Harvard Catalyst Profiles

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Roy Lester Freeman, M.B.Ch.B.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01NS105844 (FREEMAN, ROY) May 15, 2019 - Mar 31, 2024
    NIH/NINDS
    The functional neuroanatomy of the human physiological stress response
    Role: Principal Investigator
  2. R01HL111465 (FREEMAN, ROY) Aug 27, 2013 - Jun 30, 2017
    NIH/NHLBI
    Hypoglycemia, Cardiovascular Autonomic Function and Type 2 Diabetes Mellitus
    Role: Principal Investigator
  3. R01HL109634 (FREEMAN, ROY) Sep 1, 2011 - Jun 30, 2015
    NIH/NHLBI
    Hypoglycemia, mineralocorticoid receptor and autonomic control
    Role: Principal Investigator
  4. U54NS065736 (ROBERTSON, DAVID HERLIE) Jul 1, 2009 - Jun 30, 2019
    NIH/NINDS
    Autonomic Rare Diseases Clinical Research Consortium
    Role: Co-Principal Investigator
  5. R01DK063296 (FREEMAN, ROY) Sep 30, 2003 - Jul 31, 2009
    NIH/NIDDK
    HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTION
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Smith SM, Dworkin RH, Turk DC, McDermott M, Eccleston C, Farrar JT, Rowbotham MC, Bhangwagar Z, Burke LB, Cowan P, Ellenberg SS, Evans SR, Freeman RL, Garrison LP, Iyengar S, Jadad A, Jensen MP, Junor R, Kamp C, Katz NP, Kesslak JP, Kopecky EA, Lissin D, Markman JD, Mease PJ, O'Connor AB, Patel KV, Raja SN, Sampaio C, Schoenfeld D, Singh J, Steigerwald I, Strand V, Tive LA, Tobias J, Wasan AD, Wilson HD. Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations. Pain. 2020 Jun 08. PMID: 32520773.
    Citations:    
  2. Freeman R, Edwards R, Baron R, Bruehl S, Cruccu G, Dworkin RH, Haroutounian S. AAPT Diagnostic Criteria for Peripheral Neuropathic Pain: Focal and Segmental Disorders. J Pain. 2019 04; 20(4):369-393. PMID: 30527971.
    Citations:    Fields:    
  3. Freeman R, Abuzinadah AR, Gibbons C, Jones P, Miglis MG, Sinn DI. Orthostatic Hypotension: JACC State-of-the-Art Review. J Am Coll Cardiol. 2018 09 11; 72(11):1294-1309. PMID: 30190008.
    Citations:    Fields:    
  4. Freeman R. Diabetic autonomic neuropathy. Handb Clin Neurol. 2014; 126:63-79. PMID: 25410215.
    Citations: 8     Fields:    Translation:HumansAnimals
  5. Freeman R, Baron R, Bouhassira D, Cabrera J, Emir B. Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs. Pain. 2014 Feb; 155(2):367-76. PMID: 24472518.
    Citations: 34     Fields:    Translation:Humans
  6. Freeman R. New and developing drugs for the treatment of neuropathic pain in diabetes. Curr Diab Rep. 2013 Aug; 13(4):500-8. PMID: 23771401.
    Citations: 3     Fields:    Translation:Humans
  7. Höke A, Simpson DM, Freeman R. Challenges in developing novel therapies for peripheral neuropathies: a summary of The Foundation for Peripheral Neuropathy Scientific Symposium 2012. J Peripher Nerv Syst. 2013 Mar; 18(1):1-6. PMID: 23521637.
    Citations: 1     Fields:    Translation:HumansAnimals
  8. Freeman R, Chapleau MW. Testing the autonomic nervous system. Handb Clin Neurol. 2013; 115:115-36. PMID: 23931777.
    Citations: 11     Fields:    Translation:HumansAnimals
  9. Siepmann T, Gibbons CH, Illigens BM, Lafo JA, Brown CM, Freeman R. Quantitative pilomotor axon reflex test: a novel test of pilomotor function. Arch Neurol. 2012 Nov; 69(11):1488-92. PMID: 22868966.
