Harvard Catalyst Profiles

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Jie Shen, PH.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS101745 (SHEN, JIE) Mar 15, 2017 - Feb 28, 2022
    Identification of Presinilin downstream targets in neuronal survival
    Role: Principal Investigator
  2. P50NS094733 (SHEN, JIE) Sep 1, 2015 - Jun 30, 2020
    alpha-Synuclein and LRRK2 in the Pathogenesis of Parkinson's Disease
    Role: Principal Investigator
  3. R13NS078790 (SHEN, JIE) May 1, 2012 - Apr 30, 2013
    2012 Neurobiology of Brain Disorders GRC
    Role: Principal Investigator
  4. R01NS071251 (SHEN, JIE) Sep 15, 2010 - Apr 30, 2015
    Function and Dysfunction of LRRK2
    Role: Principal Investigator
  5. R37NS071251 (SHEN, JIE) Jul 1, 2010 - Apr 30, 2022
    LRRK in Autophagy Function and Dopaminergic Neuron Survival
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tong Y, Shen J. Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2. Biochem Soc Trans. 2012 Oct; 40(5):1042-6. PMID: 22988862.
    Citations: 4     Fields:    Translation:HumansAnimals
  2. Giaime E, Yamaguchi H, Gautier CA, Kitada T, Shen J. Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening. PLoS One. 2012; 7(7):e40501. PMID: 22792356.
    Citations: 28     Fields:    Translation:AnimalsCells
  3. Gautier CA, Giaime E, Caballero E, Núñez L, Song Z, Chan D, Villalobos C, Shen J. Regulation of mitochondrial permeability transition pore by PINK1. Mol Neurodegener. 2012 May 25; 7:22. PMID: 22630785.
    Citations: 25     Fields:    Translation:AnimalsCells
  4. Li Z, Zhao ZJ, Zhu XQ, Ren QS, Nie FF, Gao JM, Gao XJ, Yang TB, Zhou WL, Shen JL, Wang Y, Lu FL, Chen XG, Hide G, Ayala FJ, Lun ZR. Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection. PLoS One. 2012; 7(4):e35834. PMID: 22558235.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  5. Zheng J, Watanabe H, Wines-Samuelson M, Zhao H, Gridley T, Kopan R, Shen J. Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem. 2012 Jun 08; 287(24):20356-68. PMID: 22505716.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  6. Watanabe H, Xia D, Kanekiyo T, Kelleher RJ, Shen J. Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice. J Neurosci. 2012 Apr 11; 32(15):5085-96. PMID: 22496554.
    Citations: 7     Fields:    Translation:Animals
  7. Tong Y, Giaime E, Yamaguchi H, Ichimura T, Liu Y, Si H, Cai H, Bonventre JV, Shen J. Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway. Mol Neurodegener. 2012 Jan 09; 7:2. PMID: 22230652.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  8. Jiang DC, Xu Y, Sun XY, Wang C, Shen JL. [The preparation, identification and physicochemical properties of anti-Porphyromonas gingivalis IgY]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2011 Oct; 46(10):586-9. PMID: 22321626.
    Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
  9. Tian Z, Shen J, Wang F, Xiao P, Yang J, Lei H, Kazlauskas A, Kohane IS, Wu E. Cambogin is preferentially cytotoxic to cells expressing PDGFR. PLoS One. 2011; 6(6):e21370. PMID: 21712951.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  10. Kelleher RJ, Shen J. Genetics. Gamma-secretase and human disease. Science. 2010 Nov 19; 330(6007):1055-6. PMID: 21097925.
    Citations: 16     Fields:    Translation:HumansAnimals
  11. Zhang D, Zhang C, Ho A, Kirkwood A, Südhof TC, Shen J. Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction. J Neurochem. 2010 Dec; 115(5):1215-21. PMID: 20854432.
    Citations: 17     Fields:    Translation:AnimalsCells
  12. Chen G, Zou X, Watanabe H, van Deursen JM, Shen J. CREB binding protein is required for both short-term and long-term memory formation. J Neurosci. 2010 Sep 29; 30(39):13066-77. PMID: 20881124.
    Citations: 52     Fields:    Translation:AnimalsCells
  13. Heilig EA, Xia W, Shen J, Kelleher RJ. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. J Biol Chem. 2010 Jul 16; 285(29):22350-9. PMID: 20460383.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  14. Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ, Shen J. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9879-84. PMID: 20457918.
    Citations: 160     Fields:    Translation:AnimalsCells
  15. Wines-Samuelson M, Schulte EC, Smith MJ, Aoki C, Liu X, Kelleher RJ, Shen J. Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice. PLoS One. 2010 Apr 15; 5(4):e10195. PMID: 20419112.
