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Tom Norbert Grossmann, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ortega Ugalde S, Wallraven K, Speer A, Bitter W, Grossmann TN, Commandeur JNM. Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis. Biochem Pharmacol. 2020 Jul; 177:113938. PMID: 32224137.
  2. Guéret SM, Thavam S, Carbajo RJ, Potowski M, Larsson N, Dahl G, Dellsén A, Grossmann TN, Plowright AT, Valeur E, Lemurell M, Waldmann H. Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments. J Am Chem Soc. 2020 Mar 11; 142(10):4904-4915. PMID: 32058716.
  3. Horne WS, Grossmann TN. Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns. Nat Chem. 2020 Apr; 12(4):331-337. PMID: 32029906.
  4. Wallraven K, Holmelin FL, Glas A, Hennig S, Frolov AI, Grossmann TN. Adapting free energy perturbation simulations for large macrocyclic ligands: how to dissect contributions from direct binding and free ligand flexibility. Chem Sci. 2020 Feb 28; 11(8):2269-2276. PMID: 32180932.
  5. Neubacher S, Saya JM, Amore A, Grossmann TN. In Situ Cyclization of Proteins (INCYPRO): Cross-Link Derivatization Modulates Protein Stability. J Org Chem. 2020 Feb 07; 85(3):1476-1483. PMID: 31790232.
  6. Cromm PM, Adihou H, Kapoor S, Vazquez-Chantada M, Davey P, Longmire D, Hennes E, Hofer W, Küchler P, Chiarparin E, Waldmann H, Grossmann TN. Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119. Chembiochem. 2019 12 13; 20(24):2987-2990. PMID: 31680402.
  7. Jeganathan S, Wendt M, Kiehstaller S, Brancaccio D, Kuepper A, Pospiech N, Carotenuto A, Novellino E, Hennig S, Grossmann TN. Constrained Peptides with Fine-Tuned Flexibility Inhibit NF-Y Transcription Factor Assembly. Angew Chem Int Ed Engl. 2019 11 25; 58(48):17351-17358. PMID: 31539186.
  8. Mueller C, Grossmann TN. Coiled-Coil Peptide Beacon: A Tunable Conformational Switch for Protein Detection. Angew Chem Int Ed Engl. 2018 12 21; 57(52):17079-17083. PMID: 30411434.
    Citations:    Fields:    
  9. Kureisaite-Ciziene D, Varadajan A, McLaughlin SH, Glas M, Montón Silva A, Luirink R, Mueller C, den Blaauwen T, Grossmann TN, Luirink J, Löwe J. Structural Analysis of the Interaction between the Bacterial Cell Division Proteins FtsQ and FtsB. mBio. 2018 09 11; 9(5). PMID: 30206170.
    Citations:    Fields:    
  10. Ortega Ugalde S, de Koning CP, Wallraven K, Bruyneel B, Vermeulen NPE, Grossmann TN, Bitter W, Commandeur JNM, Vos JC. Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners. Appl Microbiol Biotechnol. 2018 Nov; 102(21):9231-9242. PMID: 30136203.
    Citations:    Fields:    Translation:Cells
  11. Krüger DM, Neubacher S, Grossmann TN. Protein-RNA interactions: structural characteristics and hotspot amino acids. RNA. 2018 11; 24(11):1457-1465. PMID: 30093489.
    Citations:    Fields:    Translation:Cells
  12. Pelay-Gimeno M, Bange T, Hennig S, Grossmann TN. In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme. Angew Chem Int Ed Engl. 2018 08 27; 57(35):11164-11170. PMID: 29847004.
    Citations: 1     Fields:    
  13. Schmidtgall B, Kuepper A, Meng M, Grossmann TN, Ducho C. Oligonucleotides with Cationic Backbone and Their Hybridization with DNA: Interplay of Base Pairing and Electrostatic Attraction. Chemistry. 2018 Feb 01; 24(7):1544-1553. PMID: 29048135.
    Citations: 2     Fields:    Translation:Cells
  14. McLoughlin NM, Mueller C, Grossmann TN. The Therapeutic Potential of PTEN Modulation: Targeting Strategies from Gene to Protein. Cell Chem Biol. 2018 01 18; 25(1):19-29. PMID: 29153852.
    Citations: 2     Fields:    Translation:Humans
  15. Krüger DM, Glas A, Bier D, Pospiech N, Wallraven K, Dietrich L, Ottmann C, Koch O, Hennig S, Grossmann TN. Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions. J Med Chem. 2017 11 09; 60(21):8982-8988. PMID: 29028171.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  16. Glas A, Wamhoff EC, Krüger DM, Rademacher C, Grossmann TN. Increased Conformational Flexibility of a Macrocycle-Receptor Complex Contributes to Reduced Dissociation Rates. Chemistry. 2017 Nov 16; 23(64):16157-16161. PMID: 28777495.