    Citations: 5     Fields:    Translation:HumansCells
  10. Raj SR, Freeman R. Highlights in clinical autonomic neurosciences: Orthostatic hypotension: insights into risks and causes. Auton Neurosci. 2012 Sep 25; 170(1-2):3-4. PMID: 22921488.
    Citations:    Fields:    
  11. Gibbons CH, Adler GK, Bonyhay I, Freeman R. Experimental hypoglycemia is a human model of stress-induced hyperalgesia. Pain. 2012 Nov; 153(11):2204-9. PMID: 22921261.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  12. Cheshire WP, Freeman R. Highlights in clinical autonomic neuroscience: latest discoveries from the octopus pot. Auton Neurosci. 2012 Jul 02; 169(1):4-6. PMID: 22579400.
    Citations:    Fields:    
  13. Raj SR, Freeman R. Highlights in clinical autonomic neurosciences: vasovagal syncope - insights on diagnosis, pathophysiology and treatment. Auton Neurosci. 2012 May 21; 168(1-2):1-3. PMID: 22444321.
    Citations: 1     Fields:    
  14. Cheshire WP, Freeman R. Highlights in clinical autonomic neuroscience: latest developments in the early detection of diabetic autonomic neuropathy. Auton Neurosci. 2012 Apr 03; 167(1-2):4-6. PMID: 22306250.
    Citations:    Fields:    
  15. Gibbons CH, Centi J, Vernino S, Freeman R. Autoimmune autonomic ganglionopathy with reversible cognitive impairment. Arch Neurol. 2012 Apr; 69(4):461-6. PMID: 22158721.
    Citations: 10     Fields:    Translation:Humans
  16. Kaufmann H, Malamut R, Norcliffe-Kaufmann L, Rosa K, Freeman R. The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale. Clin Auton Res. 2012 Apr; 22(2):79-90. PMID: 22045363.
    Citations: 36     Fields:    Translation:HumansCTClinical Trials
  17. Ziegler D, Low PA, Litchy WJ, Boulton AJ, Vinik AI, Freeman R, Samigullin R, Tritschler H, Munzel U, Maus J, Schütte K, Dyck PJ. Efficacy and safety of antioxidant treatment with a-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care. 2011 Sep; 34(9):2054-60. PMID: 21775755.
    Citations: 55     Fields:    Translation:Humans
  18. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz I, Schondorff R, Stewart JM, van Dijk JG. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011 Apr; 21(2):69-72. PMID: 21431947.
    Citations: 199     Fields:    Translation:Humans
  19. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz IJ, Schondorf R, Stewart JM, van Dijk JG. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Auton Neurosci. 2011 Apr 26; 161(1-2):46-8. PMID: 21393070.
    Citations: 59     Fields:    Translation:Humans
  20. Wang N, Gibbons CH, Freeman R. Novel immunohistochemical techniques using discrete signal amplification systems for human cutaneous peripheral nerve fiber imaging. J Histochem Cytochem. 2011 Apr; 59(4):382-90. PMID: 21411809.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  21. Gibbons CH, Wang N, Freeman R. Capsaicin induces degeneration of cutaneous autonomic nerve fibers. Ann Neurol. 2010 Dec; 68(6):888-98. PMID: 21061393.
    Citations: 24     Fields:    Translation:HumansCTClinical Trials
  22. Adler GK, Bonyhay I, Curren V, Waring E, Freeman R. Hypoglycaemia increases aldosterone in a dose-dependent fashion. Diabet Med. 2010 Nov; 27(11):1250-5. PMID: 20950382.
    Citations: 2     Fields:    Translation:Humans
  23. Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, Lauria G, Malik RA, Spallone V, Vinik A, Bernardi L, Valensi P. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010 Oct; 33(10):2285-93. PMID: 20876709.
    Citations: 345     Fields:    Translation:Humans
  24. Gibbons CH, Freeman R, Veves A. Diabetic neuropathy: a cross-sectional study of the relationships among tests of neurophysiology. Diabetes Care. 2010 Dec; 33(12):2629-34. PMID: 20805259.
