Harvard Catalyst Profiles

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Kai-Ting Shade, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shade KC, Conroy ME, Washburn N, Kitaoka M, Huynh DJ, Laprise E, Patil SU, Shreffler WG, Anthony RM. Sialylation of immunoglobulin E is a determinant of allergic pathogenicity. Nature. 2020 06; 582(7811):265-270. PMID: 32499653.
    Citations:    
  2. Shade KT, Conroy ME, Anthony RM. IgE Glycosylation in Health and Disease. Curr Top Microbiol Immunol. 2019; 423:77-93. PMID: 30820668.
    Citations:    
  3. Azimi E, Reddy VB, Shade KC, Anthony RM, Talbot S, Pereira PJS, Lerner EA. Dual action of neurokinin-1 antagonists on Mas-related GPCRs. JCI Insight. 2016 Oct 06; 1(16):e89362. PMID: 27734033.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  4. Capel RA, Bolton EL, Lin WK, Aston D, Wang Y, Liu W, Wang X, Burton RA, Bloor-Young D, Shade KT, Ruas M, Parrington J, Churchill GC, Lei M, Galione A, Terrar DA. Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic ß-Adrenoceptor Signaling in the Heart. J Biol Chem. 2015 Dec 11; 290(50):30087-98. PMID: 26438825.
    Citations:    
  5. Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A. Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic ß Cells. J Biol Chem. 2015 Aug 28; 290(35):21376-92. PMID: 26152717.
    Citations:    
  6. Ruas M, Davis LC, Chen CC, Morgan AJ, Chuang KT, Walseth TF, Grimm C, Garnham C, Powell T, Platt N, Platt FM, Biel M, Wahl-Schott C, Parrington J, Galione A. Expression of Ca²?-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. EMBO J. 2015 Jul 02; 34(13):1743-58. PMID: 25872774.
    Citations:    
  7. Shade KT, Platzer B, Washburn N, Mani V, Bartsch YC, Conroy M, Pagan JD, Bosques C, Mempel TR, Fiebiger E, Anthony RM. A single glycan on IgE is indispensable for initiation of anaphylaxis. J Exp Med. 2015 Apr 06; 212(4):457-67. PMID: 25824821.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  8. Platzer B, Elpek KG, Cremasco V, Baker K, Stout MM, Schultz C, Dehlink E, Shade KC, Anthony RM, Blumberg RS, Turley SJ, Fiebiger E. IgE/FceRI-Mediated Antigen Cross-Presentation by Dendritic Cells Enhances Anti-Tumor Immune Responses. Cell Rep. 2015 Mar 10; 10(9):1487-1495. PMID: 25753415.
    Citations: 9     Fields:    
  9. Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC. Synthesis of caged NAADP. Cold Spring Harb Protoc. 2014 Oct 01; 2014(10):pdb.prot076943. PMID: 25275103.
    Citations:    
  10. Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC. Measurement of luminal pH of acidic stores as a readout for NAADP action. Cold Spring Harb Protoc. 2014 Oct 01; 2014(10):pdb.prot076935. PMID: 25275102.
    Citations:    
  11. Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC. Synthesis of NAADP-AM as a membrane-permeant NAADP analog. Cold Spring Harb Protoc. 2014 Oct 01; 2014(10):pdb.prot076927. PMID: 25275101.
    Citations:    
  12. Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC. Synthesis of [³²P]NAADP for the radioreceptor binding assay. Cold Spring Harb Protoc. 2014 Sep 02; 2014(9):993-5. PMID: 25183813.
    Citations:    
  13. Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC. Preparation and use of sea urchin egg homogenates for studying NAADP-mediated Ca²? release. Cold Spring Harb Protoc. 2014 Sep 02; 2014(9):988-92. PMID: 25183812.
    Citations:    
  14. Ruas M, Chuang KT, Davis LC, Al-Douri A, Tynan PW, Tunn R, Teboul L, Galione A, Parrington J. TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2. Mol Cell Biol. 2014 Nov; 34(21):3981-92. PMID: 25135478.
    Citations:    
  15. Swinney DC, Beavis P, Chuang KT, Zheng Y, Lee I, Gee P, Deval J, Rotstein DM, Dioszegi M, Ravendran P, Zhang J, Sankuratri S, Kondru R, Vauquelin G. A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands. Br J Pharmacol. 2014 Jul; 171(14):3364-75. PMID: 24628038.
    Citations:    
  16. Galione A, Chuang KT. Pyridine nucleotide metabolites and calcium release from intracellular stores. Adv Exp Med Biol. 2012; 740:305-23. PMID: 22453948.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  17. Tugba Durlu-Kandilci N, Ruas M, Chuang KT, Brading A, Parrington J, Galione A. TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle. J Biol Chem. 2010 Aug 06; 285(32):24925-32. PMID: 20547763.
    Citations: 29     Fields:    Translation:AnimalsCells
  18. Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R, Wang C, Zhu Y, Lin Y, Wyatt CN, Parrington J, Ma J, Evans AM, Galione A, Zhu MX. NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature. 2009 May 28; 459(7246):596-600. PMID: 19387438.
    Citations: 241     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.