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Aaron Dominic Aguirre, M.D.,Ph.D.

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University of Michigan, Ann Arbor, MIB.S.EElectrical Engineering
Massachusetts Institute of Technology, Cambridge, MAS.M., Ph.D.Electrical and Medical Engineering
Harvard Medical School, Boston, MAM.D.Medicine

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL144515 (AGUIRRE, AARON D) Dec 15, 2018 - Nov 30, 2023
    Dynamic Single Cell Imaging of Coronary Microvascular Dysfunction in the Failing Heart
    Role: Principal Investigator
  2. R21EB026762 (AGUIRRE, AARON D) Sep 30, 2018 - Jun 30, 2021
    All optical in vivo cardiac electrophysiology at cellular resolution
    Role: Principal Investigator
  3. F31EB005978 (AGUIRRE, AARON D) Jan 16, 2006 - Jan 15, 2009
    Optical Coherence Microscopy for Endoscopic Diagnostics
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wang C, Keliher E, Zeller MWG, Wojtkiewicz GR, Aguirre AD, Buckbinder L, Kim HY, Chen J, Maresca K, Ahmed MS, Motlagh NJ, Nahrendorf M, Chen JW. An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo. Proc Natl Acad Sci U S A. 2019 06 11; 116(24):11966-11971. PMID: 31123149.
  2. Ahmed MS, Rodell CB, Hulsmans M, Kohler RH, Aguirre AD, Nahrendorf M, Weissleder R. A Supramolecular Nanocarrier for Delivery of Amiodarone Anti-Arrhythmic Therapy to the Heart. Bioconjug Chem. 2019 03 20; 30(3):733-740. PMID: 30615425.
    Citations:    Fields:    
  3. Hulsmans M, Aguirre AD, Bonner MD, Bapat A, Cremer S, Iwamoto Y, King KR, Swirski FK, Milan DJ, Weissleder R, Nahrendorf M. A Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse. Circ Res. 2018 11 09; 123(11):1208-1219. PMID: 30571465.
    Citations:    Fields:    
  4. Aguirre AD, Apiou-Sbirlea G, Roblyer D, Tromberg BJ. Special Section Guest Editorial: Translational Biophotonics. J Biomed Opt. 2017 12; 22(12):1-2. PMID: 29282907.
    Citations:    Fields:    
  5. King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R. IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nat Med. 2017 Dec; 23(12):1481-1487. PMID: 29106401.
    Citations: 12     Fields:    Translation:AnimalsCells
  6. Yamamoto E, Xing L, Higuma T, Minami Y, Bryniarski K, Zanchin T, Wang Z, Aguirre AD, Lee H, Jang IK. Dynamic neointimal pattern after drug-eluting stent implantation defined by optical coherence tomography. Coron Artery Dis. 2017 Nov; 28(7):557-563. PMID: 28704243.
    Citations:    Fields:    Translation:Humans
  7. Minami Y, Wang Z, Aguirre AD, Ong DS, Kim CJ, Uemura S, Soeda T, Lee H, Fujimoto J, Jang IK. Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study. J Am Heart Assoc. 2017 Nov 01; 6(11). PMID: 29092845.
    Citations:    Fields:    Translation:Humans
  8. Xing L, Higuma T, Wang Z, Aguirre AD, Mizuno K, Takano M, Dauerman HL, Park SJ, Jang Y, Kim CJ, Kim SJ, Choi SY, Itoh T, Uemura S, Lowe H, Walters DL, Barlis P, Lee S, Lerman A, Toma C, Tan JWC, Yamamoto E, Bryniarski K, Dai J, Zanchin T, Zhang S, Yu B, Lee H, Fujimoto J, Fuster V, Jang IK. Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography: A 4-Year Follow-Up Study. J Am Coll Cardiol. 2017 May 23; 69(20):2502-2513. PMID: 28521888.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  9. Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M. Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017 04 20; 169(3):510-522.e20. PMID: 28431249.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  10. Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M. Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease. Nat Commun. 2017 01 16; 8:14064. PMID: 28091604.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  11. Vergallo R, Uemura S, Soeda T, Minami Y, Cho JM, Ong DS, Aguirre AD, Gao L, Biasucci LM, Crea F, Yu B, Lee H, Kim CJ, Jang IK. Prevalence and Predictors of Multiple Coronary Plaque Ruptures: In Vivo 3-Vessel Optical Coherence Tomography Imaging Study. Arterioscler Thromb Vasc Biol. 2016 11; 36(11):2229-2238. PMID: 27634834.
