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Carola Ledderose, D.V.M.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tiwari-Heckler S, Lee GR, Harbison J, Ledderose C, Csizmadia E, Melton D, Zhang Q, Junger W, Chen G, Hauser CJ, Otterbein LE, Longhi MS, Robson SC. Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39. Thorax. 2022 May 25. PMID: 35613855.
    Citations:    Fields:    
  2. Ledderose C, Valsami EA, Junger WG. Optimized HPLC method to elucidate the complex purinergic signaling dynamics that regulate ATP, ADP, AMP, and adenosine levels in human blood. Purinergic Signal. 2022 06; 18(2):223-239. PMID: 35132577; PMCID: PMC9123122.
    Citations:    Fields:    Translation:Humans
  3. Englhard AS, Ledderose C, Volgger V, Ledderose GJ. Evaluation of an image enhancement system for the assessment of nasal and paranasal sinus diseases. Am J Otolaryngol. 2022 Mar-Apr; 43(2):103323. PMID: 34933164.
    Citations:    Fields:    Translation:Humans
  4. Ledderose S, Ledderose C, Penkava J, Ledderose GJ. Prognostic Value of Tumor-Infiltrating Lymphocytes in Sinonasal Mucosal Melanoma. Laryngoscope. 2022 07; 132(7):1334-1339. PMID: 34415055.
    Citations:    Fields:    Translation:HumansCells
  5. Ledderose GJ, Havel M, Ledderose C, Betz CS. Endoscopic endonasal repair of complete bilateral choanal atresia in neonates. Eur J Pediatr. 2021 Jul; 180(7):2245-2251. PMID: 33709157.
    Citations: 1     Fields:    Translation:Humans
  6. Zhong EH, Ledderose C, De Andrade Mello P, Enjyoji K, Lunderberg JM, Junger W, Robson SC. Structural and functional characterization of engineered bifunctional fusion proteins of CD39 and CD73 ectonucleotidases. Am J Physiol Cell Physiol. 2021 01 01; 320(1):C15-C29. PMID: 33052071; PMCID: PMC7846972.
    Citations: 3     Fields:    Translation:HumansCells
  7. Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru JO, Ledderose C, Kutlu MG, Wheeler MA, Kahan A, Ishikawa M, Wang YC, Loh YE, Jiang JX, Surmeier DJ, Robson SC, Junger WG, Sebra R, Calipari ES, Kenny PJ, Eyo UB, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A. Negative feedback control of neuronal activity by microglia. Nature. 2020 10; 586(7829):417-423. PMID: 32999463; PMCID: PMC7577179.
    Citations: 137     Fields:    Translation:HumansAnimalsCells
  8. Ledderose C, Junger WG. Mitochondria Synergize With P2 Receptors to Regulate Human T Cell Function. Front Immunol. 2020; 11:549889. PMID: 33133068; PMCID: PMC7550529.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  9. Ledderose C, Bromberger S, Slubowski CJ, Sueyoshi K, Aytan D, Shen Y, Junger WG. The purinergic receptor P2Y11 choreographs the polarization, mitochondrial metabolism, and migration of T lymphocytes. Sci Signal. 2020 09 29; 13(651). PMID: 32994212; PMCID: PMC8826773.
    Citations: 17     Fields:    Translation:HumansCells
  10. Kondo Y, Sueyoshi K, Zhang J, Bao Y, Li X, Fakhari M, Slubowski CJ, Bahrami S, Ledderose C, Junger WG. Adenosine 5'-Monophosphate Protects from Hypoxia by Lowering Mitochondrial Metabolism and Oxygen Demand. Shock. 2020 08; 54(2):237-244. PMID: 31460871.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Ledderose C, Bromberger S, Slubowski CJ, Sueyoshi K, Junger WG. Frontline Science: P2Y11 receptors support T cell activation by directing mitochondrial trafficking to the immune synapse. J Leukoc Biol. 2021 03; 109(3):497-508. PMID: 32531829; PMCID: PMC8772287.
    Citations: 6     Fields:    Translation:HumansCells
  12. Ualiyeva S, Hallen N, Kanaoka Y, Ledderose C, Matsumoto I, Junger WG, Barrett NA, Bankova LG. Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2. Sci Immunol. 2020 01 17; 5(43). PMID: 31953256.
    Citations: 25     Fields:    Translation:AnimalsCells
  13. Kondo Y, Ledderose C, Slubowski CJ, Fakhari M, Sumi Y, Sueyoshi K, Bezler AK, Aytan D, Arbab M, Junger WG. Frontline Science: Escherichia coli use LPS as decoy to impair neutrophil chemotaxis and defeat antimicrobial host defense. J Leukoc Biol. 2019 12; 106(6):1211-1219. PMID: 31392789.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  14. Sumi Y, Ledderose C, Li L, Inoue Y, Okamoto K, Kondo Y, Sueyoshi K, Junger WG, Tanaka H. Plasma Adenylate Levels are Elevated in Cardiopulmonary Arrest Patients and May Predict Mortality. Shock. 2019 06; 51(6):698-705. PMID: 30052576.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  15. Woehrle T, Ledderose C, Rink J, Slubowski C, Junger WG. Autocrine stimulation of P2Y1 receptors is part of the purinergic signaling mechanism that regulates T cell activation. Purinergic Signal. 2019 06; 15(2):127-137. PMID: 30919205; PMCID: PMC6635541.
