Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Roy Lester Freeman, M.B.Ch.B.

Title
Institution
Department
Address
Phone
Fax
Profile Picture

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS105844 (FREEMAN, ROY) May 15, 2019 - Mar 31, 2024
    NIH
    The functional neuroanatomy of the human physiological stress response
    Role: Principal Investigator
  2. R01HL111465 (FREEMAN, ROY) Aug 27, 2013 - Jun 30, 2019
    NIH
    Hypoglycemia, Cardiovascular Autonomic Function and Type 2 Diabetes Mellitus
    Role: Principal Investigator
  3. R01HL109634 (FREEMAN, ROY) Sep 1, 2011 - Jun 30, 2016
    NIH
    Hypoglycemia, mineralocorticoid receptor and autonomic control
    Role: Principal Investigator
  4. U54NS065736 (ROBERTSON, DAVID HERLIE) Jul 1, 2009 - Jun 30, 2019
    NIH/NINDS
    Autonomic Rare Diseases Clinical Research Consortium
    Role: Co-Principal Investigator
  5. R01DK063296 (FREEMAN, ROY) Sep 30, 2003 - Jul 31, 2009
    NIH
    HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTION
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Doshi TL, Dworkin RH, Polomano RC, Carr DB, Edwards RR, Finnerup NB, Freeman RL, Paice JA, Weisman SJ, Raja SN. AAAPT Diagnostic Criteria for Acute Neuropathic Pain. Pain Med. 2021 Mar 18; 22(3):616-636. PMID: 33575803.
    Citations:    Fields:    
  2. Gibbons CH, Silva G, Freeman R. Cardiovascular exercise as a treatment of postural orthostatic tachycardia syndrome: A pragmatic treatment trial. Heart Rhythm. 2021 Jan 19. PMID: 33482385.
    Citations: 1     Fields:    
  3. Cheshire WP, Freeman R, Gibbons CH, Cortelli P, Wenning GK, Hilz MJ, Spies JM, Lipp A, Sandroni P, Wada N, Mano A, Ah Kim H, Kimpinski K, Iodice V, Idiáquez J, Thaisetthawatkul P, Coon EA, Low PA, Singer W. Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology. Clin Neurophysiol. 2021 Feb; 132(2):666-682. PMID: 33419664.
    Citations: 1     Fields:    
  4. Smith SM, Dworkin RH, Turk DC, McDermott MP, Eccleston C, Farrar JT, Rowbotham MC, Bhagwagar Z, Burke LB, Cowan P, Ellenberg SS, Evans SR, Freeman RL, Garrison LP, Iyengar S, Jadad A, Jensen MP, Junor R, Kamp C, Katz NP, Kesslak JP, Kopecky EA, Lissin D, Markman JD, Mease PJ, O'Connor AB, Patel KV, Raja SN, Sampaio C, Schoenfeld D, Singh J, Steigerwald I, Strand V, Tive LA, Tobias J, Wasan AD, Wilson HD. Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations. Pain. 2020 11; 161(11):2446-2461. PMID: 32520773.
    Citations: 2     Fields:    Translation:Humans
  5. Freeman R, Gewandter JS, Faber CG, Gibbons C, Haroutounian S, Lauria G, Levine T, Malik RA, Singleton JR, Smith AG, Bell J, Dworkin RH, Feldman E, Herrmann DN, Hoke A, Kolb N, Mansikka H, Oaklander AL, Peltier A, Polydefkis M, Ritt E, Russell JW, Sainati S, Steiner D, Treister R, Üçeyler N. Idiopathic distal sensory polyneuropathy: ACTTION diagnostic criteria. Neurology. 2020 12 01; 95(22):1005-1014. PMID: 33055271.
    Citations:    Fields:    Translation:HumansCells
  6. Koulouris AE, Edwards RR, Dorado K, Schreiber KL, Lazaridou A, Rajan S, White J, Garcia J, Gibbons C, Freeman R. Reliability and Validity of the Boston Bedside Quantitative Sensory Testing Battery for Neuropathic Pain. Pain Med. 2020 10 01; 21(10):2336-2347. PMID: 32895703.
    Citations: 1     Fields:    
  7. Haroutounian S, Todorovic MS, Leinders M, Campagnolo M, Gewandter JS, Dworkin RH, Freeman R. Diagnostic criteria for idiopathic small fiber neuropathy: A systematic review. Muscle Nerve. 2021 02; 63(2):170-177. PMID: 32989823.
    Citations: 1     Fields:    Translation:HumansCells
  8. Wang N, Garcia J, Freeman R, Gibbons CH. Phosphorylated Alpha-Synuclein Within Cutaneous Autonomic Nerves of Patients With Parkinson's Disease: The Implications of Sample Thickness on Results. J Histochem Cytochem. 2020 10; 68(10):669-678. PMID: 32921251.
    Citations:    Fields:    Translation:HumansCells
  9. Gibbons CH, Freeman R. Delayed orthostatic hypotension. Auton Neurosci. 2020 12; 229:102724. PMID: 32942225.
    Citations:    Fields:    
  10. Leung JH, Bayomy OF, Bonyhay I, Celli J, White J, Freeman R, Adler GK. ACTH Infusion Impairs Baroreflex Sensitivity-Implications for Cardiovascular Hypoglycemia-Associated Autonomic Failure. J Clin Endocrinol Metab. 2020 07 01; 105(7). PMID: 32353115.
    Citations:    Fields:    Translation:Humans
  11. Sohn E, Suh BC, Wang N, Freeman R, Gibbons CH. A novel method to quantify cutaneous vascular innervation. Muscle Nerve. 2020 10; 62(4):492-501. PMID: 32270499.
    Citations: 1     Fields:    Translation:Humans
  12. Freeman R, Illigens BMW, Lapusca R, Campagnolo M, Abuzinadah AR, Bonyhay I, Sinn DI, Miglis M, White J, Gibbons CH. Symptom Recognition Is Impaired in Patients With Orthostatic Hypotension. Hypertension. 2020 05; 75(5):1325-1332. PMID: 32223377.
    Citations: 7     Fields:    
  13. Gibbons CH, Wang N, Kim JY, Campagnolo M, Freeman R. Skin Biopsy in Evaluation of Autonomic Disorders. Continuum (Minneap Minn). 2020 Feb; 26(1):200-212. PMID: 31996629.
    Citations: 1     Fields:    Translation:Humans
  14. Freeman R. Autonomic Peripheral Neuropathy. Continuum (Minneap Minn). 2020 Feb; 26(1):58-71. PMID: 31996622.
    Citations:    Fields:    Translation:Humans
  15. Barboi A, Gibbons CH, Axelrod F, Benarroch EE, Biaggioni I, Chapleau MW, Chelimsky G, Chelimsky T, Cheshire WP, Claydon VE, Freeman R, Goldstein DS, Joyner MJ, Kaufmann H, Low PA, Norcliffe-Kaufmann L, Robertson D, Shibao CA, Singer W, Snapper H, Vernino S, Raj SR. Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. Auton Neurosci. 2020 01; 223:102550. PMID: 31928708.
    Citations: 2     Fields:    Translation:Humans
  16. Gewandter JS, Dworkin RH, Turk DC, Devine EG, Hewitt D, Jensen MP, Katz NP, Kirkwood AA, Malamut R, Markman JD, Vrijens B, Burke L, Campbell JN, Carr DB, Conaghan PG, Cowan P, Doyle MK, Edwards RR, Evans SR, Farrar JT, Freeman R, Gilron I, Juge D, Kerns RD, Kopecky EA, McDermott MP, Niebler G, Patel KV, Rauck R, Rice ASC, Rowbotham M, Sessler NE, Simon LS, Singla N, Skljarevski V, Tockarshewsky T, Vanhove GF, Wasan AD, Witter J. Improving Study Conduct and Data Quality in Clinical Trials of Chronic Pain Treatments: IMMPACT Recommendations. J Pain. 2020 Sep - Oct; 21(9-10):931-942. PMID: 31843583.
