Title Associate Professor of Psychiatry Institution Massachusetts General Hospital Address Massachusetts General Hospital
Center for Regenerative Medicine, Psychiatry and HSCI
185 Cambridge St
Boston MA 02114
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Overview
The incidence and complexity of mental illnesses and cognitive impairments associated with ageing and Alzheimer’s disease underscores the need to develop novel treatments. Our mission is to improve hippocampal functions in cognition.
Given the centrality of hippocampal dysfunction in neurological and psychiatric disorders and our efforts targeting convergent mechanisms (eg: PV mediated GABAergic inhibition, neuroinflammation), we aspire to develop strategies with broad therapeutic impact that improve cognition in not only Age-related cognitive decline and Mild Cognitive Impairment (MCI, Alzheimer’s disease) but also social cognition impairments in Autism spectrum disorders and overgeneralization of traumatic memories in PTSD. Take a look at our Research Page and DM me (Amar) to discuss ongoing efforts to de-risk preclinical gene therapy assets for translation.
For more information, please go to http://www.sahaylab.com/
Research
The research activities and funding listed below are automatically derived from
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1R01AG076612-01
(Sahay)
Jun 1, 2022 - Mar 31, 2027
Targeting neurogenesis-inhibition coupling to improve memory in aging
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R56NS117529
(SAHAY, AMAR)
Sep 1, 2020 - Aug 31, 2021
Transcriptional Control of adult hippocampal neural stem cell homeostasis
Role: Principal Investigator
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R01MH111729
(SAHAY, AMAR)
Nov 15, 2017 - Oct 31, 2023
Contributions of hippocampal oxytocin receptors to social recognition
Role: Principal Investigator
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RF1AG048908
(SAHAY, AMAR)
Aug 1, 2016 - Mar 31, 2021
Re-engineering excitation-inhibition connectivity to rejuvenate memory circuits in aging
Role: Principal Investigator
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R01MH104175
(SAHAY, AMAR)
Jul 1, 2014 - Mar 31, 2020
Molecular control of excitation-inhibition balance to encode ambiguous threats
Role: Principal Investigator
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R00MH086615
(SAHAY, AMAR)
Aug 1, 2009 - May 31, 2014
Harnessing Adult Hippocampal Neurogenesis to Enhance Learning and Modulate Mood
Role: Principal Investigator
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K99MH086615
(SAHAY, AMAR)
Aug 1, 2009 - Jul 31, 2011
Harnessing Adult Hippocampal Neurogenesis to Enhance Learning and Modulate Mood
Role: Principal Investigator
Bibliographic
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