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Amar Sahay, Ph.D.

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The incidence and complexity of mental illnesses and cognitive impairments associated with ageing and Alzheimer’s disease underscores the need to develop novel treatments. Our mission is to generate fundamental insights into the role of adult hippocampal neurogenesis, the process by which neural stem cells generate dentate granule neurons throughout life, in hippocampal functions in encoding, memory processing and modulation of mood. By integrating cellular, circuit, systems and behavioral interrogation of adult hippocampal neurogenesis, we aspire to rejuvenate and re-engineer hippocampal circuitry to optimize circuit performance in diseases such as depression, anxiety disorders, Alzheimer’s disease and ageing.

For more information, please go to http://www.sahaylab.com/

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH111729 (SAHAY, AMAR) Nov 15, 2017 - Oct 31, 2022
    Contributions of hippocampal oxytocin receptors to social recognition
    Role: Principal Investigator
  2. R01AG048908 (SAHAY, AMAR) Aug 1, 2016 - Apr 30, 2021
    Re-engineering excitation-inhibition connectivity to rejuvenate memory circuits in aging
    Role: Principal Investigator
  3. R01MH104175 (SAHAY, AMAR) Jul 1, 2014 - Mar 31, 2019
    Molecular control of excitation-inhibition balance to encode ambiguous threats
    Role: Principal Investigator
  4. R00MH086615 (SAHAY, AMAR) Aug 1, 2009 - May 31, 2014
    Harnessing Adult Hippocampal Neurogenesis to Enhance Learning and Modulate Mood
    Role: Principal Investigator
  5. K99MH086615 (SAHAY, AMAR) Aug 1, 2009 - Jul 31, 2011
    Harnessing Adult Hippocampal Neurogenesis to Enhance Learning and Modulate Mood
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Besnard A, Sahay A. Enhancing adult neurogenesis promotes contextual fear memory discrimination and activation of hippocampal-dorsolateral septal circuits. Behav Brain Res. 2020 Sep 16; 112917. PMID: 32949641.
  2. Goode TD, Tanaka KZ, Sahay A, McHugh TJ. An Integrated Index: Engrams, Place Cells, and Hippocampal Memory. Neuron. 2020 Sep 09; 107(5):805-820. PMID: 32763146.
  3. Besnard A, Miller SM, Sahay A. Distinct Dorsal and Ventral Hippocampal CA3 Outputs Govern Contextual Fear Discrimination. Cell Rep. 2020 02 18; 30(7):2360-2373.e5. PMID: 32075769.
  4. Vicidomini C, Guo N, Sahay A. Communication, Cross Talk, and Signal Integration in the Adult Hippocampal Neurogenic Niche. Neuron. 2020 01 22; 105(2):220-235. PMID: 31972145.
  5. Miller SM, Sahay A. Functions of adult-born neurons in hippocampal memory interference and indexing. Nat Neurosci. 2019 10; 22(10):1565-1575. PMID: 31477897.
  6. Besnard A, Gao Y, TaeWoo Kim M, Twarkowski H, Reed AK, Langberg T, Feng W, Xu X, Saur D, Zweifel LS, Davison I, Sahay A. Dorsolateral septum somatostatin interneurons gate mobility to calibrate context-specific behavioral fear responses. Nat Neurosci. 2019 03; 22(3):436-446. PMID: 30718902.
  7. Besnard A, Langberg T, Levinson S, Chu D, Vicidomini C, Scobie KN, Dwork AJ, Arango V, Rosoklija GB, Mann JJ, Hen R, Leonardo ED, Boldrini M, Sahay A. Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects against Chronic Stress-Induced Impairments in Dendritic Spines and Fear Responses. Cell Rep. 2018 06 12; 23(11):3183-3196. PMID: 29898391.
    Citations:    Fields:    
  8. Dietrich J, Baryawno N, Nayyar N, Valtis YK, Yang B, Ly I, Besnard A, Severe N, Gustafsson KU, Andronesi OC, Batchelor TT, Sahay A, Scadden DT. Bone marrow drives central nervous system regeneration after radiation injury. J Clin Invest. 2018 06 01; 128(6):2651. PMID: 29856368.
    Citations:    Fields:    
  9. Guo N, Soden ME, Herber C, Kim MT, Besnard A, Lin P, Ma X, Cepko CL, Zweifel LS, Sahay A. Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization. Nat Med. 2018 05; 24(4):438-449. PMID: 29529016.
