Harvard Catalyst Profiles

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Bruce Colston Trapnell, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HG010632 (SHENDURE, JAY ASHOK) Sep 15, 2019 - Jun 30, 2023
    Versatile, exponentially scalable methods for single cell molecular profiling
    Role: Co-Principal Investigator
  2. U54HL145611 (CAI, LONG) Sep 20, 2018 - Jun 30, 2022
    A Spatially Resolved Molecular Atlas of Human Endothelium
    Role: Co-Principal Investigator
  3. R13HL144006 (TRAPNELL, BRUCE C) Aug 1, 2018 - Jul 31, 2019
    The 2018 International Rare Lung Diseases Clinical Research Conference
    Role: Principal Investigator
  4. RC2DK114777 (BERNSTEIN, IRWIN D) Sep 1, 2017 - Jun 30, 2022
    Niche signals in HSC genesis
    Role: Co-Principal Investigator
  5. R13HL134326 (TRAPNELL, BRUCE C) Aug 1, 2016 - Jul 31, 2017
    The 2016 International Rare Lung Diseases Clinical Research Conference
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Applequist J, Burroughs C, Ramirez A, Merkel PA, Rothenberg ME, Trapnell B, Desnick RJ, Sahin M, Krischer JP. A novel approach to conducting clinical trials in the community setting: utilizing patient-driven platforms and social media to drive web-based patient recruitment. BMC Med Res Methodol. 2020 03 13; 20(1):58. PMID: 32169041.
  2. Hudock KM, Collins MS, Imbrogno M, Snowball J, Kramer EL, Brewington JJ, Gollomp K, McCarthy C, Ostmann AJ, Kopras EJ, Davidson CR, Srdiharan A, Arumugam P, Sengupta S, Xu Y, Worthen GS, Trapnell BC, Clancy JP. Neutrophil extracellular traps activate IL-8 and IL-1 expression in human bronchial epithelia. Am J Physiol Lung Cell Mol Physiol. 2020 Jul 01; 319(1):L137-L147. PMID: 32159969.
  3. Trapnell BC, Chen S, Khurmi R, Bodhani A, Kapoor M, Haupt M. Hospitalization rates among patients with cystic fibrosis using pancreatic enzyme replacement therapy. Chron Respir Dis. 2020 Jan-Dec; 17:1479973119900612. PMID: 31984768.
  4. Suzuki T, McCarthy C, Carey BC, Borchers M, Beck D, Wikenheiser-Brokamp KA, Black D, Chalk C, Trapnell BC. Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis. Am J Respir Cell Mol Biol. 2020 01; 62(1):87-94. PMID: 31310562.
  5. Sinner DI, Carey B, Zgherea D, Kaufman KM, Leesman L, Wood RE, Rutter MJ, de Alarcon A, Elluru RG, Harley JB, Whitsett JA, Trapnell BC. Complete Tracheal Ring Deformity. A Translational Genomics Approach to Pathogenesis. Am J Respir Crit Care Med. 2019 11 15; 200(10):1267-1281. PMID: 31215789.
  6. Trapnell BC, McCarthy C. The Alveolar Lipidome in Pulmonary Alveolar Proteinosis. A New Target for Therapeutic Development? Am J Respir Crit Care Med. 2019 Oct 01; 200(7):800-802. PMID: 31162934.
  7. Schulert GS, Yasin S, Carey B, Chalk C, Do T, Schapiro AH, Husami A, Watts A, Brunner HI, Huggins J, Mellins ED, Morgan EM, Ting T, Trapnell BC, Wikenheiser-Brokamp KA, Towe C, Grom AA. Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease: Characterization and Risk Factors. Arthritis Rheumatol. 2019 11; 71(11):1943-1954. PMID: 31379071.
  8. Hetzel M, Lopez-Rodriguez E, Mucci A, Nguyen AHH, Suzuki T, Shima K, Buchegger T, Dettmer S, Rodt T, Bankstahl JP, Malik P, Knudsen L, Schambach A, Hansen G, Trapnell BC, Lachmann N, Moritz T. Effective hematopoietic stem cell-based gene therapy in a murine model of hereditary pulmonary alveolar proteinosis. Haematologica. 2020 Apr; 105(4):1147-1157. PMID: 31289207.
  9. Arumugam P, Suzuki T, Shima K, McCarthy C, Sallese A, Wessendarp M, Ma Y, Meyer J, Black D, Chalk C, Carey B, Lachmann N, Moritz T, Trapnell BC. Long-Term Safety and Efficacy of Gene-Pulmonary Macrophage Transplantation Therapy of PAP in Csf2ra-/- Mice. Mol Ther. 2019 09 04; 27(9):1597-1611. PMID: 31326401.
  10. McCarthy C, Bartholmai BJ, Woods JC, McCormack FX, Trapnell BC. Automated Parenchymal Pattern Analysis of Treatment Responses in Pulmonary Alveolar Proteinosis. Am J Respir Crit Care Med. 2019 05 01; 199(9):1151-1152. PMID: 30822107.
  11. Gupta N, Lee HS, Young LR, Strange C, Moss J, Singer LG, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP, Goldberg HJ, Downey GP, Taveira-DaSilva AM, Krischer JP, Setchell K, Trapnell BC, Inoue Y, McCormack FX. Analysis of the MILES cohort reveals determinants of disease progression and treatment response in lymphangioleiomyomatosis. Eur Respir J. 2019 04; 53(4). PMID: 30846465.
  12. Trapnell BC, Nakata K, Bonella F, Campo I, Griese M, Hamilton J, Wang T, Morgan C, Cottin V, McCarthy C. Pulmonary alveolar proteinosis. Nat Rev Dis Primers. 2019 03 07; 5(1):16. PMID: 30846703.
  13. Anderson K, Carey B, Martin A, Roark C, Chalk C, Nowell-Bostic M, Freed B, Aubrey M, Trapnell B, Fontenot A. Pulmonary alveolar proteinosis: An autoimmune disease lacking an HLA association. PLoS One. 2019; 14(3):e0213179. PMID: 30845238.
  14. McCarthy C, Carey B, Trapnell BC. Blood Testing for Differential Diagnosis of Pulmonary Alveolar Proteinosis Syndrome. Chest. 2019 02; 155(2):450-452. PMID: 30732696.
  15. McCarthy C, Carey B, Trapnell BC. Blood testing in the diagnosis of pulmonary alveolar proteinosis. Lancet Respir Med. 2018 11; 6(11):e54. PMID: 30484430.
    Citations:    Fields:    
  16. Mucci A, Lopez-Rodriguez E, Hetzel M, Liu S, Suzuki T, Happle C, Ackermann M, Kempf H, Hillje R, Kunkiel J, Janosz E, Brennig S, Glage S, Bankstahl JP, Dettmer S, Rodt T, Gohring G, Trapnell B, Hansen G, Trapnell C, Knudsen L, Lachmann N, Moritz T. iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice. Stem Cell Reports. 2018 09 11; 11(3):696-710. PMID: 30100408.
