Harvard Catalyst Profiles

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Maria Serena Longhi, Ph.D., M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK124408 (LONGHI, MARIA SERENA) Sep 15, 2020 - Aug 31, 2023
    NIH/NIDDK
    Alterations of aryl hydrocarbon receptor signaling in autoimmune hepatitis
    Role: Principal Investigator
  2. AASLD Pilot Research Award (LONGHI, MARIA SERENA) Jul 1, 2018 - Sep 30, 2019
    AASLD Foundation
    Regulation of aryl hydrocarbon receptor signaling in autoimmune hepatitis
    Role: Principal Investigator
  3. R01DK108894 (LONGHI, MARIA SERENA) Feb 1, 2017 - Jan 31, 2022
    NIH
    Immunomodulatory effects of bilirubin are mediated through aryl hydrocarbon receptor, O2 and purinergic pathways
    Role: Principal Investigator
  4. R130579 (LONGHI, MARIA SERENA) Nov 1, 2013 - Oct 31, 2014
    King’s Health Partners - R&D Challenge Fund, UK
    Role of CD39 in modulating Th17 immune responses in autoimmune sclerosing cholangitis
    Role: Principal Investigator
  5. G0902288 (LONGHI, MARIA SERENA) Oct 1, 2010 - Sep 30, 2014
    Medical Research Council, UK
    Autoantigen-specific regulatory T-cells: a new tool for tolerance induction in autoimmune hepatitis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lee GR, Gallo D, Alves de Souza RW, Tiwari-Heckler S, Csizmadia E, Harbison JD, Shankar S, Banner-Goodspeed V, Yaffe MB, Longhi MS, Hauser CJ, Otterbein LE. Trauma-induced heme release increases susceptibility to bacterial infection. JCI Insight. 2021 Oct 22; 6(20). PMID: 34520397.
    Citations:    Fields:    
  2. Graham JJ, Mukherjee S, Yuksel M, Sanabria Mateos R, Si T, Huang Z, Huang X, Arbuq H, Patel V, McPhail MJ, Zen Y, Heaton ND, Longhi MS, Heneghan MA, Liberal R, Vergani D, Mieli-Vergani G, Ma Y, Hayee B. Aberrant hepatic trafficking of gut-derived T-cells is not specific to primary sclerosing cholangitis. Hepatology. 2021 Oct 11. PMID: 34633679.
    Citations:    Fields:    
  3. Wang N, Vuerich M, Kalbasi A, Graham JJ, Csizmadia E, Manickas-Hill ZJ, Woolley A, David C, Miller EM, Gorman K, Hecht JL, Shaefi S, Robson SC, Longhi MS. Limited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19. iScience. 2021 Oct 22; 24(10):103205. PMID: 34608452.
    Citations:    
  4. Vuerich M, Wang N, Kalbasi A, Graham JJ, Longhi MS. Dysfunctional Immune Regulation in Autoimmune Hepatitis: From Pathogenesis to Novel Therapies. Front Immunol. 2021; 12:746436. PMID: 34650567.
    Citations:    Fields:    
  5. Ma Y, Su H, Yuksel M, Longhi MS, McPhail MJ, Wang P, Bansal S, Wong GW, Graham J, Yang L, J Thompson R, Doherty DG, Hadzic N, Zen Y, Quaglia A, Heneghan MA, Samyn M, Vergani D, Mieli-Vergani G. Human Leukocyte Antigen Profile Predicts Severity of Autoimmune Liver Disease in Children of European Ancestry. Hepatology. 2021 Oct; 74(4):2032-2046. PMID: 33971035.
    Citations: 2     Fields:    
  6. Graham JJ, Longhi MS, Heneghan MA. T helper cell immunity in pregnancy and influence on autoimmune disease progression. J Autoimmun. 2021 07; 121:102651. PMID: 34020252.
    Citations:    Fields:    
  7. Longhi MS, Mieli-Vergani G, Vergani D. Regulatory T cells in autoimmune hepatitis: an updated overview. J Autoimmun. 2021 05; 119:102619. PMID: 33652348.
    Citations: 4     Fields:    
  8. Savio LEB, Robson SC, Longhi MS. Ectonucleotidase Modulation of Lymphocyte Function in Gut and Liver. Front Cell Dev Biol. 2020; 8:621760. PMID: 33553158.