    Citations: 8     Fields:    
  17. Barboi A, Gibbons CH, Bennaroch EE, Biaggioni I, Chapleau MW, Chelimsky G, Chelimsky T, Cheshire WP, Claydon VE, Freeman R, Goldstein DS, Joyner MJ, Kaufmann H, Low PA, Norcliffe-Kaufmann L, Robertson D, Shibao CA, Singer W, Snapper H, Vernino S, Raj SR. Response to: Human papillomavirus (HPV) vaccine safety concerning POTS, CRPS and related conditions. Clin Auton Res. 2020 04; 30(2):183-184. PMID: 31802304.
    Citations:    Fields:    Translation:HumansCells
  18. Isonaka R, Gibbons CH, Wang N, Freeman R, Goldstein DS. Association of innervation-adjusted alpha-synuclein in arrector pili muscles with cardiac noradrenergic deficiency in autonomic synucleinopathies. Clin Auton Res. 2019 12; 29(6):587-593. PMID: 31673840.
    Citations: 2     Fields:    Translation:HumansCells
  19. Barboi A, Gibbons CH, Axelrod F, Benarroch EE, Biaggioni I, Chapleau MW, Chelimsky G, Chelimsky T, Cheshire WP, Claydon VE, Freeman R, Goldstein DS, Joyner MJ, Kaufmann H, Low PA, Norcliffe-Kaufmann L, Robertson D, Shibao CA, Singer W, Snapper H, Vernino S, Raj SR. Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. Clin Auton Res. 2020 02; 30(1):13-18. PMID: 31475305.
    Citations: 3     Fields:    
  20. Gewandter JS, Gibbons CH, Campagnolo M, Lee J, Chaudari J, Ward N, Burke L, Cavaletti G, Herrmann DN, McArthur JC, Russell JW, Smith AG, Smith SM, Turk DC, Dworkin RH, Freeman R. Clinician-rated measures for distal symmetrical axonal polyneuropathy: ACTTION systematic review. Neurology. 2019 08 20; 93(8):346-360. PMID: 31320471.
    Citations: 3     Fields:    Translation:Humans
  21. Stankovic I, Quinn N, Vignatelli L, Antonini A, Berg D, Coon E, Cortelli P, Fanciulli A, Ferreira JJ, Freeman R, Halliday G, Höglinger GU, Iodice V, Kaufmann H, Klockgether T, Kostic V, Krismer F, Lang A, Levin J, Low P, Mathias C, Meissner WG, Kaufmann LN, Palma JA, Panicker JN, Pellecchia MT, Sakakibara R, Schmahmann J, Scholz SW, Singer W, Stamelou M, Tolosa E, Tsuji S, Seppi K, Poewe W, Wenning GK. A critique of the second consensus criteria for multiple system atrophy. Mov Disord. 2019 07; 34(7):975-984. PMID: 31034671.
    Citations: 13     Fields:    Translation:Humans
  22. Karlsson P, Hincker AM, Jensen TS, Freeman R, Haroutounian S. Structural, functional, and symptom relations in painful distal symmetric polyneuropathies: a systematic review. Pain. 2019 Feb; 160(2):286-297. PMID: 30157133.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  23. Thomas S, Ajroud-Driss S, Dimachkie MM, Gibbons C, Freeman R, Simpson DM, Singleton JR, Smith AG, Höke A. Peripheral Neuropathy Research Registry: A prospective cohort. J Peripher Nerv Syst. 2019 03; 24(1):39-47. PMID: 30629307.
    Citations: 1     Fields:    Translation:Humans
  24. González-Duarte A, Cárdenas-Soto K, Fueyo O, Bañuelos CE, Gibbons C, Freeman R. Small fibre neuropathy assessments in early stages of hATTR amyloidosis. Amyloid. 2019; 26(sup1):55-56. PMID: 31343296.
    Citations:    Fields:    Translation:Humans
  25. Freeman R, Edwards R, Baron R, Bruehl S, Cruccu G, Dworkin RH, Haroutounian S. AAPT Diagnostic Criteria for Peripheral Neuropathic Pain: Focal and Segmental Disorders. J Pain. 2019 04; 20(4):369-393. PMID: 30527971.
    Citations: 5     Fields:    Translation:Humans
  26. Freeman R, Abuzinadah AR, Gibbons C, Jones P, Miglis MG, Sinn DI. Orthostatic Hypotension: JACC State-of-the-Art Review. J Am Coll Cardiol. 2018 09 11; 72(11):1294-1309. PMID: 30190008.
    Citations: 20     Fields:    Translation:Humans
  27. Gewandter JS, Brell J, Cavaletti G, Dougherty PM, Evans S, Howie L, McDermott MP, O'Mara A, Smith AG, Dastros-Pitei D, Gauthier LR, Haroutounian S, Jarpe M, Katz NP, Loprinzi C, Richardson P, Lavoie-Smith EM, Wen PY, Turk DC, Dworkin RH, Freeman R. Trial designs for chemotherapy-induced peripheral neuropathy prevention: ACTTION recommendations. Neurology. 2018 08 28; 91(9):403-413. PMID: 30054438.
    Citations: 14     Fields:    Translation:Humans
  28. Norcliffe-Kaufmann L, Kaufmann H, Palma JA, Shibao CA, Biaggioni I, Peltier AC, Singer W, Low PA, Goldstein DS, Gibbons CH, Freeman R, Robertson D. Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies. Ann Neurol. 2018 03; 83(3):522-531. PMID: 29405350.
    Citations: 27     Fields:    Translation:Humans
  29. Wadhawan S, Pant S, Golhar R, Kirov S, Thompson J, Jacobsen L, Qureshi I, Ajroud-Driss S, Freeman R, Simpson DM, Smith AG, Hoke A, Bristow LJ. NaV channel variants in patients with painful and nonpainful peripheral neuropathy. Neurol Genet. 2017 Dec; 3(6):e207. PMID: 29264398.
    Citations: 7     
  30. Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang J. Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting. Neurology. 2018 01 09; 90(2):74-82. PMID: 29237794.
    Citations: 5     Fields:    Translation:Humans
  31. Centi J, Freeman R, Gibbons CH, Neargarder S, Canova AO, Cronin-Golomb A. Author response: Effects of orthostatic hypotension on cognition in Parkinson disease. Neurology. 2017 11 14; 89(20):2122. PMID: 29133613.
    Citations:    Fields:    Translation:Humans
  32. Terkelsen AJ, Karlsson P, Lauria G, Freeman R, Finnerup NB, Jensen TS. The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol. 2017 11; 16(11):934-944. PMID: 29029847.
    Citations: 18     Fields:    Translation:Humans
  33. Gewandter JS, Freeman R, Kitt RA, Cavaletti G, Gauthier LR, McDermott MP, Mohile NA, Mohlie SG, Smith AG, Tejani MA, Turk DC, Dworkin RH. Chemotherapy-induced peripheral neuropathy clinical trials: Review and recommendations. Neurology. 2017 Aug 22; 89(8):859-869. PMID: 28747442.
    Citations: 10     Fields:    Translation:Humans
  34. Siepmann T, Pintér A, Buchmann SJ, Stibal L, Arndt M, Kubasch AS, Kubasch ML, Penzlin AI, Frenz E, Zago W, Horváth T, Szatmári S, Bereczki D, Takáts A, Ziemssen T, Lipp A, Freeman R, Reichmann H, Barlinn K, Illigens BM. Cutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson's Disease (CAPTURE PD): Protocol for a Multicenter Study. Front Neurol. 2017; 8:212. PMID: 28603514.