    Citations: 5     Fields:    Translation:Humans
  12. Wang Z, Cho YS, Soeda T, Minami Y, Xing L, Jia H, Aguirre A, Vergallo R, Lee H, Fujimoto JG, Yu B, Jang IK. Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy: a serial optical coherence tomography study. Coron Artery Dis. 2016 Aug; 27(5):350-6. PMID: 27105047.
    Citations:    Fields:    Translation:Humans
  13. Minami Y, Wang Z, Aguirre AD, Lee S, Uemura S, Soeda T, Vergallo R, Raffel OC, Barlis P, Itoh T, Lee H, Fujimoto J, Jang IK. Quantitative analysis of the side-branch orifice after bifurcation stenting using en-face processing of OCT images: a comparison between Xience V and Resolute Integrity stents. Coron Artery Dis. 2016 Jan; 27(1):19-28. PMID: 26554662.
    Citations:    Fields:    Translation:Humans
  14. Vinegoni C, Aguirre AD, Lee S, Weissleder R. Imaging the beating heart in the mouse using intravital microscopy techniques. Nat Protoc. 2015 Nov; 10(11):1802-19. PMID: 26492138.
    Citations: 8     Fields:    Translation:Animals
  15. Vergallo R, Aguirre AD, Abtahian F, Minami Y, Soeda T, Chatzizisis YS, Croce K, Jang IK. Recurrent myocardial infarctions and premature coronary atherosclerosis in a 23-year-old man with antiphospholipid syndrome. Thromb Haemost. 2016 Jan; 115(2):237-9. PMID: 26423215.
    Citations: 2     Fields:    Translation:Humans
  16. Vinegoni C, Lee S, Aguirre AD, Weissleder R. New techniques for motion-artifact-free in vivo cardiac microscopy. Front Physiol. 2015; 6:147. PMID: 26029116.
    Citations: 6     
  17. Minami Y, Ong DS, Uemura S, Wang Z, Aguirre AD, Mukhopadhyay S, Soeda T, Vergallo R, Jia H, Tian J, Hu S, Kim SJ, Park CB, Dauerman HL, Lee S, Jang IK. Impacts of lesion angle on incidence and distribution of acute vessel wall injuries and strut malapposition after drug-eluting stent implantation assessed by optical coherence tomography. Eur Heart J Cardiovasc Imaging. 2015 Dec; 16(12):1390-8. PMID: 25925215.
    Citations: 1     Fields:    Translation:Humans
  18. Aguirre AD, Vinegoni C, Sebas M, Weissleder R. Intravital imaging of cardiac function at the single-cell level. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):11257-62. PMID: 25053815.
    Citations: 21     Fields:    Translation:AnimalsCells
  19. Wang Z, Jia H, Tian J, Soeda T, Vergallo R, Minami Y, Lee H, Aguirre A, Fujimoto JG, Jang IK. Computer-aided image analysis algorithm to enhance in vivo diagnosis of plaque erosion by intravascular optical coherence tomography. Circ Cardiovasc Imaging. 2014 Sep; 7(5):805-10. PMID: 25034595.
    Citations: 2     Fields:    Translation:Humans
  20. Hiremath P, Bauer M, Aguirre AD, Cheng HW, Unno K, Patel RB, Harvey BW, Chang WT, Groarke JD, Liao R, Cheng S. Identifying early changes in myocardial microstructure in hypertensive heart disease. PLoS One. 2014; 9(5):e97424. PMID: 24831515.
    Citations: 4     Fields:    Translation:HumansAnimals
  21. Liong M, Im H, Majmudar MD, Aguirre AD, Sebas M, Lee H, Weissleder R. Magnetic ligation method for quantitative detection of microRNAs. Adv Healthc Mater. 2014 Jul; 3(7):1015-9. PMID: 24532323.
    Citations: 1     Fields:    
  22. Hu S, Yonetsu T, Jia H, Karanasos A, Aguirre AD, Tian J, Abtahian F, Vergallo R, Soeda T, Lee H, McNulty I, Kato K, Yu B, Mizuno K, Toutouzas K, Stefanadis C, Jang IK. Residual thrombus pattern in patients with ST-segment elevation myocardial infarction caused by plaque erosion versus plaque rupture after successful fibrinolysis: an optical coherence tomography study. J Am Coll Cardiol. 2014 Apr 08; 63(13):1336-1338. PMID: 24361315.