    Citations:    Fields:    
  17. McCarthy C, Lee E, Bridges JP, Sallese A, Suzuki T, Woods JC, Bartholmai BJ, Wang T, Chalk C, Carey BC, Arumugam P, Shima K, Tarling EJ, Trapnell BC. Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis. Nat Commun. 2018 08 07; 9(1):3127. PMID: 30087322.
    Citations:    Fields:    Translation:HumansAnimalsCells
  18. Happle C, Lachmann N, Ackermann M, Mirenska A, Göhring G, Thomay K, Mucci A, Hetzel M, Glomb T, Suzuki T, Chalk C, Glage S, Dittrich-Breiholz O, Trapnell B, Moritz T, Hansen G. Pulmonary Transplantation of Human Induced Pluripotent Stem Cell-derived Macrophages Ameliorates Pulmonary Alveolar Proteinosis. Am J Respir Crit Care Med. 2018 08 01; 198(3):350-360. PMID: 29652170.
    Citations: 2     Fields:    
  19. McCarthy C, Avetisyan R, Carey BC, Chalk C, Trapnell BC. Prevalence and healthcare burden of pulmonary alveolar proteinosis. Orphanet J Rare Dis. 2018 07 31; 13(1):129. PMID: 30064481.
    Citations:    Fields:    
  20. Hiruma T, Tsuyuzaki H, Uchida K, Trapnell BC, Yamamura Y, Kusakabe Y, Totsu T, Suzuki T, Morita S, Doi K, Noiri E, Nakamura K, Nakajima S, Yahagi N, Morimura N, Chang K, Yamada Y. IFN-ß Improves Sepsis-related Alveolar Macrophage Dysfunction and Postseptic Acute Respiratory Distress Syndrome-related Mortality. Am J Respir Cell Mol Biol. 2018 07; 59(1):45-55. PMID: 29365277.
    Citations:    Fields:    
  21. McCarthy C, Brewington JJ, Harkness B, Clancy JP, Trapnell BC. Personalised CFTR pharmacotherapeutic response testing and therapy of cystic fibrosis. Eur Respir J. 2018 06; 51(6). PMID: 29563174.
    Citations:    Fields:    
  22. Wright SS, Trauernicht A, Bonkowski E, McCall CA, Maier EA, Bezold R, Lake K, Chalk C, Trapnell BC, Kim MO, Kugathasan S, Denson LA. Familial Association of Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2018 05; 66(5):767-772. PMID: 29216019.
    Citations:    Fields:    
  23. Aoki A, Sakagami T, Yoshizawa K, Shima K, Toyama M, Tanabe Y, Moro H, Aoki N, Watanabe S, Koya T, Hasegawa T, Morimoto K, Kurashima A, Hoshino Y, Trapnell BC, Kikuchi T. Clinical Significance of Interferon-? Neutralizing Autoantibodies Against Disseminated Nontuberculous Mycobacterial Disease. Clin Infect Dis. 2018 04 03; 66(8):1239-1245. PMID: 29126235.
    Citations: 2     Fields:    
  24. Gathungu G, Zhang Y, Tian X, Bonkowski E, Rowehl L, Krumsiek J, Nix B, Chalk C, Trapnell B, Zhu W, Newberry R, Denson L, Li E. Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal Crohn's disease. World J Gastroenterol. 2018 Feb 07; 24(5):623-630. PMID: 29434451.
    Citations:    Fields:    Translation:Humans
  25. Trapnell BC, Bridges J. Does Granulocyte-Macrophage Colony-Stimulating Factor Coordinate a Hepatopulmonary Axis of Lipid Metabolism? Am J Respir Cell Mol Biol. 2017 10; 57(4):383-385. PMID: 28960104.
    Citations:    Fields:    Translation:HumansAnimalsCells
  26. Sallese A, Suzuki T, McCarthy C, Bridges J, Filuta A, Arumugam P, Shima K, Ma Y, Wessendarp M, Black D, Chalk C, Carey B, Trapnell BC. Targeting cholesterol homeostasis in lung diseases. Sci Rep. 2017 08 31; 7(1):10211. PMID: 28860566.
    Citations:    Fields:    
  27. Hetzel M, Suzuki T, Hashtchin AR, Arumugam P, Carey B, Schwabbauer M, Kuhn A, Meyer J, Schambach A, Van Der Loo J, Moritz T, Trapnell BC, Lachmann N. Function and Safety of Lentivirus-Mediated Gene Transfer for CSF2RA-Deficiency. Hum Gene Ther Methods. 2017 12; 28(6):318-329. PMID: 28854814.
    Citations:    Fields:    Translation:HumansAnimalsCells
  28. Kristof AS, Petrof BJ, Hamid Q, Kolb M, Landry JS, MacKenzie A, McCormack FX, Murawski IJ, Moss J, Rauch F, Rosas IO, Shapiro AJ, Smith BM, Thomas DY, Trapnell BC, Young LR, Zariwala MA. An Official American Thoracic Society Workshop Report: Translational Research in Rare Respiratory Diseases. Ann Am Thorac Soc. 2017 Aug; 14(8):1239-1247. PMID: 28763267.
    Citations:    Fields:    Translation:HumansAnimals
  29. Beiko T, Janech MG, Alekseyenko AV, Atkinson C, Coxson HO, Barth JL, Stephenson SE, Wilson CL, Schnapp LM, Barker A, Brantly M, Sandhaus RA, Silverman EK, Stoller JK, Trapnell B, Charlie S. Serum Proteins Associated with Emphysema Progression in Severe Alpha-1 Antitrypsin Deficiency. Chronic Obstr Pulm Dis. 2017 Jul 15; 4(3):204-216. PMID: 28848932.
  30. Mueller C, Gernoux G, Gruntman AM, Borel F, Reeves EP, Calcedo R, Rouhani FN, Yachnis A, Humphries M, Campbell-Thompson M, Messina L, Chulay JD, Trapnell B, Wilson JM, McElvaney NG, Flotte TR. 5 Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency. Mol Ther. 2017 06 07; 25(6):1387-1394. PMID: 28408179.
    Citations: 6     Fields:    Translation:HumansCells
  31. Kugathasan S, Denson LA, Walters TD, Kim MO, Marigorta UM, Schirmer M, Mondal K, Liu C, Griffiths A, Noe JD, Crandall WV, Snapper S, Rabizadeh S, Rosh JR, Shapiro JM, Guthery S, Mack DR, Kellermayer R, Kappelman MD, Steiner S, Moulton DE, Keljo D, Cohen S, Oliva-Hemker M, Heyman MB, Otley AR, Baker SS, Evans JS, Kirschner BS, Patel AS, Ziring D, Trapnell BC, Sylvester FA, Stephens MC, Baldassano RN, Markowitz JF, Cho J, Xavier RJ, Huttenhower C, Aronow BJ, Gibson G, Hyams JS, Dubinsky MC. Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study. Lancet. 2017 04 29; 389(10080):1710-1718. PMID: 28259484.
    Citations: 15     Fields:    Translation:HumansCTClinical Trials
  32. McCarthy C, Lara Gallego B, Trapnell BC, McCormack FX. Epidemiology of Rare Lung Diseases: The Challenges and Opportunities to Improve Research and Knowledge. Adv Exp Med Biol. 2017; 1031:419-442. PMID: 29214586.