    Citations:    
  9. Longhi MS, Feng L, Robson SC. Targeting ectonucleotidases to treat inflammation and halt cancer development in the gut. Biochem Pharmacol. 2021 05; 187:114417. PMID: 33460629.
    Citations:    Fields:    Translation:HumansAnimals
  10. Harshe RP, Xie A, Vuerich M, Frank LA, Gromova B, Zhang H, Robles RJ, Mukherjee S, Csizmadia E, Kokkotou E, Cheifetz AS, Moss AC, Kota SK, Robson SC, Longhi MS. Endogenous antisense RNA curbs CD39 expression in Crohn's disease. Nat Commun. 2020 11 18; 11(1):5894. PMID: 33208731.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  11. Longhi MS, Kokkotou E. Lnc-ing RNA Expression with Disease Pathogenesis: MALAT1 and ANRIL in Ulcerative Colitis. Dig Dis Sci. 2020 11; 65(11):3061-3063. PMID: 32232616.
    Citations: 1     Fields:    Translation:Humans
  12. Vuerich M, Mukherjee S, Robson SC, Longhi MS. Control of Gut Inflammation by Modulation of Purinergic Signaling. Front Immunol. 2020; 11:1882. PMID: 33072065.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Vuerich M, Harshe R, Frank LA, Mukherjee S, Gromova B, Csizmadia E, Nasser IAM, Ma Y, Bonder A, Patwardhan V, Robson SC, Longhi MS. Altered aryl-hydrocarbon-receptor signalling affects regulatory and effector cell immunity in autoimmune hepatitis. J Hepatol. 2021 01; 74(1):48-57. PMID: 32663496.
    Citations: 10     Fields:    
  14. Robles RJ, Mukherjee S, Vuerich M, Xie A, Harshe R, Cowan PJ, Csizmadia E, Wu Y, Moss AC, Chen R, Robson SC, Longhi MS. Modulation of CD39 and Exogenous APT102 Correct Immune Dysfunction in Experimental Colitis and Crohn's Disease. J Crohns Colitis. 2020 Jul 09; 14(6):818-830. PMID: 31693091.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  15. Ferrari D, Vuerich M, Casciano F, Longhi MS, Melloni E, Secchiero P, Zech A, Robson SC, Müller T, Idzko M. Eosinophils and Purinergic Signaling in Health and Disease. Front Immunol. 2020; 11:1339. PMID: 32733449.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  16. Bai A, Moss A, Rothweiler S, Longhi MS, Wu Y, Junger WG, Robson SC. Author Correction: NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine. Nat Commun. 2020 06 10; 11(1):3036. PMID: 32522986.
    Citations:    Fields:    
  17. Gubatan J, Mehigan GA, Villegas F, Mitsuhashi S, Longhi MS, Malvar G, Csizmadia E, Robson S, Moss AC. Cathelicidin Mediates a Protective Role of Vitamin D in Ulcerative Colitis and Human Colonic Epithelial Cells. Inflamm Bowel Dis. 2020 05 12; 26(6):885-897. PMID: 31955203.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  18. Savio LEB, de Andrade Mello P, Santos SACS, de Sousa JC, Oliveira SDS, Minshall RD, Kurtenbach E, Wu Y, Longhi MS, Robson SC, Coutinho-Silva R. P2X7 receptor activation increases expression of caveolin-1 and formation of macrophage lipid rafts, thereby boosting CD39 activity. J Cell Sci. 2020 03 06; 133(5). PMID: 32005701.
    Citations: 3     Fields:    Translation:Cells
  19. Savio LEB, de Andrade Mello P, Santos SACS, de Sousa JC, Oliveira SDS, Minshall RD, Kurtenbach E, Wu Y, Longhi MS, Robson SC, Coutinho-Silva R. P2X7 receptor activation increases caveolin-1 expression and macrophage lipid raft formation boosting CD39 activity. J Cell Sci. 2020 Jan 01. PMID: 34005161.
    Citations:    Fields:    
  20. Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Latremoliere A, Wirnsberger G, Lametschwandtner G, Busslinger M, Zicha S, Latini A, Robson SC, Waisman A, Andrews N, Costigan M, Channon KM, Weiss G, Kozlov AV, Tebbe M, Johnsson K, Woolf CJ, Penninger JM. Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2019 Aug; 572(7769):E18. PMID: 31363232.