    Citations: 3     Fields:    Translation:Cells
  17. Dietrich L, Rathmer B, Ewan K, Bange T, Heinrichs S, Dale TC, Schade D, Grossmann TN. Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets ß-Catenin Protein-Protein Interactions. Cell Chem Biol. 2017 Aug 17; 24(8):958-968.e5. PMID: 28757184.
    Citations: 3     Fields:    Translation:HumansCells
  18. Valeur E, Guéret SM, Adihou H, Gopalakrishnan R, Lemurell M, Waldmann H, Grossmann TN, Plowright AT. New Modalities for Challenging Targets in Drug Discovery. Angew Chem Int Ed Engl. 2017 08 21; 56(35):10294-10323. PMID: 28186380.
    Citations: 10     Fields:    
  19. White MD, Klecker M, Hopkinson RJ, Weits DA, Mueller C, Naumann C, O'Neill R, Wickens J, Yang J, Brooks-Bartlett JC, Garman EF, Grossmann TN, Dissmeyer N, Flashman E. Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets. Nat Commun. 2017 03 23; 8:14690. PMID: 28332493.
    Citations: 8     Fields:    Translation:AnimalsCells
  20. Stiller C, Krüger DM, Brauckhoff N, Schmidt M, Janning P, Salamon H, Grossmann TN. Translocation of an Intracellular Protein via Peptide-Directed Ligation. ACS Chem Biol. 2017 02 17; 12(2):504-509. PMID: 28001046.
    Citations: 1     Fields:    Translation:HumansCells
  21. Cromm PM, Wallraven K, Glas A, Bier D, Fürstner A, Ottmann C, Grossmann TN. Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis. Chembiochem. 2016 10 17; 17(20):1915-1919. PMID: 27596722.
    Citations: 3     Fields:    Translation:Cells
  22. Cromm PM, Spiegel J, Küchler P, Dietrich L, Kriegesmann J, Wendt M, Goody RS, Waldmann H, Grossmann TN. Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase. ACS Chem Biol. 2016 08 19; 11(8):2375-82. PMID: 27336832.
    Citations: 4     Fields:    Translation:HumansCells
  23. Viennet T, Viegas A, Kuepper A, Arens S, Gelev V, Petrov O, Grossmann TN, Heise H, Etzkorn M. Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization. Angew Chem Int Ed Engl. 2016 08 26; 55(36):10746-50. PMID: 27351143.
    Citations: 4     Fields:    Translation:Cells
  24. Cromm PM, Schaubach S, Spiegel J, Fürstner A, Grossmann TN, Waldmann H. Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides. Nat Commun. 2016 Apr 14; 7:11300. PMID: 27075966.
    Citations: 3     Fields:    Translation:Cells
  25. Cromm PM, Spiegel J, Grossmann TN, Waldmann H. Direct Modulation of Small GTPase Activity and Function. Angew Chem Int Ed Engl. 2015 Nov 09; 54(46):13516-37. PMID: 26470842.
    Citations: 14     Fields:    Translation:Humans
  26. Lee CU, Hahne G, Hanske J, Bange T, Bier D, Rademacher C, Hennig S, Grossmann TN. Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angew Chem Int Ed Engl. 2015 Nov 09; 54(46):13796-800. PMID: 26418532.
    Citations: 6     Fields:    Translation:HumansCells
  27. Pelay-Gimeno M, Glas A, Koch O, Grossmann TN. Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes. Angew Chem Int Ed Engl. 2015 Jul 27; 54(31):8896-927. PMID: 26119925.
    Citations: 44     Fields:    Translation:Cells
  28. Cromm PM, Spiegel J, Grossmann TN. Hydrocarbon stapled peptides as modulators of biological function. ACS Chem Biol. 2015 Jun 19; 10(6):1362-75. PMID: 25798993.
    Citations: 24     Fields:    Translation:HumansCells
  29. Spiegel J, Cromm PM, Zimmermann G, Grossmann TN, Waldmann H. Small-molecule modulation of Ras signaling. Nat Chem Biol. 2014 Aug; 10(8):613-22. PMID: 24929527.
    Citations: 37     Fields:    Translation:HumansCells
  30. Milroy LG, Grossmann TN, Hennig S, Brunsveld L, Ottmann C. Modulators of protein-protein interactions. Chem Rev. 2014 May 14; 114(9):4695-748. PMID: 24735440.
    Citations: 43     Fields:    Translation:Cells
  31. Brauckhoff N, Hahne G, Yeh JT, Grossmann TN. Protein-templated peptide ligation. Angew Chem Int Ed Engl. 2014 Apr 22; 53(17):4337-40. PMID: 24644125.
    Citations: 2     Fields:    Translation:HumansCells
  32. Glas A, Bier D, Hahne G, Rademacher C, Ottmann C, Grossmann TN. Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew Chem Int Ed Engl. 2014 Feb 24; 53(9):2489-93. PMID: 24504455.
