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Amar Sahay, Ph.D.

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The incidence and complexity of mental illnesses and cognitive impairments associated with ageing and Alzheimer’s disease underscores the need to develop novel treatments. Our mission is to generate fundamental insights into the role of adult hippocampal neurogenesis, the process by which neural stem cells generate dentate granule neurons throughout life, in hippocampal functions in encoding, memory processing and modulation of mood. By integrating cellular, circuit, systems and behavioral interrogation of adult hippocampal neurogenesis, we aspire to rejuvenate and re-engineer hippocampal circuitry to optimize circuit performance in diseases such as depression, anxiety disorders, Alzheimer’s disease and ageing.

For more information, please go to http://www.sahaylab.com/

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56NS117529 (SAHAY, AMAR) Sep 1, 2020 - Aug 31, 2021
    Transcriptional Control of adult hippocampal neural stem cell homeostasis
    Role: Principal Investigator
  2. R01MH111729 (SAHAY, AMAR) Nov 15, 2017 - Oct 31, 2022
    Contributions of hippocampal oxytocin receptors to social recognition
    Role: Principal Investigator
  3. R01AG048908 (SAHAY, AMAR) Aug 1, 2016 - Apr 30, 2021
    Re-engineering excitation-inhibition connectivity to rejuvenate memory circuits in aging
    Role: Principal Investigator
  4. RF1AG048908 (SAHAY, AMAR) Aug 1, 2016 - Mar 31, 2021
    Re-engineering excitation-inhibition connectivity to rejuvenate memory circuits in aging
    Role: Principal Investigator
  5. R01MH104175 (SAHAY, AMAR) Jul 1, 2014 - Mar 31, 2020
    Molecular control of excitation-inhibition balance to encode ambiguous threats
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Twarkowski H, Steininger V, Kim MJ, Sahay A. A dentate gyrus-CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation. Elife. 2022 02 22; 11. PMID: 35191834.
    Citations:    Fields:    
  2. Guo N, McDermott KD, Shih YT, Zanga H, Ghosh D, Herber C, Meara WR, Coleman J, Zagouras A, Wong LP, Sadreyev R, Gonçalves JT, Sahay A. Transcriptional regulation of neural stem cell expansion in the adult hippocampus. Elife. 2022 01 04; 11. PMID: 34982030.
    Citations:    Fields:    Translation:AnimalsCells
  3. Choi S, Zhang B, Ma S, Gonzalez-Celeiro M, Stein D, Jin X, Kim ST, Kang YL, Besnard A, Rezza A, Grisanti L, Buenrostro JD, Rendl M, Nahrendorf M, Sahay A, Hsu YC. Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence. Nature. 2021 04; 592(7854):428-432. PMID: 33790465.
    Citations: 7     Fields:    Translation:AnimalsCells
  4. Besnard A, Sahay A. Enhancing adult neurogenesis promotes contextual fear memory discrimination and activation of hippocampal-dorsolateral septal circuits. Behav Brain Res. 2021 02 05; 399:112917. PMID: 32949641.
    Citations: 2     Fields:    Translation:AnimalsCells
  5. Goode TD, Tanaka KZ, Sahay A, McHugh TJ. An Integrated Index: Engrams, Place Cells, and Hippocampal Memory. Neuron. 2020 09 09; 107(5):805-820. PMID: 32763146.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  6. Besnard A, Miller SM, Sahay A. Distinct Dorsal and Ventral Hippocampal CA3 Outputs Govern Contextual Fear Discrimination. Cell Rep. 2020 02 18; 30(7):2360-2373.e5. PMID: 32075769.
    Citations: 10     Fields:    Translation:HumansAnimals
  7. Vicidomini C, Guo N, Sahay A. Communication, Cross Talk, and Signal Integration in the Adult Hippocampal Neurogenic Niche. Neuron. 2020 01 22; 105(2):220-235. PMID: 31972145.
    Citations: 24     Fields:    Translation:AnimalsCells
  8. Miller SM, Sahay A. Functions of adult-born neurons in hippocampal memory interference and indexing. Nat Neurosci. 2019 10; 22(10):1565-1575. PMID: 31477897.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  9. Besnard A, Gao Y, TaeWoo Kim M, Twarkowski H, Reed AK, Langberg T, Feng W, Xu X, Saur D, Zweifel LS, Davison I, Sahay A. Dorsolateral septum somatostatin interneurons gate mobility to calibrate context-specific behavioral fear responses. Nat Neurosci. 2019 03; 22(3):436-446. PMID: 30718902.
    Citations: 15     Fields:    Translation:AnimalsCells
  10. Besnard A, Langberg T, Levinson S, Chu D, Vicidomini C, Scobie KN, Dwork AJ, Arango V, Rosoklija GB, Mann JJ, Hen R, Leonardo ED, Boldrini M, Sahay A. Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects against Chronic Stress-Induced Impairments in Dendritic Spines and Fear Responses. Cell Rep. 2018 06 12; 23(11):3183-3196. PMID: 29898391.
    Citations: 11     Fields:    Translation:AnimalsCells
  11. Dietrich J, Baryawno N, Nayyar N, Valtis YK, Yang B, Ly I, Besnard A, Severe N, Gustafsson KU, Andronesi OC, Batchelor TT, Sahay A, Scadden DT. Bone marrow drives central nervous system regeneration after radiation injury. J Clin Invest. 2018 06 01; 128(6):2651. PMID: 29856368.
    Citations: 3     Fields:    
  12. Guo N, Soden ME, Herber C, Kim MT, Besnard A, Lin P, Ma X, Cepko CL, Zweifel LS, Sahay A. Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization. Nat Med. 2018 05; 24(4):438-449. PMID: 29529016.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  13. Raam T, McAvoy KM, Besnard A, Veenema AH, Sahay A. Author Correction: Hippocampal oxytocin receptors are necessary for discrimination of social stimuli. Nat Commun. 2018 02 02; 9(1):552. PMID: 29396556.
    Citations:    Fields:    
  14. Raam T, McAvoy KM, Besnard A, Veenema AH, Sahay A. Hippocampal oxytocin receptors are necessary for discrimination of social stimuli. Nat Commun. 2017 12 08; 8(1):2001. PMID: 29222469.
    Citations: 59     Fields:    Translation:AnimalsCells
  15. Dietrich J, Baryawno N, Nayyar N, Valtis YK, Yang B, Ly I, Besnard A, Severe N, Gustafsson KU, Andronesi OC, Batchelor TT, Sahay A, Scadden DT. Bone marrow drives central nervous system regeneration after radiation injury. J Clin Invest. 2018 01 02; 128(1):281-293. PMID: 29202481.
    Citations: 20     Fields:    Translation:AnimalsCellsPHPublic Health
  16. Guo N, Sahay A. Neural Circuits Serve as Periscopes for NSCs. Cell Stem Cell. 2017 11 02; 21(5):557-559. PMID: 29100005.
    Citations: 2     Fields:    Translation:Cells
  17. Culig L, Surget A, Bourdey M, Khemissi W, Le Guisquet AM, Vogel E, Sahay A, Hen R, Belzung C. Increasing adult hippocampal neurogenesis in mice after exposure to unpredictable chronic mild stress may counteract some of the effects of stress. Neuropharmacology. 2017 Nov; 126:179-189. PMID: 28890366.
    Citations: 19     Fields:    Translation:Animals
  18. McAvoy KM, Sahay A. Targeting Adult Neurogenesis to Optimize Hippocampal Circuits in Aging. Neurotherapeutics. 2017 Jul; 14(3):630-645. PMID: 28536851.
    Citations: 17     Fields:    Translation:HumansAnimals
  19. Kaluski S, Portillo M, Besnard A, Stein D, Einav M, Zhong L, Ueberham U, Arendt T, Mostoslavsky R, Sahay A, Toiber D. Neuroprotective Functions for the Histone Deacetylase SIRT6. Cell Rep. 2017 03 28; 18(13):3052-3062. PMID: 28355558.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  20. McAvoy KM, Scobie KN, Berger S, Russo C, Guo N, Decharatanachart P, Vega-Ramirez H, Miake-Lye S, Whalen M, Nelson M, Bergami M, Bartsch D, Hen R, Berninger B, Sahay A. Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits. Neuron. 2016 Sep 21; 91(6):1356-1373. PMID: 27593178.
    Citations: 56     Fields:    Translation:AnimalsCells
  21. Widge AS, Sahay A. Closing the Loop in Deep Brain Stimulation for Psychiatric Disorders: Lessons from Motor Neural Prosthetics. Neuropsychopharmacology. 2016 Jan; 41(1):379-80. PMID: 26657958.
    Citations: 4     Fields:    Translation:HumansAnimals
  22. McAvoy K, Besnard A, Sahay A. Adult hippocampal neurogenesis and pattern separation in DG: a role for feedback inhibition in modulating sparseness to govern population-based coding. Front Syst Neurosci. 2015; 9:120. PMID: 26347621.
    Citations: 26     
  23. Wu MV, Sahay A, Duman RS, Hen R. Functional differentiation of adult-born neurons along the septotemporal axis of the dentate gyrus. Cold Spring Harb Perspect Biol. 2015 Aug 03; 7(8):a018978. PMID: 26238355.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  24. Besnard A, Sahay A. Adult Hippocampal Neurogenesis, Fear Generalization, and Stress. Neuropsychopharmacology. 2016 Jan; 41(1):24-44. PMID: 26068726.
    Citations: 63     Fields:    Translation:HumansAnimals
  25. McAvoy K, Russo C, Kim S, Rankin G, Sahay A. Fluoxetine induces input-specific hippocampal dendritic spine remodeling along the septotemporal axis in adulthood and middle age. Hippocampus. 2015 Nov; 25(11):1429-46. PMID: 25850664.
