Harvard Catalyst Profiles

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Roy Freeman, M.B.Ch.B.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS105844 (FREEMAN, ROY) May 15, 2019 - Mar 31, 2024
    The functional neuroanatomy of the human physiological stress response
    Role: Principal Investigator
  2. R01HL111465 (FREEMAN, ROY) Aug 27, 2013 - Jun 30, 2019
    Hypoglycemia, Cardiovascular Autonomic Function and Type 2 Diabetes Mellitus
    Role: Principal Investigator
  3. R01HL109634 (FREEMAN, ROY) Sep 1, 2011 - Jun 30, 2016
    Hypoglycemia, mineralocorticoid receptor and autonomic control
    Role: Principal Investigator
  4. U54NS065736 (ROBERTSON, DAVID HERLIE) Jul 1, 2009 - Jun 30, 2019
    Autonomic Rare Diseases Clinical Research Consortium
    Role: Co-Principal Investigator
  5. R01DK063296 (FREEMAN, ROY) Sep 30, 2003 - Jul 31, 2009
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gibbons CH, Freeman R, Bellaire B, Adler CH, Moore D, Levine T. Synuclein-One study: skin biopsy detection of phosphorylated a-synuclein for diagnosis of synucleinopathies. Biomark Med. 2022 May; 16(7):499-509. PMID: 35272481.
    Citations:    Fields:    
  2. Forstenpointner J, Elman I, Freeman R, Borsook D. The omnipresence of autonomic modulation in health and disease. Prog Neurobiol. 2022 03; 210:102218. PMID: 35033599.
    Citations:    Fields:    
  3. Zaheer S, Meyer K, Easly R, Bayomy O, Leung J, Koefoed AW, Heydarpour M, Freeman R, Adler GK. Effect of adrenocorticotropic hormone infusion on circulating sclerostin levels. Endocr Connect. 2021 Dec 14; 10(12):1607-1614. PMID: 34788228.
  4. Miglis MG, Zitser J, Schneider L, During E, Jaradeh S, Freeman R, Gibbons CH. Cutaneous a-synuclein is correlated with autonomic impairment in isolated rapid eye movement sleep behavior disorder. Sleep. 2021 12 10; 44(12). PMID: 34244806.
    Citations: 2     Fields:    
  5. Gewandter JS, Smith SM, Dworkin RH, Turk DC, Gan TJ, Gilron I, Hertz S, Katz NP, Markman JD, Raja SN, Rowbotham MC, Stacey BR, Strain EC, Ward DS, Farrar JT, Kroenke K, Rathmell JP, Rauck R, Brown C, Cowan P, Edwards RR, Eisenach JC, Ferguson M, Freeman R, Gray R, Giblin K, Grol-Prokopczyk H, Haythornthwaite J, Jamison RN, Martel M, McNicol E, L Oshinsky M, Sandbrink F, Scholz J, Scranton R, Simon LS, Steiner D, Verburg K, Wasan AD, Wentworth K. Research approaches for evaluating opioid sparing in clinical trials of acute and chronic pain treatments: Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials recommendations. Pain. 2021 11 01; 162(11):2669-2681. PMID: 33863862.
    Citations:    Fields:    Translation:Humans
  6. van Twist DJL, Harms MPM, van Wijnen VK, Claydon VE, Freeman R, Cheshire WP, Wieling W. Diagnostic criteria for initial orthostatic hypotension: a narrative review. Clin Auton Res. 2021 12; 31(6):685-698. PMID: 34677720.
    Citations:    Fields:    Translation:Humans
  7. Man JJ, Lu Q, Moss ME, Carvajal B, Baur W, Garza AE, Freeman R, Anastasiou M, Ngwenyama N, Adler GK, Alcaide P, Jaffe IZ. Myeloid Mineralocorticoid Receptor Transcriptionally Regulates P-Selectin Glycoprotein Ligand-1 and Promotes Monocyte Trafficking and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2021 11; 41(11):2740-2755. PMID: 34615372.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Rice ASC, Dworkin RH, Finnerup NB, Attal N, Anand P, Freeman R, Piaia A, Callegari F, Doerr C, Mondal S, Narayanan N, Ecochard L, Flossbach Y, Pandhi S. Efficacy and safety of EMA401 in peripheral neuropathic pain: results of 2 randomised, double-blind, phase 2 studies in patients with postherpetic neuralgia and painful diabetic neuropathy. Pain. 2021 10 01; 162(10):2578-2589. PMID: 33675631.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  9. González-Duarte A, Varma-Doyle A, Freeman R. Pure autonomic failure and the differential diagnosis of autonomic peripheral neuropathies. Curr Opin Neurol. 2021 10 01; 34(5):675-682. PMID: 34392300.
    Citations:    Fields:    Translation:Humans
  10. Evidente VGH, Evidente DH, Ortega SC, Levine TD, Freeman R, Gibbons CH. X-Linked Dystonia-Parkinsonism ("Lubag") May Present with Peripheral Synucleinopathy. Mov Disord. 2022 01; 37(1):130-136. PMID: 34582053.
    Citations:    Fields:    
  11. Ziegler D, Tesfaye S, Spallone V, Gurieva I, Al Kaabi J, Mankovsky B, Martinka E, Radulian G, Nguyen KT, Stirban AO, Tankova T, Varkonyi T, Freeman R, Kempler P, Boulton AJ. Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations. Diabetes Res Clin Pract. 2021 Sep 20; 109063. PMID: 34547367.
    Citations: 1     Fields:    
  12. Jain SM, Balamurugan R, Tandon M, Mozaffarian N, Gudi G, Salhi Y, Holland R, Freeman R, Baron R. Randomized, double-blind, placebo-controlled trial of ISC 17536, an oral inhibitor of transient receptor potential ankyrin 1, in patients with painful diabetic peripheral neuropathy: impact of preserved small nerve fiber function. Pain. 2021 Sep 02. PMID: 34490850.
    Citations:    Fields:    
  13. Sohn EH, Gibbons CH, Freeman R, Lee AY, Jung MS, Kim S. Validation of the Korean version of the Boston Autonomic Symptom Questionnaire. J Clin Neurol. 2021 Jul; 17(3):463-469. PMID: 34184455.
  14. Raj SR, Bourne KM, Stiles LE, Miglis MG, Cortez MM, Miller AJ, Freeman R, Biaggioni I, Rowe PC, Sheldon RS, Shibao CA, Diedrich A, Systrom DM, Cook GA, Doherty TA, Abdallah HI, Grubb BP, Fedorowski A, Stewart JM, Arnold AC, Pace LA, Axelsson J, Boris JR, Moak JP, Goodman BP, Chémali KR, Chung TH, Goldstein DS, Darbari A, Vernino S. Postural orthostatic tachycardia syndrome (POTS): Priorities for POTS care and research from a 2019 National Institutes of Health Expert Consensus Meeting - Part 2. Auton Neurosci. 2021 11; 235:102836. PMID: 34246578.
    Citations: 2     Fields:    Translation:Humans
  15. Vernino S, Bourne KM, Stiles LE, Grubb BP, Fedorowski A, Stewart JM, Arnold AC, Pace LA, Axelsson J, Boris JR, Moak JP, Goodman BP, Chémali KR, Chung TH, Goldstein DS, Diedrich A, Miglis MG, Cortez MM, Miller AJ, Freeman R, Biaggioni I, Rowe PC, Sheldon RS, Shibao CA, Systrom DM, Cook GA, Doherty TA, Abdallah HI, Darbari A, Raj SR. Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1. Auton Neurosci. 2021 11; 235:102828. PMID: 34144933.
    Citations: 5     Fields:    Translation:Humans
  16. Gibbons C, Donadio V, Sommer C, Liguori R, Lauria Pinter G, Lombardi R, Doppler K, Freeman R. Reader Response: In Vivo Distribution of a-Synuclein in Multiple Tissues and Biofluids in Parkinson Disease. Neurology. 2021 05 18; 96(20):964-965. PMID: 34001543.