    Citations:    Fields:    
  21. Rothweiler S, Feldbrügge L, Jiang ZG, Csizmadia E, Longhi MS, Vaid K, Enjyoji K, Popov YV, Robson SC. Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis. Purinergic Signal. 2019 09; 15(3):375-385. PMID: 31243614.
    Citations: 8     Fields:    Translation:AnimalsCells
  22. Vuerich M, Robson SC, Longhi MS. Ectonucleotidases in Intestinal and Hepatic Inflammation. Front Immunol. 2019; 10:507. PMID: 30941139.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  23. Vuerich M, Harshe RP, Robson SC, Longhi MS. Dysregulation of Adenosinergic Signaling in Systemic and Organ-Specific Autoimmunity. Int J Mol Sci. 2019 Jan 27; 20(3). PMID: 30691212.
    Citations: 5     Fields:    Translation:HumansCells
  24. Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Latremoliere A, Wirnsberger G, Lametschwandtner G, Busslinger M, Zicha S, Latini A, Robson SC, Waisman A, Andrews N, Costigan M, Channon KM, Weiss G, Kozlov AV, Tebbe M, Johnsson K, Woolf CJ, Penninger JM. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2018 11; 563(7732):564-568. PMID: 30405245.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  25. Xie A, Robles RJ, Mukherjee S, Zhang H, Feldbrügge L, Csizmadia E, Wu Y, Enjyoji K, Moss AC, Otterbein LE, Quintana FJ, Robson SC, Longhi MS. HIF-1a-induced xenobiotic transporters promote Th17 responses in Crohn's disease. J Autoimmun. 2018 11; 94:122-133. PMID: 30098863.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  26. Gubatan J, Mitsuhashi S, Longhi MS, Zenlea T, Rosenberg L, Robson S, Moss AC. Higher serum vitamin D levels are associated with protective serum cytokine profiles in patients with ulcerative colitis. Cytokine. 2018 03; 103:38-45. PMID: 29324259.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  27. Liberal R, Grant CR, Yuksel M, Graham J, Kalbasi A, Ma Y, Heneghan MA, Mieli-Vergani G, Vergani D, Longhi MS. Regulatory T-cell conditioning endows activated effector T cells with suppressor function in autoimmune hepatitis/autoimmune sclerosing cholangitis. Hepatology. 2017 11; 66(5):1570-1584. PMID: 28597951.
    Citations: 12     Fields:    Translation:HumansCells
  28. Peng ZW, Rothweiler S, Wei G, Ikenaga N, Liu SB, Sverdlov DY, Vaid KA, Longhi MS, Kuang M, Robson SC, Popov YV. The ectonucleotidase ENTPD1/CD39 limits biliary injury and fibrosis in mouse models of sclerosing cholangitis. Hepatol Commun. 2017 11; 1(9):957-972. PMID: 29404503.
    Citations: 13     
  29. Feldbrügge L, Moss AC, Yee EU, Csizmadia E, Mitsuhashi S, Longhi MS, Sandhu B, Stephan H, Wu Y, Cheifetz AS, Müller CE, Sévigny J, Robson SC, Jiang ZG. Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease. J Crohns Colitis. 2017 Sep 01; 11(9):1113-1123. PMID: 28472257.
    Citations: 8     Fields:    Translation:HumansAnimals
  30. Savio LEB, de Andrade Mello P, Figliuolo VR, de Avelar Almeida TF, Santana PT, Oliveira SDS, Silva CLM, Feldbrügge L, Csizmadia E, Minshall RD, Longhi MS, Wu Y, Robson SC, Coutinho-Silva R. CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury. J Hepatol. 2017 10; 67(4):716-726. PMID: 28554875.
    Citations: 39     Fields:    Translation:AnimalsCells
  31. Longhi MS, Moss A, Jiang ZG, Robson SC. Purinergic signaling during intestinal inflammation. J Mol Med (Berl). 2017 Sep; 95(9):915-925. PMID: 28547076.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  32. Longhi MS, Vuerich M, Kalbasi A, Kenison JE, Yeste A, Csizmadia E, Vaughn B, Feldbrugge L, Mitsuhashi S, Wegiel B, Otterbein L, Moss A, Quintana FJ, Robson SC. Bilirubin suppresses Th17 immunity in colitis by upregulating CD39. JCI Insight. 2017 May 04; 2(9). PMID: 28469075.
