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Laura Cornelissen, Ph.D.

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Biography
University of Bristol, United KingdomMSci2006Pharmacology
University College London, United KingdomPhD2011Neuroscience

Overview
Laura Cornelissen is a Research Associate at Boston Children's Hospital and an affiliated faculty member at Harvard Medical School, Boston. Laura's research interests focus on the development of neural circuits underlying general anesthesia and pain processing in children.

Laura has over 10 years experience in studying pediatric neurophysiology. She has expertise in non-invasive brain monitoring, electromyography, quantitative sensory testing, clinical trial design, and advanced signal processing analysis.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Desowska A, Berde CB, Cornelissen L. Emerging functional connectivity patterns during sevoflurane anaesthesia in the developing human brain. Br J Anaesth. 2022 Jul 05. PMID: 35803755.
    Citations:    Fields:    
  2. Madan E, Carrié S, Donado C, Lobo K, Souris M, Laine R, Beers E, Cornelissen L, Darras BT, Koka A, Riley B, Dinakar P, Stone S, Snyder B, Graham RJ, Padua H, Sethna N, Berde C. Nusinersen for Patients With Spinal Muscular Atrophy: 1415 Doses via an Interdisciplinary Institutional Approach. Pediatr Neurol. 2022 07; 132:33-40. PMID: 35636280.
    Citations:    Fields:    Translation:Humans
  3. Cornelissen L, Donado C, Yu TW, Berde CB. Modified Sensory Testing in Non-verbal Patients Receiving Novel Intrathecal Therapies for Neurological Disorders. Front Neurol. 2022; 13:664710. PMID: 35222234; PMCID: PMC8866183.
    Citations:    
  4. Tutelman PR, Chambers CT, Cornelissen L, Fernandez CV, Flanders A, MacLeod J, Sherry SB, Stewart SH, Urquhart R, de Gagne S, Guilcher GMT, Hashmi J, Heathcote LC, Noel M, Schulte FSM, Stinson JN, Stern M. Long-term alterations in somatosensory functioning in survivors of childhood cancer. Pain. 2022 06 01; 163(6):1193-1205. PMID: 34855647; PMCID: PMC9100454.
    Citations:    Fields:    Translation:Humans
  5. Brandt SP, Walsh EC, Cornelissen L, Lee JM, Berde C, Shank ES, Purdon PL. Case Studies Using the Electroencephalogram to Monitor Anesthesia-Induced Brain States in Children. Anesth Analg. 2020 10; 131(4):1043-1056. PMID: 32925322; PMCID: PMC7467151.
    Citations: 1     Fields:    Translation:Humans
  6. Soffer OD, Kim A, Underwood E, Hansen A, Cornelissen L, Berde C. Neurophysiological Assessment of Prolonged Recovery From Neuromuscular Blockade in the Neonatal Intensive Care Unit. Front Pediatr. 2020; 8:580. PMID: 33072662.
    Citations:    
  7. Brandt SP, Walsh EC, Cornelissen L, Lee JM, Berde C, Shank ES, Purdon PL. Case Studies Using the Electroencephalogram to Monitor Anesthesia-Induced Brain States in Children. Anesth Analg. 2020 Aug 17. PMID: 32833713.
    Citations:    
  8. Pappas I, Cornelissen L, Menon DK, Berde CB, Stamatakis EA. d-Oscillation Correlates of Anesthesia-induced Unconsciousness in Large-scale Brain Networks of Human Infants. Anesthesiology. 2019 12; 131(6):1239-1253. PMID: 31567366.
    Citations:    Fields:    Translation:Humans
  9. Kim J, Hu C, Moufawad El Achkar C, Black LE, Douville J, Larson A, Pendergast MK, Goldkind SF, Lee EA, Kuniholm A, Soucy A, Vaze J, Belur NR, Fredriksen K, Stojkovska I, Tsytsykova A, Armant M, DiDonato RL, Choi J, Cornelissen L, Pereira LM, Augustine EF, Genetti CA, Dies K, Barton B, Williams L, Goodlett BD, Riley BL, Pasternak A, Berry ER, Pflock KA, Chu S, Reed C, Tyndall K, Agrawal PB, Beggs AH, Grant PE, Urion DK, Snyder RO, Waisbren SE, Poduri A, Park PJ, Patterson A, Biffi A, Mazzulli JR, Bodamer O, Berde CB, Yu TW. Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease. N Engl J Med. 2019 10 24; 381(17):1644-1652. PMID: 31597037; PMCID: PMC6961983.
    Citations: 157     Fields:    Translation:Humans
  10. Agrawal U, Berde CB, Cornelissen L. Electroencephalographic features of discontinuous activity in anesthetized infants and children. PLoS One. 2019; 14(10):e0223324. PMID: 31581269; PMCID: PMC6776336.
    Citations: 3     Fields:    Translation:Humans
  11. Soffer OD, Cornelissen L, Cummings C, Berde C. Morphine compared to placebo for procedural pain in preterm infants: safety, efficacy and equipoise. J Perinatol. 2019 10; 39(10):1428-1431. PMID: 31455824.
    Citations: 1     Fields:    Translation:Humans
  12. Chini M, Gretenkord S, Kostka JK, Pöpplau JA, Cornelissen L, Berde CB, Hanganu-Opatz IL, Bitzenhofer SH. Neural Correlates of Anesthesia in Newborn Mice and Humans. Front Neural Circuits. 2019; 13:38. PMID: 31191258; PMCID: PMC6538977.
    Citations: 8     Fields:    Translation:HumansAnimals