    Citations: 2     Fields:    Translation:Humans
  17. Levine TD, Bellaire B, Gibbons C, Freeman R. Cutaneous alpha-synuclein deposition in postural tachycardia patients. Ann Clin Transl Neurol. 2021 04; 8(4):908-917. PMID: 33764697.
    Citations: 1     Fields:    Translation:HumansCells
  18. Thijs RD, Brignole M, Falup-Pecurariu C, Fanciulli A, Freeman R, Guaraldi P, Jordan J, Habek M, Hilz M, Pavy-LeTraon A, Stankovic I, Struhal W, Sutton R, Wenning G, van Dijk JG. Recommendations for tilt table testing and other provocative cardiovascular autonomic tests in conditions that may cause transient loss of consciousness : Consensus statement of the European Federation of Autonomic Societies (EFAS) endorsed by the American Autonomic Society (AAS) and the European Academy of Neurology (EAN). Auton Neurosci. 2021 07; 233:102792. PMID: 33752997.
    Citations: 4     Fields:    Translation:Humans
  19. Thijs RD, Brignole M, Falup-Pecurariu C, Fanciulli A, Freeman R, Guaraldi P, Jordan J, Habek M, Hilz M, Traon AP, Stankovic I, Struhal W, Sutton R, Wenning G, Van Dijk JG. Recommendations for tilt table testing and other provocative cardiovascular autonomic tests in conditions that may cause transient loss of consciousness : Consensus statement of the European Federation of Autonomic Societies (EFAS) endorsed by the American Autonomic Society (AAS) and the European Academy of Neurology (EAN). Clin Auton Res. 2021 06; 31(3):369-384. PMID: 33740206.
    Citations: 4     Fields:    Translation:Humans
  20. Doshi TL, Dworkin RH, Polomano RC, Carr DB, Edwards RR, Finnerup NB, Freeman RL, Paice JA, Weisman SJ, Raja SN. AAAPT Diagnostic Criteria for Acute Neuropathic Pain. Pain Med. 2021 03 18; 22(3):616-636. PMID: 33575803.
    Citations:    Fields:    Translation:Humans
  21. Cheshire WP, Freeman R, Gibbons CH, Cortelli P, Wenning GK, Hilz MJ, Spies JM, Lipp A, Sandroni P, Wada N, Mano T, Kim HA, Kimpinski K, Iodice V, Idiáquez J, Thaisetthawatkul P, Coon EA, Low PA, Singer W. Corrigendum to "Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology" [Clin. Neurophysiol. 132(2) (2021) 666-682]. Clin Neurophysiol. 2021 May; 132(5):1194. PMID: 33685802.
    Citations:    Fields:    
  22. Gibbons CH, Silva G, Freeman R. Cardiovascular exercise as a treatment of postural orthostatic tachycardia syndrome: A pragmatic treatment trial. Heart Rhythm. 2021 08; 18(8):1361-1368. PMID: 33482385.
    Citations: 2     Fields:    Translation:Humans
  23. Cheshire WP, Freeman R, Gibbons CH, Cortelli P, Wenning GK, Hilz MJ, Spies JM, Lipp A, Sandroni P, Wada N, Mano A, Ah Kim H, Kimpinski K, Iodice V, Idiáquez J, Thaisetthawatkul P, Coon EA, Low PA, Singer W. Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology. Clin Neurophysiol. 2021 02; 132(2):666-682. PMID: 33419664.
    Citations: 7     Fields:    Translation:Humans
  24. Smith SM, Dworkin RH, Turk DC, McDermott MP, Eccleston C, Farrar JT, Rowbotham MC, Bhagwagar Z, Burke LB, Cowan P, Ellenberg SS, Evans SR, Freeman RL, Garrison LP, Iyengar S, Jadad A, Jensen MP, Junor R, Kamp C, Katz NP, Kesslak JP, Kopecky EA, Lissin D, Markman JD, Mease PJ, O'Connor AB, Patel KV, Raja SN, Sampaio C, Schoenfeld D, Singh J, Steigerwald I, Strand V, Tive LA, Tobias J, Wasan AD, Wilson HD. Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations. Pain. 2020 11; 161(11):2446-2461. PMID: 32520773.
    Citations: 11     Fields:    Translation:Humans
  25. Freeman R, Gewandter JS, Faber CG, Gibbons C, Haroutounian S, Lauria G, Levine T, Malik RA, Singleton JR, Smith AG, Bell J, Dworkin RH, Feldman E, Herrmann DN, Hoke A, Kolb N, Mansikka H, Oaklander AL, Peltier A, Polydefkis M, Ritt E, Russell JW, Sainati S, Steiner D, Treister R, Üçeyler N. Idiopathic distal sensory polyneuropathy: ACTTION diagnostic criteria. Neurology. 2020 12 01; 95(22):1005-1014. PMID: 33055271.
    Citations: 7     Fields:    Translation:HumansCells
  26. Koulouris AE, Edwards RR, Dorado K, Schreiber KL, Lazaridou A, Rajan S, White J, Garcia J, Gibbons C, Freeman R. Reliability and Validity of the Boston Bedside Quantitative Sensory Testing Battery for Neuropathic Pain. Pain Med. 2020 10 01; 21(10):2336-2347. PMID: 32895703.
    Citations: 3     Fields:    Translation:Humans
  27. Haroutounian S, Todorovic MS, Leinders M, Campagnolo M, Gewandter JS, Dworkin RH, Freeman R. Diagnostic criteria for idiopathic small fiber neuropathy: A systematic review. Muscle Nerve. 2021 02; 63(2):170-177. PMID: 32989823.
    Citations: 5     Fields:    Translation:HumansCells
  28. Wang N, Garcia J, Freeman R, Gibbons CH. Phosphorylated Alpha-Synuclein Within Cutaneous Autonomic Nerves of Patients With Parkinson's Disease: The Implications of Sample Thickness on Results. J Histochem Cytochem. 2020 10; 68(10):669-678. PMID: 32921251.
    Citations: 5     Fields:    Translation:HumansCells
  29. Gibbons CH, Freeman R. Delayed orthostatic hypotension. Auton Neurosci. 2020 12; 229:102724. PMID: 32942225.
    Citations:    Fields:    Translation:Humans
  30. Leung JH, Bayomy OF, Bonyhay I, Celli J, White J, Freeman R, Adler GK. ACTH Infusion Impairs Baroreflex Sensitivity-Implications for Cardiovascular Hypoglycemia-Associated Autonomic Failure. J Clin Endocrinol Metab. 2020 07 01; 105(7). PMID: 32353115.
    Citations: 1     Fields:    Translation:Humans
  31. Sohn E, Suh BC, Wang N, Freeman R, Gibbons CH. A novel method to quantify cutaneous vascular innervation. Muscle Nerve. 2020 10; 62(4):492-501. PMID: 32270499.
    Citations: 1     Fields:    Translation:Humans
  32. Freeman R, Illigens BMW, Lapusca R, Campagnolo M, Abuzinadah AR, Bonyhay I, Sinn DI, Miglis M, White J, Gibbons CH. Symptom Recognition Is Impaired in Patients With Orthostatic Hypotension. Hypertension. 2020 05; 75(5):1325-1332. PMID: 32223377.
    Citations: 13     Fields:    Translation:Humans
  33. Gibbons CH, Wang N, Kim JY, Campagnolo M, Freeman R. Skin Biopsy in Evaluation of Autonomic Disorders. Continuum (Minneap Minn). 2020 Feb; 26(1):200-212. PMID: 31996629.
    Citations: 1     Fields:    Translation:Humans
  34. Freeman R. Autonomic Peripheral Neuropathy. Continuum (Minneap Minn). 2020 Feb; 26(1):58-71. PMID: 31996622.
    Citations: 1     Fields:    Translation:Humans
  35. Barboi A, Gibbons CH, Axelrod F, Benarroch EE, Biaggioni I, Chapleau MW, Chelimsky G, Chelimsky T, Cheshire WP, Claydon VE, Freeman R, Goldstein DS, Joyner MJ, Kaufmann H, Low PA, Norcliffe-Kaufmann L, Robertson D, Shibao CA, Singer W, Snapper H, Vernino S, Raj SR. Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. Auton Neurosci. 2020 01; 223:102550. PMID: 31928708.