    Citations: 5     
  35. Gibbons CH, Simon DK, Huang M, Tilley B, Aminoff MJ, Bainbridge JL, Brodsky M, Freeman R, Goudreau J, Hamill RW, Luo ST, Singer C, Videnovic A, Bodis-Wollner I, Wong PS. Autonomic and electrocardiographic findings in Parkinson's disease. Auton Neurosci. 2017 07; 205:93-98. PMID: 28506500.
    Citations: 2     Fields:    Translation:Humans
  36. Serrador JM, Freeman R. Enhanced Cholinergic Activity Improves Cerebral Blood Flow during Orthostatic Stress. Front Neurol. 2017; 8:103. PMID: 28373858.
    Citations: 6     
  37. Smith SM, Dworkin RH, Turk DC, Baron R, Polydefkis M, Tracey I, Borsook D, Edwards RR, Harris RE, Wager TD, Arendt-Nielsen L, Burke LB, Carr DB, Chappell A, Farrar JT, Freeman R, Gilron I, Goli V, Haeussler J, Jensen T, Katz NP, Kent J, Kopecky EA, Lee DA, Maixner W, Markman JD, McArthur JC, McDermott MP, Parvathenani L, Raja SN, Rappaport BA, Rice ASC, Rowbotham MC, Tobias JK, Wasan AD, Witter J. The Potential Role of Sensory Testing, Skin Biopsy, and Functional Brain Imaging as Biomarkers in Chronic Pain Clinical Trials: IMMPACT Considerations. J Pain. 2017 07; 18(7):757-777. PMID: 28254585.
    Citations: 25     Fields:    Translation:Humans
  38. Fedorowski A, Hamrefors V, Sutton R, van Dijk JG, Freeman R, Lenders JW, Wieling W. Do we need to evaluate diastolic blood pressure in patients with suspected orthostatic hypotension? Clin Auton Res. 2017 Jun; 27(3):167-173. PMID: 28243824.
    Citations: 7     Fields:    Translation:Humans
  39. Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, Freeman R, Truini A, Attal N, Finnerup NB, Eccleston C, Kalso E, Bennett DL, Dworkin RH, Raja SN. Neuropathic pain. Nat Rev Dis Primers. 2017 Feb 16; 3:17002. PMID: 28205574.
    Citations: 200     Fields:    Translation:Humans
  40. Kaufmann H, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Low PA, Singer W, Goldstein DS, Peltier AC, Shibao CA, Gibbons CH, Freeman R, Robertson D. Natural history of pure autonomic failure: A United States prospective cohort. Ann Neurol. 2017 Feb; 81(2):287-297. PMID: 28093795.
    Citations: 61     Fields:    Translation:Humans
  41. Gibbons CH, Schmidt P, Biaggioni I, Frazier-Mills C, Freeman R, Isaacson S, Karabin B, Kuritzky L, Lew M, Low P, Mehdirad A, Raj SR, Vernino S, Kaufmann H. The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension. J Neurol. 2017 Aug; 264(8):1567-1582. PMID: 28050656.
    Citations: 60     Fields:    Translation:Humans
  42. Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, Sosenko JM, Ziegler D. Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2017 01; 40(1):136-154. PMID: 27999003.
    Citations: 229     Fields:    
  43. Gewandter JS, Dworkin RH, Finnerup NB, Freeman R, Mohile NA. Reply. Pain. 2017 01; 158(1):182-183. PMID: 27984531.
    Citations:    Fields:    
  44. Lee JM, Derkinderen P, Kordower JH, Freeman R, Munoz DG, Kremer T, Zago W, Hutten SJ, Adler CH, Serrano GE, Beach TG. The Search for a Peripheral Biopsy Indicator of a-Synuclein Pathology for Parkinson Disease. J Neuropathol Exp Neurol. 2017 01 01; 76(1):2-15. PMID: 28069931.
    Citations: 19     Fields:    Translation:Humans
  45. Gibbons CH, Wang N, Freeman R. Cutaneous Alpha-Synuclein From Paraffin Embedded Autopsy Specimens in Parkinson's Disease. J Parkinsons Dis. 2017; 7(3):503-509. PMID: 28582870.
    Citations: 4     Fields:    Translation:HumansCells
  46. Gewandter JS, Burke L, Cavaletti G, Dworkin RH, Gibbons C, Gover TD, Herrmann DN, Mcarthur JC, McDermott MP, Rappaport BA, Reeve BB, Russell JW, Smith AG, Smith SM, Turk DC, Vinik AI, Freeman R. Content validity of symptom-based measures for diabetic, chemotherapy, and HIV peripheral neuropathy. Muscle Nerve. 2017 03; 55(3):366-372. PMID: 27447116.
    Citations: 5     Fields:    Translation:Humans
  47. Centi J, Freeman R, Gibbons CH, Neargarder S, Canova AO, Cronin-Golomb A. Effects of orthostatic hypotension on cognition in Parkinson disease. Neurology. 2017 Jan 03; 88(1):17-24. PMID: 27903817.
    Citations: 20     Fields:    Translation:Humans
  48. Edwards RR, Dworkin RH, Turk DC, Angst MS, Dionne R, Freeman R, Hansson P, Haroutounian S, Arendt-Nielsen L, Attal N, Baron R, Brell J, Bujanover S, Burke LB, Carr D, Chappell AS, Cowan P, Etropolski M, Fillingim RB, Gewandter JS, Katz NP, Kopecky EA, Markman JD, Nomikos G, Porter L, Rappaport BA, Rice ASC, Scavone JM, Scholz J, Simon LS, Smith SM, Tobias J, Tockarshewsky T, Veasley C, Versavel M, Wasan AD, Wen W, Yarnitsky D. Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations. Pain. 2016 Sep; 157(9):1851-1871. PMID: 27152687.
    Citations: 54     Fields:    Translation:Humans
  49. Taylor AM, Phillips K, Patel KV, Turk DC, Dworkin RH, Beaton D, Clauw DJ, Gignac MAM, Markman JD, Williams DA, Bujanover S, Burke LB, Carr DB, Choy EH, Conaghan PG, Cowan P, Farrar JT, Freeman R, Gewandter J, Gilron I, Goli V, Gover TD, Haddox JD, Kerns RD, Kopecky EA, Lee DA, Malamut R, Mease P, Rappaport BA, Simon LS, Singh JA, Smith SM, Strand V, Tugwell P, Vanhove GF, Veasley C, Walco GA, Wasan AD, Witter J. Assessment of physical function and participation in chronic pain clinical trials: IMMPACT/OMERACT recommendations. Pain. 2016 Sep; 157(9):1836-1850. PMID: 27058676.
    Citations: 39     Fields:    Translation:Humans
  50. Thakur S, Dworkin RH, Freeman R, Gorson KC, Herrmann DN. Pain in acquired inflammatory demyelinating polyneuropathies. Pain. 2016 09; 157(9):1887-1894. PMID: 26945234.
    Citations:    Fields:    Translation:Humans
  51. Abuzinadah AR, Sinn DI, Freeman R, Gibbons CH. Blood pressure oscillations in baroreflex failure. Clin Auton Res. 2016 12; 26(6):465-466. PMID: 27541037.
    Citations: 1     Fields:    Translation:Humans
  52. Finnerup NB, Haroutounian S, Kamerman P, Baron R, Bennett DLH, Bouhassira D, Cruccu G, Freeman R, Hansson P, Nurmikko T, Raja SN, Rice ASC, Serra J, Smith BH, Treede RD, Jensen TS. Neuropathic pain: an updated grading system for research and clinical practice. Pain. 2016 08; 157(8):1599-1606. PMID: 27115670.
    Citations: 127     Fields:    Translation:Humans
  53. Gibbons CH, Garcia J, Wang N, Shih LC, Freeman R. The diagnostic discrimination of cutaneous a-synuclein deposition in Parkinson disease. Neurology. 2016 Aug 02; 87(5):505-12. PMID: 27385742.
