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Last Name

profileJie Shen, PH.D.

TitleProfessor of Neurology
InstitutionBrigham and Women's Hospital
AddressHarvard Medical School
New Research Building 636
77 Avenue Louis Pasteur
Boston MA 02115
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01NS101745     (SHEN, JIE)Mar 15, 2017 - Feb 28, 2022
Identification of Presinilin downstream targets in neuronal survival
Role: Principal Investigator

P50NS094733     (SHEN, JIE)Sep 1, 2015 - Jun 30, 2020
alpha-Synuclein and LRRK2 in the Pathogenesis of Parkinson's Disease
Role: Principal Investigator

R13NS078790     (SHEN, JIE)May 1, 2012 - Apr 30, 2013
2012 Neurobiology of Brain Disorders GRC
Role: Principal Investigator

R01NS071251     (SHEN, JIE)Sep 15, 2010 - Apr 30, 2015
Function and Dysfunction of LRRK2
Role: Principal Investigator

R37NS071251     (SHEN, JIE)Jul 1, 2010 - Apr 30, 2019
LRRK in Autophagy Function and Dopaminergic Neuron Survival
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Tong Y, Shen J. Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2. Biochem Soc Trans. 2012 Oct; 40(5):1042-6. PMID: 22988862.
    View in: PubMed
  2. Giaime E, Yamaguchi H, Gautier CA, Kitada T, Shen J. Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening. PLoS One. 2012; 7(7):e40501. PMID: 22792356; PMCID: PMC3392228.
  3. Gautier CA, Giaime E, Caballero E, Núñez L, Song Z, Chan D, Villalobos C, Shen J. Regulation of mitochondrial permeability transition pore by PINK1. Mol Neurodegener. 2012 May 25; 7:22. PMID: 22630785; PMCID: PMC3405481.
  4. Li Z, Zhao ZJ, Zhu XQ, Ren QS, Nie FF, Gao JM, Gao XJ, Yang TB, Zhou WL, Shen JL, Wang Y, Lu FL, Chen XG, Hide G, Ayala FJ, Lun ZR. Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection. PLoS One. 2012; 7(4):e35834. PMID: 22558235; PMCID: PMC3338469.
  5. Zheng J, Watanabe H, Wines-Samuelson M, Zhao H, Gridley T, Kopan R, Shen J. Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem. 2012 Jun 08; 287(24):20356-68. PMID: 22505716; PMCID: PMC3370217.
  6. Watanabe H, Xia D, Kanekiyo T, Kelleher RJ, Shen J. Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice. J Neurosci. 2012 Apr 11; 32(15):5085-96. PMID: 22496554; PMCID: PMC3340902.
  7. Tong Y, Giaime E, Yamaguchi H, Ichimura T, Liu Y, Si H, Cai H, Bonventre JV, Shen J. Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway. Mol Neurodegener. 2012 Jan 09; 7:2. PMID: 22230652; PMCID: PMC3296570.
  8. Jiang DC, Xu Y, Sun XY, Wang C, Shen JL. [The preparation, identification and physicochemical properties of anti-Porphyromonas gingivalis IgY]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2011 Oct; 46(10):586-9. PMID: 22321626.
    View in: PubMed
  9. Tian Z, Shen J, Wang F, Xiao P, Yang J, Lei H, Kazlauskas A, Kohane IS, Wu E. Cambogin is preferentially cytotoxic to cells expressing PDGFR. PLoS One. 2011; 6(6):e21370. PMID: 21712951; PMCID: PMC3119700.
  10. Kelleher RJ, Shen J. Genetics. Gamma-secretase and human disease. Science. 2010 Nov 19; 330(6007):1055-6. PMID: 21097925; PMCID: PMC4556372.
  11. Zhang D, Zhang C, Ho A, Kirkwood A, Südhof TC, Shen J. Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction. J Neurochem. 2010 Dec; 115(5):1215-21. PMID: 20854432; PMCID: PMC2972413.
  12. Chen G, Zou X, Watanabe H, van Deursen JM, Shen J. CREB binding protein is required for both short-term and long-term memory formation. J Neurosci. 2010 Sep 29; 30(39):13066-77. PMID: 20881124; PMCID: PMC2953943.
  13. Heilig EA, Xia W, Shen J, Kelleher RJ. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. J Biol Chem. 2010 Jul 16; 285(29):22350-9. PMID: 20460383; PMCID: PMC2903357.
  14. Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ, Shen J. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9879-84. PMID: 20457918; PMCID: PMC2906862.