    Citations: 4     Fields:    Translation:Humans
  36. Gewandter JS, Dworkin RH, Turk DC, Devine EG, Hewitt D, Jensen MP, Katz NP, Kirkwood AA, Malamut R, Markman JD, Vrijens B, Burke L, Campbell JN, Carr DB, Conaghan PG, Cowan P, Doyle MK, Edwards RR, Evans SR, Farrar JT, Freeman R, Gilron I, Juge D, Kerns RD, Kopecky EA, McDermott MP, Niebler G, Patel KV, Rauck R, Rice ASC, Rowbotham M, Sessler NE, Simon LS, Singla N, Skljarevski V, Tockarshewsky T, Vanhove GF, Wasan AD, Witter J. Improving Study Conduct and Data Quality in Clinical Trials of Chronic Pain Treatments: IMMPACT Recommendations. J Pain. 2020 Sep - Oct; 21(9-10):931-942. PMID: 31843583.
    Citations: 15     Fields:    Translation:Humans
  37. Barboi A, Gibbons CH, Bennaroch EE, Biaggioni I, Chapleau MW, Chelimsky G, Chelimsky T, Cheshire WP, Claydon VE, Freeman R, Goldstein DS, Joyner MJ, Kaufmann H, Low PA, Norcliffe-Kaufmann L, Robertson D, Shibao CA, Singer W, Snapper H, Vernino S, Raj SR. Response to: Human papillomavirus (HPV) vaccine safety concerning POTS, CRPS and related conditions. Clin Auton Res. 2020 04; 30(2):183-184. PMID: 31802304.
    Citations:    Fields:    Translation:HumansCells
  38. Isonaka R, Gibbons CH, Wang N, Freeman R, Goldstein DS. Association of innervation-adjusted alpha-synuclein in arrector pili muscles with cardiac noradrenergic deficiency in autonomic synucleinopathies. Clin Auton Res. 2019 12; 29(6):587-593. PMID: 31673840.
    Citations: 5     Fields:    Translation:HumansCells
  39. Barboi A, Gibbons CH, Axelrod F, Benarroch EE, Biaggioni I, Chapleau MW, Chelimsky G, Chelimsky T, Cheshire WP, Claydon VE, Freeman R, Goldstein DS, Joyner MJ, Kaufmann H, Low PA, Norcliffe-Kaufmann L, Robertson D, Shibao CA, Singer W, Snapper H, Vernino S, Raj SR. Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. Clin Auton Res. 2020 02; 30(1):13-18. PMID: 31475305.
    Citations: 7     Fields:    Translation:Humans
  40. Gewandter JS, Gibbons CH, Campagnolo M, Lee J, Chaudari J, Ward N, Burke L, Cavaletti G, Herrmann DN, McArthur JC, Russell JW, Smith AG, Smith SM, Turk DC, Dworkin RH, Freeman R. Clinician-rated measures for distal symmetrical axonal polyneuropathy: ACTTION systematic review. Neurology. 2019 08 20; 93(8):346-360. PMID: 31320471.
    Citations: 8     Fields:    Translation:Humans
  41. Stankovic I, Quinn N, Vignatelli L, Antonini A, Berg D, Coon E, Cortelli P, Fanciulli A, Ferreira JJ, Freeman R, Halliday G, Höglinger GU, Iodice V, Kaufmann H, Klockgether T, Kostic V, Krismer F, Lang A, Levin J, Low P, Mathias C, Meissner WG, Kaufmann LN, Palma JA, Panicker JN, Pellecchia MT, Sakakibara R, Schmahmann J, Scholz SW, Singer W, Stamelou M, Tolosa E, Tsuji S, Seppi K, Poewe W, Wenning GK. A critique of the second consensus criteria for multiple system atrophy. Mov Disord. 2019 07; 34(7):975-984. PMID: 31034671.
    Citations: 20     Fields:    Translation:Humans
  42. Karlsson P, Hincker AM, Jensen TS, Freeman R, Haroutounian S. Structural, functional, and symptom relations in painful distal symmetric polyneuropathies: a systematic review. Pain. 2019 Feb; 160(2):286-297. PMID: 30157133.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  43. Thomas S, Ajroud-Driss S, Dimachkie MM, Gibbons C, Freeman R, Simpson DM, Singleton JR, Smith AG, Höke A. Peripheral Neuropathy Research Registry: A prospective cohort. J Peripher Nerv Syst. 2019 03; 24(1):39-47. PMID: 30629307.
    Citations: 3     Fields:    Translation:Humans
  44. González-Duarte A, Cárdenas-Soto K, Fueyo O, Bañuelos CE, Gibbons C, Freeman R. Small fibre neuropathy assessments in early stages of hATTR amyloidosis. Amyloid. 2019; 26(sup1):55-56. PMID: 31343296.
    Citations:    Fields:    Translation:Humans
  45. Freeman R, Edwards R, Baron R, Bruehl S, Cruccu G, Dworkin RH, Haroutounian S. AAPT Diagnostic Criteria for Peripheral Neuropathic Pain: Focal and Segmental Disorders. J Pain. 2019 04; 20(4):369-393. PMID: 30527971.
    Citations: 6     Fields:    Translation:Humans
  46. Freeman R, Abuzinadah AR, Gibbons C, Jones P, Miglis MG, Sinn DI. Orthostatic Hypotension: JACC State-of-the-Art Review. J Am Coll Cardiol. 2018 09 11; 72(11):1294-1309. PMID: 30190008.
    Citations: 43     Fields:    Translation:Humans
  47. Gewandter JS, Brell J, Cavaletti G, Dougherty PM, Evans S, Howie L, McDermott MP, O'Mara A, Smith AG, Dastros-Pitei D, Gauthier LR, Haroutounian S, Jarpe M, Katz NP, Loprinzi C, Richardson P, Lavoie-Smith EM, Wen PY, Turk DC, Dworkin RH, Freeman R. Trial designs for chemotherapy-induced peripheral neuropathy prevention: ACTTION recommendations. Neurology. 2018 08 28; 91(9):403-413. PMID: 30054438.
    Citations: 16     Fields:    Translation:Humans
  48. Norcliffe-Kaufmann L, Kaufmann H, Palma JA, Shibao CA, Biaggioni I, Peltier AC, Singer W, Low PA, Goldstein DS, Gibbons CH, Freeman R, Robertson D. Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies. Ann Neurol. 2018 03; 83(3):522-531. PMID: 29405350.
    Citations: 45     Fields:    Translation:Humans
  49. Wadhawan S, Pant S, Golhar R, Kirov S, Thompson J, Jacobsen L, Qureshi I, Ajroud-Driss S, Freeman R, Simpson DM, Smith AG, Hoke A, Bristow LJ. NaV channel variants in patients with painful and nonpainful peripheral neuropathy. Neurol Genet. 2017 Dec; 3(6):e207. PMID: 29264398.
    Citations: 9     
  50. Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang J. Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting. Neurology. 2018 01 09; 90(2):74-82. PMID: 29237794.
    Citations: 7     Fields:    Translation:Humans
  51. Centi J, Freeman R, Gibbons CH, Neargarder S, Canova AO, Cronin-Golomb A. Author response: Effects of orthostatic hypotension on cognition in Parkinson disease. Neurology. 2017 11 14; 89(20):2122. PMID: 29133613.
    Citations:    Fields:    Translation:Humans
  52. Terkelsen AJ, Karlsson P, Lauria G, Freeman R, Finnerup NB, Jensen TS. The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol. 2017 11; 16(11):934-944. PMID: 29029847.
    Citations: 42     Fields:    Translation:Humans
  53. Gewandter JS, Freeman R, Kitt RA, Cavaletti G, Gauthier LR, McDermott MP, Mohile NA, Mohlie SG, Smith AG, Tejani MA, Turk DC, Dworkin RH. Chemotherapy-induced peripheral neuropathy clinical trials: Review and recommendations. Neurology. 2017 Aug 22; 89(8):859-869. PMID: 28747442.