    Citations: 23     Fields:    Translation:Humans
  54. Ziegler D, Low PA, Freeman R, Tritschler H, Vinik AI. Predictors of improvement and progression of diabetic polyneuropathy following treatment with a-lipoic acid for 4 years in the NATHAN 1 trial. J Diabetes Complications. 2016 Mar; 30(2):350-6. PMID: 26651260.
    Citations: 12     Fields:    Translation:Humans
  55. van Hecke O, Kamerman PR, Attal N, Baron R, Bjornsdottir G, Bennett DLH, Bennett MI, Bouhassira D, Diatchenko L, Freeman R, Freynhagen R, Haanpää M, Jensen TS, Raja SN, Rice ASC, Seltzer Z, Thorgeirsson TE, Yarnitsky D, Smith BH. Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations. Pain. 2015 Nov; 156(11):2337-2353. PMID: 26469320.
    Citations: 16     Fields:    Translation:Humans
  56. Dineen J, Freeman R. Autonomic Neuropathy. Semin Neurol. 2015 Aug; 35(4):458-68. PMID: 26502768.
    Citations: 5     Fields:    Translation:Humans
  57. Rao AD, Bonyhay I, Dankwa J, Baimas-George M, Kneen L, Ballatori S, Freeman R, Adler GK. Baroreflex Sensitivity Impairment During Hypoglycemia: Implications for Cardiovascular Control. Diabetes. 2016 Jan; 65(1):209-15. PMID: 26438610.
    Citations: 4     Fields:    Translation:Humans
  58. Freeman R, Barroso F. Recent advances in familial amyloid polyneuropathy. Curr Opin Neurol. 2015 Oct; 28(5):494-9. PMID: 26356411.
    Citations: 4     Fields:    Translation:Humans
  59. Gibbons CH, Freeman R. Clinical implications of delayed orthostatic hypotension: A 10-year follow-up study. Neurology. 2015 Oct 20; 85(16):1362-7. PMID: 26400576.
    Citations: 30     Fields:    Translation:Humans
  60. Freeman R, Wallace MS, Sweeney M, Backonja MM. Relationships Among Pain Quality, Pain Impact, and Overall Improvement in Patients with Postherpetic Neuralgia Treated with Gastroretentive Gabapentin. Pain Med. 2015 Oct; 16(10):2000-11. PMID: 26115203.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  61. Freeman R, Emir B, Parsons B. Predictors of placebo response in peripheral neuropathic pain: insights from pregabalin clinical trials. J Pain Res. 2015; 8:257-68. PMID: 26082659.
    Citations: 8     
  62. Laurens B, Constantinescu R, Freeman R, Gerhard A, Jellinger K, Jeromin A, Krismer F, Mollenhauer B, Schlossmacher MG, Shaw LM, Verbeek MM, Wenning GK, Winge K, Zhang J, Meissner WG. Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative. Neurobiol Dis. 2015 Aug; 80:29-41. PMID: 25982836.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  63. Freeman R. The puzzle of orthostatic tolerance in hereditary sensory and autonomic neuropathy, type IV. Ann Neurol. 2015 May; 77(5):741-2. PMID: 25866260.
    Citations:    Fields:    Translation:Humans
  64. Gibbons CH, Freeman R. Treatment-induced neuropathy of diabetes: an acute, iatrogenic complication of diabetes. Brain. 2015 Jan; 138(Pt 1):43-52. PMID: 25392197.
    Citations: 30     Fields:    Translation:Humans
  65. Biaggioni I, Freeman R, Mathias CJ, Low P, Hewitt LA, Kaufmann H. Randomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsive to droxidopa. Hypertension. 2015 Jan; 65(1):101-7. PMID: 25350981.
    Citations: 35     Fields:    Translation:HumansCTClinical Trials
  66. Kaufmann H, Freeman R, Biaggioni I, Low P, Pedder S, Hewitt LA, Mauney J, Feirtag M, Mathias CJ. Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial. Neurology. 2014 Jul 22; 83(4):328-35. PMID: 24944260.
    Citations: 60     Fields:    Translation:HumansCTClinical Trials
  67. Fillingim RB, Bruehl S, Dworkin RH, Dworkin SF, Loeser JD, Turk DC, Widerstrom-Noga E, Arnold L, Bennett R, Edwards RR, Freeman R, Gewandter J, Hertz S, Hochberg M, Krane E, Mantyh PW, Markman J, Neogi T, Ohrbach R, Paice JA, Porreca F, Rappaport BA, Smith SM, Smith TJ, Sullivan MD, Verne GN, Wasan AD, Wesselmann U. The ACTTION-American Pain Society Pain Taxonomy (AAPT): an evidence-based and multidimensional approach to classifying chronic pain conditions. J Pain. 2014 Mar; 15(3):241-9. PMID: 24581634.
    Citations: 41     Fields:    Translation:Humans
  68. Low PA, Robertson D, Gilman S, Kaufmann H, Singer W, Biaggioni I, Freeman R, Perlman S, Hauser RA, Cheshire W, Lessig S, Vernino S, Mandrekar J, Dupont WD, Chelimsky T, Galpern WR. Efficacy and safety of rifampicin for multiple system atrophy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2014 Mar; 13(3):268-75. PMID: 24507091.
    Citations: 32     Fields:    Translation:Humans
  69. Freeman R. Diabetic autonomic neuropathy. Handb Clin Neurol. 2014; 126:63-79. PMID: 25410215.
    Citations: 21     Fields:    Translation:HumansAnimals
  70. Gibbons CH, Bonyhay I, Benson A, Wang N, Freeman R. Structural and functional small fiber abnormalities in the neuropathic postural tachycardia syndrome. PLoS One. 2013; 8(12):e84716. PMID: 24386408.
    Citations: 12     Fields:    Translation:HumansCellsCTClinical Trials
  71. Bonyhay I, Risk M, Freeman R. High-pass filter characteristics of the baroreflex--a comparison of frequency domain and pharmacological methods. PLoS One. 2013; 8(11):e79513. PMID: 24244518.
    Citations: 2     Fields:    Translation:Humans
  72. Gibbons C, Cheshire W, Barboi A, Levine B, Olshansky B, Kinsella L, Claydon VE, Crandall C, Fink G, Joyner M, Macefield V, Norcliffe-Kaufmann L, Freeman R, Raj S, Stewart J, Sandroni P, Kaufmann H, Chelimsky T. Endovascular procedures for the treatment of autonomic dysfunction. Clin Auton Res. 2014 Feb; 24(1):1-2. PMID: 24178965.
    Citations:    Fields:    Translation:Humans
  73. Freeman R, Baron R, Bouhassira D, Cabrera J, Emir B. Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs. Pain. 2014 Feb; 155(2):367-376. PMID: 24472518.
    Citations: 49     Fields:    Translation:Humans
  74. Wang N, Gibbons CH, Lafo J, Freeman R. a-Synuclein in cutaneous autonomic nerves. Neurology. 2013 Oct 29; 81(18):1604-10. PMID: 24089386.
    Citations: 67     Fields:    Translation:HumansCells
  75. Harden RN, Freeman R, Rainka M, Zhang L, Bell C, Berges A, Chen C, Graff O, Harding K, Hunter S, Kavanagh S, Schwartzbach C, Warren S, McClung C. A phase 2a, randomized, crossover trial of gabapentin enacarbil for the treatment of postherpetic neuralgia in gabapentin inadequate responders. Pain Med. 2013 Dec; 14(12):1918-32. PMID: 24102928.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  76. Freeman R. New and developing drugs for the treatment of neuropathic pain in diabetes. Curr Diab Rep. 2013 Aug; 13(4):500-8. PMID: 23771401.
    Citations: 4     Fields:    Translation:Humans
  77. Backonja MM, Attal N, Baron R, Bouhassira D, Drangholt M, Dyck PJ, Edwards RR, Freeman R, Gracely R, Haanpaa MH, Hansson P, Hatem SM, Krumova EK, Jensen TS, Maier C, Mick G, Rice AS, Rolke R, Treede RD, Serra J, Toelle T, Tugnoli V, Walk D, Walalce MS, Ware M, Yarnitsky D, Ziegler D. Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus. Pain. 2013 Sep; 154(9):1807-1819. PMID: 23742795.