    Citations: 25     Fields:    
  33. Seth P, Csizmadia E, Hedblom A, Vuerich M, Xie H, Li M, Longhi MS, Wegiel B. Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity. Cancer Res. 2017 07 01; 77(13):3632-3643. PMID: 28446465.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  34. Zhang H, Chan LL, Rice W, Kassam N, Longhi MS, Zhao H, Robson SC, Gao W, Wu Y. Novel high-throughput cell-based hybridoma screening methodology using the Celigo Image Cytometer. J Immunol Methods. 2017 08; 447:23-30. PMID: 28414024.
    Citations: 5     Fields:    Translation:AnimalsCells
  35. Grant CR, Holder BS, Liberal R, Heneghan MA, Ma Y, Mieli-Vergani G, Vergani D, Longhi MS. Immunosuppressive drugs affect interferon (IFN)-? and programmed cell death 1 (PD-1) kinetics in patients with newly diagnosed autoimmune hepatitis. Clin Exp Immunol. 2017 07; 189(1):71-82. PMID: 28257599.
    Citations: 7     Fields:    Translation:HumansCells
  36. Allard B, Longhi MS, Robson SC, Stagg J. The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets. Immunol Rev. 2017 03; 276(1):121-144. PMID: 28258700.
    Citations: 235     Fields:    Translation:HumansAnimals
  37. Pasikowska M, Walsby E, Apollonio B, Cuthill K, Phillips E, Coulter E, Longhi MS, Ma Y, Yallop D, Barber LD, Patten P, Fegan C, Ramsay AG, Pepper C, Devereux S, Buggins AG. Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration. Blood. 2016 07 28; 128(4):563-73. PMID: 27252234.
    Citations: 12     Fields:    Translation:HumansCells
  38. Liberal R, Grant CR, Ma Y, Csizmadia E, Jiang ZG, Heneghan MA, Yee EU, Mieli-Vergani G, Vergani D, Robson SC, Longhi MS. CD39 mediated regulation of Th17-cell effector function is impaired in juvenile autoimmune liver disease. J Autoimmun. 2016 08; 72:102-12. PMID: 27210814.
    Citations: 14     Fields:    Translation:HumansCells
  39. Bai A, Moss A, Rothweiler S, Serena Longhi M, Wu Y, Junger WG, Robson SC. NADH oxidase-dependent CD39 expression by CD8(+) T cells modulates interferon gamma responses via generation of adenosine. Nat Commun. 2015 Nov 09; 6:8819. PMID: 26549640.
    Citations: 31     Fields:    Translation:HumansCells
  40. Liberal R, Grant CR, Holder BS, Cardone J, Martinez-Llordella M, Ma Y, Heneghan MA, Mieli-Vergani G, Vergani D, Longhi MS. In autoimmune hepatitis type 1 or the autoimmune hepatitis-sclerosing cholangitis variant defective regulatory T-cell responsiveness to IL-2 results in low IL-10 production and impaired suppression. Hepatology. 2015 Sep; 62(3):863-75. PMID: 25953611.
    Citations: 26     Fields:    Translation:HumansCells
  41. Liberal R, Grant CR, Longhi MS, Mieli-Vergani G, Vergani D. Regulatory T cells: Mechanisms of suppression and impairment in autoimmune liver disease. IUBMB Life. 2015 Feb; 67(2):88-97. PMID: 25850692.
    Citations: 20     Fields:    Translation:HumansCells
  42. Grant CR, Liberal R, Ma Y, Robson SC, Mieli-Vergani G, Vergani D, Longhi MS. Reply: To PMID 23787765. Hepatology. 2015 Feb; 61(2):737-8. PMID: 25042541.
    Citations:    Fields:    Translation:HumansCells
  43. Jitraruch S, Dhawan A, Hughes RD, Filippi C, Soong D, Philippeos C, Lehec SC, Heaton ND, Longhi MS, Mitry RR. Alginate microencapsulated hepatocytes optimised for transplantation in acute liver failure. PLoS One. 2014; 9(12):e113609. PMID: 25438038.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  44. Grant CR, Liberal R, Mieli-Vergani G, Vergani D, Longhi MS. Regulatory T-cells in autoimmune diseases: challenges, controversies and--yet--unanswered questions. Autoimmun Rev. 2015 Feb; 14(2):105-16. PMID: 25449680.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  45. Bai A, Moss A, Kokkotou E, Usheva A, Sun X, Cheifetz A, Zheng Y, Longhi MS, Gao W, Wu Y, Robson SC. CD39 and CD161 modulate Th17 responses in Crohn's disease. J Immunol. 2014 Oct 01; 193(7):3366-77. PMID: 25172498.
