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Christian Rask-Madsen, Ph.D., M.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21CA185196 (RASK-MADSEN, CHRISTIAN) May 1, 2014 - Apr 30, 2016
    NIH/NCI
    Endothelial cell insulin and increased intestinal tumor formation in obesity
    Role: Principal Investigator
  2. R01NS077006 (FEENER, EDWARD P) Jun 1, 2012 - May 31, 2017
    NIH/NINDS
    Role of Hyperglycemia in Intracerebral Hemorrhage
    Role: Co-Principal Investigator
  3. K08EY018677 (RASK-MADSEN, CHRISTIAN) Feb 1, 2008 - Jan 31, 2013
    NIH/NEI
    The role of PKCepsilon in diabetic retinopathy
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Rhea EM, Rask-Madsen C, Banks WA. Insulin transport across the blood-brain barrier can occur independently of the insulin receptor. J Physiol. 2018 Oct; 596(19):4753-4765. PMID: 30044494.
    View in: PubMed
  2. Park K, Li Q, Evcimen ND, Rask-Madsen C, Maeda Y, Maddaloni E, Yokomizo H, Shinjo T, St-Louis R, Fu J, Gordin D, Khamaisi M, Pober D, Keenan H, King GL. Exogenous Insulin Infusion Can Decrease Atherosclerosis in Diabetic Rodents by Improving Lipids, Inflammation, and Endothelial Function. Arterioscler Thromb Vasc Biol. 2018 Jan; 38(1):92-101. PMID: 29162603.
    View in: PubMed
  3. Konishi M, Sakaguchi M, Lockhart SM, Cai W, Li ME, Homan EP, Rask-Madsen C, Kahn CR. Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice. Proc Natl Acad Sci U S A. 2017 10 03; 114(40):E8478-E8487. PMID: 28923931.
    View in: PubMed
  4. Li Q, Park K, Xia Y, Matsumoto M, Qi W, Fu J, Yokomizo H, Khamaisi M, Wang X, Rask-Madsen C, King GL. Regulation of Macrophage Apoptosis and Atherosclerosis by Lipid-Induced PKCd Isoform Activation. Circ Res. 2017 Oct 27; 121(10):1153-1167. PMID: 28855204.
    View in: PubMed
  5. Wang X, Häring MF, Rathjen T, Lockhart SM, Sørensen D, Ussar S, Rasmussen LM, Bertagnolli MM, Kahn CR, Rask-Madsen C. Insulin resistance in vascular endothelial cells promotes intestinal tumour formation. Oncogene. 2017 08 31; 36(35):4987-4996. PMID: 28459466.
    View in: PubMed
  6. Rask-Madsen C, Park K, Li Q, King GL. Letter by Rask-Madsen et al Regarding Article, "Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop". Circ Res. 2017 Feb 17; 120(4):e2-e3. PMID: 28209799.
    View in: PubMed
  7. Qi W, Li Q, Liew CW, Rask-Madsen C, Lockhart SM, Rasmussen LM, Xia Y, Wang X, Khamaisi M, Croce K, King GL. SHP-1 activation inhibits vascular smooth muscle cell proliferation and intimal hyperplasia in a rodent model of insulin resistance and diabetes. Diabetologia. 2017 03; 60(3):585-596. PMID: 27933336.
    View in: PubMed
  8. Wang X, Lockhart SM, Rathjen T, Albadawi H, Sørensen D, O'Neill BT, Dwivedi N, Preil SR, Beck HC, Dunwoodie SL, Watkins MT, Rasmussen LM, Rask-Madsen C. Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells. Diabetes. 2016 Dec; 65(12):3680-3690. PMID: 27561725.
    View in: PubMed
  9. Albadawi H, Tzika AA, Rask-Madsen C, Crowley LM, Koulopoulos MW, Yoo HJ, Watkins MT. Revascularization and muscle adaptation to limb demand ischemia in diet-induced obese mice. J Surg Res. 2016 09; 205(1):49-58. PMID: 27620999.