    Citations: 1     Fields:    
  10. Raam T, McAvoy KM, Besnard A, Veenema AH, Sahay A. Author Correction: Hippocampal oxytocin receptors are necessary for discrimination of social stimuli. Nat Commun. 2018 02 02; 9(1):552. PMID: 29396556.
    Citations:    Fields:    
  11. Raam T, McAvoy KM, Besnard A, Veenema AH, Sahay A. Hippocampal oxytocin receptors are necessary for discrimination of social stimuli. Nat Commun. 2017 12 08; 8(1):2001. PMID: 29222469.
    Citations: 3     Fields:    Translation:AnimalsCells
  12. Dietrich J, Baryawno N, Nayyar N, Valtis YK, Yang B, Ly I, Besnard A, Severe N, Gustafsson KU, Andronesi OC, Batchelor TT, Sahay A, Scadden DT. Bone marrow drives central nervous system regeneration after radiation injury. J Clin Invest. 2018 01 02; 128(1):281-293. PMID: 29202481.
    Citations: 2     Fields:    
  13. Guo N, Sahay A. Neural Circuits Serve as Periscopes for NSCs. Cell Stem Cell. 2017 11 02; 21(5):557-559. PMID: 29100005.
    Citations:    Fields:    
  14. Culig L, Surget A, Bourdey M, Khemissi W, Le Guisquet AM, Vogel E, Sahay A, Hen R, Belzung C. Increasing adult hippocampal neurogenesis in mice after exposure to unpredictable chronic mild stress may counteract some of the effects of stress. Neuropharmacology. 2017 Nov; 126:179-189. PMID: 28890366.
    Citations: 1     Fields:    Translation:Animals
  15. McAvoy KM, Sahay A. Targeting Adult Neurogenesis to Optimize Hippocampal Circuits in Aging. Neurotherapeutics. 2017 Jul; 14(3):630-645. PMID: 28536851.
    Citations: 1     Fields:    Translation:HumansAnimals
  16. Kaluski S, Portillo M, Besnard A, Stein D, Einav M, Zhong L, Ueberham U, Arendt T, Mostoslavsky R, Sahay A, Toiber D. Neuroprotective Functions for the Histone Deacetylase SIRT6. Cell Rep. 2017 03 28; 18(13):3052-3062. PMID: 28355558.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  17. McAvoy KM, Scobie KN, Berger S, Russo C, Guo N, Decharatanachart P, Vega-Ramirez H, Miake-Lye S, Whalen M, Nelson M, Bergami M, Bartsch D, Hen R, Berninger B, Sahay A. Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits. Neuron. 2016 Sep 21; 91(6):1356-1373. PMID: 27593178.
    Citations: 18     Fields:    Translation:AnimalsCells
  18. Widge AS, Sahay A. Closing the Loop in Deep Brain Stimulation for Psychiatric Disorders: Lessons from Motor Neural Prosthetics. Neuropsychopharmacology. 2016 Jan; 41(1):379-80. PMID: 26657958.
    Citations: 2     Fields:    Translation:HumansAnimals
  19. McAvoy K, Besnard A, Sahay A. Adult hippocampal neurogenesis and pattern separation in DG: a role for feedback inhibition in modulating sparseness to govern population-based coding. Front Syst Neurosci. 2015; 9:120. PMID: 26347621.
    Citations: 10     
  20. Wu MV, Sahay A, Duman RS, Hen R. Functional differentiation of adult-born neurons along the septotemporal axis of the dentate gyrus. Cold Spring Harb Perspect Biol. 2015 Aug 03; 7(8):a018978. PMID: 26238355.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  21. Besnard A, Sahay A. Adult Hippocampal Neurogenesis, Fear Generalization, and Stress. Neuropsychopharmacology. 2016 Jan; 41(1):24-44. PMID: 26068726.
    Citations: 27     Fields:    Translation:HumansAnimals
  22. McAvoy K, Russo C, Kim S, Rankin G, Sahay A. Fluoxetine induces input-specific hippocampal dendritic spine remodeling along the septotemporal axis in adulthood and middle age. Hippocampus. 2015 Nov; 25(11):1429-46. PMID: 25850664.
    Citations: 9     Fields:    Translation:AnimalsCells
  23. Hill AS, Sahay A, Hen R. Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors. Neuropsychopharmacology. 2015 Sep; 40(10):2368-78. PMID: 25833129.