    Citations: 5     Fields:    Translation:HumansCells
  16. Sueyoshi K, Ledderose C, Shen Y, Lee AH, Shapiro NI, Junger WG. Lipopolysaccharide suppresses T cells by generating extracellular ATP that impairs their mitochondrial function via P2Y11 receptors. J Biol Chem. 2019 04 19; 294(16):6283-6293. PMID: 30787105.
    Citations: 12     Fields:    Translation:HumansCells
  17. Lee AH, Ledderose C, Li X, Slubowski CJ, Sueyoshi K, Staudenmaier L, Bao Y, Zhang J, Junger WG. Adenosine Triphosphate Release is Required for Toll-Like Receptor-Induced Monocyte/Macrophage Activation, Inflammasome Signaling, Interleukin-1ß Production, and the Host Immune Response to Infection. Crit Care Med. 2018 12; 46(12):e1183-e1189. PMID: 30247270; PMCID: PMC6239954.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  18. Ledderose C, Liu K, Kondo Y, Slubowski CJ, Dertnig T, Denicoló S, Arbab M, Hubner J, Konrad K, Fakhari M, Lederer JA, Robson SC, Visner GA, Junger WG. Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration. J Clin Invest. 2018 08 01; 128(8):3583-3594. PMID: 29894310; PMCID: PMC6063471.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  19. Ledderose GJ, Stelter K, Betz CS, Englhard AS, Ledderose C, Leunig A. Cerebrospinal fluid leaks during endoscopic sinus surgery in thirty-two patients. Clin Otolaryngol. 2017 10; 42(5):1105-1108. PMID: 28317322.
    Citations: 2     Fields:    Translation:Humans
  20. Li X, Kondo Y, Bao Y, Staudenmaier L, Lee A, Zhang J, Ledderose C, Junger WG. Systemic Adenosine Triphosphate Impairs Neutrophil Chemotaxis and Host Defense in Sepsis. Crit Care Med. 2017 Jan; 45(1):e97-e104. PMID: 27548819; PMCID: PMC5546305.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  21. Ledderose C, Hefti MM, Chen Y, Bao Y, Seier T, Li L, Woehrle T, Zhang J, Junger WG. Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signal. 2016 12; 12(4):673-685. PMID: 27577957; PMCID: PMC5124008.
    Citations: 10     Fields:    Translation:HumansCells
  22. Ledderose C, Bao Y, Kondo Y, Fakhari M, Slubowski C, Zhang J, Junger WG. Purinergic Signaling and the Immune Response in Sepsis: A Review. Clin Ther. 2016 05; 38(5):1054-65. PMID: 27156007.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  23. Ledderose C, Woehrle T, Ledderose S, Strasser K, Seist R, Bao Y, Zhang J, Junger WG. Cutting off the power: inhibition of leukemia cell growth by pausing basal ATP release and P2X receptor signaling? Purinergic Signal. 2016 09; 12(3):439-51. PMID: 27020575.
    Citations: 16     Fields:    Translation:HumansCells
  24. Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJ, Klenerman P, Sharpe AH, Lauer GM, Haining WN. CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. PLoS Pathog. 2015 Oct; 11(10):e1005177. PMID: 26485519; PMCID: PMC4618999.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  25. Bao Y, Ledderose C, Graf AF, Brix B, Birsak T, Lee A, Zhang J, Junger WG. mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis. J Cell Biol. 2015 Sep 28; 210(7):1153-64. PMID: 26416965; PMCID: PMC4586745.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  26. Chen Y, Bao Y, Zhang J, Woehrle T, Sumi Y, Ledderose S, Li X, Ledderose C, Junger WG. Inhibition of Neutrophils by Hypertonic Saline Involves Pannexin-1, CD39, CD73, and Other Ectonucleotidases. Shock. 2015 Sep; 44(3):221-7. PMID: 26009814; PMCID: PMC4537693.
    Citations: 11     Fields:    Translation:HumansCells
  27. Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, Zhang J, Robson SC, Shapiro NI, Junger WG. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016 Feb 01; 213(3):456-64. PMID: 26150546; PMCID: PMC4704665.
    Citations: 22     Fields:    Translation:HumansCells
  28. Ledderose C, Bao Y, Zhang J, Junger WG. Novel method for real-time monitoring of ATP release reveals multiple phases of autocrine purinergic signalling during immune cell activation. Acta Physiol (Oxf). 2015 Feb; 213(2):334-45. PMID: 25482154.