  15. Wines-Samuelson M, Schulte EC, Smith MJ, Aoki C, Liu X, Kelleher RJ, Shen J. Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice. PLoS One. 2010 Apr 15; 5(4):e10195. PMID: 20419112; PMCID: PMC2855368.
  16. Shen J. Impaired neurotransmitter release in Alzheimer's and Parkinson's diseases. Neurodegener Dis. 2010; 7(1-3):80-3. PMID: 20173332; PMCID: PMC2859234.
  17. Tong Y, Shen J. alpha-synuclein and LRRK2: partners in crime. Neuron. 2009 Dec 24; 64(6):771-3. PMID: 20064381; PMCID: PMC2826885.
  18. Yang Y, Kim AH, Yamada T, Wu B, Bilimoria PM, Ikeuchi Y, de la Iglesia N, Shen J, Bonni A. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science. 2009 Oct 23; 326(5952):575-8. PMID: 19900895; PMCID: PMC2846784.
  19. Kitada T, Tong Y, Gautier CA, Shen J. Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice. J Neurochem. 2009 Nov; 111(3):696-702. PMID: 19694908; PMCID: PMC2952933.
  20. Tong Y, Pisani A, Martella G, Karouani M, Yamaguchi H, Pothos EN, Shen J. R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14622-7. PMID: 19667187; PMCID: PMC2732807.
  21. Zhang C, Wu B, Beglopoulos V, Wines-Samuelson M, Zhang D, Dragatsis I, Südhof TC, Shen J. Presenilins are essential for regulating neurotransmitter release. Nature. 2009 Jul 30; 460(7255):632-6. PMID: 19641596; PMCID: PMC2744588.
  22. Wang W, Shen YX, Li J, Zhang SH, Luo QL, Zhong ZR, Jiang ZJ, Shen JL. Enhanced expression of the decoy receptor IL-13Ralpha2 in macrophages of Schistosoma japonicum-infected mice. Chin Med J (Engl). 2009 Jul 20; 122(14):1650-4. PMID: 19719966.
    View in: PubMed
  23. Kitada T, Pisani A, Karouani M, Haburcak M, Martella G, Tscherter A, Platania P, Wu B, Pothos EN, Shen J. Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice. J Neurochem. 2009 Jul; 110(2):613-21. PMID: 19457102.
    View in: PubMed
  24. Watanabe H, Smith MJ, Heilig E, Beglopoulos V, Kelleher RJ, Shen J. Indirect regulation of presenilins in CREB-mediated transcription. J Biol Chem. 2009 May 15; 284(20):13705-13. PMID: 19289467; PMCID: PMC2679472.
  25. Baulac S, Lu H, Strahle J, Yang T, Goldberg MS, Shen J, Schlossmacher MG, Lemere CA, Lu Q, Xia W. Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains. Mol Neurodegener. 2009 Feb 25; 4:12. PMID: 19243613; PMCID: PMC2654450.
  26. Gautier CA, Kitada T, Shen J. Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32):11364-9. PMID: 18687901; PMCID: PMC2516271.
  27. Frenkel D, Puckett L, Petrovic S, Xia W, Chen G, Vega J, Dembinsky-Vaknin A, Shen J, Plante M, Burt DS, Weiner HL. A nasal proteosome adjuvant activates microglia and prevents amyloid deposition. Ann Neurol. 2008 May; 63(5):591-601. PMID: 18360829; PMCID: PMC2747093.
  28. Kim WY, Shen J. Presenilins are required for maintenance of neural stem cells in the developing brain. Mol Neurodegener. 2008 Jan 08; 3:2. PMID: 18182109; PMCID: PMC2235867.
  29. Tian Z, Shen J, Moseman AP, Yang Q, Yang J, Xiao P, Wu E, Kohane IS. Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells. Int J Cancer. 2008 Jan 01; 122(1):31-8. PMID: 17847033.
    View in: PubMed
  30. Rajagopal SK, Ma Q, Obler D, Shen J, Manichaikul A, Tomita-Mitchell A, Boardman K, Briggs C, Garg V, Srivastava D, Goldmuntz E, Broman KW, Benson DW, Smoot LB, Pu WT. Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol. 2007 Dec; 43(6):677-85. PMID: 17643447; PMCID: PMC2573470.
  31. Kitada T, Pisani A, Porter DR, Yamaguchi H, Tscherter A, Martella G, Bonsi P, Zhang C, Pothos EN, Shen J. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A. 2007 Jul 03; 104(27):11441-6. PMID: 17563363; PMCID: PMC1890561.
  32. Yamaguchi H, Shen J. Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Mol Neurodegener. 2007 May 29; 2:10. PMID: 17535435; PMCID: PMC1891294.
  33. Shen J, Kelleher RJ. The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci U S A. 2007 Jan 09; 104(2):403-9. PMID: 17197420; PMCID: PMC1766397.