    Citations: 108     Fields:    Translation:Humans
  78. Gibbons CH, Freeman R, Tecilazich F, Dinh T, Lyons TE, Gnardellis C, Veves A. The evolving natural history of neurophysiologic function in patients with well-controlled diabetes. J Peripher Nerv Syst. 2013 Jun; 18(2):153-61. PMID: 23781962.
    Citations: 5     Fields:    Translation:Humans
  79. Schestatsky P, Simis M, Freeman R, Pascual-Leone A, Fregni F. Non-invasive brain stimulation and the autonomic nervous system. Clin Neurophysiol. 2013 Sep; 124(9):1716-28. PMID: 23684898.
    Citations: 16     Fields:    Translation:Humans
  80. Zhang L, Rainka M, Freeman R, Harden RN, Bell CF, Chen C, Graff O, Harding K, Hunter S, Kavanagh S, Laurijssens B, Schwartzbach C, Warren S, McClung C. A randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of gabapentin enacarbil in subjects with neuropathic pain associated with postherpetic neuralgia (PXN110748). J Pain. 2013 Jun; 14(6):590-603. PMID: 23602345.
    Citations: 12     Fields:    Translation:Humans
  81. Höke A, Simpson DM, Freeman R. Challenges in developing novel therapies for peripheral neuropathies: a summary of The Foundation for Peripheral Neuropathy Scientific Symposium 2012. J Peripher Nerv Syst. 2013 Mar; 18(1):1-6. PMID: 23521637.
    Citations: 1     Fields:    Translation:HumansAnimals
  82. Freeman R. Objective evidence of autonomic dysfunction and the role of stress in the Gulf War syndrome. JAMA Neurol. 2013 Feb; 70(2):158-9. PMID: 23407742.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  83. Freeman R, Chapleau MW. Testing the autonomic nervous system. Handb Clin Neurol. 2013; 115:115-36. PMID: 23931777.
    Citations: 16     Fields:    Translation:HumansAnimals
  84. Siepmann T, Gibbons CH, Illigens BM, Lafo JA, Brown CM, Freeman R. Quantitative pilomotor axon reflex test: a novel test of pilomotor function. Arch Neurol. 2012 Nov; 69(11):1488-92. PMID: 22868966.
    Citations: 8     Fields:    Translation:HumansCells
  85. Raj SR, Freeman R. Highlights in clinical autonomic neurosciences: Orthostatic hypotension: insights into risks and causes. Auton Neurosci. 2012 Sep 25; 170(1-2):3-4. PMID: 22921488.
    Citations:    Fields:    
  86. Gibbons CH, Adler GK, Bonyhay I, Freeman R. Experimental hypoglycemia is a human model of stress-induced hyperalgesia. Pain. 2012 Nov; 153(11):2204-2209. PMID: 22921261.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  87. Cheshire WP, Freeman R. Highlights in clinical autonomic neuroscience: latest discoveries from the octopus pot. Auton Neurosci. 2012 Jul 02; 169(1):4-6. PMID: 22579400.
    Citations:    Fields:    
  88. Raj SR, Freeman R. Highlights in clinical autonomic neurosciences: vasovagal syncope - insights on diagnosis, pathophysiology and treatment. Auton Neurosci. 2012 May 21; 168(1-2):1-3. PMID: 22444321.
    Citations: 1     Fields:    
  89. Cheshire WP, Freeman R. Highlights in clinical autonomic neuroscience: latest developments in the early detection of diabetic autonomic neuropathy. Auton Neurosci. 2012 Apr 03; 167(1-2):4-6. PMID: 22306250.
    Citations:    Fields:    
  90. Gibbons CH, Centi J, Vernino S, Freeman R. Autoimmune autonomic ganglionopathy with reversible cognitive impairment. Arch Neurol. 2012 Apr; 69(4):461-6. PMID: 22158721.
    Citations: 11     Fields:    Translation:Humans
  91. Kaufmann H, Malamut R, Norcliffe-Kaufmann L, Rosa K, Freeman R. The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale. Clin Auton Res. 2012 Apr; 22(2):79-90. PMID: 22045363.
    Citations: 58     Fields:    Translation:HumansCTClinical Trials
  92. Spallone V, Ziegler D, Freeman R, Bernardi L, Frontoni S, Pop-Busui R, Stevens M, Kempler P, Hilsted J, Tesfaye S, Low P, Valensi P. Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management. Diabetes Metab Res Rev. 2011 Oct; 27(7):639-53. PMID: 21695768.
    Citations: 205     Fields:    Translation:Humans
  93. Bernardi L, Spallone V, Stevens M, Hilsted J, Frontoni S, Pop-Busui R, Ziegler D, Kempler P, Freeman R, Low P, Tesfaye S, Valensi P. Methods of investigation for cardiac autonomic dysfunction in human research studies. Diabetes Metab Res Rev. 2011 Oct; 27(7):654-64. PMID: 21695761.
    Citations: 47     Fields:    Translation:Humans
  94. Ziegler D, Low PA, Litchy WJ, Boulton AJ, Vinik AI, Freeman R, Samigullin R, Tritschler H, Munzel U, Maus J, Schütte K, Dyck PJ. Efficacy and safety of antioxidant treatment with a-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care. 2011 Sep; 34(9):2054-60. PMID: 21775755.
    Citations: 84     Fields:    Translation:Humans
  95. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz I, Schondorff R, Stewart JM, van Dijk JG. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011 Apr; 21(2):69-72. PMID: 21431947.
    Citations: 329     Fields:    Translation:Humans
  96. Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz IJ, Schondorf R, Stewart JM, van Dijk JG. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Auton Neurosci. 2011 Apr 26; 161(1-2):46-8. PMID: 21393070.
    Citations: 85     Fields:    Translation:Humans
  97. Wang N, Gibbons CH, Freeman R. Novel immunohistochemical techniques using discrete signal amplification systems for human cutaneous peripheral nerve fiber imaging. J Histochem Cytochem. 2011 Apr; 59(4):382-90. PMID: 21411809.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  98. Gibbons CH, Wang N, Freeman R. Capsaicin induces degeneration of cutaneous autonomic nerve fibers. Ann Neurol. 2010 Dec; 68(6):888-98. PMID: 21061393.
    Citations: 35     Fields:    Translation:HumansCTClinical Trials
  99. Adler GK, Bonyhay I, Curren V, Waring E, Freeman R. Hypoglycaemia increases aldosterone in a dose-dependent fashion. Diabet Med. 2010 Nov; 27(11):1250-5. PMID: 20950382.
    Citations: 2     Fields:    Translation:Humans
  100. Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, Lauria G, Malik RA, Spallone V, Vinik A, Bernardi L, Valensi P. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010 Oct; 33(10):2285-93. PMID: 20876709.
    Citations: 518     Fields:    Translation:Humans
  101. Gibbons CH, Freeman R, Veves A. Diabetic neuropathy: a cross-sectional study of the relationships among tests of neurophysiology. Diabetes Care. 2010 Dec; 33(12):2629-34. PMID: 20805259.
    Citations: 16     Fields:    Translation:Humans
  102. Gibbons CH, Illigens BM, Wang N, Freeman R. Quantification of sudomotor innervation: a comparison of three methods. Muscle Nerve. 2010 Jul; 42(1):112-9. PMID: 20544913.
    Citations: 13     Fields:    Translation:HumansCells
  103. Gibbons CH, Freeman R. Treatment-induced diabetic neuropathy: a reversible painful autonomic neuropathy. Ann Neurol. 2010 Apr; 67(4):534-41. PMID: 20437589.
    Citations: 41     Fields:    Translation:HumansCells
  104. Simpson DM, Schifitto G, Clifford DB, Murphy TK, Durso-De Cruz E, Glue P, Whalen E, Emir B, Scott GN, Freeman R. Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial. Neurology. 2010 Feb 02; 74(5):413-20. PMID: 20124207.
    Citations: 46     Fields:    Translation:Humans
  105. Freeman R. Not all neuropathy in diabetes is of diabetic etiology: differential diagnosis of diabetic neuropathy. Curr Diab Rep. 2009 Dec; 9(6):423-31. PMID: 19954686.
    Citations: 11     Fields:    Translation:Humans
  106. Gibbons CH, Illigens BM, Wang N, Freeman R. Quantification of sweat gland innervation: a clinical-pathologic correlation. Neurology. 2009 Apr 28; 72(17):1479-86. PMID: 19398703.
    Citations: 37     Fields:    Translation:HumansCells
  107. Gibbons CH, Freeman R. Antibody titers predict clinical features of autoimmune autonomic ganglionopathy. Auton Neurosci. 2009 Mar 12; 146(1-2):8-12. PMID: 19144572.
    Citations: 19     Fields:    Translation:Humans
  108. Adler GK, Bonyhay I, Failing H, Waring E, Dotson S, Freeman R. Antecedent hypoglycemia impairs autonomic cardiovascular function: implications for rigorous glycemic control. Diabetes. 2009 Feb; 58(2):360-6. PMID: 19056608.
    Citations: 69     Fields:    Translation:Humans
  109. Lair L, Gibbons C, Freeman R. Phantom sweating: a novel autonomic paresthesia. Clin Auton Res. 2008 Dec; 18(6):352-4. PMID: 18850064.
    Citations:    Fields:    Translation:Humans
  110. Gibbons CH, Illigens BM, Centi J, Freeman R. QDIRT: quantitative direct and indirect test of sudomotor function. Neurology. 2008 Jun 10; 70(24):2299-304. PMID: 18541883.
    Citations: 17     Fields:    Translation:HumansCells
  111. Freeman R. Current pharmacologic treatment for orthostatic hypotension. Clin Auton Res. 2008 Mar; 18 Suppl 1:14-8. PMID: 18368302.
    Citations: 11     Fields:    Translation:Humans
  112. Freeman R, Durso-Decruz E, Emir B. Efficacy, safety, and tolerability of pregabalin treatment for painful diabetic peripheral neuropathy: findings from seven randomized, controlled trials across a range of doses. Diabetes Care. 2008 Jul; 31(7):1448-54. PMID: 18356405.
    Citations: 64     Fields:    Translation:Humans
  113. Dotson S, Freeman R, Failing HJ, Adler GK. Hypoglycemia increases serum interleukin-6 levels in healthy men and women. Diabetes Care. 2008 Jun; 31(6):1222-3. PMID: 18332163.
    Citations: 23     Fields:    Translation:Humans
  114. Freeman R. Clinical practice. Neurogenic orthostatic hypotension. N Engl J Med. 2008 Feb 07; 358(6):615-24. PMID: 18256396.
    Citations: 90     Fields:    Translation:Humans
  115. Gibbons CH, Vernino SA, Freeman R. Combined immunomodulatory therapy in autoimmune autonomic ganglionopathy. Arch Neurol. 2008 Feb; 65(2):213-7. PMID: 18268189.
    Citations: 19     Fields:    Translation:Humans
  116. Ahn AC, Bennani T, Freeman R, Hamdy O, Kaptchuk TJ. Two styles of acupuncture for treating painful diabetic neuropathy--a pilot randomised control trial. Acupunct Med. 2007 Jun; 25(1-2):11-7. PMID: 17641562.
    Citations: 23     Fields:    Translation:Humans
  117. Freeman R, McIntosh KA, Vijapurkar U, Thienel U. Topiramate and physiologic measures of nerve function in polyneuropathy. Acta Neurol Scand. 2007 Apr; 115(4):222-31. PMID: 17376119.
    Citations: 1     Fields:    Translation:Humans
  118. Bonyhay I, Freeman R. Sympathetic neural activity, sex dimorphism, and postural tachycardia syndrome. Ann Neurol. 2007 Apr; 61(4):332-9. PMID: 17358006.
    Citations: 6     Fields:    Translation:Humans
  119. Cornblath DR, Vinik A, Feldman E, Freeman R, Boulton AJ. Surgical decompression for diabetic sensorimotor polyneuropathy. Diabetes Care. 2007 Feb; 30(2):421-2. PMID: 17259523.
    Citations: 8     Fields:    Translation:Humans
  120. Freeman R. Autonomic peripheral neuropathy. Neurol Clin. 2007 Feb; 25(1):277-301. PMID: 17324728.
    Citations: 5     Fields:    Translation:Humans
  121. Freeman R, Raskin P, Hewitt DJ, Vorsanger GJ, Jordan DM, Xiang J, Rosenthal NR. Randomized study of tramadol/acetaminophen versus placebo in painful diabetic peripheral neuropathy. Curr Med Res Opin. 2007 Jan; 23(1):147-61. PMID: 17257476.
    Citations: 25     Fields:    Translation:Humans
  122. Gibbons CH, Freeman R. Delayed orthostatic hypotension: a frequent cause of orthostatic intolerance. Neurology. 2006 Jul 11; 67(1):28-32. PMID: 16832073.
    Citations: 55     Fields:    Translation:Humans
  123. Berghoff M, Kilo S, Hilz MJ, Freeman R. Differential impairment of the sudomotor and nociceptor axon-reflex in diabetic peripheral neuropathy. Muscle Nerve. 2006 Apr; 33(4):494-9. PMID: 16411196.
    Citations: 9     Fields:    Translation:HumansCells
  124. Latov N, Gorson KC, Brannagan TH, Freeman RL, Apostolski S, Berger AR, Bradley WG, Briani C, Bril V, Busis NA, Cros DP, Dalakas MC, Donofrio PD, Dyck PJ, England JD, Fisher MA, Herrmann DN, Menkes DL, Sahenk Z, Sander HW, Triggs WJ, Vallat JM. Diagnosis and Treatment of Chronic Immune-mediated Neuropathies. J Clin Neuromuscul Dis. 2006 Mar; 7(3):141-57. PMID: 19078800.
    Citations: 1     Fields:    
  125. Gibbons CH, Freeman R. Treatment options for autonomic neuropathies. Curr Treat Options Neurol. 2006 Mar; 8(2):119-32. PMID: 16464408.
    Citations: 3     
  126. Freeman R. Assessment of cardiovascular autonomic function. Clin Neurophysiol. 2006 Apr; 117(4):716-30. PMID: 16464634.
    Citations: 47     Fields:    Translation:HumansAnimals
  127. Freeman R. Cardiovascular manifestations of autonomic epilepsy. Clin Auton Res. 2006 Feb; 16(1):12-7. PMID: 16477490.
    Citations: 6     Fields:    Translation:HumansAnimals
  128. Freeman R. Newer agents for the treatment of painful diabetic peripheral neuropathy. Curr Diab Rep. 2005 Dec; 5(6):409-16. PMID: 16316590.
    Citations: 1     Fields:    Translation:HumansAnimals
  129. Freeman R, Gibbons C. Is time of the essence? The continuing search for a noninvasive measure of sympathetic adrenergic function. Neurology. 2005 Nov 22; 65(10):1517. PMID: 16304717.
    Citations:    Fields:    Translation:HumansCells
  130. Gibbons CH, Vernino SA, Kaufmann H, Freeman R. L-DOPS therapy for refractory orthostatic hypotension in autoimmune autonomic neuropathy. Neurology. 2005 Oct 11; 65(7):1104-6. PMID: 16217067.
    Citations: 7     Fields:    Translation:Humans
  131. Freeman R. The treatment of neuropathic pain. CNS Spectr. 2005 Sep; 10(9):698-706. PMID: 16142210.
    Citations: 5     Fields:    Translation:HumansCells
  132. Boulton AJ, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, Malik RA, Maser RE, Sosenko JM, Ziegler D. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care. 2005 Apr; 28(4):956-62. PMID: 15793206.