    Citations: 53     Fields:    Translation:Animals
  24. Ikrar T, Guo N, He K, Besnard A, Levinson S, Hill A, Lee HK, Hen R, Xu X, Sahay A. Adult neurogenesis modifies excitability of the dentate gyrus. Front Neural Circuits. 2013; 7:204. PMID: 24421758.
    Citations: 43     Fields:    Translation:AnimalsCells
  25. Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature. 2013 Nov 14; 503(7475):218-23. PMID: 24196716.
    Citations: 157     Fields:    Translation:AnimalsCells
  26. Ho NF, Hooker JM, Sahay A, Holt DJ, Roffman JL. In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise. Mol Psychiatry. 2013 Apr; 18(4):404-16. PMID: 23439487.
    Citations: 23     Fields:    Translation:HumansAnimals
  27. Kheirbek MA, Klemenhagen KC, Sahay A, Hen R. Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders. Nat Neurosci. 2012 Dec; 15(12):1613-20. PMID: 23187693.
    Citations: 117     Fields:    Translation:HumansAnimals
  28. Sahay A, Wilson DA, Hen R. Pattern separation: a common function for new neurons in hippocampus and olfactory bulb. Neuron. 2011 May 26; 70(4):582-8. PMID: 21609817.
    Citations: 163     Fields:    Translation:HumansAnimalsCells
  29. Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS, Fenton AA, Dranovsky A, Hen R. Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature. 2011 Apr 28; 472(7344):466-70. PMID: 21460835.
    Citations: 398     Fields:    Translation:AnimalsCells
  30. Weber T, Baier V, Pauly R, Sahay A, Baur M, Herrmann E, Ciccolini F, Hen R, Kronenberg G, Bartsch D. Inducible gene expression in GFAP+ progenitor cells of the SGZ and the dorsal wall of the SVZ-A novel tool to manipulate and trace adult neurogenesis. Glia. 2011 Apr; 59(4):615-26. PMID: 21294160.
    Citations: 5     Fields:    Translation:AnimalsCells
  31. Scobie KN, Hall BJ, Wilke SA, Klemenhagen KC, Fujii-Kuriyama Y, Ghosh A, Hen R, Sahay A. Krüppel-like factor 9 is necessary for late-phase neuronal maturation in the developing dentate gyrus and during adult hippocampal neurogenesis. J Neurosci. 2009 Aug 05; 29(31):9875-87. PMID: 19657039.
    Citations: 53     Fields:    Translation:AnimalsCells
  32. Sahay A, Hen R. Hippocampal neurogenesis and depression. Novartis Found Symp. 2008; 289:152-60; discussion 160-4, 193-5. PMID: 18497101.
    Citations: 14     Fields:    Translation:HumansCells
  33. Sahay A, Hen R. Adult hippocampal neurogenesis in depression. Nat Neurosci. 2007 Sep; 10(9):1110-5. PMID: 17726477.
    Citations: 315     Fields:    Translation:HumansAnimals
  34. Sahay A, Drew MR, Hen R. Dentate gyrus neurogenesis and depression. Prog Brain Res. 2007; 163:697-722. PMID: 17765746.
    Citations: 35     Fields:    Translation:HumansAnimals
  35. Sahay A, Kim CH, Sepkuty JP, Cho E, Huganir RL, Ginty DD, Kolodkin AL. Secreted semaphorins modulate synaptic transmission in the adult hippocampus. J Neurosci. 2005 Apr 06; 25(14):3613-20. PMID: 15814792.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  36. Cloutier JF, Sahay A, Chang EC, Tessier-Lavigne M, Dulac C, Kolodkin AL, Ginty DD. Differential requirements for semaphorin 3F and Slit-1 in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections. J Neurosci. 2004 Oct 13; 24(41):9087-96. PMID: 15483127.
    Citations: 24     Fields:    Translation:AnimalsCells
  37. Sahay A, Molliver ME, Ginty DD, Kolodkin AL. Semaphorin 3F is critical for development of limbic system circuitry and is required in neurons for selective CNS axon guidance events. J Neurosci. 2003 Jul 30; 23(17):6671-80. PMID: 12890759.
    Citations: 50     Fields:    Translation:AnimalsCells
  38. Giger RJ, Cloutier JF, Sahay A, Prinjha RK, Levengood DV, Moore SE, Pickering S, Simmons D, Rastan S, Walsh FS, Kolodkin AL, Ginty DD, Geppert M. Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins. Neuron. 2000 Jan; 25(1):29-41. PMID: 10707970.
    Citations: 100     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.