    Citations: 17     Fields:    Translation:Humans
  54. Siepmann T, Pintér A, Buchmann SJ, Stibal L, Arndt M, Kubasch AS, Kubasch ML, Penzlin AI, Frenz E, Zago W, Horváth T, Szatmári S, Bereczki D, Takáts A, Ziemssen T, Lipp A, Freeman R, Reichmann H, Barlinn K, Illigens BM. Cutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson's Disease (CAPTURE PD): Protocol for a Multicenter Study. Front Neurol. 2017; 8:212. PMID: 28603514.
    Citations: 8     
  55. Gibbons CH, Simon DK, Huang M, Tilley B, Aminoff MJ, Bainbridge JL, Brodsky M, Freeman R, Goudreau J, Hamill RW, Luo ST, Singer C, Videnovic A, Bodis-Wollner I, Wong PS. Autonomic and electrocardiographic findings in Parkinson's disease. Auton Neurosci. 2017 07; 205:93-98. PMID: 28506500.
    Citations: 6     Fields:    Translation:Humans
  56. Serrador JM, Freeman R. Enhanced Cholinergic Activity Improves Cerebral Blood Flow during Orthostatic Stress. Front Neurol. 2017; 8:103. PMID: 28373858.
    Citations: 8     
  57. Smith SM, Dworkin RH, Turk DC, Baron R, Polydefkis M, Tracey I, Borsook D, Edwards RR, Harris RE, Wager TD, Arendt-Nielsen L, Burke LB, Carr DB, Chappell A, Farrar JT, Freeman R, Gilron I, Goli V, Haeussler J, Jensen T, Katz NP, Kent J, Kopecky EA, Lee DA, Maixner W, Markman JD, McArthur JC, McDermott MP, Parvathenani L, Raja SN, Rappaport BA, Rice ASC, Rowbotham MC, Tobias JK, Wasan AD, Witter J. The Potential Role of Sensory Testing, Skin Biopsy, and Functional Brain Imaging as Biomarkers in Chronic Pain Clinical Trials: IMMPACT Considerations. J Pain. 2017 07; 18(7):757-777. PMID: 28254585.
    Citations: 42     Fields:    Translation:Humans
  58. Fedorowski A, Hamrefors V, Sutton R, van Dijk JG, Freeman R, Lenders JW, Wieling W. Do we need to evaluate diastolic blood pressure in patients with suspected orthostatic hypotension? Clin Auton Res. 2017 Jun; 27(3):167-173. PMID: 28243824.
    Citations: 13     Fields:    Translation:Humans
  59. Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, Freeman R, Truini A, Attal N, Finnerup NB, Eccleston C, Kalso E, Bennett DL, Dworkin RH, Raja SN. Neuropathic pain. Nat Rev Dis Primers. 2017 Feb 16; 3:17002. PMID: 28205574.
    Citations: 368     Fields:    Translation:Humans
  60. Kaufmann H, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Low PA, Singer W, Goldstein DS, Peltier AC, Shibao CA, Gibbons CH, Freeman R, Robertson D. Natural history of pure autonomic failure: A United States prospective cohort. Ann Neurol. 2017 Feb; 81(2):287-297. PMID: 28093795.
    Citations: 90     Fields:    Translation:Humans
  61. Gibbons CH, Schmidt P, Biaggioni I, Frazier-Mills C, Freeman R, Isaacson S, Karabin B, Kuritzky L, Lew M, Low P, Mehdirad A, Raj SR, Vernino S, Kaufmann H. The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension. J Neurol. 2017 Aug; 264(8):1567-1582. PMID: 28050656.
    Citations: 87     Fields:    Translation:Humans
  62. Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, Sosenko JM, Ziegler D. Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2017 01; 40(1):136-154. PMID: 27999003.
    Citations: 392     Fields:    
  63. Gewandter JS, Dworkin RH, Finnerup NB, Freeman R, Mohile NA. Reply. Pain. 2017 01; 158(1):182-183. PMID: 27984531.
    Citations:    Fields:    
  64. Lee JM, Derkinderen P, Kordower JH, Freeman R, Munoz DG, Kremer T, Zago W, Hutten SJ, Adler CH, Serrano GE, Beach TG. The Search for a Peripheral Biopsy Indicator of a-Synuclein Pathology for Parkinson Disease. J Neuropathol Exp Neurol. 2017 01 01; 76(1):2-15. PMID: 28069931.
    Citations: 30     Fields:    Translation:Humans
  65. Gibbons CH, Wang N, Freeman R. Cutaneous Alpha-Synuclein From Paraffin Embedded Autopsy Specimens in Parkinson's Disease. J Parkinsons Dis. 2017; 7(3):503-509. PMID: 28582870.
    Citations: 6     Fields:    Translation:HumansCells
  66. Gewandter JS, Burke L, Cavaletti G, Dworkin RH, Gibbons C, Gover TD, Herrmann DN, Mcarthur JC, McDermott MP, Rappaport BA, Reeve BB, Russell JW, Smith AG, Smith SM, Turk DC, Vinik AI, Freeman R. Content validity of symptom-based measures for diabetic, chemotherapy, and HIV peripheral neuropathy. Muscle Nerve. 2017 03; 55(3):366-372. PMID: 27447116.
    Citations: 5     Fields:    Translation:Humans
  67. Centi J, Freeman R, Gibbons CH, Neargarder S, Canova AO, Cronin-Golomb A. Effects of orthostatic hypotension on cognition in Parkinson disease. Neurology. 2017 Jan 03; 88(1):17-24. PMID: 27903817.
    Citations: 26     Fields:    Translation:Humans
  68. Edwards RR, Dworkin RH, Turk DC, Angst MS, Dionne R, Freeman R, Hansson P, Haroutounian S, Arendt-Nielsen L, Attal N, Baron R, Brell J, Bujanover S, Burke LB, Carr D, Chappell AS, Cowan P, Etropolski M, Fillingim RB, Gewandter JS, Katz NP, Kopecky EA, Markman JD, Nomikos G, Porter L, Rappaport BA, Rice ASC, Scavone JM, Scholz J, Simon LS, Smith SM, Tobias J, Tockarshewsky T, Veasley C, Versavel M, Wasan AD, Wen W, Yarnitsky D. Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations. Pain. 2016 Sep; 157(9):1851-1871. PMID: 27152687.
    Citations: 93     Fields:    Translation:Humans
  69. Taylor AM, Phillips K, Patel KV, Turk DC, Dworkin RH, Beaton D, Clauw DJ, Gignac MAM, Markman JD, Williams DA, Bujanover S, Burke LB, Carr DB, Choy EH, Conaghan PG, Cowan P, Farrar JT, Freeman R, Gewandter J, Gilron I, Goli V, Gover TD, Haddox JD, Kerns RD, Kopecky EA, Lee DA, Malamut R, Mease P, Rappaport BA, Simon LS, Singh JA, Smith SM, Strand V, Tugwell P, Vanhove GF, Veasley C, Walco GA, Wasan AD, Witter J. Assessment of physical function and participation in chronic pain clinical trials: IMMPACT/OMERACT recommendations. Pain. 2016 Sep; 157(9):1836-1850. PMID: 27058676.
    Citations: 49     Fields:    Translation:Humans
  70. Thakur S, Dworkin RH, Freeman R, Gorson KC, Herrmann DN. Pain in acquired inflammatory demyelinating polyneuropathies. Pain. 2016 09; 157(9):1887-1894. PMID: 26945234.
    Citations: 1     Fields:    Translation:Humans
  71. Abuzinadah AR, Sinn DI, Freeman R, Gibbons CH. Blood pressure oscillations in baroreflex failure. Clin Auton Res. 2016 12; 26(6):465-466. PMID: 27541037.
    Citations: 1     Fields:    Translation:Humans
  72. Finnerup NB, Haroutounian S, Kamerman P, Baron R, Bennett DLH, Bouhassira D, Cruccu G, Freeman R, Hansson P, Nurmikko T, Raja SN, Rice ASC, Serra J, Smith BH, Treede RD, Jensen TS. Neuropathic pain: an updated grading system for research and clinical practice. Pain. 2016 08; 157(8):1599-1606. PMID: 27115670.