    Citations: 14     Fields:    Translation:Humans
  25. Gibbons CH, Illigens BM, Wang N, Freeman R. Quantification of sudomotor innervation: a comparison of three methods. Muscle Nerve. 2010 Jul; 42(1):112-9. PMID: 20544913.
    Citations: 9     Fields:    Translation:HumansCells
  26. Gibbons CH, Freeman R. Treatment-induced diabetic neuropathy: a reversible painful autonomic neuropathy. Ann Neurol. 2010 Apr; 67(4):534-41. PMID: 20437589.
    Citations: 31     Fields:    Translation:HumansCells
  27. Simpson DM, Schifitto G, Clifford DB, Murphy TK, Durso-De Cruz E, Glue P, Whalen E, Emir B, Scott GN, Freeman R. Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial. Neurology. 2010 Feb 02; 74(5):413-20. PMID: 20124207.
    Citations: 37     Fields:    Translation:Humans
  28. Freeman R. Not all neuropathy in diabetes is of diabetic etiology: differential diagnosis of diabetic neuropathy. Curr Diab Rep. 2009 Dec; 9(6):423-31. PMID: 19954686.
    Citations: 11     Fields:    Translation:Humans
  29. Gibbons CH, Illigens BM, Wang N, Freeman R. Quantification of sweat gland innervation: a clinical-pathologic correlation. Neurology. 2009 Apr 28; 72(17):1479-86. PMID: 19398703.
    Citations: 32     Fields:    Translation:HumansCells
  30. Gibbons CH, Freeman R. Antibody titers predict clinical features of autoimmune autonomic ganglionopathy. Auton Neurosci. 2009 Mar 12; 146(1-2):8-12. PMID: 19144572.
    Citations: 18     Fields:    Translation:Humans
  31. Adler GK, Bonyhay I, Failing H, Waring E, Dotson S, Freeman R. Antecedent hypoglycemia impairs autonomic cardiovascular function: implications for rigorous glycemic control. Diabetes. 2009 Feb; 58(2):360-6. PMID: 19056608.
    Citations: 61     Fields:    Translation:Humans
  32. Lair L, Gibbons C, Freeman R. Phantom sweating: a novel autonomic paresthesia. Clin Auton Res. 2008 Dec; 18(6):352-4. PMID: 18850064.
    Citations:    Fields:    Translation:Humans
  33. Gibbons CH, Illigens BM, Centi J, Freeman R. QDIRT: quantitative direct and indirect test of sudomotor function. Neurology. 2008 Jun 10; 70(24):2299-304. PMID: 18541883.
    Citations: 14     Fields:    Translation:HumansCells
  34. Freeman R. Current pharmacologic treatment for orthostatic hypotension. Clin Auton Res. 2008 Mar; 18 Suppl 1:14-8. PMID: 18368302.
    Citations: 9     Fields:    Translation:Humans
  35. Freeman R, Durso-Decruz E, Emir B. Efficacy, safety, and tolerability of pregabalin treatment for painful diabetic peripheral neuropathy: findings from seven randomized, controlled trials across a range of doses. Diabetes Care. 2008 Jul; 31(7):1448-54. PMID: 18356405.
    Citations: 50     Fields:    Translation:Humans
  36. Dotson S, Freeman R, Failing HJ, Adler GK. Hypoglycemia increases serum interleukin-6 levels in healthy men and women. Diabetes Care. 2008 Jun; 31(6):1222-3. PMID: 18332163.
    Citations: 22     Fields:    Translation:Humans
  37. Freeman R. Clinical practice. Neurogenic orthostatic hypotension. N Engl J Med. 2008 Feb 07; 358(6):615-24. PMID: 18256396.
    Citations: 63     Fields:    Translation:Humans
  38. Gibbons CH, Vernino SA, Freeman R. Combined immunomodulatory therapy in autoimmune autonomic ganglionopathy. Arch Neurol. 2008 Feb; 65(2):213-7. PMID: 18268189.
    Citations: 16     Fields:    Translation:Humans
  39. Ahn AC, Bennani T, Freeman R, Hamdy O, Kaptchuk TJ. Two styles of acupuncture for treating painful diabetic neuropathy--a pilot randomised control trial. Acupunct Med. 2007 Jun; 25(1-2):11-7. PMID: 17641562.