    Citations: 17     Fields:    Translation:AnimalsCells
  26. Hill AS, Sahay A, Hen R. Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors. Neuropsychopharmacology. 2015 Sep; 40(10):2368-78. PMID: 25833129.
    Citations: 171     Fields:    Translation:Animals
  27. Ikrar T, Guo N, He K, Besnard A, Levinson S, Hill A, Lee HK, Hen R, Xu X, Sahay A. Adult neurogenesis modifies excitability of the dentate gyrus. Front Neural Circuits. 2013; 7:204. PMID: 24421758.
    Citations: 87     Fields:    Translation:AnimalsCells
  28. Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature. 2013 Nov 14; 503(7475):218-23. PMID: 24196716.
    Citations: 266     Fields:    Translation:AnimalsCells
  29. Ho NF, Hooker JM, Sahay A, Holt DJ, Roffman JL. In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise. Mol Psychiatry. 2013 Apr; 18(4):404-16. PMID: 23439487.
    Citations: 34     Fields:    Translation:HumansAnimals
  30. Kheirbek MA, Klemenhagen KC, Sahay A, Hen R. Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders. Nat Neurosci. 2012 Dec; 15(12):1613-20. PMID: 23187693.
    Citations: 193     Fields:    Translation:HumansAnimals
  31. Sahay A, Wilson DA, Hen R. Pattern separation: a common function for new neurons in hippocampus and olfactory bulb. Neuron. 2011 May 26; 70(4):582-8. PMID: 21609817.
    Citations: 225     Fields:    Translation:HumansAnimalsCells
  32. Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS, Fenton AA, Dranovsky A, Hen R. Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature. 2011 Apr 28; 472(7344):466-70. PMID: 21460835.
    Citations: 641     Fields:    Translation:AnimalsCells
  33. Weber T, Baier V, Pauly R, Sahay A, Baur M, Herrmann E, Ciccolini F, Hen R, Kronenberg G, Bartsch D. Inducible gene expression in GFAP+ progenitor cells of the SGZ and the dorsal wall of the SVZ-A novel tool to manipulate and trace adult neurogenesis. Glia. 2011 Apr; 59(4):615-26. PMID: 21294160.
    Citations: 7     Fields:    Translation:AnimalsCells
  34. Scobie KN, Hall BJ, Wilke SA, Klemenhagen KC, Fujii-Kuriyama Y, Ghosh A, Hen R, Sahay A. Krüppel-like factor 9 is necessary for late-phase neuronal maturation in the developing dentate gyrus and during adult hippocampal neurogenesis. J Neurosci. 2009 Aug 05; 29(31):9875-87. PMID: 19657039.
    Citations: 66     Fields:    Translation:AnimalsCells
  35. Sahay A, Hen R. Hippocampal neurogenesis and depression. Novartis Found Symp. 2008; 289:152-60; discussion 160-4, 193-5. PMID: 18497101.
    Citations: 20     Fields:    Translation:HumansCells
  36. Sahay A, Hen R. Adult hippocampal neurogenesis in depression. Nat Neurosci. 2007 Sep; 10(9):1110-5. PMID: 17726477.
    Citations: 434     Fields:    Translation:HumansAnimals
  37. Sahay A, Drew MR, Hen R. Dentate gyrus neurogenesis and depression. Prog Brain Res. 2007; 163:697-722. PMID: 17765746.
    Citations: 45     Fields:    Translation:HumansAnimals
  38. Sahay A, Kim CH, Sepkuty JP, Cho E, Huganir RL, Ginty DD, Kolodkin AL. Secreted semaphorins modulate synaptic transmission in the adult hippocampus. J Neurosci. 2005 Apr 06; 25(14):3613-20. PMID: 15814792.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  39. Cloutier JF, Sahay A, Chang EC, Tessier-Lavigne M, Dulac C, Kolodkin AL, Ginty DD. Differential requirements for semaphorin 3F and Slit-1 in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections. J Neurosci. 2004 Oct 13; 24(41):9087-96. PMID: 15483127.
    Citations: 37     Fields:    Translation:AnimalsCells
  40. Sahay A, Molliver ME, Ginty DD, Kolodkin AL. Semaphorin 3F is critical for development of limbic system circuitry and is required in neurons for selective CNS axon guidance events. J Neurosci. 2003 Jul 30; 23(17):6671-80. PMID: 12890759.
    Citations: 75     Fields:    Translation:AnimalsCells
  41. Giger RJ, Cloutier JF, Sahay A, Prinjha RK, Levengood DV, Moore SE, Pickering S, Simmons D, Rastan S, Walsh FS, Kolodkin AL, Ginty DD, Geppert M. Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins. Neuron. 2000 Jan; 25(1):29-41. PMID: 10707970.
    Citations: 135     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.