    Citations: 4     Fields:    Translation:Humans
  23. Vergallo R, Ren X, Yonetsu T, Kato K, Uemura S, Yu B, Jia H, Abtahian F, Aguirre AD, Tian J, Hu S, Soeda T, Lee H, McNulty I, Park SJ, Jang Y, Prasad A, Lee S, Zhang S, Porto I, Biasucci LM, Crea F, Jang IK. Pancoronary plaque vulnerability in patients with acute coronary syndrome and ruptured culprit plaque: a 3-vessel optical coherence tomography study. Am Heart J. 2014 Jan; 167(1):59-67. PMID: 24332143.
    Citations: 8     Fields:    Translation:Humans
  24. Lee HC, Liu JJ, Sheikine Y, Aguirre AD, Connolly JL, Fujimoto JG. Ultrahigh speed spectral-domain optical coherence microscopy. Biomed Opt Express. 2013; 4(8):1236-54. PMID: 24009989.
    Citations: 5     
  25. Jia H, Abtahian F, Aguirre AD, Lee S, Chia S, Lowe H, Kato K, Yonetsu T, Vergallo R, Hu S, Tian J, Lee H, Park SJ, Jang YS, Raffel OC, Mizuno K, Uemura S, Itoh T, Kakuta T, Choi SY, Dauerman HL, Prasad A, Toma C, McNulty I, Zhang S, Yu B, Fuster V, Narula J, Virmani R, Jang IK. In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography. J Am Coll Cardiol. 2013 Nov 05; 62(19):1748-58. PMID: 23810884.
    Citations: 52     Fields:    Translation:Humans
  26. Lee HC, Zhou C, Cohen DW, Mondelblatt AE, Wang Y, Aguirre AD, Shen D, Sheikine Y, Fujimoto JG, Connolly JL. Integrated optical coherence tomography and optical coherence microscopy imaging of ex vivo human renal tissues. J Urol. 2012 Feb; 187(2):691-9. PMID: 22177199.
    Citations: 11     Fields:    Translation:Humans
  27. Zhou C, Cohen DW, Wang Y, Lee HC, Mondelblatt AE, Tsai TH, Aguirre AD, Fujimoto JG, Connolly JL. Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues. Cancer Res. 2010 Dec 15; 70(24):10071-9. PMID: 21056988.
    Citations: 25     Fields:    Translation:Humans
  28. Aguirre AD, Sawinski J, Huang SW, Zhou C, Denk W, Fujimoto JG. High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe. Opt Express. 2010 Mar 01; 18(5):4222-39. PMID: 20389435.
    Citations: 15     Fields:    Translation:Humans
  29. Zhou C, Wang Y, Aguirre AD, Tsai TH, Cohen DW, Connolly JL, Fujimoto JG. Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy. J Biomed Opt. 2010 Jan-Feb; 15(1):016001. PMID: 20210448.
    Citations: 14     Fields:    Translation:Humans
  30. Aguirre AD, Chen Y, Bryan B, Mashimo H, Huang Q, Connolly JL, Fujimoto JG. Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy. J Biomed Opt. 2010 Jan-Feb; 15(1):016025. PMID: 20210470.
    Citations: 12     Fields:    Translation:Humans
  31. Chen Y, Aguirre AD, Ruvinskaya L, Devor A, Boas DA, Fujimoto JG. Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation. J Neurosci Methods. 2009 Mar 30; 178(1):162-73. PMID: 19121336.
    Citations: 27     Fields:    Translation:AnimalsCells
  32. Chen Y, Aguirre AD, Hsiung PL, Huang SW, Mashimo H, Schmitt JM, Fujimoto JG. Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues. Opt Express. 2008 Feb 18; 16(4):2469-85. PMID: 18542326.
    Citations: 9     Fields:    Translation:Humans
  33. Chen Y, Huang SW, Aguirre AD, Fujimoto JG. High-resolution line-scanning optical coherence microscopy. Opt Lett. 2007 Jul 15; 32(14):1971-3. PMID: 17632613.