    Citations: 17     Fields:    Translation:Humans
  40. Freeman R, McIntosh KA, Vijapurkar U, Thienel U. Topiramate and physiologic measures of nerve function in polyneuropathy. Acta Neurol Scand. 2007 Apr; 115(4):222-31. PMID: 17376119.
    Citations: 1     Fields:    Translation:Humans
  41. Bonyhay I, Freeman R. Sympathetic neural activity, sex dimorphism, and postural tachycardia syndrome. Ann Neurol. 2007 Apr; 61(4):332-9. PMID: 17358006.
    Citations: 6     Fields:    Translation:Humans
  42. Cornblath DR, Vinik A, Feldman E, Freeman R, Boulton AJ. Surgical decompression for diabetic sensorimotor polyneuropathy. Diabetes Care. 2007 Feb; 30(2):421-2. PMID: 17259523.
    Citations: 5     Fields:    Translation:Humans
  43. Freeman R. Autonomic peripheral neuropathy. Neurol Clin. 2007 Feb; 25(1):277-301. PMID: 17324728.
    Citations: 5     Fields:    Translation:Humans
  44. Freeman R, Raskin P, Hewitt DJ, Vorsanger GJ, Jordan DM, Xiang J, Rosenthal NR. Randomized study of tramadol/acetaminophen versus placebo in painful diabetic peripheral neuropathy. Curr Med Res Opin. 2007 Jan; 23(1):147-61. PMID: 17257476.
    Citations: 20     Fields:    Translation:Humans
  45. Gibbons CH, Freeman R. Delayed orthostatic hypotension: a frequent cause of orthostatic intolerance. Neurology. 2006 Jul 11; 67(1):28-32. PMID: 16832073.
    Citations: 48     Fields:    Translation:Humans
  46. Berghoff M, Kilo S, Hilz MJ, Freeman R. Differential impairment of the sudomotor and nociceptor axon-reflex in diabetic peripheral neuropathy. Muscle Nerve. 2006 Apr; 33(4):494-9. PMID: 16411196.
    Citations: 9     Fields:    Translation:HumansCells
  47. Latov N, Gorson KC, Brannagan TH, Freeman RL, Apostolski S, Berger AR, Bradley WG, Briani C, Bril V, Busis NA, Cros DP, Dalakas MC, Donofrio PD, Dyck PJ, England JD, Fisher MA, Herrmann DN, Menkes DL, Sahenk Z, Sander HW, Triggs WJ, Vallat JM. Diagnosis and Treatment of Chronic Immune-mediated Neuropathies. J Clin Neuromuscul Dis. 2006 Mar; 7(3):141-57. PMID: 19078800.
    Citations:    
  48. Gibbons CH, Freeman R. Treatment options for autonomic neuropathies. Curr Treat Options Neurol. 2006 Mar; 8(2):119-32. PMID: 16464408.
    Citations: 3     
  49. Freeman R. Assessment of cardiovascular autonomic function. Clin Neurophysiol. 2006 Apr; 117(4):716-30. PMID: 16464634.
    Citations: 40     Fields:    Translation:HumansAnimals
  50. Freeman R. Cardiovascular manifestations of autonomic epilepsy. Clin Auton Res. 2006 Feb; 16(1):12-7. PMID: 16477490.
    Citations: 6     Fields:    Translation:HumansAnimals
  51. Freeman R. Newer agents for the treatment of painful diabetic peripheral neuropathy. Curr Diab Rep. 2005 Dec; 5(6):409-16. PMID: 16316590.
    Citations:    Fields:    Translation:HumansAnimals
  52. Freeman R, Gibbons C. Is time of the essence? The continuing search for a noninvasive measure of sympathetic adrenergic function. Neurology. 2005 Nov 22; 65(10):1517. PMID: 16304717.