    Citations: 26     Fields:    Translation:AnimalsCells
  16. Shen J. Impaired neurotransmitter release in Alzheimer's and Parkinson's diseases. Neurodegener Dis. 2010; 7(1-3):80-3. PMID: 20173332.
    Citations: 12     Fields:    Translation:HumansAnimals
  17. Tong Y, Shen J. alpha-synuclein and LRRK2: partners in crime. Neuron. 2009 Dec 24; 64(6):771-3. PMID: 20064381.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  18. Yang Y, Kim AH, Yamada T, Wu B, Bilimoria PM, Ikeuchi Y, de la Iglesia N, Shen J, Bonni A. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science. 2009 Oct 23; 326(5952):575-8. PMID: 19900895.
    Citations: 48     Fields:    Translation:AnimalsCells
  19. Kitada T, Tong Y, Gautier CA, Shen J. Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice. J Neurochem. 2009 Nov; 111(3):696-702. PMID: 19694908.
    Citations: 66     Fields:    Translation:AnimalsCells
  20. Tong Y, Pisani A, Martella G, Karouani M, Yamaguchi H, Pothos EN, Shen J. R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14622-7. PMID: 19667187.
    Citations: 106     Fields:    Translation:AnimalsCells
  21. Zhang C, Wu B, Beglopoulos V, Wines-Samuelson M, Zhang D, Dragatsis I, Südhof TC, Shen J. Presenilins are essential for regulating neurotransmitter release. Nature. 2009 Jul 30; 460(7255):632-6. PMID: 19641596.
    Citations: 112     Fields:    Translation:AnimalsCells
  22. Wang W, Shen YX, Li J, Zhang SH, Luo QL, Zhong ZR, Jiang ZJ, Shen JL. Enhanced expression of the decoy receptor IL-13Ralpha2 in macrophages of Schistosoma japonicum-infected mice. Chin Med J (Engl). 2009 Jul 20; 122(14):1650-4. PMID: 19719966.
    Citations: 4     Fields:    Translation:AnimalsCells
  23. Kitada T, Pisani A, Karouani M, Haburcak M, Martella G, Tscherter A, Platania P, Wu B, Pothos EN, Shen J. Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice. J Neurochem. 2009 Jul; 110(2):613-21. PMID: 19457102.
    Citations: 40     Fields:    Translation:AnimalsCells
  24. Watanabe H, Smith MJ, Heilig E, Beglopoulos V, Kelleher RJ, Shen J. Indirect regulation of presenilins in CREB-mediated transcription. J Biol Chem. 2009 May 15; 284(20):13705-13. PMID: 19289467.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  25. Baulac S, Lu H, Strahle J, Yang T, Goldberg MS, Shen J, Schlossmacher MG, Lemere CA, Lu Q, Xia W. Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains. Mol Neurodegener. 2009 Feb 25; 4:12. PMID: 19243613.
    Citations: 15     Fields:    
  26. Gautier CA, Kitada T, Shen J. Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32):11364-9. PMID: 18687901.
    Citations: 224     Fields:    Translation:AnimalsCells
  27. Frenkel D, Puckett L, Petrovic S, Xia W, Chen G, Vega J, Dembinsky-Vaknin A, Shen J, Plante M, Burt DS, Weiner HL. A nasal proteosome adjuvant activates microglia and prevents amyloid deposition. Ann Neurol. 2008 May; 63(5):591-601. PMID: 18360829.
    Citations: 16     Fields:    Translation:AnimalsCells
  28. Kim WY, Shen J. Presenilins are required for maintenance of neural stem cells in the developing brain. Mol Neurodegener. 2008 Jan 08; 3:2. PMID: 18182109.
    Citations: 25     Fields:    
  29. Tian Z, Shen J, Moseman AP, Yang Q, Yang J, Xiao P, Wu E, Kohane IS. Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells. Int J Cancer. 2008 Jan 01; 122(1):31-8. PMID: 17847033.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  30. Rajagopal SK, Ma Q, Obler D, Shen J, Manichaikul A, Tomita-Mitchell A, Boardman K, Briggs C, Garg V, Srivastava D, Goldmuntz E, Broman KW, Benson DW, Smoot LB, Pu WT. Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol. 2007 Dec; 43(6):677-85. PMID: 17643447.
    Citations: 65     Fields:    Translation:HumansAnimals
  31. Kitada T, Pisani A, Porter DR, Yamaguchi H, Tscherter A, Martella G, Bonsi P, Zhang C, Pothos EN, Shen J. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A. 2007 Jul 03; 104(27):11441-6. PMID: 17563363.
    Citations: 150     Fields:    Translation:AnimalsCells
  32. Yamaguchi H, Shen J. Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Mol Neurodegener. 2007 May 29; 2:10. PMID: 17535435.
