Harvard Catalyst Profiles

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Tobias Elze, Ph.D.

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Personal homepage: http://www.tobias-elze.de

Available: 11/01/18, Expires: 09/30/19

The project aims to detect and describe how the disease of glaucoma progresses over time. Embedded in an interdisciplinary group of clinicians, engineers, and bioinformaticists, the student will have access to large datasets of glaucoma patient measurements from clinical practice, in particular to assessments of functional vision loss combined with retinal imaging. The student will contribute to the development of a personalized prognosis of glaucoma progression. Background in eye physiology and/or ophthalmology will be beneficial. The student should be open to learning novel statistical tools, such as machine learning, that are dedicated to high-dimensional data sets. Furthermore, the student is expected to complete at least one first-authored peer-reviewed article, so scientific writing skills are highly desirable.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Smits DJ, Elze T, Wang H, Pasquale LR. Machine Learning in the Detection of the Glaucomatous Disc and Visual Field. Semin Ophthalmol. 2019 May 27; 1-11. PMID: 31132292.
  2. Saeedi OJ, Elze T, D'Acunto L, Swamy R, Hegde V, Gupta S, Venjara A, Tsai J, Myers JS, Wellik SR, De Moraes CG, Pasquale LR, Shen LQ, Boland MV. Agreement and Predictors of Discordance of 6 Visual Field Progression Algorithms. Ophthalmology. 2019 Jun; 126(6):822-828. PMID: 30731101.
  3. Wang M, Shen LQ, Pasquale LR, Petrakos P, Formica S, Boland MV, Wellik SR, De Moraes CG, Myers JS, Saeedi O, Wang H, Baniasadi N, Li D, Tichelaar J, Bex PJ, Elze T. An Artificial Intelligence Approach to Detect Visual Field Progression in Glaucoma Based on Spatial Pattern Analysis. Invest Ophthalmol Vis Sci. 2019 Jan 02; 60(1):365-375. PMID: 30682206.
    Citations:    Fields:    
  4. Wang M, Zhang Y, Wu W, Young JA, Hatch KM, Pineda R, Elze T, Wang Y. Predicting Refractive Outcome of Small Incision Lenticule Extraction for Myopia Using Corneal Properties. Transl Vis Sci Technol. 2018 Sep; 7(5):11. PMID: 30271678.
  5. Wang M, Pasquale LR, Shen LQ, Boland MV, Wellik SR, De Moraes CG, Myers JS, Wang H, Baniasadi N, Li D, Silva RNE, Bex PJ, Elze T. Reply. Ophthalmology. 2018 Sep; 125(9):e66-e67. PMID: 30143107.
    Citations:    Fields:    
  6. Mauschitz MM, Bonnemaijer PWM, Diers K, Rauscher FG, Elze T, Engel C, Loeffler M, Colijn JM, Ikram MA, Vingerling JR, Williams KM, Hammond CJ, Creuzot-Garcher C, Bron AM, Silva R, Nunes S, Delcourt C, Cougnard-Grégoire A, Holz FG, Klaver CCW, Breteler MMB, Finger RP. Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population. Ophthalmology. 2018 Oct; 125(10):1526-1536. PMID: 29716786.
    Citations:    Fields:    
  7. Wang M, Jin Q, Wang H, Baniasadi N, Elze T. Quantifying positional variation of retinal blood vessels in glaucoma. PLoS One. 2018; 13(3):e0193555. PMID: 29543886.
    Citations:    Fields:    Translation:Humans
  8. Wang M, Jin Q, Wang H, Li D, Baniasadi N, Elze T. The Interrelationship between Refractive Error, Blood Vessel Anatomy, and Glaucomatous Visual Field Loss. Transl Vis Sci Technol. 2018 Jan; 7(1):4. PMID: 29359110.
  9. Elze T, Baniasadi N, Jin Q, Wang H, Wang M. Ametropia, retinal anatomy, and OCT abnormality patterns in glaucoma. 1. Impacts of refractive error and interartery angle. J Biomed Opt. 2017 Dec; 22(12):1-11. PMID: 29247496.
    Citations:    Fields:    Translation:Humans
  10. Baniasadi N, Wang M, Wang H, Jin Q, Elze T. Ametropia, retinal anatomy, and OCT abnormality patterns in glaucoma. 2. Impacts of optic nerve head parameters. J Biomed Opt. 2017 Dec; 22(12):1-9. PMID: 29256238.
    Citations:    Fields:    Translation:Humans
  11. Wang M, Elze T, Li D, Baniasadi N, Wirkner K, Kirsten T, Thiery J, Loeffler M, Engel C, Rauscher FG. Age, ocular magnification, and circumpapillary retinal nerve fiber layer thickness. J Biomed Opt. 2017 12; 22(12):1-19. PMID: 29275546.
    Citations:    Fields:    
  12. Wang M, Pasquale LR, Shen LQ, Boland MV, Wellik SR, De Moraes CG, Myers JS, Wang H, Baniasadi N, Li D, Silva RNE, Bex PJ, Elze T. Reversal of Glaucoma Hemifield Test Results and Visual Field Features in Glaucoma. Ophthalmology. 2018 03; 125(3):352-360. PMID: 29103791.
    Citations: 2     Fields:    Translation:Humans
  13. Wang M, Shen LQ, Boland MV, Wellik SR, De Moraes CG, Myers JS, Bex PJ, Elze T. Impact of Natural Blind Spot Location on Perimetry. Sci Rep. 2017 07 21; 7(1):6143. PMID: 28733615.
    Citations:    Fields:    Translation:Humans