    Citations: 38     Fields:    Translation:HumansCellsCTClinical Trials
  46. Vaughn BP, Robson SC, Longhi MS. Purinergic signaling in liver disease. Dig Dis. 2014; 32(5):516-24. PMID: 25034284.
    Citations: 14     Fields:    Translation:HumansCells
  47. Ham M, Longhi MS, Lahiff C, Cheifetz A, Robson S, Moss AC. Vitamin D levels in adults with Crohn's disease are responsive to disease activity and treatment. Inflamm Bowel Dis. 2014 May; 20(5):856-60. PMID: 24681654.
    Citations: 20     Fields:    Translation:HumansCells
  48. Wang P, Su H, Underhill J, Blackmore LJ, Longhi MS, Grammatikopoulos T, Okokon EV, Davies ET, Vergani D, Mieli-Vergani G, Ma Y. Autoantibody and human leukocyte antigen profiles in children with autoimmune liver disease and their first-degree relatives. J Pediatr Gastroenterol Nutr. 2014 Apr; 58(4):457-62. PMID: 24231645.
    Citations: 5     Fields:    Translation:Humans
  49. Holder BS, Grant CR, Liberal R, Ma Y, Heneghan MA, Mieli-Vergani G, Vergani D, Longhi MS. Retinoic acid stabilizes antigen-specific regulatory T-cell function in autoimmune hepatitis type 2. J Autoimmun. 2014 Sep; 53:26-32. PMID: 24566085.
    Citations: 11     Fields:    Translation:HumansCellsCTClinical Trials
  50. Longhi MS, Moss A, Bai A, Wu Y, Huang H, Cheifetz A, Quintana FJ, Robson SC. Characterization of human CD39+ Th17 cells with suppressor activity and modulation in inflammatory bowel disease. PLoS One. 2014; 9(2):e87956. PMID: 24505337.
    Citations: 32     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  51. Grant CR, Liberal R, Holder BS, Cardone J, Ma Y, Robson SC, Mieli-Vergani G, Vergani D, Longhi MS. Dysfunctional CD39(POS) regulatory T cells and aberrant control of T-helper type 17 cells in autoimmune hepatitis. Hepatology. 2014 Mar; 59(3):1007-15. PMID: 23787765.
    Citations: 64     Fields:    Translation:HumansCells
  52. Liberal R, Grant CR, Longhi MS, Mieli-Vergani G, Vergani D. Diagnostic criteria of autoimmune hepatitis. Autoimmun Rev. 2014 Apr-May; 13(4-5):435-40. PMID: 24418295.
    Citations: 28     Fields:    Translation:Humans
  53. Longhi MS, Mieli-Vergani G, Vergani D. Autoimmune hepatitis. Curr Pediatr Rev. 2014; 10(4):268-74. PMID: 25403636.
    Citations: 6     Fields:    Translation:HumansCells
  54. Kapila N, Higa JT, Longhi MS, Robson SC. Autoimmune Hepatitis: Clinical Review with Insights into the Purinergic Mechanism of Disease. J Clin Transl Hepatol. 2013 Dec; 1(2):79-86. PMID: 26356124.
    Citations: 3     
  55. Muratori L, Longhi MS. The interplay between regulatory and effector T cells in autoimmune hepatitis: Implications for innovative treatment strategies. J Autoimmun. 2013 Oct; 46:74-80. PMID: 23871639.
    Citations: 18     Fields:    Translation:HumansCells
  56. Heneghan MA, Yeoman AD, Verma S, Smith AD, Longhi MS. Autoimmune hepatitis. Lancet. 2013 Oct 26; 382(9902):1433-44. PMID: 23768844.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  57. Longhi MS, Robson SC, Bernstein SH, Serra S, Deaglio S. Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states. J Mol Med (Berl). 2013 Feb; 91(2):165-72. PMID: 23292173.
    Citations: 33     Fields:    Translation:HumansAnimals
  58. Longhi MS, Ma Y, Grant CR, Samyn M, Gordon P, Mieli-Vergani G, Vergani D. T-regs in autoimmune hepatitis-systemic lupus erythematosus/mixed connective tissue disease overlap syndrome are functionally defective and display a Th1 cytokine profile. J Autoimmun. 2013 Mar; 41:146-51. PMID: 23287048.