    Citations: 30     Fields:    
  33. Shen J, Kelleher RJ. The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci U S A. 2007 Jan 09; 104(2):403-9. PMID: 17197420.
    Citations: 152     Fields:    Translation:HumansAnimalsCells
  34. Yang X, Tomita T, Wines-Samuelson M, Beglopoulos V, Tansey MG, Kopan R, Shen J. Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. Dev Neurosci. 2006; 28(1-2):102-17. PMID: 16508308.
    Citations: 30     Fields:    Translation:AnimalsCells
  35. Beglopoulos V, Shen J. Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer's disease. Trends Pharmacol Sci. 2006 Jan; 27(1):33-40. PMID: 16337694.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  36. Wines-Samuelson M, Shen J. Presenilins in the developing, adult, and aging cerebral cortex. Neuroscientist. 2005 Oct; 11(5):441-51. PMID: 16151045.
    Citations: 27     Fields:    Translation:HumansAnimals
  37. Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J. Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice. J Neurosci. 2005 Jul 20; 25(29):6755-64. PMID: 16033885.
    Citations: 62     Fields:    Translation:AnimalsCells
  38. Goldberg MS, Pisani A, Haburcak M, Vortherms TA, Kitada T, Costa C, Tong Y, Martella G, Tscherter A, Martins A, Bernardi G, Roth BL, Pothos EN, Calabresi P, Shen J. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron. 2005 Feb 17; 45(4):489-96. PMID: 15721235.
    Citations: 160     Fields:    Translation:HumansAnimalsCells
  39. Wines-Samuelson M, Handler M, Shen J. Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons. Dev Biol. 2005 Jan 15; 277(2):332-46. PMID: 15617678.
    Citations: 21     Fields:    Translation:AnimalsCells
  40. Sun X, Beglopoulos V, Mattson MP, Shen J. Hippocampal spatial memory impairments caused by the familial Alzheimer's disease-linked presenilin 1 M146V mutation. Neurodegener Dis. 2005; 2(1):6-15. PMID: 16908998.
    Citations: 15     Fields:    Translation:Animals
  41. Shen J. Protein kinases linked to the pathogenesis of Parkinson's disease. Neuron. 2004 Nov 18; 44(4):575-7. PMID: 15541303.
    Citations: 9     Fields:    Translation:HumansAnimals
  42. Pan Y, Lin MH, Tian X, Cheng HT, Gridley T, Shen J, Kopan R. gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell. 2004 Nov; 7(5):731-43. PMID: 15525534.
    Citations: 99     Fields:    Translation:Animals
  43. Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD, Shen J. Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J Biol Chem. 2004 Nov 05; 279(45):46907-14. PMID: 15345711.
    Citations: 48     Fields:    Translation:AnimalsCells
  44. Shen J, Cookson MR. Mitochondria and dopamine: new insights into recessive parkinsonism. Neuron. 2004 Aug 05; 43(3):301-4. PMID: 15294138.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  45. Yang X, Klein R, Tian X, Cheng HT, Kopan R, Shen J. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol. 2004 May 01; 269(1):81-94. PMID: 15081359.
    Citations: 116     Fields:    Translation:AnimalsCells
  46. Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher RJ, Kandel ER, Duff K, Kirkwood A, Shen J. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron. 2004 Apr 08; 42(1):23-36. PMID: 15066262.
    Citations: 219     Fields:    Translation:Animals
  47. Palacino JJ, Sagi D, Goldberg MS, Krauss S, Motz C, Wacker M, Klose J, Shen J. Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J Biol Chem. 2004 Apr 30; 279(18):18614-22. PMID: 14985362.
    Citations: 288     Fields:    Translation:AnimalsCells
  48. Beglopoulos V, Shen J. Gene-targeting technologies for the study of neurological disorders. Neuromolecular Med. 2004; 6(1):13-30. PMID: 15781974.
    Citations: 8     Fields:    Translation:HumansAnimals
  49. Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, Bhatnagar A, Meloni EG, Wu N, Ackerson LC, Klapstein GJ, Gajendiran M, Roth BL, Chesselet MF, Maidment NT, Levine MS, Shen J. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J Biol Chem. 2003 Oct 31; 278(44):43628-35. PMID: 12930822.
    Citations: 225     Fields:    Translation:AnimalsCells
  50. Wang ZX, Hu Y, Shen JL, Wang KC, Wang HY, Jiang BL, Zhao P, Wang ZC, Ding W, Wang F, Xia XF. [Longitudinal investigation and experimental studies on thelaziasis and the intermediate host of Thelazia callipaeda in Guanghua county of Hubei province]. Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Jul; 24(7):588-90. PMID: 12975015.
    Citations: 5     Fields:    Translation:HumansAnimals
  51. Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T. alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol. 2002 Feb; 4(2):160-4. PMID: 11813001.
    Citations: 419     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.