    Citations: 211     Fields:    Translation:Humans
  73. Gibbons CH, Garcia J, Wang N, Shih LC, Freeman R. The diagnostic discrimination of cutaneous a-synuclein deposition in Parkinson disease. Neurology. 2016 Aug 02; 87(5):505-12. PMID: 27385742.
    Citations: 35     Fields:    Translation:Humans
  74. Ziegler D, Low PA, Freeman R, Tritschler H, Vinik AI. Predictors of improvement and progression of diabetic polyneuropathy following treatment with a-lipoic acid for 4 years in the NATHAN 1 trial. J Diabetes Complications. 2016 Mar; 30(2):350-6. PMID: 26651260.
    Citations: 18     Fields:    Translation:Humans
  75. van Hecke O, Kamerman PR, Attal N, Baron R, Bjornsdottir G, Bennett DLH, Bennett MI, Bouhassira D, Diatchenko L, Freeman R, Freynhagen R, Haanpää M, Jensen TS, Raja SN, Rice ASC, Seltzer Z, Thorgeirsson TE, Yarnitsky D, Smith BH. Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations. Pain. 2015 Nov; 156(11):2337-2353. PMID: 26469320.
    Citations: 20     Fields:    Translation:Humans
  76. Dineen J, Freeman R. Autonomic Neuropathy. Semin Neurol. 2015 Aug; 35(4):458-68. PMID: 26502768.
    Citations: 7     Fields:    Translation:Humans
  77. Rao AD, Bonyhay I, Dankwa J, Baimas-George M, Kneen L, Ballatori S, Freeman R, Adler GK. Baroreflex Sensitivity Impairment During Hypoglycemia: Implications for Cardiovascular Control. Diabetes. 2016 Jan; 65(1):209-15. PMID: 26438610.
    Citations: 6     Fields:    Translation:Humans
  78. Freeman R, Barroso F. Recent advances in familial amyloid polyneuropathy. Curr Opin Neurol. 2015 Oct; 28(5):494-9. PMID: 26356411.
    Citations: 4     Fields:    Translation:Humans
  79. Gibbons CH, Freeman R. Clinical implications of delayed orthostatic hypotension: A 10-year follow-up study. Neurology. 2015 Oct 20; 85(16):1362-7. PMID: 26400576.
    Citations: 37     Fields:    Translation:Humans
  80. Freeman R, Wallace MS, Sweeney M, Backonja MM. Relationships Among Pain Quality, Pain Impact, and Overall Improvement in Patients with Postherpetic Neuralgia Treated with Gastroretentive Gabapentin. Pain Med. 2015 Oct; 16(10):2000-11. PMID: 26115203.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  81. Freeman R, Emir B, Parsons B. Predictors of placebo response in peripheral neuropathic pain: insights from pregabalin clinical trials. J Pain Res. 2015; 8:257-68. PMID: 26082659.
    Citations: 10     
  82. Laurens B, Constantinescu R, Freeman R, Gerhard A, Jellinger K, Jeromin A, Krismer F, Mollenhauer B, Schlossmacher MG, Shaw LM, Verbeek MM, Wenning GK, Winge K, Zhang J, Meissner WG. Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative. Neurobiol Dis. 2015 Aug; 80:29-41. PMID: 25982836.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  83. Freeman R. The puzzle of orthostatic tolerance in hereditary sensory and autonomic neuropathy, type IV. Ann Neurol. 2015 May; 77(5):741-2. PMID: 25866260.
    Citations:    Fields:    Translation:Humans
  84. Gibbons CH, Freeman R. Treatment-induced neuropathy of diabetes: an acute, iatrogenic complication of diabetes. Brain. 2015 Jan; 138(Pt 1):43-52. PMID: 25392197.
    Citations: 47     Fields:    Translation:Humans
  85. Biaggioni I, Freeman R, Mathias CJ, Low P, Hewitt LA, Kaufmann H. Randomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsive to droxidopa. Hypertension. 2015 Jan; 65(1):101-7. PMID: 25350981.
    Citations: 42     Fields:    Translation:HumansCTClinical Trials
  86. Kaufmann H, Freeman R, Biaggioni I, Low P, Pedder S, Hewitt LA, Mauney J, Feirtag M, Mathias CJ. Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial. Neurology. 2014 Jul 22; 83(4):328-35. PMID: 24944260.
    Citations: 71     Fields:    Translation:HumansCTClinical Trials
  87. Fillingim RB, Bruehl S, Dworkin RH, Dworkin SF, Loeser JD, Turk DC, Widerstrom-Noga E, Arnold L, Bennett R, Edwards RR, Freeman R, Gewandter J, Hertz S, Hochberg M, Krane E, Mantyh PW, Markman J, Neogi T, Ohrbach R, Paice JA, Porreca F, Rappaport BA, Smith SM, Smith TJ, Sullivan MD, Verne GN, Wasan AD, Wesselmann U. The ACTTION-American Pain Society Pain Taxonomy (AAPT): an evidence-based and multidimensional approach to classifying chronic pain conditions. J Pain. 2014 Mar; 15(3):241-9. PMID: 24581634.
    Citations: 51     Fields:    Translation:Humans
  88. Low PA, Robertson D, Gilman S, Kaufmann H, Singer W, Biaggioni I, Freeman R, Perlman S, Hauser RA, Cheshire W, Lessig S, Vernino S, Mandrekar J, Dupont WD, Chelimsky T, Galpern WR. Efficacy and safety of rifampicin for multiple system atrophy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2014 Mar; 13(3):268-75. PMID: 24507091.
    Citations: 36     Fields:    Translation:Humans
  89. Freeman R. Diabetic autonomic neuropathy. Handb Clin Neurol. 2014; 126:63-79. PMID: 25410215.
    Citations: 35     Fields:    Translation:HumansAnimals
  90. Gibbons CH, Bonyhay I, Benson A, Wang N, Freeman R. Structural and functional small fiber abnormalities in the neuropathic postural tachycardia syndrome. PLoS One. 2013; 8(12):e84716. PMID: 24386408.
    Citations: 19     Fields:    Translation:HumansCellsCTClinical Trials
  91. Bonyhay I, Risk M, Freeman R. High-pass filter characteristics of the baroreflex--a comparison of frequency domain and pharmacological methods. PLoS One. 2013; 8(11):e79513. PMID: 24244518.
    Citations: 2     Fields:    Translation:Humans
  92. Gibbons C, Cheshire W, Barboi A, Levine B, Olshansky B, Kinsella L, Claydon VE, Crandall C, Fink G, Joyner M, Macefield V, Norcliffe-Kaufmann L, Freeman R, Raj S, Stewart J, Sandroni P, Kaufmann H, Chelimsky T. Endovascular procedures for the treatment of autonomic dysfunction. Clin Auton Res. 2014 Feb; 24(1):1-2. PMID: 24178965.
    Citations:    Fields:    Translation:Humans
  93. Freeman R, Baron R, Bouhassira D, Cabrera J, Emir B. Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs. Pain. 2014 Feb; 155(2):367-376. PMID: 24472518.
    Citations: 62     Fields:    Translation:Humans
  94. Wang N, Gibbons CH, Lafo J, Freeman R. a-Synuclein in cutaneous autonomic nerves. Neurology. 2013 Oct 29; 81(18):1604-10. PMID: 24089386.
    Citations: 82     Fields:    Translation:HumansCells
  95. Harden RN, Freeman R, Rainka M, Zhang L, Bell C, Berges A, Chen C, Graff O, Harding K, Hunter S, Kavanagh S, Schwartzbach C, Warren S, McClung C. A phase 2a, randomized, crossover trial of gabapentin enacarbil for the treatment of postherpetic neuralgia in gabapentin inadequate responders. Pain Med. 2013 Dec; 14(12):1918-32. PMID: 24102928.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  96. Freeman R. New and developing drugs for the treatment of neuropathic pain in diabetes. Curr Diab Rep. 2013 Aug; 13(4):500-8. PMID: 23771401.