    Citations: 21     Fields:    Translation:HumansCells
  59. Doherty GA, Bai A, Hanidziar D, Longhi MS, Lawlor GO, Putheti P, Csizmadia E, Nowak M, Cheifetz AS, Moss AC, Robson SC. CD73 is a phenotypic marker of effector memory Th17 cells in inflammatory bowel disease. Eur J Immunol. 2012 Nov; 42(11):3062-72. PMID: 22965858.
    Citations: 33     Fields:    Translation:HumansCells
  60. Liberal R, Grant CR, Holder BS, Ma Y, Mieli-Vergani G, Vergani D, Longhi MS. The impaired immune regulation of autoimmune hepatitis is linked to a defective galectin-9/tim-3 pathway. Hepatology. 2012 Aug; 56(2):677-86. PMID: 22371007.
    Citations: 41     Fields:    Translation:HumansCells
  61. Longhi MS, Ma Y, Mieli-Vergani G, Vergani D. Regulatory T cells in autoimmune hepatitis. J Hepatol. 2012 Oct; 57(4):932-3; author reply 933-4. PMID: 22748772.
    Citations: 7     Fields:    Translation:HumansCells
  62. Longhi MS, Liberal R, Holder B, Robson SC, Ma Y, Mieli-Vergani G, Vergani D. Inhibition of interleukin-17 promotes differentiation of CD25? cells into stable T regulatory cells in patients with autoimmune hepatitis. Gastroenterology. 2012 Jun; 142(7):1526-35.e6. PMID: 22387392.
    Citations: 38     Fields:    Translation:HumansCells
  63. Su H, Longhi MS, Wang P, Vergani D, Ma Y. Human CD4+CD25(high)CD127 (low/neg) regulatory T cells. Methods Mol Biol. 2012; 806:287-99. PMID: 22057460.
    Citations: 16     Fields:    Translation:HumansCells
  64. Liberal R, Longhi MS, Mieli-Vergani G, Vergani D. Pathogenesis of autoimmune hepatitis. Best Pract Res Clin Gastroenterol. 2011 Dec; 25(6):653-64. PMID: 22117632.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  65. Liberal R, Longhi MS, Grant CR, Mieli-Vergani G, Vergani D. Autoimmune hepatitis after liver transplantation. Clin Gastroenterol Hepatol. 2012 Apr; 10(4):346-53. PMID: 22056300.
    Citations: 14     Fields:    Translation:Humans
  66. Longhi MS, Hussain MJ, Kwok WW, Mieli-Vergani G, Ma Y, Vergani D. Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis. Hepatology. 2011 Feb; 53(2):536-47. PMID: 21274874.
    Citations: 28     Fields:    Translation:HumansCells
  67. Carey I, D'Antiga L, Bansal S, Longhi MS, Ma Y, Mesa IR, Mieli-Vergani G, Vergani D. Immune and viral profile from tolerance to hepatitis B surface antigen clearance: a longitudinal study of vertically hepatitis B virus-infected children on combined therapy. J Virol. 2011 Mar; 85(5):2416-28. PMID: 21147914.
    Citations: 18     Fields:    Translation:HumansCells
  68. Ferri S, Longhi MS, De Molo C, Lalanne C, Muratori P, Granito A, Hussain MJ, Ma Y, Lenzi M, Mieli-Vergani G, Bianchi FB, Vergani D, Muratori L. A multifaceted imbalance of T cells with regulatory function characterizes type 1 autoimmune hepatitis. Hepatology. 2010 Sep; 52(3):999-1007. PMID: 20683931.
    Citations: 66     Fields:    Translation:HumansCells
  69. Longhi MS, Ma Y, Mieli-Vergani G, Vergani D. Adaptive immunity in autoimmune hepatitis. Dig Dis. 2010; 28(1):63-9. PMID: 20460892.