    Citations: 16     Fields:    Translation:HumansCells
  33. Spiegel J, Cromm PM, Itzen A, Goody RS, Grossmann TN, Waldmann H. Direct targeting of Rab-GTPase-effector interactions. Angew Chem Int Ed Engl. 2014 Feb 24; 53(9):2498-503. PMID: 24481744.
    Citations: 10     Fields:    Translation:HumansCells
  34. Hahne G, Grossmann TN. Direct targeting of ß-catenin: Inhibition of protein-protein interactions for the inactivation of Wnt signaling. Bioorg Med Chem. 2013 Jul 15; 21(14):4020-6. PMID: 23566764.
    Citations: 5     Fields:    Translation:HumansCells
  35. Socher E, Grossmann TN. Chemical biology 2012: from drug targets to biological systems and back. Chembiochem. 2013 Jan 02; 14(1):23-7. PMID: 23184865.
    Citations:    Fields:    Translation:Humans
  36. Grossmann TN, Yeh JT, Bowman BR, Chu Q, Moellering RE, Verdine GL. Inhibition of oncogenic Wnt signaling through direct targeting of ß-catenin. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):17942-7. PMID: 23071338.
    Citations: 35     Fields:    Translation:HumansCells
  37. Lee CU, Grossmann TN. Reversible covalent inhibition of a protein target. Angew Chem Int Ed Engl. 2012 Aug 27; 51(35):8699-700. PMID: 22806944.
    Citations: 8     Fields:    Translation:Cells
  38. Erben A, Grossmann TN, Seitz O. DNA-instructed acyl transfer reactions for the synthesis of bioactive peptides. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):4993-7. PMID: 21664815.
    Citations: 1     Fields:    Translation:HumansCells
  39. Kim YW, Grossmann TN, Verdine GL. Synthesis of all-hydrocarbon stapled a-helical peptides by ring-closing olefin metathesis. Nat Protoc. 2011 Jun; 6(6):761-71. PMID: 21637196.
    Citations: 39     Fields:    Translation:Cells
  40. Erben A, Grossmann TN, Seitz O. DNA-triggered synthesis and bioactivity of proapoptotic peptides. Angew Chem Int Ed Engl. 2011 Mar 14; 50(12):2828-32. PMID: 21387498.
    Citations: 2     Fields:    
  41. Grossmann TN, Seitz O. Nucleic acid templated reactions: consequences of probe reactivity and readout strategy for amplified signaling and sequence selectivity. Chemistry. 2009 Jul 06; 15(27):6723-30. PMID: 19496097.
    Citations: 7     Fields:    Translation:Cells
  42. Ziehe M, Grossmann TN, Seitz O, Linscheid MW. New aspects in fragmentation of peptide nucleic acids: comparison of positive and negative ions by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun Mass Spectrom. 2009 Apr; 23(8):1132-8. PMID: 19280610.
    Citations: 1     Fields:    Translation:Cells
  43. Albright TA, Dosa PI, Grossmann TN, Khrustalev VN, Oloba OA, Padilla R, Paubelle R, Stanger A, Timofeeva TV, Vollhardt KP. Photo-thermal haptotropism in cyclopentadienylcobalt complexes of linear phenylenes: intercyclobutadiene metal migration. Angew Chem Int Ed Engl. 2009; 48(52):9853-7. PMID: 19943301.
    Citations:    Fields:    
  44. Grossmann TN, Strohbach A, Seitz O. Achieving turnover in DNA-templated reactions. Chembiochem. 2008 Sep 22; 9(14):2185-92. PMID: 18752239.
    Citations: 11     Fields:    Translation:Cells
  45. Seitz O, Grossmann TN, Thurley S, Röglin L. Recognizing and controlling biomolecules with "Smart" hybridization-based switches. Nucleic Acids Symp Ser (Oxf). 2008; (52):29-30. PMID: 18776237.
    Citations:    Fields:    Translation:Cells
  46. Grossmann TN, Röglin L, Seitz O. Target-catalyzed transfer reactions for the amplified detection of RNA. Angew Chem Int Ed Engl. 2008; 47(37):7119-22. PMID: 18677727.
    Citations: 8     Fields:    Translation:Cells
  47. Grossmann TN, Sasaki S, Ritzefeld M, Choi SW, Maruyama A, Seitz O. Inducing the replacement of PNA in DNA.PNA duplexes by DNA. Bioorg Med Chem. 2008 Jan 01; 16(1):34-9. PMID: 17513114.
    Citations: 1     Fields:    Translation:Cells
  48. Grossmann TN, Röglin L, Seitz O. Triplex molecular beacons as modular probes for DNA detection. Angew Chem Int Ed Engl. 2007; 46(27):5223-5. PMID: 17535003.
    Citations: 14     Fields:    Translation:Cells
  49. Grossmann TN, Seitz O. DNA-catalyzed transfer of a reporter group. J Am Chem Soc. 2006 Dec 13; 128(49):15596-7. PMID: 17147362.
    Citations: 15     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.