    Citations:    Fields:    Translation:Humans
  33. Kleff V, Sorg UR, Bury C, Suzuki T, Rattmann I, Jerabek-Willemsen M, Poremba C, Flasshove M, Opalka B, Trapnell B, Dirksen U, Moritz T. Gene Therapy of ßc-Deficient Pulmonary Alveolar Proteinosis (ßc-PAP): Studies in a Murine in vivo Model. Mol Ther. 2008 Apr; 16(4):757-764. PMID: 28178466.
    Citations:    Fields:    
  34. Young LR, Trapnell BC, Mandl KD, Swarr DT, Wambach JA, Blaisdell CJ. Accelerating Scientific Advancement for Pediatric Rare Lung Disease Research. Report from a National Institutes of Health-NHLBI Workshop, September 3 and 4, 2015. Ann Am Thorac Soc. 2016 12; 13(12):385-393. PMID: 27925785.
    Citations: 1     Fields:    Translation:Humans
  35. Campo I, Luisetti M, Griese M, Trapnell BC, Bonella F, Grutters J, Nakata K, Van Moorsel CH, Costabel U, Cottin V, Ichiwata T, Inoue Y, Braschi A, Bonizzoni G, Iotti GA, Tinelli C, Rodi G. Whole lung lavage therapy for pulmonary alveolar proteinosis: a global survey of current practices and procedures. Orphanet J Rare Dis. 2016 08 31; 11(1):115. PMID: 27577926.
    Citations: 8     Fields:    Translation:Humans
  36. Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel MP, Ackermann M, Happle C, Kuhn A, Schambach A, Trapnell BC, Hansen G, Moritz T, Lachmann N. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem Cell Reports. 2016 08 09; 7(2):292-305. PMID: 27453007.
    Citations: 6     Fields:    Translation:AnimalsCells
  37. Campo I, Luisetti M, Griese M, Trapnell BC, Bonella F, Grutters JC, Nakata K, Van Moorsel CH, Costabel U, Cottin V, Ichiwata T, Inoue Y, Braschi A, Bonizzoni G, Iotti GA, Tinelli C, Rodi G. A Global Survey on Whole Lung Lavage in Pulmonary Alveolar Proteinosis. Chest. 2016 07; 150(1):251-3. PMID: 27396783.
    Citations:    Fields:    Translation:Humans
  38. Suzuki T, Trapnell BC. Pulmonary Alveolar Proteinosis Syndrome. Clin Chest Med. 2016 09; 37(3):431-40. PMID: 27514590.
    Citations: 9     Fields:    Translation:HumansCells
  39. Cummings KJ, Virji MA, Park JY, Stanton ML, Edwards NT, Trapnell BC, Carey B, Stefaniak AB, Kreiss K. Respirable indium exposures, plasma indium, and respiratory health among indium-tin oxide (ITO) workers. Am J Ind Med. 2016 07; 59(7):522-31. PMID: 27219296.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  40. Acciani TH, Suzuki T, Trapnell BC, Le Cras TD. Epidermal growth factor receptor signalling regulates granulocyte-macrophage colony-stimulating factor production by airway epithelial cells and established allergic airway disease. Clin Exp Allergy. 2016 Feb; 46(2):317-28. PMID: 26263242.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  41. Schnepp BC, Chulay JD, Ye GJ, Flotte TR, Trapnell BC, Johnson PR. Recombinant Adeno-Associated Virus Vector Genomes Take the Form of Long-Lived, Transcriptionally Competent Episomes in Human Muscle. Hum Gene Ther. 2016 Jan; 27(1):32-42. PMID: 26650966.
    Citations: 3     Fields:    Translation:HumansCells
  42. Fan LL, Dishop MK, Galambos C, Askin FB, White FV, Langston C, Liptzin DR, Kroehl ME, Deutsch GH, Young LR, Kurland G, Hagood J, Dell S, Trapnell BC, Deterding RR. Diffuse Lung Disease in Biopsied Children 2 to 18 Years of Age. Application of the chILD Classification Scheme. Ann Am Thorac Soc. 2015 Oct; 12(10):1498-505. PMID: 26291470.
    Citations: 4     Fields:    Translation:Humans
  43. Trapnell BC. A lymphocyte-mediated cause of secondary PAP. Blood. 2015 Jan 08; 125(2):215-6. PMID: 25573969.
    Citations: 1     Fields:    Translation:AnimalsCells
  44. Cummings KJ, Virji MA, Trapnell BC, Carey B, Healey T, Kreiss K. Early changes in clinical, functional, and laboratory biomarkers in workers at risk of indium lung disease. Ann Am Thorac Soc. 2014 Nov; 11(9):1395-403. PMID: 25295756.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  45. Suzuki T, Arumugam P, Sakagami T, Lachmann N, Chalk C, Sallese A, Abe S, Trapnell C, Carey B, Moritz T, Malik P, Lutzko C, Wood RE, Trapnell BC. Pulmonary macrophage transplantation therapy. Nature. 2014 Oct 23; 514(7523):450-4. PMID: 25274301.
    Citations: 59     Fields:    Translation:AnimalsCells
  46. Kusakabe Y, Uchida K, Hiruma T, Suzuki Y, Totsu T, Suzuki T, Carey BC, Yamada Y, Trapnell BC. A standardized blood test for the routine clinical diagnosis of impaired GM-CSF signaling using flow cytometry. J Immunol Methods. 2014 Nov; 413:1-11. PMID: 25068538.
    Citations:    Fields:    Translation:HumansCells
  47. Suzuki T, Mayhew C, Sallese A, Chalk C, Carey BC, Malik P, Wood RE, Trapnell BC. Use of induced pluripotent stem cells to recapitulate pulmonary alveolar proteinosis pathogenesis. Am J Respir Crit Care Med. 2014 Jan 15; 189(2):183-93. PMID: 24279752.
    Citations: 15     Fields:    Translation:HumansCells
  48. Trapnell BC. The dawn of protein-folding therapeutics. Am J Respir Crit Care Med. 2014 Jan 01; 189(1):1-3. PMID: 24381984.
    Citations:    Fields:    Translation:Humans
  49. Uchida K, Nakata K, Carey B, Chalk C, Suzuki T, Sakagami T, Koch DE, Stevens C, Inoue Y, Yamada Y, Trapnell BC. Standardized serum GM-CSF autoantibody testing for the routine clinical diagnosis of autoimmune pulmonary alveolar proteinosis. J Immunol Methods. 2014 Jan 15; 402(1-2):57-70. PMID: 24275678.
    Citations: 9     Fields:    Translation:HumansCells
  50. Mueller C, Chulay JD, Trapnell BC, Humphries M, Carey B, Sandhaus RA, McElvaney NG, Messina L, Tang Q, Rouhani FN, Campbell-Thompson M, Fu AD, Yachnis A, Knop DR, Ye GJ, Brantly M, Calcedo R, Somanathan S, Richman LP, Vonderheide RH, Hulme MA, Brusko TM, Wilson JM, Flotte TR. Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression. J Clin Invest. 2013 Dec; 123(12):5310-8. PMID: 24231351.