    Citations: 5     Fields:    Translation:Humans
  97. Backonja MM, Attal N, Baron R, Bouhassira D, Drangholt M, Dyck PJ, Edwards RR, Freeman R, Gracely R, Haanpaa MH, Hansson P, Hatem SM, Krumova EK, Jensen TS, Maier C, Mick G, Rice AS, Rolke R, Treede RD, Serra J, Toelle T, Tugnoli V, Walk D, Walalce MS, Ware M, Yarnitsky D, Ziegler D. Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus. Pain. 2013 Sep; 154(9):1807-1819. PMID: 23742795.
    Citations: 138     Fields:    Translation:Humans
  98. Gibbons CH, Freeman R, Tecilazich F, Dinh T, Lyons TE, Gnardellis C, Veves A. The evolving natural history of neurophysiologic function in patients with well-controlled diabetes. J Peripher Nerv Syst. 2013 Jun; 18(2):153-61. PMID: 23781962.
    Citations: 8     Fields:    Translation:Humans
  99. Schestatsky P, Simis M, Freeman R, Pascual-Leone A, Fregni F. Non-invasive brain stimulation and the autonomic nervous system. Clin Neurophysiol. 2013 Sep; 124(9):1716-28. PMID: 23684898.
    Citations: 16     Fields:    Translation:Humans
  100. Zhang L, Rainka M, Freeman R, Harden RN, Bell CF, Chen C, Graff O, Harding K, Hunter S, Kavanagh S, Laurijssens B, Schwartzbach C, Warren S, McClung C. A randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of gabapentin enacarbil in subjects with neuropathic pain associated with postherpetic neuralgia (PXN110748). J Pain. 2013 Jun; 14(6):590-603. PMID: 23602345.
    Citations: 14     Fields:    Translation:Humans
  101. Höke A, Simpson DM, Freeman R. Challenges in developing novel therapies for peripheral neuropathies: a summary of The Foundation for Peripheral Neuropathy Scientific Symposium 2012. J Peripher Nerv Syst. 2013 Mar; 18(1):1-6. PMID: 23521637.
    Citations: 1     Fields:    Translation:HumansAnimals
  102. Freeman R. Objective evidence of autonomic dysfunction and the role of stress in the Gulf War syndrome. JAMA Neurol. 2013 Feb; 70(2):158-9. PMID: 23407742.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  103. Freeman R, Chapleau MW. Testing the autonomic nervous system. Handb Clin Neurol. 2013; 115:115-36. PMID: 23931777.
    Citations: 25     Fields:    Translation:HumansAnimals
  104. Siepmann T, Gibbons CH, Illigens BM, Lafo JA, Brown CM, Freeman R. Quantitative pilomotor axon reflex test: a novel test of pilomotor function. Arch Neurol. 2012 Nov; 69(11):1488-92. PMID: 22868966.
    Citations: 10     Fields:    Translation:HumansCells
  105. Raj SR, Freeman R. Highlights in clinical autonomic neurosciences: Orthostatic hypotension: insights into risks and causes. Auton Neurosci. 2012 Sep 25; 170(1-2):3-4. PMID: 22921488.
    Citations:    Fields:    
  106. Gibbons CH, Adler GK, Bonyhay I, Freeman R. Experimental hypoglycemia is a human model of stress-induced hyperalgesia. Pain. 2012 Nov; 153(11):2204-2209. PMID: 22921261.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  107. Cheshire WP, Freeman R. Highlights in clinical autonomic neuroscience: latest discoveries from the octopus pot. Auton Neurosci. 2012 Jul 02; 169(1):4-6. PMID: 22579400.
    Citations: 1     Fields:    
  108. Raj SR, Freeman R. Highlights in clinical autonomic neurosciences: vasovagal syncope - insights on diagnosis, pathophysiology and treatment. Auton Neurosci. 2012 May 21; 168(1-2):1-3. PMID: 22444321.
    Citations: 3     Fields:    
  109. Cheshire WP, Freeman R. Highlights in clinical autonomic neuroscience: latest developments in the early detection of diabetic autonomic neuropathy. Auton Neurosci. 2012 Apr 03; 167(1-2):4-6. PMID: 22306250.
    Citations:    Fields:    
  110. Gibbons CH, Centi J, Vernino S, Freeman R. Autoimmune autonomic ganglionopathy with reversible cognitive impairment. Arch Neurol. 2012 Apr; 69(4):461-6. PMID: 22158721.
    Citations: 13     Fields:    Translation:Humans
  111. Kaufmann H, Malamut R, Norcliffe-Kaufmann L, Rosa K, Freeman R. The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale. Clin Auton Res. 2012 Apr; 22(2):79-90. PMID: 22045363.
    Citations: 72     Fields:    Translation:HumansCTClinical Trials
  112. Spallone V, Ziegler D, Freeman R, Bernardi L, Frontoni S, Pop-Busui R, Stevens M, Kempler P, Hilsted J, Tesfaye S, Low P, Valensi P. Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management. Diabetes Metab Res Rev. 2011 Oct; 27(7):639-53. PMID: 21695768.
    Citations: 245     Fields:    Translation:Humans
  113. Bernardi L, Spallone V, Stevens M, Hilsted J, Frontoni S, Pop-Busui R, Ziegler D, Kempler P, Freeman R, Low P, Tesfaye S, Valensi P. Methods of investigation for cardiac autonomic dysfunction in human research studies. Diabetes Metab Res Rev. 2011 Oct; 27(7):654-64. PMID: 21695761.
    Citations: 58     Fields:    Translation:Humans
  114. Ziegler D, Low PA, Litchy WJ, Boulton AJ, Vinik AI, Freeman R, Samigullin R, Tritschler H, Munzel U, Maus J, Schütte K, Dyck PJ. Efficacy and safety of antioxidant treatment with a-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care. 2011 Sep; 34(9):2054-60. PMID: 21775755.
    Citations: 105     Fields:    Translation:Humans
  115. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz I, Schondorff R, Stewart JM, van Dijk JG. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011 Apr; 21(2):69-72. PMID: 21431947.
    Citations: 414     Fields:    Translation:Humans
  116. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz IJ, Schondorf R, Stewart JM, van Dijk JG. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Auton Neurosci. 2011 Apr 26; 161(1-2):46-8. PMID: 21393070.
    Citations: 125     Fields:    Translation:Humans
  117. Wang N, Gibbons CH, Freeman R. Novel immunohistochemical techniques using discrete signal amplification systems for human cutaneous peripheral nerve fiber imaging. J Histochem Cytochem. 2011 Apr; 59(4):382-90. PMID: 21411809.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  118. Gibbons CH, Wang N, Freeman R. Capsaicin induces degeneration of cutaneous autonomic nerve fibers. Ann Neurol. 2010 Dec; 68(6):888-98. PMID: 21061393.
    Citations: 40     Fields:    Translation:HumansCTClinical Trials
  119. Adler GK, Bonyhay I, Curren V, Waring E, Freeman R. Hypoglycaemia increases aldosterone in a dose-dependent fashion. Diabet Med. 2010 Nov; 27(11):1250-5. PMID: 20950382.
    Citations: 3     Fields:    Translation:Humans
  120. Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, Lauria G, Malik RA, Spallone V, Vinik A, Bernardi L, Valensi P. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010 Oct; 33(10):2285-93. PMID: 20876709.
    Citations: 680     Fields:    Translation:Humans
  121. Gibbons CH, Freeman R, Veves A. Diabetic neuropathy: a cross-sectional study of the relationships among tests of neurophysiology. Diabetes Care. 2010 Dec; 33(12):2629-34. PMID: 20805259.
    Citations: 20     Fields:    Translation:Humans
  122. Gibbons CH, Illigens BM, Wang N, Freeman R. Quantification of sudomotor innervation: a comparison of three methods. Muscle Nerve. 2010 Jul; 42(1):112-9. PMID: 20544913.