    Citations: 466     Fields:    Translation:Humans
  133. Gibbons CH, Freeman R. Autonomic neuropathy and coeliac disease. J Neurol Neurosurg Psychiatry. 2005 Apr; 76(4):579-81. PMID: 15774451.
    Citations: 8     Fields:    Translation:Humans
  134. Freeman R. Autonomic peripheral neuropathy. Lancet. 2005 Apr 2-8; 365(9466):1259-70. PMID: 15811460.
    Citations: 52     Fields:    Translation:Humans
  135. Gibbons CH, Freeman R. Orthostatic dyspnea: a neglected symptom of orthostatic hypotension. Clin Auton Res. 2005 Feb; 15(1):40-4. PMID: 15768201.
    Citations: 12     Fields:    Translation:Humans
  136. Goldstein DS, Holmes C, Kaufmann H, Freeman R. Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failure. Clin Auton Res. 2004 Dec; 14(6):363-8. PMID: 15666063.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  137. Bonyhay I, Freeman R. Sympathetic nerve activity in response to hypotensive stress in the postural tachycardia syndrome. Circulation. 2004 Nov 16; 110(20):3193-8. PMID: 15533861.
    Citations: 29     Fields:    Translation:HumansCells
  138. Kaufmann H, Freeman R. Pharmacological treatment of reflex syncope. Clin Auton Res. 2004 Oct; 14 Suppl 1:71-5. PMID: 15480933.
    Citations: 4     Fields:    Translation:Humans
  139. Wieling W, Colman N, Krediet CT, Freeman R. Nonpharmacological treatment of reflex syncope. Clin Auton Res. 2004 Oct; 14 Suppl 1:62-70. PMID: 15480932.
    Citations: 15     Fields:    Translation:Humans
  140. Freeman R. Pure autonomic failure: an immaculate misconception? Neurology. 2004 Sep 28; 63(6):953-4. PMID: 15452282.
    Citations: 1     Fields:    Translation:HumansCells
  141. Gibbons C, Freeman R. The evaluation of small fiber function-autonomic and quantitative sensory testing. Neurol Clin. 2004 Aug; 22(3):683-702, vii. PMID: 15207880.
    Citations: 10     Fields:    Translation:HumansCells
  142. Freeman R. Assessment of cardiovascular autonomic function. Suppl Clin Neurophysiol. 2004; 57:369-75. PMID: 16106635.
    Citations: 2     Fields:    Translation:Humans
  143. Berger AR, Bradley WG, Brannagan TH, Busis NA, Cros DP, Dalakas MC, Danon MJ, Donofrio P, Engel WK, England JD, Feldman EL, Freeman RL, Kinsella LJ, Lacomis D, Latov N, Menkes DL, Sander HW, Thomas FP, Triggs WJ, Windebank AJ, Wolfe GI. Guidelines for the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy. J Peripher Nerv Syst. 2003 Dec; 8(4):282-4. PMID: 14641652.
    Citations: 10     Fields:    Translation:HumansCells
  144. Vinik AI, Freeman R, Erbas T. Diabetic autonomic neuropathy. Semin Neurol. 2003 Dec; 23(4):365-72. PMID: 15088257.
    Citations: 41     Fields:    Translation:HumansAnimals
  145. Freeman R. Treatment of orthostatic hypotension. Semin Neurol. 2003 Dec; 23(4):435-42. PMID: 15088264.
    Citations: 19     Fields:    Translation:HumansAnimals
  146. Cheshire WP, Freeman R. Disorders of sweating. Semin Neurol. 2003 Dec; 23(4):399-406. PMID: 15088261.
    Citations: 20     Fields:    Translation:HumansAnimals
  147. Risk MR, Lirofonis V, Armentano RL, Freeman R. A biphasic model of limb venous compliance: a comparison with linear and exponential models. J Appl Physiol (1985). 2003 Sep; 95(3):1207-15. PMID: 12909601.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  148. Kaufmann H, Saadia D, Voustianiouk A, Goldstein DS, Holmes C, Yahr MD, Nardin R, Freeman R. Norepinephrine precursor therapy in neurogenic orthostatic hypotension. Circulation. 2003 Aug 12; 108(6):724-8. PMID: 12885750.
    Citations: 52     Fields:    Translation:HumansCTClinical Trials
  149. Nahm F, Freeman R. Sphincter electromyography and multiple system atrophy. Muscle Nerve. 2003 Jul; 28(1):18-26. PMID: 12811769.
    Citations: 2     Fields:    Translation:Humans
  150. Maser RE, Mitchell BD, Vinik AI, Freeman R. The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis. Diabetes Care. 2003 Jun; 26(6):1895-901. PMID: 12766130.
    Citations: 160     Fields:    Translation:Humans
  151. Berghoff M, Kathpal M, Khan F, Skinner M, Falk R, Freeman R. Endothelial dysfunction precedes C-fiber abnormalities in primary (AL) amyloidosis. Ann Neurol. 2003 Jun; 53(6):725-30. PMID: 12783418.
    Citations: 16     Fields:    Translation:HumansCells
  152. Vinik AI, Maser RE, Mitchell BD, Freeman R. Diabetic autonomic neuropathy. Diabetes Care. 2003 May; 26(5):1553-79. PMID: 12716821.
    Citations: 394     Fields:    Translation:Humans
  153. Freeman R, Chase KP, Risk MR. Quantitative sensory testing cannot differentiate simulated sensory loss from sensory neuropathy. Neurology. 2003 Feb 11; 60(3):465-70. PMID: 12578928.
    Citations: 20     Fields:    Translation:HumansCTClinical Trials
  154. Nahm F, Freeman R. Syncope and the history of nervous influences on the heart. Arch Neurol. 2003 Feb; 60(2):282-7. PMID: 12580718.
    Citations:    Fields:    Translation:Humans
  155. Freeman R. The chronic fatigue syndrome is a disease of the autonomic nervous system. Sometimes. Clin Auton Res. 2002 Aug; 12(4):231-3. PMID: 12357274.
    Citations: 3     Fields:    Translation:Humans
  156. Freeman R, Lirofonis V, Farquhar WB, Risk M. Limb venous compliance in patients with idiopathic orthostatic intolerance and postural tachycardia. J Appl Physiol (1985). 2002 Aug; 93(2):636-44. PMID: 12133874.
    Citations: 19     Fields:    Translation:Humans
  157. Gutierrez J, Santiesteban R, Garcia H, Voustianiouk A, Freeman R, Kaufmann H. High blood pressure and decreased heart rate variability in the Cuban epidemic neuropathy. J Neurol Neurosurg Psychiatry. 2002 Jul; 73(1):71-2. PMID: 12082051.
    Citations: 2     Fields:    Translation:Humans
  158. Lopez MR, Freeman R, Schomer D. Spindle coma secondary to vasovagal syncope. Epilepsy Behav. 2002 Jun; 3(3):289-291. PMID: 12662612.
    Citations: 1     Fields:    
  159. Berghoff M, Kathpal M, Kilo S, Hilz MJ, Freeman R. Vascular and neural mechanisms of ACh-mediated vasodilation in the forearm cutaneous microcirculation. J Appl Physiol (1985). 2002 Feb; 92(2):780-8. PMID: 11796692.
    Citations: 30     Fields:    Translation:HumansCells
  160. Farquhar WB, Hunt BE, Taylor JA, Darling SE, Freeman R. Blood volume and its relation to peak O(2) consumption and physical activity in patients with chronic fatigue. . 2002 Jan; 282(1):H66-71. PMID: 11748048.
    Citations: 14     Translation:Humans
  161. Nahm F, Freeman R. Vasovagal syncope: the contributions of Sir William R. Gowers and Sir Thomas Lewis. Arch Neurol. 2001 Mar; 58(3):509-11. PMID: 11255458.