    Citations: 39     Fields:    Translation:HumansCellsCTClinical Trials
  51. Däbritz J, Bonkowski E, Chalk C, Trapnell BC, Langhorst J, Denson LA, Foell D. Granulocyte macrophage colony-stimulating factor auto-antibodies and disease relapse in inflammatory bowel disease. Am J Gastroenterol. 2013 Dec; 108(12):1901-10. PMID: 24145675.
    Citations: 15     Fields:    Translation:Humans
  52. Trapnell BC, Luisetti M. The parallel lives of alpha1-antitrypsin deficiency and pulmonary alveolar proteinosis. Orphanet J Rare Dis. 2013 Sep 30; 8:153. PMID: 24079310.
    Citations:    Fields:    Translation:Humans
  53. Dykes DM, Towbin AJ, Bonkowski E, Chalk C, Bezold R, Lake K, Kim MO, Heubi JE, Trapnell BC, Podberesky DJ, Denson LA. Increased prevalence of luminal narrowing and stricturing identified by enterography in pediatric Crohn's disease patients with elevated granulocyte-macrophage colony stimulating factor autoantibodies. Inflamm Bowel Dis. 2013 Sep; 19(10):2146-54. PMID: 23893081.
    Citations: 2     Fields:    Translation:Humans
  54. Young L, Lee HS, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP, Goldberg HJ, Downey GP, Swigris JJ, Taveira-DaSilva AM, Krischer JP, Trapnell BC, McCormack FX. Serum VEGF-D a concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial. Lancet Respir Med. 2013 Aug; 1(6):445-52. PMID: 24159565.
    Citations: 34     Fields:    Translation:Humans
  55. Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ. Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. Am J Respir Crit Care Med. 2013 Aug 01; 188(3):370-5. PMID: 23713908.
    Citations: 13     Fields:    Translation:Humans
  56. Gathungu G, Kim MO, Ferguson JP, Sharma Y, Zhang W, Ng SM, Bonkowski E, Ning K, Simms LA, Croft AR, Stempak JM, Walker N, Huang N, Xiao Y, Silverberg MS, Trapnell B, Cho JH, Radford-Smith GL, Denson LA. Granulocyte-macrophage colony-stimulating factor autoantibodies: a marker of aggressive Crohn's disease. Inflamm Bowel Dis. 2013 Jul; 19(8):1671-80. PMID: 23749272.
    Citations: 24     Fields:    Translation:Humans
  57. Jurickova I, Collins MH, Chalk C, Seese A, Bezold R, Lake K, von Allmen D, Frischer JS, Falcone RA, Trapnell BC, Denson LA. Paediatric Crohn disease patients with stricturing behaviour exhibit ileal granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody production and reduced neutrophil bacterial killing and GM-CSF bioactivity. Clin Exp Immunol. 2013 Jun; 172(3):455-65. PMID: 23600834.
    Citations: 5     Fields:    Translation:HumansCells
  58. Campo I, Mariani F, Rodi G, Paracchini E, Tsana E, Piloni D, Nobili I, Kadija Z, Corsico A, Cerveri I, Chalk C, Trapnell BC, Braschi A, Tinelli C, Luisetti M. Assessment and management of pulmonary alveolar proteinosis in a reference center. Orphanet J Rare Dis. 2013 Mar 13; 8:40. PMID: 23497546.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  59. Trapnell BC. Induced sputum biomarkers for monitoring cystic fibrosis lung disease. Am J Respir Crit Care Med. 2012 Nov 01; 186(9):812-4. PMID: 23118078.
    Citations: 1     Fields:    Translation:Humans
  60. Trapnell BC. Inhaled dry powder mannitol: a solution for cystic fibrosis. Am J Respir Crit Care Med. 2012 Mar 15; 185(6):596-8. PMID: 22422901.
    Citations: 1     Fields:    Translation:Humans
  61. Luisetti M, Balfour-Lynn IM, Johnson SR, Miravitlles M, Strange C, Trapnell BC, van Bronswijk H, Vogelmeier C. Perspectives for improving the evaluation and access of therapies for rare lung diseases in Europe. Respir Med. 2012 Jun; 106(6):759-68. PMID: 22414566.
    Citations: 4     Fields:    Translation:Humans
  62. Cummings KJ, Nakano M, Omae K, Takeuchi K, Chonan T, Xiao YL, Harley RA, Roggli VL, Hebisawa A, Tallaksen RJ, Trapnell BC, Day GA, Saito R, Stanton ML, Suarthana E, Kreiss K. Indium lung disease. Chest. 2012 Jun; 141(6):1512-1521. PMID: 22207675.
    Citations: 21     Fields:    Translation:HumansPHPublic Health
  63. Trapnell BC, McColley SA, Kissner DG, Rolfe MW, Rosen JM, McKevitt M, Moorehead L, Montgomery AB, Geller DE. Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with pseudomonas airway infection. Am J Respir Crit Care Med. 2012 Jan 15; 185(2):171-8. PMID: 22095545.
    Citations: 22     Fields:    Translation:HumansCells
  64. Flotte TR, Trapnell BC, Humphries M, Carey B, Calcedo R, Rouhani F, Campbell-Thompson M, Yachnis AT, Sandhaus RA, McElvaney NG, Mueller C, Messina LM, Wilson JM, Brantly M, Knop DR, Ye GJ, Chulay JD. Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing a1-antitrypsin: interim results. Hum Gene Ther. 2011 Oct; 22(10):1239-47. PMID: 21609134.
    Citations: 90     Fields:    Translation:HumansCellsCTClinical Trials
  65. Trapnell BC, Strausbaugh SD, Woo MS, Tong SY, Silber SA, Mulberg AE, Leitz G. Efficacy and safety of PANCREAZE® for treatment of exocrine pancreatic insufficiency due to cystic fibrosis. J Cyst Fibros. 2011 Sep; 10(5):350-6. PMID: 21632288.
    Citations: 4     Fields:    Translation:Humans
  66. Nylund CM, D'Mello S, Kim MO, Bonkowski E, Däbritz J, Foell D, Meddings J, Trapnell BC, Denson LA. Granulocyte macrophage-colony-stimulating factor autoantibodies and increased intestinal permeability in Crohn disease. J Pediatr Gastroenterol Nutr. 2011 May; 52(5):542-8. PMID: 21502824.
    Citations: 12     Fields:    Translation:Humans
  67. Luisetti M, Bruno P, Kadija Z, Suzuki T, Raffa S, Torrisi MR, Campo I, Mariani F, Pozzi E, Trapnell BC, Mariotta S. Relationship between diffuse pulmonary fibrosis, alveolar proteinosis, and granulocyte-macrophage colony stimulating factor autoantibodies. Respir Care. 2011 Oct; 56(10):1608-10. PMID: 21513605.
    Citations: 1     Fields:    Translation:Humans
  68. Duvoix A, Miranda E, Perez J, Sorensen GL, Holmskov U, Trapnell BC, Madsen J, Clark HW, Edwards LD, Miller BE, Tal-Singer RM, Lomas DA. Evaluation of full-length, cleaved and nitrosylated serum surfactant protein D as biomarkers for COPD. COPD. 2011 Apr; 8(2):79-95. PMID: 21495836.