    Citations:    Fields:    Translation:HumansCells
  53. Gibbons CH, Vernino SA, Kaufmann H, Freeman R. L-DOPS therapy for refractory orthostatic hypotension in autoimmune autonomic neuropathy. Neurology. 2005 Oct 11; 65(7):1104-6. PMID: 16217067.
    Citations: 7     Fields:    Translation:Humans
  54. Freeman R. The treatment of neuropathic pain. CNS Spectr. 2005 Sep; 10(9):698-706. PMID: 16142210.
    Citations: 4     Fields:    Translation:HumansCells
  55. Boulton AJ, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, Malik RA, Maser RE, Sosenko JM, Ziegler D. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care. 2005 Apr; 28(4):956-62. PMID: 15793206.
    Citations: 373     Fields:    Translation:Humans
  56. Gibbons CH, Freeman R. Autonomic neuropathy and coeliac disease. J Neurol Neurosurg Psychiatry. 2005 Apr; 76(4):579-81. PMID: 15774451.
    Citations: 5     Fields:    Translation:Humans
  57. Freeman R. Autonomic peripheral neuropathy. Lancet. 2005 Apr 2-8; 365(9466):1259-70. PMID: 15811460.
    Citations: 43     Fields:    Translation:Humans
  58. Gibbons CH, Freeman R. Orthostatic dyspnea: a neglected symptom of orthostatic hypotension. Clin Auton Res. 2005 Feb; 15(1):40-4. PMID: 15768201.
    Citations: 9     Fields:    Translation:Humans
  59. Goldstein DS, Holmes C, Kaufmann H, Freeman R. Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failure. Clin Auton Res. 2004 Dec; 14(6):363-8. PMID: 15666063.
    Citations: 16     Fields:    Translation:HumansCTClinical Trials
  60. Bonyhay I, Freeman R. Sympathetic nerve activity in response to hypotensive stress in the postural tachycardia syndrome. Circulation. 2004 Nov 16; 110(20):3193-8. PMID: 15533861.
    Citations: 23     Fields:    Translation:HumansCells
  61. Kaufmann H, Freeman R. Pharmacological treatment of reflex syncope. Clin Auton Res. 2004 Oct; 14 Suppl 1:71-5. PMID: 15480933.
    Citations: 4     Fields:    Translation:Humans
  62. Wieling W, Colman N, Krediet CT, Freeman R. Nonpharmacological treatment of reflex syncope. Clin Auton Res. 2004 Oct; 14 Suppl 1:62-70. PMID: 15480932.
    Citations: 12     Fields:    Translation:Humans
  63. Freeman R. Pure autonomic failure: an immaculate misconception? Neurology. 2004 Sep 28; 63(6):953-4. PMID: 15452282.
    Citations: 1     Fields:    Translation:HumansCells
  64. Gibbons C, Freeman R. The evaluation of small fiber function-autonomic and quantitative sensory testing. Neurol Clin. 2004 Aug; 22(3):683-702, vii. PMID: 15207880.
    Citations: 10     Fields:    Translation:HumansCells
  65. Freeman R. Assessment of cardiovascular autonomic function. Suppl Clin Neurophysiol. 2004; 57:369-75. PMID: 16106635.
    Citations: 2     Fields:    Translation:Humans
  66. Berger AR, Bradley WG, Brannagan TH, Busis NA, Cros DP, Dalakas MC, Danon MJ, Donofrio P, Engel WK, England JD, Feldman EL, Freeman RL, Kinsella LJ, Lacomis D, Latov N, Menkes DL, Sander HW, Thomas FP, Triggs WJ, Windebank AJ, Wolfe GI. Guidelines for the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy. J Peripher Nerv Syst. 2003 Dec; 8(4):282-4. PMID: 14641652.