    Citations: 2     Fields:    Translation:Humans
  162. Apfel SC, Schwartz S, Adornato BT, Freeman R, Biton V, Rendell M, Vinik A, Giuliani M, Stevens JC, Barbano R, Dyck PJ. Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy: A randomized controlled trial. rhNGF Clinical Investigator Group. JAMA. 2000 Nov 01; 284(17):2215-21. PMID: 11056593.
    Citations: 72     Fields:    Translation:HumansCTClinical Trials
  163. Kilo S, Berghoff M, Hilz M, Freeman R. Neural and endothelial control of the microcirculation in diabetic peripheral neuropathy. Neurology. 2000 Mar 28; 54(6):1246-52. PMID: 10746593.
    Citations: 19     Fields:    Translation:Humans
  164. Freeman R, Landsberg L, Young J. The treatment of neurogenic orthostatic hypotension with 3,4-DL-threo-dihydroxyphenylserine: a randomized, placebo-controlled, crossover trial. Neurology. 1999 Dec 10; 53(9):2151-7. PMID: 10599797.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  165. Mukkamala R, Mathias JM, Mullen TJ, Cohen RJ, Freeman R. System identification of closed-loop cardiovascular control mechanisms: diabetic autonomic neuropathy. Am J Physiol. 1999 Mar; 276(3 Pt 2):R905-12. PMID: 10070154.
    Citations: 10     Fields:    Translation:Humans
  166. Freeman R. Human studies of recombinant human nerve growth factor and diabetic peripheral neuropathy. Eur Neurol. 1999; 41 Suppl 1:20-6. PMID: 10023125.
    Citations:    Fields:    Translation:Humans
  167. Arora S, Smakowski P, Frykberg RG, Simeone LR, Freeman R, LoGerfo FW, Veves A. Differences in foot and forearm skin microcirculation in diabetic patients with and without neuropathy. Diabetes Care. 1998 Aug; 21(8):1339-44. PMID: 9702444.
    Citations: 16     Fields:    Translation:HumansCells
  168. Veves A, Akbari CM, Primavera J, Donaghue VM, Zacharoulis D, Chrzan JS, DeGirolami U, LoGerfo FW, Freeman R. Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration. Diabetes. 1998 Mar; 47(3):457-63. PMID: 9519754.
    Citations: 51     Fields:    Translation:Humans
  169. Blaber AP, Bondar RL, Stein F, Dunphy PT, Moradshahi P, Kassam MS, Freeman R. Complexity of middle cerebral artery blood flow velocity: effects of tilt and autonomic failure. Am J Physiol. 1997 11; 273(5):H2209-16. PMID: 9374755.
    Citations: 3     Fields:    Translation:Humans
  170. Low PA, Gilden JL, Freeman R, Sheng KN, McElligott MA. Efficacy of midodrine for neurogenic orthostatic hypotension. Reply. JAMA. 1997 Aug 06; 278(5):388. PMID: 11536812.
    Citations:    Fields:    Translation:Humans
  171. Araujo LM, Freeman R, Broadbridge C. Cardiovascular autonomic tests in diabetic patients with gastroparesis. Arq Neuropsiquiatr. 1997 Jun; 55(2):227-30. PMID: 9629382.
    Citations:    Fields:    Translation:Humans
  172. Freeman R, Komaroff AL. Does the chronic fatigue syndrome involve the autonomic nervous system? Am J Med. 1997 Apr; 102(4):357-64. PMID: 9217617.
    Citations: 47     Fields:    Translation:Humans
  173. Freeman R, Young J, Landsberg L, Lipsitz L. The treatment of postprandial hypotension in autonomic failure with 3,4-DL-threo-dihydroxyphenylserine. Neurology. 1996 Dec; 47(6):1414-20. PMID: 8960720.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  174. Blaber AP, Bondar RL, Freeman R. Coarse graining spectral analysis of HR and BP variability in patients with autonomic failure. Am J Physiol. 1996 Oct; 271(4 Pt 2):H1555-64. PMID: 8897952.
    Citations: 3     Fields:    Translation:Humans
  175. Freeman R, Weiss ST, Roberts M, Zbikowski SM, Sparrow D. The relationship between heart rate variability and measures of body habitus. Clin Auton Res. 1995 Oct; 5(5):261-6. PMID: 8563458.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  176. Freeman R, Schachter SC. Autonomic epilepsy. Semin Neurol. 1995 Jun; 15(2):158-66. PMID: 7481135.
    Citations: 11     Fields:    Translation:Humans
  177. Freeman R, Cohen RJ, Saul JP. Transfer function analysis of respiratory sinus arrhythmia: a measure of autonomic function in diabetic neuropathy. Muscle Nerve. 1995 Jan; 18(1):74-84. PMID: 7800001.
    Citations: 3     Fields:    Translation:Humans
  178. Zarich S, Waxman S, Freeman RT, Mittleman M, Hegarty P, Nesto RW. Effect of autonomic nervous system dysfunction on the circadian pattern of myocardial ischemia in diabetes mellitus. J Am Coll Cardiol. 1994 Oct; 24(4):956-62. PMID: 7930230.
    Citations: 9     Fields:    Translation:Humans
  179. Harry JD, Freeman R. Determining heart-rate variability: comparing methodologies using computer simulations. Muscle Nerve. 1993 Mar; 16(3):267-77. PMID: 8446124.
    Citations:    Fields:    Translation:Humans
  180. Lipsitz LA, Ryan SM, Parker JA, Freeman R, Wei JY, Goldberger AL. Hemodynamic and autonomic nervous system responses to mixed meal ingestion in healthy young and old subjects and dysautonomic patients with postprandial hypotension. Circulation. 1993 Feb; 87(2):391-400. PMID: 8425288.
    Citations: 33     Fields:    Translation:Humans
  181. Freeman R, Miyawaki E. The treatment of autonomic dysfunction. J Clin Neurophysiol. 1993 Jan; 10(1):61-82. PMID: 8458996.
    Citations:    Fields:    Translation:Humans
  182. Freeman R, Waldorf HA, Dover JS. Autonomic neurodermatology (Part II): Disorders of sweating and flushing. Semin Neurol. 1992 Dec; 12(4):394-407. PMID: 1485049.
    Citations: 3     Fields:    Translation:Humans
  183. Freeman R, Dover JS. Autonomic neurodermatology (Part I): Erythromelalgia, reflex sympathetic dystrophy, and livedo reticularis. Semin Neurol. 1992 Dec; 12(4):385-93. PMID: 1485048.
    Citations: 2     Fields:    Translation:Humans
  184. Freeman R, Landsberg L. The treatment of orthostatic hypotension with dihydroxyphenylserine. Clin Neuropharmacol. 1991 Aug; 14(4):296-304. PMID: 1913697.
    Citations: 4     Fields:    Translation:Humans
  185. Freeman R, Saul JP, Roberts MS, Berger RD, Broadbridge C, Cohen RJ. Spectral analysis of heart rate in diabetic autonomic neuropathy. A comparison with standard tests of autonomic function. Arch Neurol. 1991 Feb; 48(2):185-90. PMID: 1993010.
    Citations: 32     Fields:    Translation:Humans
  186. Freeman R, Roberts MS, Friedman LS, Broadbridge C. Autonomic function and human immunodeficiency virus infection. Neurology. 1990 Apr; 40(4):575-80. PMID: 2320229.
    Citations: 30     Fields:    Translation:Humans
  187. Brown FM, Brink SJ, Freeman R, Rabinowe SL. Anti-sympathetic nervous system autoantibodies. Diminished catecholamines with orthostasis. Diabetes. 1989 Jul; 38(7):938-41. PMID: 2737366.
    Citations: 3     Fields:    Translation:Humans
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Freeman's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (496)
Explore
_
Co-Authors (44)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.