    Citations: 5     Fields:    Translation:HumansAnimalsCTClinical Trials
  69. McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP, Goldberg HJ, Young LR, Kinder BW, Downey GP, Sullivan EJ, Colby TV, McKay RT, Cohen MM, Korbee L, Taveira-DaSilva AM, Lee HS, Krischer JP, Trapnell BC. Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med. 2011 Apr 28; 364(17):1595-606. PMID: 21410393.
    Citations: 229     Fields:    Translation:Humans
  70. Samson CM, Jurickova I, Molden E, Schreiner W, Colliver J, Bonkowski E, Han X, Trapnell BC, Denson LA. Granulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient mice. Inflamm Bowel Dis. 2011 Dec; 17(12):2443-55. PMID: 21381154.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  71. Wu H, Suzuki T, Carey B, Trapnell BC, McCormack FX. Keratinocyte growth factor augments pulmonary innate immunity through epithelium-driven, GM-CSF-dependent paracrine activation of alveolar macrophages. J Biol Chem. 2011 Apr 29; 286(17):14932-40. PMID: 21343299.
    Citations: 13     Fields:    Translation:AnimalsCells
  72. D'Mello S, Trauernicht A, Ryan A, Bonkowski E, Willson T, Trapnell BC, Frank SJ, Kugasathan S, Denson LA. Innate dysfunction promotes linear growth failure in pediatric Crohn's disease and growth hormone resistance in murine ileitis. Inflamm Bowel Dis. 2012 Feb; 18(2):236-45. PMID: 21337672.
    Citations: 6     Fields:    Translation:HumansAnimals
  73. Ishii H, Tazawa R, Kaneko C, Saraya T, Inoue Y, Hamano E, Kogure Y, Tomii K, Terada M, Takada T, Hojo M, Nishida A, Ichiwata T, Trapnell BC, Goto H, Nakata K. Clinical features of secondary pulmonary alveolar proteinosis: pre-mortem cases in Japan. Eur Respir J. 2011 Feb; 37(2):465-8. PMID: 21282812.
    Citations: 9     Fields:    Translation:Humans
  74. Suzuki T, Maranda B, Sakagami T, Catellier P, Couture CY, Carey BC, Chalk C, Trapnell BC. Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations. Eur Respir J. 2011 Jan; 37(1):201-4. PMID: 21205713.
    Citations: 20     Fields:    Translation:HumansCells
  75. Luisetti M, Kroneberg P, Suzuki T, Kadija Z, Muellinger B, Campo I, Gleske J, Rodi G, Zimlich WC, Mariani F, Ferrari F, Frey M, Trapnell BC. Physical properties, lung deposition modeling, and bioactivity of recombinant GM-CSF aerosolised with a highly efficient nebulizer. Pulm Pharmacol Ther. 2011 Feb; 24(1):123-7. PMID: 20728558.
    Citations: 4     Fields:    Translation:Animals
  76. Luisetti M, Kadija Z, Mariani F, Rodi G, Campo I, Trapnell BC. Therapy options in pulmonary alveolar proteinosis. Ther Adv Respir Dis. 2010 Aug; 4(4):239-48. PMID: 20647242.
    Citations: 14     Fields:    Translation:HumansAnimals
  77. Suzuki T, Sakagami T, Young LR, Carey BC, Wood RE, Luisetti M, Wert SE, Rubin BK, Kevill K, Chalk C, Whitsett JA, Stevens C, Nogee LM, Campo I, Trapnell BC. Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am J Respir Crit Care Med. 2010 Nov 15; 182(10):1292-304. PMID: 20622029.
    Citations: 30     Fields:    Translation:Humans
  78. Han X, Gilbert S, Groschwitz K, Hogan S, Jurickova I, Trapnell B, Samson C, Gully J. Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury. Gut. 2010 Aug; 59(8):1066-78. PMID: 20584783.
    Citations: 8     Fields:    Translation:AnimalsCells
  79. Watanabe M, Uchida K, Nakagaki K, Trapnell BC, Nakata K. High avidity cytokine autoantibodies in health and disease: pathogenesis and mechanisms. Cytokine Growth Factor Rev. 2010 Aug; 21(4):263-73. PMID: 20417147.
    Citations: 14     Fields:    Translation:HumansCells
  80. Young LR, Vandyke R, Gulleman PM, Inoue Y, Brown KK, Schmidt LS, Linehan WM, Hajjar F, Kinder BW, Trapnell BC, Bissler JJ, Franz DN, McCormack FX. Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases. Chest. 2010 Sep; 138(3):674-81. PMID: 20382711.
    Citations: 45     Fields:    Translation:Humans
  81. Carey B, Trapnell BC. The molecular basis of pulmonary alveolar proteinosis. Clin Immunol. 2010 May; 135(2):223-35. PMID: 20338813.
    Citations: 53     Fields:    Translation:HumansAnimals
  82. Sakagami T, Beck D, Uchida K, Suzuki T, Carey BC, Nakata K, Keller G, Wood RE, Wert SE, Ikegami M, Whitsett JA, Luisetti M, Davies S, Krischer JP, Brody A, Ryckman F, Trapnell BC. Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. Am J Respir Crit Care Med. 2010 Jul 01; 182(1):49-61. PMID: 20224064.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  83. Tazawa R, Trapnell BC, Inoue Y, Arai T, Takada T, Nasuhara Y, Hizawa N, Kasahara Y, Tatsumi K, Hojo M, Ishii H, Yokoba M, Tanaka N, Yamaguchi E, Eda R, Tsuchihashi Y, Morimoto K, Akira M, Terada M, Otsuka J, Ebina M, Kaneko C, Nukiwa T, Krischer JP, Akazawa K, Nakata K. Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis. Am J Respir Crit Care Med. 2010 Jun 15; 181(12):1345-54. PMID: 20167854.
    Citations: 35     Fields:    Translation:HumansCTClinical Trials
  84. Uchida K, Carey B, Suzuki T, Nakata K, Trapnell B. Response: Granulocyte/macrophage colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy persons. Blood. 2010 Jan 14; 115(2):431-3. PMID: 20075172.
    Citations:    Fields:    Translation:Humans
  85. Sakagami T, Uchida K, Suzuki T, Carey BC, Wood RE, Wert SE, Whitsett JA, Trapnell BC, Luisetti M. Human GM-CSF autoantibodies and reproduction of pulmonary alveolar proteinosis. N Engl J Med. 2009 Dec 31; 361(27):2679-81. PMID: 20042763.
    Citations: 34     Fields:    Translation:HumansAnimals
  86. Ishii H, Trapnell BC, Tazawa R, Inoue Y, Akira M, Kogure Y, Tomii K, Takada T, Hojo M, Ichiwata T, Goto H, Nakata K. Comparative study of high-resolution CT findings between autoimmune and secondary pulmonary alveolar proteinosis. Chest. 2009 Nov; 136(5):1348-1355. PMID: 19892674.
    Citations: 17     Fields:    Translation:Humans
  87. Trapnell BC, Maguiness K, Graff GR, Boyd D, Beckmann K, Caras S. Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis. J Cyst Fibros. 2009 Dec; 8(6):370-7. PMID: 19815466.