    Citations: 6     Fields:    Translation:HumansCells
  70. Yeoman AD, Longhi MS, Heneghan MA. Review article: the modern management of autoimmune hepatitis. Aliment Pharmacol Ther. 2010 Apr; 31(8):771-87. PMID: 20096018.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  71. Longhi MS, Ma Y, Mieli-Vergani G, Vergani D. Aetiopathogenesis of autoimmune hepatitis. J Autoimmun. 2010 Feb; 34(1):7-14. PMID: 19766456.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  72. Longhi MS, Mitry RR, Samyn M, Scalori A, Hussain MJ, Quaglia A, Mieli-Vergani G, Ma Y, Vergani D. Vigorous activation of monocytes in juvenile autoimmune liver disease escapes the control of regulatory T-cells. Hepatology. 2009 Jul; 50(1):130-42. PMID: 19437492.
    Citations: 24     Fields:    Translation:HumansCells
  73. Vergani D, Longhi MS, Bogdanos DP, Ma Y, Mieli-Vergani G. Autoimmune hepatitis. Semin Immunopathol. 2009 Sep; 31(3):421-35. PMID: 19533129.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  74. Longhi MS, Meda F, Wang P, Samyn M, Mieli-Vergani G, Vergani D, Ma Y. Expansion and de novo generation of potentially therapeutic regulatory T cells in patients with autoimmune hepatitis. Hepatology. 2008 Feb; 47(2):581-91. PMID: 18220288.
    Citations: 32     Fields:    Translation:HumansCells
  75. Longhi MS, Hussain MJ, Bogdanos DP, Quaglia A, Mieli-Vergani G, Ma Y, Vergani D. Cytochrome P450IID6-specific CD8 T cell immune responses mirror disease activity in autoimmune hepatitis type 2. Hepatology. 2007 Aug; 46(2):472-84. PMID: 17559153.
    Citations: 41     Fields:    Translation:HumansCells
  76. Longhi MS, Hussain MJ, Mitry RR, Arora SK, Mieli-Vergani G, Vergani D, Ma Y. Functional study of CD4+CD25+ regulatory T cells in health and autoimmune hepatitis. J Immunol. 2006 Apr 01; 176(7):4484-91. PMID: 16547287.
    Citations: 104     Fields:    Translation:HumansCells
  77. Ma Y, Bogdanos DP, Hussain MJ, Underhill J, Bansal S, Longhi MS, Cheeseman P, Mieli-Vergani G, Vergani D. Polyclonal T-cell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2. Gastroenterology. 2006 Mar; 130(3):868-82. PMID: 16530525.
    Citations: 53     Fields:    Translation:HumansCells
  78. Longhi MS, Ma Y, Mitry RR, Bogdanos DP, Heneghan M, Cheeseman P, Mieli-Vergani G, Vergani D. Effect of CD4+ CD25+ regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis. J Autoimmun. 2005 Aug; 25(1):63-71. PMID: 16005184.
    Citations: 61     Fields:    Translation:HumansCells
  79. Longhi MS, Ma Y, Bogdanos DP, Cheeseman P, Mieli-Vergani G, Vergani D. Impairment of CD4(+)CD25(+) regulatory T-cells in autoimmune liver disease. J Hepatol. 2004 Jul; 41(1):31-7. PMID: 15246204.
    Citations: 113     Fields:    Translation:HumansCells
  80. Vento S, Cainelli F, Longhi MS. Reactivation of replication of hepatitis B and C viruses after immunosuppressive therapy: an unresolved issue. Lancet Oncol. 2002 Jun; 3(6):333-40. PMID: 12107020.
    Citations: 36     Fields:    Translation:HumansCells
  81. Longhi MS, Cainelli F, Concia E, Vento S. No increase in liver decompensation risk with atypical hepatitis C virus antibody pattern. J Infect Dis. 2001 May 01; 183(9):1428. PMID: 11294682.
    Citations:    Fields:    Translation:Humans
  82. Cainelli F, Longhi MS, Concia E, Vento S. Failure of lamivudine therapy for chemotherapy-induced reactivation of hepatitis B. Am J Gastroenterol. 2001 May; 96(5):1651-2. PMID: 11374725.
    Citations: 3     Fields:    Translation:HumansCells
  83. Cainelli F, Longhi MS, Concia E, Vento S. HIV-1 progression in hepatitis-C-infected drug users. Lancet. 2001 Apr 28; 357(9265):1361; author reply 1363. PMID: 11347578.
    Citations:    Fields:    Translation:HumansCells
  84. Vento S, Longhi MS, Cainelli F, Concia E. Effect of pregnancy on chronic hepatitis C. Lancet. 2001 Feb 03; 357(9253):389-90. PMID: 11211018.
    Citations: 3     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.