Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Amar Sahay, Ph.D.

Profile Picture

The incidence and complexity of mental illnesses and cognitive impairments associated with ageing and Alzheimer’s disease underscores the need to develop novel treatments. Our mission is to improve hippocampal functions in cognition.

Given the centrality of hippocampal dysfunction in neurological and psychiatric disorders and our efforts targeting convergent mechanisms (eg: PV mediated GABAergic inhibition, neuroinflammation), we aspire to develop strategies with broad therapeutic impact that improve cognition in not only Age-related cognitive decline and Mild Cognitive Impairment (MCI, Alzheimer’s disease) but also social cognition impairments in Autism spectrum disorders and overgeneralization of traumatic memories in PTSD. Take a look at our Research Page and DM me (Amar) to discuss ongoing efforts to de-risk preclinical gene therapy assets for translation.

For more information, please go to http://www.sahaylab.com/

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH131652 (SAHAY, AMAR) Aug 1, 2023 - May 31, 2028
    Hippocampal synaptic and circuit mechanisms mediating Dyrk1a functions in social cognition
    Role: Principal Investigator
  2. 1R01AG076612-01 (Sahay) Jun 1, 2022 - Mar 31, 2027
    Targeting neurogenesis-inhibition coupling to improve memory in aging
    Role: PI
  3. R56NS117529 (SAHAY, AMAR) Sep 1, 2020 - Aug 31, 2021
    Transcriptional Control of adult hippocampal neural stem cell homeostasis
    Role: Principal Investigator
  4. R01MH111729 (SAHAY, AMAR) Nov 15, 2017 - Oct 31, 2023
    Contributions of hippocampal oxytocin receptors to social recognition
    Role: Principal Investigator
  5. RF1AG048908 (SAHAY, AMAR) Aug 1, 2016 - Mar 31, 2021
    Re-engineering excitation-inhibition connectivity to rejuvenate memory circuits in aging
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
This operation might take several minutes to complete. Please do not close your browser.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Sahay's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (183)
Co-Authors (26)
Similar People (60)
Same Department 
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.