    Citations: 11     Fields:    Translation:HumansCells
  67. Vinik AI, Freeman R, Erbas T. Diabetic autonomic neuropathy. Semin Neurol. 2003 Dec; 23(4):365-72. PMID: 15088257.
    Citations: 28     Fields:    Translation:HumansAnimals
  68. Freeman R. Treatment of orthostatic hypotension. Semin Neurol. 2003 Dec; 23(4):435-42. PMID: 15088264.
    Citations: 18     Fields:    Translation:HumansAnimals
  69. Cheshire WP, Freeman R. Disorders of sweating. Semin Neurol. 2003 Dec; 23(4):399-406. PMID: 15088261.
    Citations: 15     Fields:    Translation:HumansAnimals
  70. Risk MR, Lirofonis V, Armentano RL, Freeman R. A biphasic model of limb venous compliance: a comparison with linear and exponential models. J Appl Physiol (1985). 2003 Sep; 95(3):1207-15. PMID: 12909601.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  71. Kaufmann H, Saadia D, Voustianiouk A, Goldstein DS, Holmes C, Yahr MD, Nardin R, Freeman R. Norepinephrine precursor therapy in neurogenic orthostatic hypotension. Circulation. 2003 Aug 12; 108(6):724-8. PMID: 12885750.
    Citations: 36     Fields:    Translation:HumansCTClinical Trials
  72. Nahm F, Freeman R. Sphincter electromyography and multiple system atrophy. Muscle Nerve. 2003 Jul; 28(1):18-26. PMID: 12811769.
    Citations: 2     Fields:    Translation:Humans
  73. Maser RE, Mitchell BD, Vinik AI, Freeman R. The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis. Diabetes Care. 2003 Jun; 26(6):1895-901. PMID: 12766130.
    Citations: 127     Fields:    Translation:Humans
  74. Berghoff M, Kathpal M, Khan F, Skinner M, Falk R, Freeman R. Endothelial dysfunction precedes C-fiber abnormalities in primary (AL) amyloidosis. Ann Neurol. 2003 Jun; 53(6):725-30. PMID: 12783418.
    Citations: 14     Fields:    Translation:HumansCells
  75. Vinik AI, Maser RE, Mitchell BD, Freeman R. Diabetic autonomic neuropathy. Diabetes Care. 2003 May; 26(5):1553-79. PMID: 12716821.
    Citations: 328     Fields:    Translation:Humans
  76. Freeman R, Chase KP, Risk MR. Quantitative sensory testing cannot differentiate simulated sensory loss from sensory neuropathy. Neurology. 2003 Feb 11; 60(3):465-70. PMID: 12578928.
    Citations: 19     Fields:    Translation:HumansCTClinical Trials
  77. Nahm F, Freeman R. Syncope and the history of nervous influences on the heart. Arch Neurol. 2003 Feb; 60(2):282-7. PMID: 12580718.
    Citations:    Fields:    Translation:Humans
  78. Freeman R. The chronic fatigue syndrome is a disease of the autonomic nervous system. Sometimes. Clin Auton Res. 2002 Aug; 12(4):231-3. PMID: 12357274.
    Citations: 3     Fields:    Translation:Humans
  79. Freeman R, Lirofonis V, Farquhar WB, Risk M. Limb venous compliance in patients with idiopathic orthostatic intolerance and postural tachycardia. J Appl Physiol (1985). 2002 Aug; 93(2):636-44. PMID: 12133874.
    Citations: 16     Fields:    Translation:Humans
  80. Gutierrez J, Santiesteban R, Garcia H, Voustianiouk A, Freeman R, Kaufmann H. High blood pressure and decreased heart rate variability in the Cuban epidemic neuropathy. J Neurol Neurosurg Psychiatry. 2002 Jul; 73(1):71-2. PMID: 12082051.
    Citations: 2     Fields:    Translation:Humans
  81. Lopez MR, Freeman R, Schomer D. Spindle coma secondary to vasovagal syncope. Epilepsy Behav. 2002 Jun; 3(3):289-291. PMID: 12662612.
    Citations: 1     Fields:    
  82. Berghoff M, Kathpal M, Kilo S, Hilz MJ, Freeman R. Vascular and neural mechanisms of ACh-mediated vasodilation in the forearm cutaneous microcirculation. J Appl Physiol (1985). 2002 Feb; 92(2):780-8. PMID: 11796692.
    Citations: 26     Fields:    Translation:HumansCells
  83. Farquhar WB, Hunt BE, Taylor JA, Darling SE, Freeman R. Blood volume and its relation to peak O(2) consumption and physical activity in patients with chronic fatigue. Am J Physiol Heart Circ Physiol. 2002 Jan; 282(1):H66-71. PMID: 11748048.