  34. Yang X, Tomita T, Wines-Samuelson M, Beglopoulos V, Tansey MG, Kopan R, Shen J. Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. Dev Neurosci. 2006; 28(1-2):102-17. PMID: 16508308.
    View in: PubMed
  35. Beglopoulos V, Shen J. Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer's disease. Trends Pharmacol Sci. 2006 Jan; 27(1):33-40. PMID: 16337694.
    View in: PubMed
  36. Wines-Samuelson M, Shen J. Presenilins in the developing, adult, and aging cerebral cortex. Neuroscientist. 2005 Oct; 11(5):441-51. PMID: 16151045.
    View in: PubMed
  37. Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J. Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice. J Neurosci. 2005 Jul 20; 25(29):6755-64. PMID: 16033885.
    View in: PubMed
  38. Goldberg MS, Pisani A, Haburcak M, Vortherms TA, Kitada T, Costa C, Tong Y, Martella G, Tscherter A, Martins A, Bernardi G, Roth BL, Pothos EN, Calabresi P, Shen J. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron. 2005 Feb 17; 45(4):489-96. PMID: 15721235.
    View in: PubMed
  39. Wines-Samuelson M, Handler M, Shen J. Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons. Dev Biol. 2005 Jan 15; 277(2):332-46. PMID: 15617678.
    View in: PubMed
  40. Sun X, Beglopoulos V, Mattson MP, Shen J. Hippocampal spatial memory impairments caused by the familial Alzheimer's disease-linked presenilin 1 M146V mutation. Neurodegener Dis. 2005; 2(1):6-15. PMID: 16908998.
    View in: PubMed
  41. Shen J. Protein kinases linked to the pathogenesis of Parkinson's disease. Neuron. 2004 Nov 18; 44(4):575-7. PMID: 15541303.
    View in: PubMed
  42. Pan Y, Lin MH, Tian X, Cheng HT, Gridley T, Shen J, Kopan R. gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell. 2004 Nov; 7(5):731-43. PMID: 15525534.
    View in: PubMed
  43. Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD, Shen J. Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J Biol Chem. 2004 Nov 05; 279(45):46907-14. PMID: 15345711.
    View in: PubMed
  44. Shen J, Cookson MR. Mitochondria and dopamine: new insights into recessive parkinsonism. Neuron. 2004 Aug 05; 43(3):301-4. PMID: 15294138.
    View in: PubMed
  45. Yang X, Klein R, Tian X, Cheng HT, Kopan R, Shen J. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol. 2004 May 01; 269(1):81-94. PMID: 15081359.
    View in: PubMed
  46. Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher RJ, Kandel ER, Duff K, Kirkwood A, Shen J. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron. 2004 Apr 08; 42(1):23-36. PMID: 15066262.
    View in: PubMed
  47. Palacino JJ, Sagi D, Goldberg MS, Krauss S, Motz C, Wacker M, Klose J, Shen J. Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J Biol Chem. 2004 Apr 30; 279(18):18614-22. PMID: 14985362.
    View in: PubMed
  48. Beglopoulos V, Shen J. Gene-targeting technologies for the study of neurological disorders. Neuromolecular Med. 2004; 6(1):13-30. PMID: 15781974.
    View in: PubMed
  49. Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, Bhatnagar A, Meloni EG, Wu N, Ackerson LC, Klapstein GJ, Gajendiran M, Roth BL, Chesselet MF, Maidment NT, Levine MS, Shen J. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J Biol Chem. 2003 Oct 31; 278(44):43628-35. PMID: 12930822.
    View in: PubMed
  50. Wang ZX, Hu Y, Shen JL, Wang KC, Wang HY, Jiang BL, Zhao P, Wang ZC, Ding W, Wang F, Xia XF. [Longitudinal investigation and experimental studies on thelaziasis and the intermediate host of Thelazia callipaeda in Guanghua county of Hubei province]. Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Jul; 24(7):588-90. PMID: 12975015.
    View in: PubMed
  51. Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T. alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol. 2002 Feb; 4(2):160-4. PMID: 11813001.
    View in: PubMed
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