  13. Gonzalez-Cano R, Boivin B, Bullock D, Cornelissen L, Andrews N, Costigan M. Up-Down Reader: An Open Source Program for Efficiently Processing 50% von Frey Thresholds. Front Pharmacol. 2018; 9:433. PMID: 29765323; PMCID: PMC5938897.
    Citations: 10     
  14. Cornelissen L, Kim SE, Lee JM, Brown EN, Purdon PL, Berde CB. Electroencephalographic markers of brain development during sevoflurane anaesthesia in children up to 3 years old. Br J Anaesth. 2018 Jun; 120(6):1274-1286. PMID: 29793594.
    Citations: 13     Fields:    Translation:Humans
  15. Cornelissen L, Donado C, Lee JM, Liang NE, Mills I, Tou A, Bilge A, Berde CB. Clinical signs and electroencephalographic patterns of emergence from sevoflurane anaesthesia in children: An observational study. Eur J Anaesthesiol. 2018 01; 35(1):49-59. PMID: 29120939.
    Citations: 4     Fields:    Translation:Humans
  16. Cornelissen L, Bergin AM, Lobo K, Donado C, Soul JS, Berde CB. Electroencephalographic discontinuity during sevoflurane anesthesia in infants and children. Paediatr Anaesth. 2017 Mar; 27(3):251-262. PMID: 28177176.
    Citations: 8     Fields:    Translation:Humans
  17. Cornelissen L, Berde C. Biomedical science: Protection for anaesthetized mice. Nature. 2016 08 04; 536(7614):36-7. PMID: 27488795.
    Citations:    Fields:    Translation:Animals
  18. Poorun R, Hartley C, Goksan S, Worley A, Boyd S, Cornelissen L, Berde C, Rogers R, Ali T, Slater R. Electroencephalography during general anaesthesia differs between term-born and premature-born children. Clin Neurophysiol. 2016 Feb; 127(2):1216-1222. PMID: 26589678.
    Citations: 6     Fields:    Translation:Humans
  19. Lobo K, Donado C, Cornelissen L, Kim J, Ortiz R, Peake RW, Kellogg M, Alexander ME, Zurakowski D, Kurgansky KE, Peyton J, Bilge A, Boretsky K, McCann ME, Berde CB, Cravero J. A Phase 1, Dose-escalation, Double-blind, Block-randomized, Controlled Trial of Safety and Efficacy of Neosaxitoxin Alone and in Combination with 0.2% Bupivacaine, with and without Epinephrine, for Cutaneous Anesthesia. Anesthesiology. 2015 Oct; 123(4):873-85. PMID: 26275090.
    Citations: 18     Fields:    Translation:HumansCTClinical Trials
  20. Cornelissen L, Kim SE, Purdon PL, Brown EN, Berde CB. Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants. Elife. 2015 Jun 23; 4:e06513. PMID: 26102526.
    Citations: 32     Fields:    Translation:Humans
  21. Garibyan L, Cornelissen L, Sipprell W, Pruessner J, Elmariah S, Luo T, Lerner EA, Jung Y, Evans C, Zurakowski D, Berde CB, Rox Anderson R. Transient Alterations of Cutaneous Sensory Nerve Function by Noninvasive Cryolipolysis. J Invest Dermatol. 2015 Nov; 135(11):2623-2631. PMID: 26099028; PMCID: PMC4640987.
    Citations: 5     Fields:    Translation:HumansCells
  22. Cornelissen L, Donado C, Kim J, Chiel L, Zurakowski D, Logan DE, Meier P, Sethna NF, Blankenburg M, Zernikow B, Sundel RP, Berde CB. Pain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study. Pediatr Rheumatol Online J. 2014; 12:39. PMID: 25249820.
    Citations: 20     Fields:    Translation:Humans
  23. Oreshkova N, Cornelissen LA, de Haan CA, Moormann RJ, Kortekaas J. Evaluation of nonspreading Rift Valley fever virus as a vaccine vector using influenza virus hemagglutinin as a model antigen. Vaccine. 2014 Sep 15; 32(41):5323-9. PMID: 25066737.
    Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
  24. Cornelissen L, Fabrizi L, Patten D, Worley A, Meek J, Boyd S, Slater R, Fitzgerald M. Postnatal temporal, spatial and modality tuning of nociceptive cutaneous flexion reflexes in human infants. PLoS One. 2013; 8(10):e76470. PMID: 24124564; PMCID: PMC3790695.
    Citations: 27     Fields:    Translation:HumansCells
  25. Fabrizi L, Worley A, Patten D, Holdridge S, Cornelissen L, Meek J, Boyd S, Slater R. Electrophysiological measurements and analysis of nociception in human infants. J Vis Exp. 2011 Dec 20; (58). PMID: 22214879.
    Citations: 7     Fields:    Translation:Humans
  26. Slater R, Cornelissen L, Fabrizi L, Patten D, Yoxen J, Worley A, Boyd S, Meek J, Fitzgerald M. Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomised controlled trial. Lancet. 2010 Oct 09; 376(9748):1225-32. PMID: 20817247; PMCID: PMC2958259.
    Citations: 77     Fields:    Translation:Humans
  27. Cornelissen LL, Misajet B, Brooks DP, Hicks A. Influence of genetic background and gender on bladder function in the mouse. Auton Neurosci. 2008 Jun; 140(1-2):53-8. PMID: 18495551.
    Citations: 16     Fields:    Translation:Animals
  28. Cornelissen LL, Brooks DP, Wibberley A. Female, but not male, serotonin reuptake transporter (5-HTT) knockout mice exhibit bladder instability. Auton Neurosci. 2005 Oct 30; 122(1-2):107-10. PMID: 16023897.
    Citations: 11     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.