    Citations: 15     Fields:    Translation:Humans
  88. Trapnell BC. A novel biomarker-guided immunomodulatory approach for the therapy of sepsis. Am J Respir Crit Care Med. 2009 Oct 01; 180(7):585-6. PMID: 19762591.
    Citations: 2     Fields:    Translation:Humans
  89. Trapnell BC, Carey BC, Uchida K, Suzuki T. Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages. Curr Opin Immunol. 2009 Oct; 21(5):514-21. PMID: 19796925.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  90. Luisetti M, Rodi G, Perotti C, Campo I, Mariani F, Pozzi E, Trapnell BC. Plasmapheresis for treatment of pulmonary alveolar proteinosis. Eur Respir J. 2009 May; 33(5):1220-2. PMID: 19407056.
    Citations: 14     Fields:    Translation:Humans
  91. Uchida K, Nakata K, Suzuki T, Luisetti M, Watanabe M, Koch DE, Stevens CA, Beck DC, Denson LA, Carey BC, Keicho N, Krischer JP, Yamada Y, Trapnell BC. Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects. Blood. 2009 Mar 12; 113(11):2547-56. PMID: 19282464.
    Citations: 35     Fields:    Translation:HumansCells
  92. Robinson TE, Trapnell BC, Goris ML, Quittell LM, Cornfield DN. Quantitative analysis of longitudinal response to aerosolized granulocyte-macrophage colony-stimulating factor in two adolescents with autoimmune pulmonary alveolar proteinosis. Chest. 2009 Mar; 135(3):842-848. PMID: 19265094.
    Citations: 9     Fields:    Translation:Humans
  93. Han X, Uchida K, Jurickova I, Koch D, Willson T, Samson C, Bonkowski E, Trauernicht A, Kim MO, Tomer G, Dubinsky M, Plevy S, Kugathsan S, Trapnell BC, Denson LA. Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology. 2009 Apr; 136(4):1261-71, e1-3. PMID: 19230854.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  94. Suzuki T, Sakagami T, Rubin BK, Nogee LM, Wood RE, Zimmerman SL, Smolarek T, Dishop MK, Wert SE, Whitsett JA, Grabowski G, Carey BC, Stevens C, van der Loo JC, Trapnell BC. Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. J Exp Med. 2008 Nov 24; 205(12):2703-10. PMID: 18955570.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  95. Spight D, Trapnell B, Zhao B, Berclaz P, Shanley TP. Granulocyte-macrophage-colony-stimulating factor-dependent peritoneal macrophage responses determine survival in experimentally induced peritonitis and sepsis in mice. Shock. 2008 Oct; 30(4):434-42. PMID: 18277945.
    Citations: 8     Fields:    Translation:AnimalsCells
  96. Sandhaus RA, Turino G, Stocks J, Strange C, Trapnell BC, Silverman EK, Everett SE, Stoller JK. alpha1-Antitrypsin augmentation therapy for PI*MZ heterozygotes: a cautionary note. Chest. 2008 Oct; 134(4):831-4. PMID: 18842915.
    Citations: 10     Fields:    Translation:Humans
  97. Kleff V, Sorg UR, Bury C, Suzuki T, Rattmann I, Jerabek-Willemsen M, Poremba C, Flasshove M, Opalka B, Trapnell B, Dirksen U, Moritz T. Gene therapy of beta(c)-deficient pulmonary alveolar proteinosis (beta(c)-PAP): studies in a murine in vivo model. Mol Ther. 2008 Apr; 16(4):757-64. PMID: 18334984.
    Citations: 9     Fields:    Translation:AnimalsCells
  98. Inoue Y, Trapnell BC, Tazawa R, Arai T, Takada T, Hizawa N, Kasahara Y, Tatsumi K, Hojo M, Ichiwata T, Tanaka N, Yamaguchi E, Eda R, Oishi K, Tsuchihashi Y, Kaneko C, Nukiwa T, Sakatani M, Krischer JP, Nakata K. Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan. Am J Respir Crit Care Med. 2008 Apr 01; 177(7):752-62. PMID: 18202348.
    Citations: 66     Fields:    Translation:Humans
  99. Deutsch GH, Young LR, Deterding RR, Fan LL, Dell SD, Bean JA, Brody AS, Nogee LM, Trapnell BC, Langston C, Albright EA, Askin FB, Baker P, Chou PM, Cool CM, Coventry SC, Cutz E, Davis MM, Dishop MK, Galambos C, Patterson K, Travis WD, Wert SE, White FV. Diffuse lung disease in young children: application of a novel classification scheme. Am J Respir Crit Care Med. 2007 Dec 01; 176(11):1120-8. PMID: 17885266.
    Citations: 78     Fields:    Translation:Humans
  100. Perlmutter DH, Brodsky JL, Balistreri WF, Trapnell BC. Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review. Hepatology. 2007 May; 45(5):1313-23. PMID: 17464974.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  101. Watanabe M, Uchida K, Nakagaki K, Kanazawa H, Trapnell BC, Hoshino Y, Kagamu H, Yoshizawa H, Keicho N, Goto H, Nakata K. Anti-cytokine autoantibodies are ubiquitous in healthy individuals. FEBS Lett. 2007 May 15; 581(10):2017-21. PMID: 17470370.
    Citations: 20     Fields:    Translation:Humans
  102. Carey B, Staudt MK, Bonaminio D, van der Loo JC, Trapnell BC. PU.1 redirects adenovirus to lysosomes in alveolar macrophages, uncoupling internalization from infection. J Immunol. 2007 Feb 15; 178(4):2440-7. PMID: 17277151.
    Citations: 14     Fields:    Translation:AnimalsCells
  103. Uchida K, Beck DC, Yamamoto T, Berclaz PY, Abe S, Staudt MK, Carey BC, Filippi MD, Wert SE, Denson LA, Puchalski JT, Hauck DM, Trapnell BC. GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis. N Engl J Med. 2007 Feb 08; 356(6):567-79. PMID: 17287477.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  104. Berclaz PY, Carey B, Fillipi MD, Wernke-Dollries K, Geraci N, Cush S, Richardson T, Kitzmiller J, O'connor M, Hermoyian C, Korfhagen T, Whitsett JA, Trapnell BC. GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS. Am J Respir Cell Mol Biol. 2007 Jan; 36(1):114-21. PMID: 16917076.
    Citations: 33     Fields:    Translation:AnimalsCells
  105. Jennings K, Miyamae T, Traister R, Marinov A, Katakura S, Sowders D, Trapnell B, Wilson JM, Gao G, Hirsch R. Proteasome inhibition enhances AAV-mediated transgene expression in human synoviocytes in vitro and in vivo. Mol Ther. 2005 Apr; 11(4):600-7. PMID: 15771962.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  106. Gonzalez-Juarrero M, Hattle JM, Izzo A, Junqueira-Kipnis AP, Shim TS, Trapnell BC, Cooper AM, Orme IM. Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection. J Leukoc Biol. 2005 Jun; 77(6):914-22. PMID: 15767289.
    Citations: 64     Fields:    Translation:AnimalsCells
  107. Whitsett JA, Wert SE, Trapnell BC. Genetic disorders influencing lung formation and function at birth. Hum Mol Genet. 2004 Oct 01; 13 Spec No 2:R207-15. PMID: 15358727.