    Citations: 10     Fields:    Translation:HumansCells
  29. Bao Y, Ledderose C, Seier T, Graf AF, Brix B, Chong E, Junger WG. Mitochondria regulate neutrophil activation by generating ATP for autocrine purinergic signaling. J Biol Chem. 2014 Sep 26; 289(39):26794-26803. PMID: 25104353.
    Citations: 48     Fields:    Translation:HumansCellsCTClinical Trials
  30. Ledderose C, Bao Y, Lidicky M, Zipperle J, Li L, Strasser K, Shapiro NI, Junger WG. Mitochondria are gate-keepers of T cell function by producing the ATP that drives purinergic signaling. J Biol Chem. 2014 Sep 12; 289(37):25936-45. PMID: 25070895; PMCID: PMC4162192.
    Citations: 39     Fields:    Translation:HumansCells
  31. Beiras-Fernandez A, Weis F, Rothkopf J, Kaczmarek I, Ledderose C, Dick A, Keller T, Beiras A, Kreth S. Local expression of myocardial galectin-3 does not correlate with its serum levels in patients undergoing heart transplantation. Ann Transplant. 2013 Nov 22; 18:643-50. PMID: 24264380.
    Citations: 5     Fields:    Translation:Humans
  32. Kreth S, Ledderose C, Schütz S, Beiras A, Heyn J, Weis F, Beiras-Fernandez A. MicroRNA-150 inhibits expression of adiponectin receptor 2 and is a potential therapeutic target in patients with chronic heart failure. J Heart Lung Transplant. 2014 Mar; 33(3):252-60. PMID: 24239242.
    Citations: 6     Fields:    Translation:HumansCells
  33. Bao Y, Chen Y, Ledderose C, Li L, Junger WG. Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils. J Biol Chem. 2013 Aug 02; 288(31):22650-7. PMID: 23798685.
    Citations: 54     Fields:    Translation:HumansCells
  34. Heyn J, Hinske LC, Ledderose C, Limbeck E, Kreth S. Experimental miRNA target validation. Methods Mol Biol. 2013; 936:83-90. PMID: 23007501.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  35. Ledderose C, Möhnle P, Limbeck E, Schütz S, Weis F, Rink J, Briegel J, Kreth S. Corticosteroid resistance in sepsis is influenced by microRNA-124--induced downregulation of glucocorticoid receptor-a. Crit Care Med. 2012 Oct; 40(10):2745-53. PMID: 22846781.
    Citations: 54     Fields:    Translation:HumansCells
  36. Heyn J, Ledderose C, Hinske LC, Limbeck E, Möhnle P, Lindner HA, Kreth S. Adenosine A2A receptor upregulation in human PMNs is controlled by miRNA-214, miRNA-15, and miRNA-16. Shock. 2012 Feb; 37(2):156-63. PMID: 22249219.
    Citations: 17     Fields:    Translation:HumansCells
  37. Ledderose C, Heyn J, Limbeck E, Kreth S. Selection of reliable reference genes for quantitative real-time PCR in human T cells and neutrophils. BMC Res Notes. 2011 Oct 20; 4:427. PMID: 22011438.
    Citations: 54     Fields:    
  38. Kreth S, Thon N, Eigenbrod S, Lutz J, Ledderose C, Egensperger R, Tonn JC, Kretzschmar HA, Hinske LC, Kreth FW. O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation. PLoS One. 2011 Feb 18; 6(2):e17156. PMID: 21365007.
    Citations: 54     Fields:    Translation:HumansCells
  39. Ledderose C, Kreth S, Beiras-Fernandez A. Ghrelin, a novel peptide hormone in the regulation of energy balance and cardiovascular function. Recent Pat Endocr Metab Immune Drug Discov. 2011 Jan; 5(1):1-6. PMID: 22074572.
    Citations: 16     Fields:    Translation:Humans
  40. Beiras-Fernandez A, Kreth S, Weis F, Ledderose C, Pöttinger T, Dieguez C, Beiras A, Reichart B. Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure. Peptides. 2010 Dec; 31(12):2222-8. PMID: 20804798.
    Citations: 24     Fields:    Translation:Humans
  41. Kreth S, Ledderose C, Luchting B, Weis F, Thiel M. Immunomodulatory properties of pentoxifylline are mediated via adenosine-dependent pathways. Shock. 2010 Jul; 34(1):10-6. PMID: 19997047.
    Citations: 19     Fields:    Translation:HumansCells
  42. Kreth S, Kaufmann I, Ledderose C, Luchting B, Thiel M. Reduced ligand affinity leads to an impaired function of the adenosine A2A receptor of human granulocytes in sepsis. J Cell Mol Med. 2009 May; 13(5):985-94. PMID: 19538256.
    Citations: 8     Fields:    Translation:HumansCells
  43. Kreth S, Ledderose C, Kaufmann I, Groeger G, Thiel M. Differential expression of 5'-UTR splice variants of the adenosine A2A receptor gene in human granulocytes: identification, characterization, and functional impact on activation. FASEB J. 2008 Sep; 22(9):3276-86. PMID: 18541693.
    Citations: 14     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.