    Citations: 17     Fields:    Translation:HumansCells
  123. Gibbons CH, Freeman R. Treatment-induced diabetic neuropathy: a reversible painful autonomic neuropathy. Ann Neurol. 2010 Apr; 67(4):534-41. PMID: 20437589.
    Citations: 51     Fields:    Translation:HumansCells
  124. Simpson DM, Schifitto G, Clifford DB, Murphy TK, Durso-De Cruz E, Glue P, Whalen E, Emir B, Scott GN, Freeman R. Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial. Neurology. 2010 Feb 02; 74(5):413-20. PMID: 20124207.
    Citations: 54     Fields:    Translation:Humans
  125. Freeman R. Not all neuropathy in diabetes is of diabetic etiology: differential diagnosis of diabetic neuropathy. Curr Diab Rep. 2009 Dec; 9(6):423-31. PMID: 19954686.
    Citations: 11     Fields:    Translation:Humans
  126. Gibbons CH, Illigens BM, Wang N, Freeman R. Quantification of sweat gland innervation: a clinical-pathologic correlation. Neurology. 2009 Apr 28; 72(17):1479-86. PMID: 19398703.
    Citations: 47     Fields:    Translation:HumansCells
  127. Gibbons CH, Freeman R. Antibody titers predict clinical features of autoimmune autonomic ganglionopathy. Auton Neurosci. 2009 Mar 12; 146(1-2):8-12. PMID: 19144572.
    Citations: 19     Fields:    Translation:Humans
  128. Adler GK, Bonyhay I, Failing H, Waring E, Dotson S, Freeman R. Antecedent hypoglycemia impairs autonomic cardiovascular function: implications for rigorous glycemic control. Diabetes. 2009 Feb; 58(2):360-6. PMID: 19056608.
    Citations: 79     Fields:    Translation:Humans
  129. Lair L, Gibbons C, Freeman R. Phantom sweating: a novel autonomic paresthesia. Clin Auton Res. 2008 Dec; 18(6):352-4. PMID: 18850064.
    Citations:    Fields:    Translation:Humans
  130. Gibbons CH, Illigens BM, Centi J, Freeman R. QDIRT: quantitative direct and indirect test of sudomotor function. Neurology. 2008 Jun 10; 70(24):2299-304. PMID: 18541883.
    Citations: 20     Fields:    Translation:HumansCells
  131. Freeman R. Current pharmacologic treatment for orthostatic hypotension. Clin Auton Res. 2008 Mar; 18 Suppl 1:14-8. PMID: 18368302.
    Citations: 11     Fields:    Translation:Humans
  132. Freeman R, Durso-Decruz E, Emir B. Efficacy, safety, and tolerability of pregabalin treatment for painful diabetic peripheral neuropathy: findings from seven randomized, controlled trials across a range of doses. Diabetes Care. 2008 Jul; 31(7):1448-54. PMID: 18356405.
    Citations: 72     Fields:    Translation:Humans
  133. Dotson S, Freeman R, Failing HJ, Adler GK. Hypoglycemia increases serum interleukin-6 levels in healthy men and women. Diabetes Care. 2008 Jun; 31(6):1222-3. PMID: 18332163.
    Citations: 29     Fields:    Translation:Humans
  134. Freeman R. A treatment for neurally mediated syncope? (Don't) hold your breath. Ann Neurol. 2008 Mar; 63(3):265-7. PMID: 18383075.
    Citations: 2     Fields:    Translation:HumansAnimals
  135. Freeman R. Clinical practice. Neurogenic orthostatic hypotension. N Engl J Med. 2008 Feb 07; 358(6):615-24. PMID: 18256396.
    Citations: 104     Fields:    Translation:Humans
  136. Gibbons CH, Vernino SA, Freeman R. Combined immunomodulatory therapy in autoimmune autonomic ganglionopathy. Arch Neurol. 2008 Feb; 65(2):213-7. PMID: 18268189.
    Citations: 19     Fields:    Translation:Humans
  137. Ahn AC, Bennani T, Freeman R, Hamdy O, Kaptchuk TJ. Two styles of acupuncture for treating painful diabetic neuropathy--a pilot randomised control trial. Acupunct Med. 2007 Jun; 25(1-2):11-7. PMID: 17641562.
    Citations: 25     Fields:    Translation:Humans
  138. Freeman R, McIntosh KA, Vijapurkar U, Thienel U. Topiramate and physiologic measures of nerve function in polyneuropathy. Acta Neurol Scand. 2007 Apr; 115(4):222-31. PMID: 17376119.
    Citations: 1     Fields:    Translation:Humans
  139. Bonyhay I, Freeman R. Sympathetic neural activity, sex dimorphism, and postural tachycardia syndrome. Ann Neurol. 2007 Apr; 61(4):332-9. PMID: 17358006.
    Citations: 6     Fields:    Translation:Humans
  140. Cornblath DR, Vinik A, Feldman E, Freeman R, Boulton AJ. Surgical decompression for diabetic sensorimotor polyneuropathy. Diabetes Care. 2007 Feb; 30(2):421-2. PMID: 17259523.
    Citations: 10     Fields:    Translation:Humans
  141. Freeman R. Autonomic peripheral neuropathy. Neurol Clin. 2007 Feb; 25(1):277-301. PMID: 17324728.
    Citations: 7     Fields:    Translation:Humans
  142. Freeman R, Raskin P, Hewitt DJ, Vorsanger GJ, Jordan DM, Xiang J, Rosenthal NR. Randomized study of tramadol/acetaminophen versus placebo in painful diabetic peripheral neuropathy. Curr Med Res Opin. 2007 Jan; 23(1):147-61. PMID: 17257476.
    Citations: 32     Fields:    Translation:Humans
  143. Gibbons CH, Freeman R. Delayed orthostatic hypotension: a frequent cause of orthostatic intolerance. Neurology. 2006 Jul 11; 67(1):28-32. PMID: 16832073.
    Citations: 64     Fields:    Translation:Humans
  144. Berghoff M, Kilo S, Hilz MJ, Freeman R. Differential impairment of the sudomotor and nociceptor axon-reflex in diabetic peripheral neuropathy. Muscle Nerve. 2006 Apr; 33(4):494-9. PMID: 16411196.
    Citations: 9     Fields:    Translation:HumansCells
  145. Latov N, Gorson KC, Brannagan TH, Freeman RL, Apostolski S, Berger AR, Bradley WG, Briani C, Bril V, Busis NA, Cros DP, Dalakas MC, Donofrio PD, Dyck PJ, England JD, Fisher MA, Herrmann DN, Menkes DL, Sahenk Z, Sander HW, Triggs WJ, Vallat JM. Diagnosis and Treatment of Chronic Immune-mediated Neuropathies. J Clin Neuromuscul Dis. 2006 Mar; 7(3):141-57. PMID: 19078800.
    Citations: 1     Fields:    
  146. Gibbons CH, Freeman R. Treatment options for autonomic neuropathies. Curr Treat Options Neurol. 2006 Mar; 8(2):119-32. PMID: 16464408.
    Citations: 3     
  147. Freeman R. Assessment of cardiovascular autonomic function. Clin Neurophysiol. 2006 Apr; 117(4):716-30. PMID: 16464634.
    Citations: 55     Fields:    Translation:HumansAnimals
  148. Freeman R. Cardiovascular manifestations of autonomic epilepsy. Clin Auton Res. 2006 Feb; 16(1):12-7. PMID: 16477490.
    Citations: 9     Fields:    Translation:HumansAnimals
  149. Freeman R. Newer agents for the treatment of painful diabetic peripheral neuropathy. Curr Diab Rep. 2005 Dec; 5(6):409-16. PMID: 16316590.
    Citations: 1     Fields:    Translation:HumansAnimals
  150. Freeman R, Gibbons C. Is time of the essence? The continuing search for a noninvasive measure of sympathetic adrenergic function. Neurology. 2005 Nov 22; 65(10):1517. PMID: 16304717.
    Citations:    Fields:    Translation:HumansCells
  151. Gibbons CH, Vernino SA, Kaufmann H, Freeman R. L-DOPS therapy for refractory orthostatic hypotension in autoimmune autonomic neuropathy. Neurology. 2005 Oct 11; 65(7):1104-6. PMID: 16217067.
