura S, Itoh T, Kakuta T, Choi SY, Dauerman HL, Prasad A, Toma C, McNulty I, Zhang S, Yu B, Fuster V, Narula J, Virmani R, Jang IK. In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography. J Am Coll Cardiol. 2013 Nov 05; 62(19):1748-58. PMID: 23810884; PMCID: PMC3874870.
  23. Lee HC, Zhou C, Cohen DW, Mondelblatt AE, Wang Y, Aguirre AD, Shen D, Sheikine Y, Fujimoto JG, Connolly JL. Integrated optical coherence tomography and optical coherence microscopy imaging of ex vivo human renal tissues. J Urol. 2012 Feb; 187(2):691-9. PMID: 22177199; PMCID: PMC3366589.
  24. Zhou C, Cohen DW, Wang Y, Lee HC, Mondelblatt AE, Tsai TH, Aguirre AD, Fujimoto JG, Connolly JL. Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues. Cancer Res. 2010 Dec 15; 70(24):10071-9. PMID: 21056988; PMCID: PMC3028517.
  25. Aguirre AD, Sawinski J, Huang SW, Zhou C, Denk W, Fujimoto JG. High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe. Opt Express. 2010 Mar 01; 18(5):4222-39. PMID: 20389435; PMCID: PMC2908909.
  26. Zhou C, Wang Y, Aguirre AD, Tsai TH, Cohen DW, Connolly JL, Fujimoto JG. Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy. J Biomed Opt. 2010 Jan-Feb; 15(1):016001. PMID: 20210448; PMCID: PMC2844129.
  27. Aguirre AD, Chen Y, Bryan B, Mashimo H, Huang Q, Connolly JL, Fujimoto JG. Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy. J Biomed Opt. 2010 Jan-Feb; 15(1):016025. PMID: 20210470; PMCID: PMC2847935.
  28. Chen Y, Aguirre AD, Ruvinskaya L, Devor A, Boas DA, Fujimoto JG. Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation. J Neurosci Methods. 2009 Mar 30; 178(1):162-73. PMID: 19121336; PMCID: PMC3004397.
  29. Chen Y, Aguirre AD, Hsiung PL, Huang SW, Mashimo H, Schmitt JM, Fujimoto JG. Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues. Opt Express. 2008 Feb 18; 16(4):2469-85. PMID: 18542326.
    View in: PubMed
  30. Chen Y, Huang SW, Aguirre AD, Fujimoto JG. High-resolution line-scanning optical coherence microscopy. Opt Lett. 2007 Jul 15; 32(14):1971-3. PMID: 17632613.
    View in: PubMed
  31. Hsiung PL, Phatak DR, Chen Y, Aguirre AD, Fujimoto JG, Connolly JL. Benign and malignant lesions in the human breast depicted with ultrahigh resolution and three-dimensional optical coherence tomography. Radiology. 2007 Sep; 244(3):865-74. PMID: 17630358.
    View in: PubMed
  32. Chen Y, Aguirre AD, Hsiung PL, Desai S, Herz PR, Pedrosa M, Huang Q, Figueiredo M, Huang SW, Koski A, Schmitt JM, Fujimoto JG, Mashimo H. Ultrahigh resolution optical coherence tomography of Barrett's esophagus: preliminary descriptive clinical study correlating images with histology. Endoscopy. 2007 Jul; 39(7):599-605. PMID: 17611914.
    View in: PubMed
  33. Huang SW, Aguirre AD, Huber RA, Adler DC, Fujimoto JG. Swept source optical coherence microscopy using a Fourier domain mode-locked laser. Opt Express. 2007 May 14; 15(10):6210-7. PMID: 19546926.
    View in: PubMed
  34. Chen Y, Andrews PM, Aguirre AD, Schmitt JM, Fujimoto JG. High-resolution three-dimensional optical coherence tomography imaging of kidney microanatomy ex vivo. J Biomed Opt. 2007 May-Jun; 12(3):034008. PMID: 17614716.
    View in: PubMed
  35. Aguirre AD, Hertz PR, Chen Y, Fujimoto JG, Piyawattanametha W, Fan L, Wu MC. Two-axis MEMS Scanning Catheter for Ultrahigh Resolution Three-dimensional and En Face Imaging. Opt Express. 2007 Mar 05; 15(5):2445-53. PMID: 19532481.
    View in: PubMed
  36. Aguirre AD, Chen Y, Fujimoto JG, Ruvinskaya L, Devor A, Boas DA. Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography. Opt Lett. 2006 Dec 01; 31(23):3459-61. PMID: 17099749; PMCID: PMC2293976.
  37. Aguirre A, Nishizawa N, Fujimoto J, Seitz W, Lederer M, Kopf D. Continuum generation in a novel photonic crystal fiber for ultrahigh resolution optical coherence tomography at 800 nm and 1300 nm. Opt Express. 2006 Feb 06; 14(3):1145-60. PMID: 19503436.
    View in: PubMed
  38. Hsiung PL, Pantanowitz L, Aguirre AD, Chen Y, Phatak D, Ko TH, Bourquin S, Schnitt SJ, Raza S, Connolly JL, Mashimo H, Fujimoto JG. Ultrahigh-resolution and 3-dimensional optical coherence tomography ex vivo imaging of the large and small intestines. Gastrointest Endosc. 2005 Oct; 62(4):561-74. PMID: 16185971.
    View in: PubMed
  39. Herz PR, Chen Y, Aguirre AD, Schneider K, Hsiung P, Fujimoto JG, Madden K, Schmitt J, Goodnow J, Petersen C. Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography. Opt Lett. 2004 Oct 01; 29(19):2261-3. PMID: 15524374.
    View in: PubMed
  40. Herz P, Chen Y, Aguirre A, Fujimoto J, Mashimo H, Schmitt J, Koski A, Goodnow J, Petersen C. Ultrahigh resolution optical biopsy with endoscopic optical coherence tomography. Opt Express. 2004 Jul 26; 12(15):3532-42. PMID: 19483882.
    View in: PubMed
  41. Bourquin S, Aguirre A, Hartl I, Hsiung P, Ko T, Fujimoto J, Birks T, Wadsworth W, Bünting U, Kopf D. Ultrahigh resolution real time OCT imaging using a compact femtosecond Nd:Glass laser and nonlinear fiber. Opt Express. 2003 Dec 01; 11(24):3290-7. PMID: 19471457.
    View in: PubMed
  42. Aguirre AD, Hsiung P, Ko TH, Hartl I, Fujimoto JG. High-resolution optical coherence microscopy for high-speed, in vivo cellular imaging. Opt Lett. 2003 Nov 01; 28(21):2064-6. PMID: 14587816.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.