    Citations: 11     Fields:    Translation:Humans
  84. Nahm F, Freeman R. Vasovagal syncope: the contributions of Sir William R. Gowers and Sir Thomas Lewis. Arch Neurol. 2001 Mar; 58(3):509-11. PMID: 11255458.
    Citations: 2     Fields:    Translation:Humans
  85. Apfel SC, Schwartz S, Adornato BT, Freeman R, Biton V, Rendell M, Vinik A, Giuliani M, Stevens JC, Barbano R, Dyck PJ. Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy: A randomized controlled trial. rhNGF Clinical Investigator Group. JAMA. 2000 Nov 01; 284(17):2215-21. PMID: 11056593.
    Citations: 66     Fields:    Translation:HumansCTClinical Trials
  86. Kilo S, Berghoff M, Hilz M, Freeman R. Neural and endothelial control of the microcirculation in diabetic peripheral neuropathy. Neurology. 2000 Mar 28; 54(6):1246-52. PMID: 10746593.
    Citations: 17     Fields:    Translation:Humans
  87. Freeman R, Landsberg L, Young J. The treatment of neurogenic orthostatic hypotension with 3,4-DL-threo-dihydroxyphenylserine: a randomized, placebo-controlled, crossover trial. Neurology. 1999 Dec 10; 53(9):2151-7. PMID: 10599797.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  88. Mukkamala R, Mathias JM, Mullen TJ, Cohen RJ, Freeman R. System identification of closed-loop cardiovascular control mechanisms: diabetic autonomic neuropathy. Am J Physiol. 1999 Mar; 276(3 Pt 2):R905-12. PMID: 10070154.
    Citations: 10     Fields:    Translation:Humans
  89. Freeman R. Human studies of recombinant human nerve growth factor and diabetic peripheral neuropathy. Eur Neurol. 1999; 41 Suppl 1:20-6. PMID: 10023125.
    Citations:    Fields:    Translation:Humans
  90. Arora S, Smakowski P, Frykberg RG, Simeone LR, Freeman R, LoGerfo FW, Veves A. Differences in foot and forearm skin microcirculation in diabetic patients with and without neuropathy. Diabetes Care. 1998 Aug; 21(8):1339-44. PMID: 9702444.
    Citations: 14     Fields:    Translation:HumansCells
  91. Veves A, Akbari CM, Primavera J, Donaghue VM, Zacharoulis D, Chrzan JS, DeGirolami U, LoGerfo FW, Freeman R. Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration. Diabetes. 1998 Mar; 47(3):457-63. PMID: 9519754.
    Citations: 41     Fields:    Translation:Humans
  92. Blaber AP, Bondar RL, Stein F, Dunphy PT, Moradshahi P, Kassam MS, Freeman R. Complexity of middle cerebral artery blood flow velocity: effects of tilt and autonomic failure. Am J Physiol. 1997 11; 273(5):H2209-16. PMID: 9374755.
    Citations: 3     Fields:    Translation:Humans
  93. Low PA, Gilden JL, Freeman R, Sheng KN, McElligott MA. Efficacy of midodrine for neurogenic orthostatic hypotension. Reply. JAMA. 1997 Aug 06; 278(5):388. PMID: 11536812.
    Citations:    Fields:    Translation:Humans
  94. Araujo LM, Freeman R, Broadbridge C. Cardiovascular autonomic tests in diabetic patients with gastroparesis. Arq Neuropsiquiatr. 1997 Jun; 55(2):227-30. PMID: 9629382.
    Citations:    Fields:    Translation:Humans
  95. Freeman R, Komaroff AL. Does the chronic fatigue syndrome involve the autonomic nervous system? Am J Med. 1997 Apr; 102(4):357-64. PMID: 9217617.
    Citations: 41     Fields:    Translation:Humans
  96. Freeman R, Young J, Landsberg L, Lipsitz L. The treatment of postprandial hypotension in autonomic failure with 3,4-DL-threo-dihydroxyphenylserine. Neurology. 1996 Dec; 47(6):1414-20. PMID: 8960720.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  97. Blaber AP, Bondar RL, Freeman R. Coarse graining spectral analysis of HR and BP variability in patients with autonomic failure. Am J Physiol. 1996 Oct; 271(4 Pt 2):H1555-64. PMID: 8897952.
    Citations: 3     Fields:    Translation:Humans
  98. Freeman R, Weiss ST, Roberts M, Zbikowski SM, Sparrow D. The relationship between heart rate variability and measures of body habitus. Clin Auton Res. 1995 Oct; 5(5):261-6. PMID: 8563458.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  99. Freeman R, Schachter SC. Autonomic epilepsy. Semin Neurol. 1995 Jun; 15(2):158-66. PMID: 7481135.
    Citations: 11     Fields:    Translation:Humans
  100. Freeman R, Cohen RJ, Saul JP. Transfer function analysis of respiratory sinus arrhythmia: a measure of autonomic function in diabetic neuropathy. Muscle Nerve. 1995 Jan; 18(1):74-84. PMID: 7800001.
    Citations: 3     Fields:    Translation:Humans
  101. Zarich S, Waxman S, Freeman RT, Mittleman M, Hegarty P, Nesto RW. Effect of autonomic nervous system dysfunction on the circadian pattern of myocardial ischemia in diabetes mellitus. J Am Coll Cardiol. 1994 Oct; 24(4):956-62. PMID: 7930230.
    Citations: 9     Fields:    Translation:Humans
  102. Harry JD, Freeman R. Determining heart-rate variability: comparing methodologies using computer simulations. Muscle Nerve. 1993 Mar; 16(3):267-77. PMID: 8446124.
    Citations:    Fields:    Translation:Humans
  103. Lipsitz LA, Ryan SM, Parker JA, Freeman R, Wei JY, Goldberger AL. Hemodynamic and autonomic nervous system responses to mixed meal ingestion in healthy young and old subjects and dysautonomic patients with postprandial hypotension. Circulation. 1993 Feb; 87(2):391-400. PMID: 8425288.
    Citations: 27     Fields:    Translation:Humans
  104. Freeman R, Miyawaki E. The treatment of autonomic dysfunction. J Clin Neurophysiol. 1993 Jan; 10(1):61-82. PMID: 8458996.
    Citations:    Fields:    Translation:Humans
  105. Freeman R, Waldorf HA, Dover JS. Autonomic neurodermatology (Part II): Disorders of sweating and flushing. Semin Neurol. 1992 Dec; 12(4):394-407. PMID: 1485049.
    Citations: 3     Fields:    Translation:Humans
  106. Freeman R, Dover JS. Autonomic neurodermatology (Part I): Erythromelalgia, reflex sympathetic dystrophy, and livedo reticularis. Semin Neurol. 1992 Dec; 12(4):385-93. PMID: 1485048.
    Citations: 2     Fields:    Translation:Humans
  107. Freeman R, Landsberg L. The treatment of orthostatic hypotension with dihydroxyphenylserine. Clin Neuropharmacol. 1991 Aug; 14(4):296-304. PMID: 1913697.
    Citations: 3     Fields:    Translation:Humans
  108. Freeman R, Saul JP, Roberts MS, Berger RD, Broadbridge C, Cohen RJ. Spectral analysis of heart rate in diabetic autonomic neuropathy. A comparison with standard tests of autonomic function. Arch Neurol. 1991 Feb; 48(2):185-90. PMID: 1993010.
    Citations: 29     Fields:    Translation:Humans
  109. Freeman R, Roberts MS, Friedman LS, Broadbridge C. Autonomic function and human immunodeficiency virus infection. Neurology. 1990 Apr; 40(4):575-80. PMID: 2320229.
    Citations: 31     Fields:    Translation:Humans
  110. Brown FM, Brink SJ, Freeman R, Rabinowe SL. Anti-sympathetic nervous system autoantibodies. Diminished catecholamines with orthostasis. Diabetes. 1989 Jul; 38(7):938-41. PMID: 2737366.
    Citations: 3     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.