    Citations: 7     Fields:    Translation:Humans
  152. Freeman R. The treatment of neuropathic pain. CNS Spectr. 2005 Sep; 10(9):698-706. PMID: 16142210.
    Citations: 5     Fields:    Translation:HumansCells
  153. Boulton AJ, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, Malik RA, Maser RE, Sosenko JM, Ziegler D. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care. 2005 Apr; 28(4):956-62. PMID: 15793206.
    Citations: 541     Fields:    Translation:Humans
  154. Gibbons CH, Freeman R. Autonomic neuropathy and coeliac disease. J Neurol Neurosurg Psychiatry. 2005 Apr; 76(4):579-81. PMID: 15774451.
    Citations: 10     Fields:    Translation:Humans
  155. Freeman R. Autonomic peripheral neuropathy. Lancet. 2005 Apr 2-8; 365(9466):1259-70. PMID: 15811460.
    Citations: 60     Fields:    Translation:Humans
  156. Gibbons CH, Freeman R. Orthostatic dyspnea: a neglected symptom of orthostatic hypotension. Clin Auton Res. 2005 Feb; 15(1):40-4. PMID: 15768201.
    Citations: 16     Fields:    Translation:Humans
  157. Goldstein DS, Holmes C, Kaufmann H, Freeman R. Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failure. Clin Auton Res. 2004 Dec; 14(6):363-8. PMID: 15666063.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  158. Bonyhay I, Freeman R. Sympathetic nerve activity in response to hypotensive stress in the postural tachycardia syndrome. Circulation. 2004 Nov 16; 110(20):3193-8. PMID: 15533861.
    Citations: 34     Fields:    Translation:HumansCells
  159. Kaufmann H, Freeman R. Pharmacological treatment of reflex syncope. Clin Auton Res. 2004 Oct; 14 Suppl 1:71-5. PMID: 15480933.
    Citations: 4     Fields:    Translation:Humans
  160. Wieling W, Colman N, Krediet CT, Freeman R. Nonpharmacological treatment of reflex syncope. Clin Auton Res. 2004 Oct; 14 Suppl 1:62-70. PMID: 15480932.
    Citations: 16     Fields:    Translation:Humans
  161. Freeman R. Pure autonomic failure: an immaculate misconception? Neurology. 2004 Sep 28; 63(6):953-4. PMID: 15452282.
    Citations: 1     Fields:    Translation:HumansCells
  162. Gibbons C, Freeman R. The evaluation of small fiber function-autonomic and quantitative sensory testing. Neurol Clin. 2004 Aug; 22(3):683-702, vii. PMID: 15207880.
    Citations: 12     Fields:    Translation:HumansCells
  163. Freeman R. Assessment of cardiovascular autonomic function. Suppl Clin Neurophysiol. 2004; 57:369-75. PMID: 16106635.
    Citations: 2     Fields:    Translation:Humans
  164. Berger AR, Bradley WG, Brannagan TH, Busis NA, Cros DP, Dalakas MC, Danon MJ, Donofrio P, Engel WK, England JD, Feldman EL, Freeman RL, Kinsella LJ, Lacomis D, Latov N, Menkes DL, Sander HW, Thomas FP, Triggs WJ, Windebank AJ, Wolfe GI. Guidelines for the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy. J Peripher Nerv Syst. 2003 Dec; 8(4):282-4. PMID: 14641652.
    Citations: 11     Fields:    Translation:HumansCells
  165. Vinik AI, Freeman R, Erbas T. Diabetic autonomic neuropathy. Semin Neurol. 2003 Dec; 23(4):365-72. PMID: 15088257.
    Citations: 47     Fields:    Translation:HumansAnimals
  166. Freeman R. Treatment of orthostatic hypotension. Semin Neurol. 2003 Dec; 23(4):435-42. PMID: 15088264.
    Citations: 21     Fields:    Translation:HumansAnimals
  167. Cheshire WP, Freeman R. Disorders of sweating. Semin Neurol. 2003 Dec; 23(4):399-406. PMID: 15088261.
    Citations: 21     Fields:    Translation:HumansAnimals
  168. Risk MR, Lirofonis V, Armentano RL, Freeman R. A biphasic model of limb venous compliance: a comparison with linear and exponential models. J Appl Physiol (1985). 2003 Sep; 95(3):1207-15. PMID: 12909601.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  169. Kaufmann H, Saadia D, Voustianiouk A, Goldstein DS, Holmes C, Yahr MD, Nardin R, Freeman R. Norepinephrine precursor therapy in neurogenic orthostatic hypotension. Circulation. 2003 Aug 12; 108(6):724-8. PMID: 12885750.
    Citations: 56     Fields:    Translation:HumansCTClinical Trials
  170. Nahm F, Freeman R. Sphincter electromyography and multiple system atrophy. Muscle Nerve. 2003 Jul; 28(1):18-26. PMID: 12811769.
    Citations: 2     Fields:    Translation:Humans
  171. Maser RE, Mitchell BD, Vinik AI, Freeman R. The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis. Diabetes Care. 2003 Jun; 26(6):1895-901. PMID: 12766130.
    Citations: 193     Fields:    Translation:Humans
  172. Berghoff M, Kathpal M, Khan F, Skinner M, Falk R, Freeman R. Endothelial dysfunction precedes C-fiber abnormalities in primary (AL) amyloidosis. Ann Neurol. 2003 Jun; 53(6):725-30. PMID: 12783418.
    Citations: 17     Fields:    Translation:HumansCells
  173. Vinik AI, Maser RE, Mitchell BD, Freeman R. Diabetic autonomic neuropathy. Diabetes Care. 2003 May; 26(5):1553-79. PMID: 12716821.
    Citations: 460     Fields:    Translation:Humans
  174. Freeman R, Chase KP, Risk MR. Quantitative sensory testing cannot differentiate simulated sensory loss from sensory neuropathy. Neurology. 2003 Feb 11; 60(3):465-70. PMID: 12578928.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  175. Nahm F, Freeman R. Syncope and the history of nervous influences on the heart. Arch Neurol. 2003 Feb; 60(2):282-7. PMID: 12580718.
    Citations:    Fields:    Translation:Humans
  176. Freeman R. The chronic fatigue syndrome is a disease of the autonomic nervous system. Sometimes. Clin Auton Res. 2002 Aug; 12(4):231-3. PMID: 12357274.
    Citations: 3     Fields:    Translation:Humans
  177. Freeman R, Lirofonis V, Farquhar WB, Risk M. Limb venous compliance in patients with idiopathic orthostatic intolerance and postural tachycardia. J Appl Physiol (1985). 2002 Aug; 93(2):636-44. PMID: 12133874.
    Citations: 21     Fields:    Translation:Humans
  178. Gutierrez J, Santiesteban R, Garcia H, Voustianiouk A, Freeman R, Kaufmann H. High blood pressure and decreased heart rate variability in the Cuban epidemic neuropathy. J Neurol Neurosurg Psychiatry. 2002 Jul; 73(1):71-2. PMID: 12082051.
    Citations: 2     Fields:    Translation:Humans
  179. Lopez MR, Freeman R, Schomer D. Spindle coma secondary to vasovagal syncope. Epilepsy Behav. 2002 Jun; 3(3):289-291. PMID: 12662612.
    Citations: 1     Fields:    
  180. Berghoff M, Kathpal M, Kilo S, Hilz MJ, Freeman R. Vascular and neural mechanisms of ACh-mediated vasodilation in the forearm cutaneous microcirculation. J Appl Physiol (1985). 2002 Feb; 92(2):780-8. PMID: 11796692.
    Citations: 30     Fields:    Translation:HumansCells
  181. Farquhar WB, Hunt BE, Taylor JA, Darling SE, Freeman R. Blood volume and its relation to peak O(2) consumption and physical activity in patients with chronic fatigue. Am J Physiol Heart Circ Physiol. 2002 Jan; 282(1):H66-71. PMID: 11748048.
    Citations: 15     Fields: