Harvard Catalyst Profiles

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Young Charles Jang, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, Miller C, Regalado SG, Loffredo FS, Pancoast JR, Hirshman MF, Lebowitz J, Shadrach JL, Cerletti M, Kim MJ, Serwold T, Goodyear LJ, Rosner B, Lee RT, Wagers AJ. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science. 2014 May 09; 344(6184):649-52. PMID: 24797481.
    Citations: 181     Fields:    Translation:AnimalsCells
  2. Burzyn D, Kuswanto W, Kolodin D, Shadrach JL, Cerletti M, Jang Y, Sefik E, Tan TG, Wagers AJ, Benoist C, Mathis D. A special population of regulatory T cells potentiates muscle repair. Cell. 2013 Dec 05; 155(6):1282-95. PMID: 24315098.
    Citations: 210     Fields:    Translation:AnimalsCells
  3. Jang YC, Liu Y, Hayworth CR, Bhattacharya A, Lustgarten MS, Muller FL, Chaudhuri A, Qi W, Li Y, Huang JY, Verdin E, Richardson A, Van Remmen H. Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD. Aging Cell. 2012 Oct; 11(5):770-82. PMID: 22672615.
    Citations: 23     Fields:    Translation:AnimalsCells
  4. Lustgarten MS, Bhattacharya A, Muller FL, Jang YC, Shimizu T, Shirasawa T, Richardson A, Van Remmen H. Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels. Biochem Biophys Res Commun. 2012 Jun 08; 422(3):515-21. PMID: 22613204.
    Citations: 19     Fields:    Translation:AnimalsCells
  5. Cerletti M, Jang YC, Finley LW, Haigis MC, Wagers AJ. Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell. 2012 May 04; 10(5):515-9. PMID: 22560075.
    Citations: 81     Fields:    Translation:AnimalsCells
  6. Liang H, Ward WF, Jang YC, Bhattacharya A, Bokov AF, Li Y, Jernigan A, Richardson A, Van Remmen H. PGC-1a protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model. Muscle Nerve. 2011 Dec; 44(6):947-56. PMID: 22102466.
    Citations: 25     Fields:    Translation:AnimalsCells
  7. Jang YC, Sinha M, Cerletti M, Dall'Osso C, Wagers AJ. Skeletal muscle stem cells: effects of aging and metabolism on muscle regenerative function. Cold Spring Harb Symp Quant Biol. 2011; 76:101-11. PMID: 21960527.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  8. Lustgarten MS, Jang YC, Liu Y, Qi W, Qin Y, Dahia PL, Shi Y, Bhattacharya A, Muller FL, Shimizu T, Shirasawa T, Richardson A, Van Remmen H. MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging. Aging Cell. 2011 Jun; 10(3):493-505. PMID: 21385310.
    Citations: 29     Fields:    Translation:AnimalsCells
  9. Bhattacharya A, Lustgarten M, Shi Y, Liu Y, Jang YC, Pulliam D, Jernigan AL, Van Remmen H. Increased mitochondrial matrix-directed superoxide production by fatty acid hydroperoxides in skeletal muscle mitochondria. Free Radic Biol Med. 2011 Mar 01; 50(5):592-601. PMID: 21172427.
    Citations: 7     Fields:    Translation:AnimalsCells
  10. Jang YC, Van Remmen H. Age-associated alterations of the neuromuscular junction. Exp Gerontol. 2011 Feb-Mar; 46(2-3):193-8. PMID: 20854887.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  11. Jang YC, Lustgarten MS, Liu Y, Muller FL, Bhattacharya A, Liang H, Salmon AB, Brooks SV, Larkin L, Hayworth CR, Richardson A, Van Remmen H. Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration. FASEB J. 2010 May; 24(5):1376-90. PMID: 20040516.
    Citations: 86     Fields:    Translation:AnimalsCells
  12. Lustgarten MS, Jang YC, Liu Y, Muller FL, Qi W, Steinhelper M, Brooks SV, Larkin L, Shimizu T, Shirasawa T, McManus LM, Bhattacharya A, Richardson A, Van Remmen H. Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity. Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1520-32. PMID: 19776389.
    Citations: 31     Fields:    Translation:AnimalsCells
  13. Jang YC, Pérez VI, Song W, Lustgarten MS, Salmon AB, Mele J, Qi W, Liu Y, Liang H, Chaudhuri A, Ikeno Y, Epstein CJ, Van Remmen H, Richardson A. Overexpression of Mn superoxide dismutase does not increase life span in mice. J Gerontol A Biol Sci Med Sci. 2009 Nov; 64(11):1114-25. PMID: 19633237.
    Citations: 86     Fields:    Translation:AnimalsCells
  14. Liang H, Ran Q, Jang YC, Holstein D, Lechleiter J, McDonald-Marsh T, Musatov A, Song W, Van Remmen H, Richardson A. Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria. Free Radic Biol Med. 2009 Aug 01; 47(3):312-20. PMID: 19447173.
    Citations: 17     Fields:    Translation:AnimalsCells
  15. Jang YC, Van Remmen H. The mitochondrial theory of aging: insight from transgenic and knockout mouse models. Exp Gerontol. 2009 Apr; 44(4):256-60. PMID: 19171187.
    Citations: 55     Fields:    Translation:Animals
  16. Bhattacharya A, Muller FL, Liu Y, Sabia M, Liang H, Song W, Jang YC, Ran Q, Van Remmen H. Denervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria. J Biol Chem. 2009 Jan 02; 284(1):46-55. PMID: 19001413.
    Citations: 23     Fields:    Translation:AnimalsCells
  17. Muller FL, Liu Y, Abdul-Ghani MA, Lustgarten MS, Bhattacharya A, Jang YC, Van Remmen H. High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates. Biochem J. 2008 Jan 15; 409(2):491-9. PMID: 17916065.
    Citations: 48     Fields:    Translation:AnimalsCells
  18. Muller FL, Song W, Jang YC, Liu Y, Sabia M, Richardson A, Van Remmen H. Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 293(3):R1159-68. PMID: 17584954.
    Citations: 82     Fields:    Translation:AnimalsCells
  19. Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H. Trends in oxidative aging theories. Free Radic Biol Med. 2007 Aug 15; 43(4):477-503. PMID: 17640558.
    Citations: 269     Fields:    Translation:HumansAnimalsCells
  20. Judge S, Jang YM, Smith A, Selman C, Phillips T, Speakman JR, Hagen T, Leeuwenburgh C. Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart. Am J Physiol Regul Integr Comp Physiol. 2005 Dec; 289(6):R1564-72. PMID: 16051717.
    Citations: 49     Fields:    Translation:AnimalsCells
  21. Judge S, Jang YM, Smith A, Hagen T, Leeuwenburgh C. Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging. FASEB J. 2005 Mar; 19(3):419-21. PMID: 15642720.
    Citations: 92     Fields:    Translation:AnimalsCells
  22. Jang YM, Kendaiah S, Drew B, Phillips T, Selman C, Julian D, Leeuwenburgh C. Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats. FEBS Lett. 2004 Nov 19; 577(3):483-90. PMID: 15556633.
    Citations: 28     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.