    Citations: 47     Fields:    Translation:Humans
  108. Cheng YH, Aronow BJ, Hossain S, Trapnell B, Kong S, Handwerger S. Critical role for transcription factor AP-2alpha in human trophoblast differentiation. Physiol Genomics. 2004 Jun 17; 18(1):99-107. PMID: 15039486.
    Citations: 11     Fields:    Translation:HumansCells
  109. Katakura S, Jennings K, Watanabe S, Adachi E, Thornton S, Gao GP, Wilson JM, Burstein H, Trapnell B, Hirsch R. Recombinant adeno-associated virus preferentially transduces human, compared to mouse, synovium: implications for arthritis therapy. Mod Rheumatol. 2004; 14(1):18-24. PMID: 17028800.
    Citations: 4     Fields:    
  110. Trapnell BC, Whitsett JA, Nakata K. Pulmonary alveolar proteinosis. N Engl J Med. 2003 Dec 25; 349(26):2527-39. PMID: 14695413.
    Citations: 151     Fields:    Translation:HumansAnimalsCells
  111. Uchida K, Nakata K, Trapnell BC, Terakawa T, Hamano E, Mikami A, Matsushita I, Seymour JF, Oh-Eda M, Ishige I, Eishi Y, Kitamura T, Yamada Y, Hanaoka K, Keicho N. High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis. Blood. 2004 Feb 01; 103(3):1089-98. PMID: 14512323.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  112. Bonfield TL, Raychaudhuri B, Malur A, Abraham S, Trapnell BC, Kavuru MS, Thomassen MJ. PU.1 regulation of human alveolar macrophage differentiation requires granulocyte-macrophage colony-stimulating factor. Am J Physiol Lung Cell Mol Physiol. 2003 Nov; 285(5):L1132-6. PMID: 12896880.
    Citations: 38     Fields:    Translation:HumansCells
  113. Hassett DJ, Cuppoletti J, Trapnell B, Lymar SV, Rowe JJ, Yoon SS, Hilliard GM, Parvatiyar K, Kamani MC, Wozniak DJ, Hwang SH, McDermott TR, Ochsner UA. Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets. Adv Drug Deliv Rev. 2002 Dec 05; 54(11):1425-43. PMID: 12458153.
    Citations: 88     Fields:    Translation:HumansCells
  114. Berclaz PY, Zsengellér Z, Shibata Y, Otake K, Strasbaugh S, Whitsett JA, Trapnell BC. Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by GM-CSF and PU.1. J Immunol. 2002 Dec 01; 169(11):6332-42. PMID: 12444140.
    Citations: 20     Fields:    Translation:AnimalsCells
  115. Berclaz PY, Shibata Y, Whitsett JA, Trapnell BC. GM-CSF, via PU.1, regulates alveolar macrophage Fcgamma R-mediated phagocytosis and the IL-18/IFN-gamma -mediated molecular connection between innate and adaptive immunity in the lung. Blood. 2002 Dec 01; 100(12):4193-200. PMID: 12393686.
    Citations: 38     Fields:    Translation:AnimalsCells
  116. Trapnell BC. Granulocyte macrophage-colony stimulating factor augmentation therapy in sepsis: is there a role? Am J Respir Crit Care Med. 2002 Jul 15; 166(2):129-30. PMID: 12119219.
    Citations: 3     Fields:    Translation:HumansCells
  117. Trapnell BC, Whitsett JA. Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense. Annu Rev Physiol. 2002; 64:775-802. PMID: 11826288.
    Citations: 86     Fields:    Translation:AnimalsCells
  118. Shibata Y, Zsengeller Z, Otake K, Palaniyar N, Trapnell BC. Alveolar macrophage deficiency in osteopetrotic mice deficient in macrophage colony-stimulating factor is spontaneously corrected with age and associated with matrix metalloproteinase expression and emphysema. Blood. 2001 Nov 01; 98(9):2845-52. PMID: 11675359.
    Citations: 17     Fields:    Translation:AnimalsCells
  119. Shibata Y, Berclaz PY, Chroneos ZC, Yoshida M, Whitsett JA, Trapnell BC. GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity. 2001 Oct; 15(4):557-67. PMID: 11672538.
    Citations: 150     Fields:    Translation:AnimalsCells
  120. Zsengellér ZK, Ross GF, Trapnell BC, Szabó C, Whitsett JA. Adenovirus infection increases iNOS and peroxynitrite production in the lung. Am J Physiol Lung Cell Mol Physiol. 2001 Mar; 280(3):L503-11. PMID: 11159034.
    Citations: 5     Fields:    Translation:Animals
  121. Zsengellér Z, Otake K, Hossain SA, Berclaz PY, Trapnell BC. Internalization of adenovirus by alveolar macrophages initiates early proinflammatory signaling during acute respiratory tract infection. J Virol. 2000 Oct; 74(20):9655-67. PMID: 11000238.
    Citations: 45     Fields:    Translation:AnimalsCells
  122. Harrod KS, Trapnell BC, Otake K, Korfhagen TR, Whitsett JA. SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection. Am J Physiol. 1999 09; 277(3):L580-8. PMID: 10484466.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  123. Iwamoto HS, Trapnell BC, McConnell CJ, Daugherty C, Whitsett JA. Pulmonary inflammation associated with repeated, prenatal exposure to an E1, E3-deleted adenoviral vector in sheep. Gene Ther. 1999 Jan; 6(1):98-106. PMID: 10341881.
    Citations: 4     Fields:    Translation:AnimalsCells
  124. March KL, Woody M, Mehdi K, Zipes DP, Brantly M, Trapnell BC. Efficient in vivo catheter-based pericardial gene transfer mediated by adenoviral vectors. Clin Cardiol. 1999 Jan; 22(1 Suppl 1):I23-9. PMID: 9929764.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  125. Otake K, Ennist DL, Harrod K, Trapnell BC. Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses. Hum Gene Ther. 1998 Oct 10; 9(15):2207-22. PMID: 9794205.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  126. Harrod KS, Hermiston TW, Trapnell BC, Wold WS, Whitsett JA. Lung-specific expression of adenovirus E3-14.7K in transgenic mice attenuates adenoviral vector-mediated lung inflammation and enhances transgene expression. Hum Gene Ther. 1998 Sep 01; 9(13):1885-98. PMID: 9741427.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  127. Connelly S, Andrews JL, Gallo AM, Kayda DB, Qian J, Hoyer L, Kadan MJ, Gorziglia MI, Trapnell BC, McClelland A, Kaleko M. Sustained phenotypic correction of murine hemophilia A by in vivo gene therapy. Blood. 1998 May 01; 91(9):3273-81. PMID: 9558383.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  128. Zsengellér ZK, Wert SE, Bachurski CJ, Kirwin KL, Trapnell BC, Whitsett JA. Recombinant adenoviral vector disrupts surfactant homeostasis in mouse lung. Hum Gene Ther. 1997 Jul 20; 8(11):1331-44. PMID: 9295128.