  14. Baniasadi N, Wang M, Wang H, Mahd M, Elze T. Associations between Optic Nerve Head-Related Anatomical Parameters and Refractive Error over the Full Range of Glaucoma Severity. Transl Vis Sci Technol. 2017 Jul; 6(4):9. PMID: 28729947.
    Citations: 1     
  15. Dorr M, Elze T, Wang H, Lu ZL, Bex PJ, Lesmes LA. New Precision Metrics for Contrast Sensitivity Testing. IEEE J Biomed Health Inform. 2018 05; 22(3):919-925. PMID: 28650831.
    Citations:    Fields:    Translation:Humans
  16. Dorr M, Lesmes LA, Elze T, Wang H, Lu ZL, Bex PJ. Evaluation of the precision of contrast sensitivity function assessment on a tablet device. Sci Rep. 2017 Apr 21; 7:46706. PMID: 28429773.
    Citations: 1     Fields:    
  17. Baniasadi N, Wang M, Wang Hui, Jin Q, Mahd M, Elze T. Impact of anatomical parameters on optical coherence tomography retinal nerve fiber layer thickness abnormality patterns. SPIE Ophthalmic Technologies. 2017; XXVII:100450P.
  18. Wang M, Wang Hui, Baniasadi Neda, Elze T. The relationship between 3D morphology of optic disc and spatial patterns of visual field loss in glaucoma. SPIE Ophthalmic Technologies. 2017; XXVII:100451W.
  19. Wang H, Wang M, Baniasadi Neda, Jin Q, Elze T. Combining retinal nerve fiber layer thickness with individual retinal blood vessel locations allows modeling of central vision loss in glaucoma. SPIE Ophthalmic Technologies. 2017; XXVII:100451M.
  20. Wang M, Wang H, Pasquale LR, Baniasadi N, Shen LQ, Bex PJ, Elze T. Relationship Between Central Retinal Vessel Trunk Location and Visual Field Loss in Glaucoma. Am J Ophthalmol. 2017 Apr; 176:53-60. PMID: 28088508.
    Citations: 5     Fields:    Translation:HumansCells
  21. Baniasadi N, Paschalis EI, Haghzadeh M, Ojha P, Elze T, Mahd M, Chen TC. Patterns of Retinal Nerve Fiber Layer Loss in Different Subtypes of Open Angle Glaucoma Using Spectral Domain Optical Coherence Tomography. J Glaucoma. 2016 10; 25(10):865-872. PMID: 27599175.
    Citations: 1     Fields:    Translation:HumansCells
  22. Cai S, Elze T, Bex PJ, Wiggs JL, Pasquale LR, Shen LQ. Clinical Correlates of Computationally Derived Visual Field Defect Archetypes in Patients from a Glaucoma Clinic. Curr Eye Res. 2017 04; 42(4):568-574. PMID: 27494512.
    Citations: 1     Fields:    Translation:Humans
  23. Elze T, Pasquale LR, Shen LQ, Chen TC, Wiggs JL, Bex PJ. Patterns of functional vision loss in glaucoma determined with archetypal analysis. J R Soc Interface. 2015 Feb 06; 12(103). PMID: 25505132.
    Citations: 5     Fields:    Translation:HumansCells
  24. Elze T, Taylor C, Bex PJ. An evaluation of organic light emitting diode monitors for medical applications: great timing, but luminance artifacts. Med Phys. 2013 Sep; 40(9):092701. PMID: 24007183.
    Citations: 3     Fields:    
  25. Elze T, Tanner TG. Temporal properties of liquid crystal displays: implications for vision science experiments. PLoS One. 2012; 7(9):e44048. PMID: 22984458.
    Citations: 12     Fields:    Translation:Cells
  26. Poppe S, Benner P, Elze T. A Predictive Approach to Nonparametric Inference for Adaptive Sequential Sampling of Psychophysical Experiments. J Math Psychol. 2012 Jun 01; 56(3):179-195. PMID: 22822269.
    Citations: 2     
  27. Stollhoff R, Kennerknecht I, Elze T, Jost J. A computational model of dysfunctional facial encoding in congenital prosopagnosia. Neural Netw. 2011 Aug; 24(6):652-64. PMID: 21458953.
    Citations: 1     Fields:    Translation:Humans
  28. Elze T, Song C, Stollhoff R, Jost J. Chinese characters reveal impacts of prior experience on very early stages of perception. BMC Neurosci. 2011 Jan 26; 12:14. PMID: 21269486.
    Citations: 1     Fields:    Translation:Humans
  29. Stollhoff R, Jost J, Elze T, Kennerknecht I. Deficits in long-term recognition memory reveal dissociated subtypes in congenital prosopagnosia. PLoS One. 2011 Jan 25; 6(1):e15702. PMID: 21283572.
    Citations: 8     Fields:    Translation:Humans
  30. Elze T. Misspecifications of stimulus presentation durations in experimental psychology: a systematic review of the psychophysics literature. PLoS One. 2010 Sep 29; 5(9). PMID: 20927362.
    Citations: 10     Fields:    Translation:HumansAnimals
  31. Stollhoff R, Jost J, Elze T, Kennerknecht I. The early time course of compensatory face processing in congenital prosopagnosia. PLoS One. 2010 Jul 21; 5(7):e11482. PMID: 20657764.
    Citations: 5     Fields:    Translation:Humans
  32. Elze T. Achieving precise display timing in visual neuroscience experiments. J Neurosci Methods. 2010 Aug 30; 191(2):171-9. PMID: 20600318.
    Citations: 11     Fields:    Translation:HumansAnimals
  33. Elze T, Tanner TG. Liquid crystal display response time estimation for medical applications. Med Phys. 2009 Nov; 36(11):4984-90. PMID: 19994507.
    Citations: 5     Fields:    
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.