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profilePeggy Sue Lai, M.D.

TitleAssistant Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Pulmonary/Crit Care, Bulfinch 148
55 Fruit St
Boston MA 02114
Phone617/726-1721
Fax617/724-9948
vCardDownload vCard (login for email)
Other Positions
TitleResearch Associate
InstitutionHarvard T.H. Chan School of Public Health
DepartmentEH - Environmental + Occupational Medicine + Epi


Collapse Biography 
Collapse education and training
Harvard School of Public Health, Boston, MAMPH05/2013Quantitative Methods

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
K23ES023700     (LAI, PEGGY SUE)Sep 23, 2013 - May 31, 2018
NIH/NIEHS
Endotoxin, the airway transcriptome, and obstructive lung disease
Role: Principal Investigator

F32ES020082     (LAI, PEGGY SUE)Apr 15, 2012 - May 31, 2013
NIH/NIEHS
Lung disease due to chronic endotoxin exposure in mouse and human models
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gaffin JM, Hauptman M, Petty CR, Sheehan WJ, Lai PS, Wolfson JM, Gold DR, Coull BA, Koutrakis P, Phipatanakul W. Nitrogen dioxide exposure in school classrooms of inner-city children with asthma. J Allergy Clin Immunol. 2017 Oct 05. PMID: 28988796.
    View in: PubMed
  2. Lai PS, Massoud AH, Xia M, Petty CR, Cunningham A, Chatila TA, Phipatanakul W. Gene-environment interaction between an IL4R variant and school endotoxin exposure contributes to asthma symptoms in inner-city children. J Allergy Clin Immunol. 2017 Sep 21. PMID: 28943468.
    View in: PubMed
  3. Lai PS, Allen JG, Hutchinson DS, Ajami NJ, Petrosino JF, Winters T, Hug C, Wartenberg GR, Vallarino J, Christiani DC. Impact of environmental microbiota on human microbiota of workers in academic mouse research facilities: An observational study. PLoS One. 2017; 12(7):e0180969. PMID: 28704437.
    View in: PubMed
  4. Jhun I, Lai PS, Phipatanakul W. Reply. J Allergy Clin Immunol Pract. 2017 Jul - Aug; 5(4):1165-1166. PMID: 28689836.
    View in: PubMed
  5. Phipatanakul W, Koutrakis P, Coull BA, Kang CM, Wolfson JM, Ferguson ST, Petty CR, Samnaliev M, Cunningham A, Sheehan WJ, Gaffin JM, Baxi SN, Lai PS, Permaul P, Liang L, Thorne PS, Adamkiewicz G, Brennan KJ, Baccarelli AA, Gold DR. The School Inner-City Asthma Intervention Study: Design, rationale, methods, and lessons learned. Contemp Clin Trials. 2017 Sep; 60:14-23. PMID: 28619649.
    View in: PubMed
  6. Muyanja D, Allen JG, Vallarino J, Valeri L, Kakuhikire B, Bangsberg DR, Christiani DC, Tsai AC, Lai PS. Kerosene lighting contributes to household air pollution in rural Uganda. Indoor Air. 2017 Sep; 27(5):1022-1029. PMID: 28267233.
    View in: PubMed
  7. White MC, Longstaff L, Lai PS. Effect of Pre-operative Anaemia on Post-operative Complications in Low-Resource Settings. World J Surg. 2017 Mar; 41(3):644-649. PMID: 27837236.
    View in: PubMed
  8. Sheehan WJ, Permaul P, Petty CR, Coull BA, Baxi SN, Gaffin JM, Lai PS, Gold DR, Phipatanakul W. Association Between Allergen Exposure in Inner-City Schools and Asthma Morbidity Among Students. JAMA Pediatr. 2017 Jan 01; 171(1):31-38. PMID: 27893060.
    View in: PubMed
  9. White MC, Horner KC, Lai PS. Retrospective Review of the Anaesthetic Management of Maxillectomies and Mandibulectomies for Benign Tumours in Sub-Saharan Africa. PLoS One. 2016; 11(10):e0165090. PMID: 27788172.
    View in: PubMed
  10. Jhun I, Gaffin JM, Coull BA, Huffaker MF, Petty CR, Sheehan WJ, Baxi SN, Lai PS, Kang CM, Wolfson JM, Gold DR, Koutrakis P, Phipatanakul W. School Environmental Intervention to Reduce Particulate Pollutant Exposures for Children with Asthma. J Allergy Clin Immunol Pract. 2017 Jan - Feb; 5(1):154-159.e3. PMID: 27641483.
    View in: PubMed
  11. Gaffin JM, Petty CR, Hauptman M, Kang CM, Wolfson JM, Abu Awad Y, Di Q, Lai PS, Sheehan WJ, Baxi S, Coull BA, Schwartz JD, Gold DR, Koutrakis P, Phipatanakul W. Modeling indoor particulate exposures in inner-city school classrooms. J Expo Sci Environ Epidemiol. 2017 Sep; 27(5):451-457. PMID: 27599884.
    View in: PubMed
  12. Lai PS, Hang JQ, Zhang FY, Sun J, Zheng BY, Su L, Washko GR, Christiani DC. Imaging Phenotype of Occupational Endotoxin-Related Lung Function Decline. Environ Health Perspect. 2016 Sep; 124(9):1436-42. PMID: 27138294; PMCID: PMC5010398.