    Citations: 6     Fields:    Translation:Humans
  34. Hsiung PL, Phatak DR, Chen Y, Aguirre AD, Fujimoto JG, Connolly JL. Benign and malignant lesions in the human breast depicted with ultrahigh resolution and three-dimensional optical coherence tomography. Radiology. 2007 Sep; 244(3):865-74. PMID: 17630358.
    Citations: 24     Fields:    Translation:Humans
  35. Chen Y, Aguirre AD, Hsiung PL, Desai S, Herz PR, Pedrosa M, Huang Q, Figueiredo M, Huang SW, Koski A, Schmitt JM, Fujimoto JG, Mashimo H. Ultrahigh resolution optical coherence tomography of Barrett's esophagus: preliminary descriptive clinical study correlating images with histology. Endoscopy. 2007 Jul; 39(7):599-605. PMID: 17611914.
    Citations: 50     Fields:    Translation:Humans
  36. Huang SW, Aguirre AD, Huber RA, Adler DC, Fujimoto JG. Swept source optical coherence microscopy using a Fourier domain mode-locked laser. Opt Express. 2007 May 14; 15(10):6210-7. PMID: 19546926.
    Citations: 15     Fields:    
  37. Chen Y, Andrews PM, Aguirre AD, Schmitt JM, Fujimoto JG. High-resolution three-dimensional optical coherence tomography imaging of kidney microanatomy ex vivo. J Biomed Opt. 2007 May-Jun; 12(3):034008. PMID: 17614716.
    Citations: 10     Fields:    Translation:Animals
  38. Aguirre AD, Hertz PR, Chen Y, Fujimoto JG, Piyawattanametha W, Fan L, Wu MC. Two-axis MEMS Scanning Catheter for Ultrahigh Resolution Three-dimensional and En Face Imaging. Opt Express. 2007 Mar 05; 15(5):2445-53. PMID: 19532481.
    Citations: 12     Fields:    
  39. Aguirre AD, Chen Y, Fujimoto JG, Ruvinskaya L, Devor A, Boas DA. Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography. Opt Lett. 2006 Dec 01; 31(23):3459-61. PMID: 17099749.
    Citations: 18     Fields:    Translation:Animals
  40. Aguirre A, Nishizawa N, Fujimoto J, Seitz W, Lederer M, Kopf D. Continuum generation in a novel photonic crystal fiber for ultrahigh resolution optical coherence tomography at 800 nm and 1300 nm. Opt Express. 2006 Feb 06; 14(3):1145-60. PMID: 19503436.
    Citations: 5     Fields:    
  41. Hsiung PL, Pantanowitz L, Aguirre AD, Chen Y, Phatak D, Ko TH, Bourquin S, Schnitt SJ, Raza S, Connolly JL, Mashimo H, Fujimoto JG. Ultrahigh-resolution and 3-dimensional optical coherence tomography ex vivo imaging of the large and small intestines. Gastrointest Endosc. 2005 Oct; 62(4):561-74. PMID: 16185971.
    Citations: 12     Fields:    Translation:Humans
  42. Herz PR, Chen Y, Aguirre AD, Schneider K, Hsiung P, Fujimoto JG, Madden K, Schmitt J, Goodnow J, Petersen C. Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography. Opt Lett. 2004 Oct 01; 29(19):2261-3. PMID: 15524374.
    Citations: 24     Fields:    Translation:Animals
  43. Herz P, Chen Y, Aguirre A, Fujimoto J, Mashimo H, Schmitt J, Koski A, Goodnow J, Petersen C. Ultrahigh resolution optical biopsy with endoscopic optical coherence tomography. Opt Express. 2004 Jul 26; 12(15):3532-42. PMID: 19483882.
    Citations: 15     Fields:    
  44. Bourquin S, Aguirre A, Hartl I, Hsiung P, Ko T, Fujimoto J, Birks T, Wadsworth W, Bünting U, Kopf D. Ultrahigh resolution real time OCT imaging using a compact femtosecond Nd:Glass laser and nonlinear fiber. Opt Express. 2003 Dec 01; 11(24):3290-7. PMID: 19471457.
    Citations: 9     Fields:    
  45. Aguirre AD, Hsiung P, Ko TH, Hartl I, Fujimoto JG. High-resolution optical coherence microscopy for high-speed, in vivo cellular imaging. Opt Lett. 2003 Nov 01; 28(21):2064-6. PMID: 14587816.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.