    Citations: 2     Fields:    Translation:AnimalsCells
  129. Zsengellér ZK, Boivin GP, Sawchuk SS, Trapnell BC, Whitsett JA, Hirsch R. Anti-T cell receptor antibody prolongs transgene expression and reduces lung inflammation after adenovirus-mediated gene transfer. Hum Gene Ther. 1997 May 20; 8(8):935-41. PMID: 9195216.
    Citations: 2     Fields:    Translation:AnimalsCells
  130. Stark JM, Amin RS, Trapnell BC. Infection of A549 cells with a recombinant adenovirus vector induces ICAM-1 expression and increased CD-18-dependent adhesion of activated neutrophils. Hum Gene Ther. 1996 Sep 10; 7(14):1669-81. PMID: 8886838.
    Citations: 3     Fields:    Translation:HumansCells
  131. Jobe AH, Ueda T, Whitsett JA, Trapnell BC, Ikegami M. Surfactant enhances adenovirus-mediated gene expression in rabbit lungs. Gene Ther. 1996 Sep; 3(9):775-9. PMID: 8875225.
    Citations: 6     Fields:    Translation:AnimalsCells
  132. Wilmott RW, Amin RS, Perez CR, Wert SE, Keller G, Boivin GP, Hirsch R, De Inocencio J, Lu P, Reising SF, Yei S, Whitsett JA, Trapnell BC. Safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lungs of nonhuman primates. Hum Gene Ther. 1996 Feb 10; 7(3):301-18. PMID: 8835218.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  133. Holzinger A, Trapnell BC, Weaver TE, Whitsett JA, Iwamoto HS. Intraamniotic administration of an adenoviral vector for gene transfer to fetal sheep and mouse tissues. Pediatr Res. 1995 Dec; 38(6):844-50. PMID: 8618783.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  134. Vincent MC, Trapnell BC, Baughman RP, Wert SE, Whitsett JA, Iwamoto HS. Adenovirus-mediated gene transfer to the respiratory tract of fetal sheep in utero. Hum Gene Ther. 1995 Aug; 6(8):1019-28. PMID: 7578414.
    Citations: 4     Fields:    Translation:AnimalsCells
  135. Zsengeller ZK, Wert SE, Hull WM, Hu X, Yei S, Trapnell BC, Whitsett JA. Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice. Hum Gene Ther. 1995 Apr; 6(4):457-67. PMID: 7612702.
    Citations: 24     Fields:    Translation:AnimalsCells
  136. March KL, Madison JE, Trapnell BC. Pharmacokinetics of adenoviral vector-mediated gene delivery to vascular smooth muscle cells: modulation by poloxamer 407 and implications for cardiovascular gene therapy. Hum Gene Ther. 1995 Jan; 6(1):41-53. PMID: 7703286.
    Citations: 13     Fields:    Translation:AnimalsCells
  137. Yei S, Bachurski CJ, Weaver TE, Wert SE, Trapnell BC, Whitsett JA. Adenoviral-mediated gene transfer of human surfactant protein B to respiratory epithelial cells. Am J Respir Cell Mol Biol. 1994 Sep; 11(3):329-36. PMID: 8086169.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  138. Mittereder N, Yei S, Bachurski C, Cuppoletti J, Whitsett JA, Tolstoshev P, Trapnell BC. Evaluation of the efficacy and safety of in vitro, adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA. Hum Gene Ther. 1994 Jun; 5(6):717-29. PMID: 7948134.
    Citations: 9     Fields:    Translation:HumansCellsCTClinical Trials
  139. Yei S, Mittereder N, Wert S, Whitsett JA, Wilmott RW, Trapnell BC. In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung. Hum Gene Ther. 1994 Jun; 5(6):731-44. PMID: 7948135.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  140. Yei S, Mittereder N, Tang K, O'Sullivan C, Trapnell BC. Adenovirus-mediated gene transfer for cystic fibrosis: quantitative evaluation of repeated in vivo vector administration to the lung. Gene Ther. 1994 May; 1(3):192-200. PMID: 7584081.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  141. Nakamura H, Yoshimura K, Bajocchi G, Trapnell BC, Pavirani A, Crystal RG. Tumor necrosis factor modulation of expression of the cystic fibrosis transmembrane conductance regulator gene. FEBS Lett. 1992 Dec 21; 314(3):366-70. PMID: 1281791.
  142. Chu CS, Trapnell BC, Curristin SM, Cutting GR, Crystal RG. Extensive posttranscriptional deletion of the coding sequences for part of nucleotide-binding fold 1 in respiratory epithelial mRNA transcripts of the cystic fibrosis transmembrane conductance regulator gene is not associated with the clinical manifestations of cystic fibrosis. J Clin Invest. 1992 Sep; 90(3):785-90. PMID: 1381723.
    Citations: 22     Fields:    Translation:HumansCells
  143. Rosenfeld MA, Yoshimura K, Trapnell BC, Yoneyama K, Rosenthal ER, Dalemans W, Fukayama M, Bargon J, Stier LE, Stratford-Perricaudet L, et al. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell. 1992 Jan 10; 68(1):143-55. PMID: 1370653.
    Citations: 177     Fields:    Translation:HumansAnimalsCells
  144. Hamosh A, Trapnell BC, Zeitlin PL, Montrose-Rafizadeh C, Rosenstein BJ, Crystal RG, Cutting GR. Severe deficiency of cystic fibrosis transmembrane conductance regulator messenger RNA carrying nonsense mutations R553X and W1316X in respiratory epithelial cells of patients with cystic fibrosis. J Clin Invest. 1991 Dec; 88(6):1880-5. PMID: 1721624.
    Citations: 42     Fields:    Translation:HumansCells
  145. Chu CS, Trapnell BC, Murtagh JJ, Moss J, Dalemans W, Jallat S, Mercenier A, Pavirani A, Lecocq JP, Cutting GR, et al. Variable deletion of exon 9 coding sequences in cystic fibrosis transmembrane conductance regulator gene mRNA transcripts in normal bronchial epithelium. EMBO J. 1991 Jun; 10(6):1355-63. PMID: 1709095.
    Citations: 29     Fields:    Translation:HumansCells
  146. Nagaoka I, Trapnell BC, Crystal RG. Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis. J Clin Invest. 1990 Jun; 85(6):2023-7. PMID: 2347924.
    Citations: 40     Fields:    Translation:HumansCells
  147. Saltini C, Kirby M, Trapnell BC, Tamura N, Crystal RG. Biased accumulation of T lymphocytes with "memory"-type CD45 leukocyte common antigen gene expression on the epithelial surface of the human lung. J Exp Med. 1990 Apr 01; 171(4):1123-40. PMID: 2139099.
    Citations: 35     Fields:    Translation:HumansCells
  148. Nagaoka I, Trapnell BC, Crystal RG. Regulation of insulin-like growth factor I gene expression in the human macrophage-like cell line U937. J Clin Invest. 1990 Feb; 85(2):448-55. PMID: 1688884.
    Citations: 8     Fields:    Translation:HumansCells
  149. Rom WN, Basset P, Fells GA, Nukiwa T, Trapnell BC, Crysal RG. Alveolar macrophages release an insulin-like growth factor I-type molecule. J Clin Invest. 1988 Nov; 82(5):1685-93. PMID: 3183063.
    Citations: 38     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.