  13. Shrime MG, Ferket BS, Scott DJ, Lee J, Barragan-Bradford D, Pollard T, Arabi YM, Al-Dorzi HM, Baron RM, Hunink MG, Celi LA, Lai PS. Time-Limited Trials of Intensive Care for Critically Ill Patients With Cancer: How Long Is Long Enough? JAMA Oncol. 2016 Jan; 2(1):76-83. PMID: 26469222; PMCID: PMC4713248 [Available on 01/01/17].
  14. Shenoy ES, Lai PS, Shepard JA, Kradin RL. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 39-2015. A 22-Year-Old Man with Hypoxemia and Shock. N Engl J Med. 2015 Dec 17; 373(25):2456-66. PMID: 26672848.
    View in: PubMed
  15. Lai PS, Sheehan WJ, Gaffin JM, Petty CR, Coull BA, Gold DR, Phipatanakul W. School Endotoxin Exposure and Asthma Morbidity in Inner-city Children. Chest. 2015 Nov; 148(5):1251-1258. PMID: 26087201; PMCID: PMC4631040 [Available on 11/01/16].
  16. Lai PS, Liang L, Cibas ES, Liu AH, Gold DR, Baccarelli A, Phipatanakul W. Alternate methods of nasal epithelial cell sampling for airway genomic studies. J Allergy Clin Immunol. 2015 Oct; 136(4):1120-3.e4. PMID: 26037550; PMCID: PMC4600430 [Available on 10/01/16].
  17. Lai PS, Hang JQ, Valeri L, Zhang FY, Zheng BY, Mehta AJ, Shi J, Su L, Brown D, Eisen EA, Christiani DC. Endotoxin and gender modify lung function recovery after occupational organic dust exposure: a 30-year study. Occup Environ Med. 2015 Aug; 72(8):546-552. PMID: 25666844; PMCID: PMC4506722.
  18. Lai P, Hang JQ, Zhang FY, Zheng BY, Valeri L, Eisen E, Christiani D. 0031 Lung Function Improvement is Sustained after Work Cessation in Shanghai Cotton and Silk Textile Workers. Occup Environ Med. 2014 Jun; 71 Suppl 1:A3. PMID: 25018313.
    View in: PubMed
  19. Lai PS, Hang JQ, Zhang FY, Lin X, Zheng BY, Dai HL, Su L, Cai T, Christiani DC. Gender differences in the effect of occupational endotoxin exposure on impaired lung function and death: the Shanghai Textile Worker Study. Occup Environ Med. 2014 Feb; 71(2):118-125. PMID: 24297825; PMCID: PMC4033669.
  20. Baxi SN, Muilenberg ML, Rogers CA, Sheehan WJ, Gaffin J, Permaul P, Kopel LS, Lai PS, Lane JP, Bailey A, Petty CR, Fu C, Gold DR, Phipatanakul W. Exposures to molds in school classrooms of children with asthma. Pediatr Allergy Immunol. 2013 Nov; 24(7):697-703. PMID: 24112429; PMCID: PMC3782748.
  21. Lai PS, Mita C, Thompson BT. What is the clinical significance of pulmonary hypertension in acute respiratory distress syndrome? A review. Minerva Anestesiol. 2014 May; 80(5):574-85. PMID: 24193181; PMCID: PMC4036117.
  22. Lai PS, Thompson BT. Why activated protein C was not successful in severe sepsis and septic shock: are we still tilting at windmills? Curr Infect Dis Rep. 2013 Oct; 15(5):407-12. PMID: 23925482; PMCID: PMC3829688.
  23. Lai PS, Hofmann O, Baron RM, Cernadas M, Meng QR, Bresler HS, Brass DM, Yang IV, Schwartz DA, Christiani DC, Hide W. Integrating murine gene expression studies to understand obstructive lung disease due to chronic inhaled endotoxin. PLoS One. 2013; 8(5):e62910. PMID: 23675439; PMCID: PMC3652821.
  24. Mayaud L, Lai PS, Clifford GD, Tarassenko L, Celi LA, Annane D. Dynamic data during hypotensive episode improves mortality predictions among patients with sepsis and hypotension. Crit Care Med. 2013 Apr; 41(4):954-62. PMID: 23385106; PMCID: PMC3609896.
  25. Lai PS, Christiani DC. Long-term respiratory health effects in textile workers. Curr Opin Pulm Med. 2013 Mar; 19(2):152-7. PMID: 23361196; PMCID: PMC3725301.
  26. Lai PS, Matteau A, Iddriss A, Hawes JC, Ranieri V, Thompson BT. An updated meta-analysis to understand the variable efficacy of drotrecogin alfa (activated) in severe sepsis and septic shock. Minerva Anestesiol. 2013 Jan; 79(1):33-43. PMID: 23174922; PMCID: PMC3725305.
  27. Lai PS, Fresco JM, Pinilla MA, Macias AA, Brown RD, Englert JA, Hofmann O, Lederer JA, Hide W, Christiani DC, Cernadas M, Baron RM. Chronic endotoxin exposure produces airflow obstruction and lung dendritic cell expansion. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):209-17. PMID: 22517795; PMCID: PMC3423463.
  28. Lai PS, Cohen DW, DeCamp MM, Fazio S, Roberts DH. A 40-year-old woman with an asymptomatic cystic lesion in her right lung. Chest. 2009 Aug; 136(2):622-627. PMID: 19666763.
    View in: PubMed
  29. Ruan B, Lai PS, Yeh CW, Wilson WK, Pang J, Xu R, Matsuda SP, Schroepfer GJ. Alternative pathways of sterol synthesis in yeast. Use of C(27) sterol tracers to study aberrant double-bond migrations and evaluate their relative importance. Steroids. 2002 Dec; 67(13-14):1109-19. PMID: 12441197.
    View in: PubMed
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