    View in: PubMed
  10. Park K, Mima A, Li Q, Rask-Madsen C, He P, Mizutani K, Katagiri S, Maeda Y, Wu IH, Khamaisi M, Preil SR, Maddaloni E, Sørensen D, Rasmussen LM, Huang PL, King GL. Insulin decreases atherosclerosis by inducing endothelin receptor B expression. JCI Insight. 2016 May 05; 1(6). PMID: 27200419.
    View in: PubMed
  11. Park K, Li Q, Rask-Madsen C, Mima A, Mizutani K, Winnay J, Maeda Y, D'Aquino K, White MF, Feener EP, King GL. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol. 2013 Aug; 33(16):3227-41. PMID: 23775122; PMCID: PMC3753901.
  12. Li Q, Park K, Li C, Rask-Madsen C, Mima A, Qi W, Mizutani K, Huang P, King GL. Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-ß isoform in the endothelium. Circ Res. 2013 Aug 02; 113(4):418-27. PMID: 23759514; PMCID: PMC3893704.
  13. Rask-Madsen C, King GL. Vascular complications of diabetes: mechanisms of injury and protective factors. Cell Metab. 2013 Jan 08; 17(1):20-33. PMID: 23312281; PMCID: PMC3546345.
  14. Mima A, Qi W, Hiraoka-Yamomoto J, Park K, Matsumoto M, Kitada M, Li Q, Mizutani K, Yu E, Shimada T, Lee J, Shoelson SE, Jobin C, Rask-Madsen C, King GL. Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Invest Ophthalmol Vis Sci. 2012 Dec 19; 53(13):8424-32. PMID: 23197686; PMCID: PMC3753893.
  15. Rask-Madsen C, Kahn CR. Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease. Arterioscler Thromb Vasc Biol. 2012 Sep; 32(9):2052-9. PMID: 22895666; PMCID: PMC3511859.
  16. Mima A, Hiraoka-Yamomoto J, Li Q, Kitada M, Li C, Geraldes P, Matsumoto M, Mizutani K, Park K, Cahill C, Nishikawa S, Rask-Madsen C, King GL. Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCß activation in diabetes. Diabetes. 2012 Nov; 61(11):2967-79. PMID: 22826029; PMCID: PMC3478518.
  17. Mima A, Kitada M, Geraldes P, Li Q, Matsumoto M, Mizutani K, Qi W, Li C, Leitges M, Rask-Madsen C, King GL. Glomerular VEGF resistance induced by PKCd/SHP-1 activation and contribution to diabetic nephropathy. FASEB J. 2012 Jul; 26(7):2963-74. PMID: 22499584; PMCID: PMC3382088.
  18. Rask-Madsen C, Buonomo E, Li Q, Park K, Clermont AC, Yerokun O, Rekhter M, King GL. Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol. 2012 May; 32(5):1124-31. PMID: 22426129; PMCID: PMC3640325.
  19. Falskov B, Hermann TS, Rask-Madsen C, Major-Pedersen A, Christiansen B, Raunsø J, Køber L, Torp-Pedersen C, Dominguez H. The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive. Vasc Health Risk Manag. 2011; 7:771-6. PMID: 22241951; PMCID: PMC3253770.
  20. Maeno Y, Li Q, Park K, Rask-Madsen C, Gao B, Matsumoto M, Liu Y, Wu IH, White MF, Feener EP, King GL. Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). J Biol Chem. 2012 Feb 10; 287(7):4518-30. PMID: 22158866; PMCID: PMC3281670.
  21. Falskov B, Hermann TS, Raunsø J, Christiansen B, Rask-Madsen C, Major-Pedersen A, Køber L, Torp-Pedersen C, Dominguez H. Endothelial function is unaffected by changing between carvedilol and metoprolol in patients with heart failure--a randomized study. Cardiovasc Diabetol. 2011 Oct 15; 10:91. PMID: 21999413; PMCID: PMC3212926.
  22. Rask-Madsen C, King GL. Endothelium-dependent delivery of insulin to muscle interstitium. Cell Metab. 2011 Mar 02; 13(3):236-8. PMID: 21356512; PMCID: PMC3232062.
  23. Mima A, Ohshiro Y, Kitada M, Matsumoto M, Geraldes P, Li C, Li Q, White GS, Cahill C, Rask-Madsen C, King GL. Glomerular-specific protein kinase C-ß-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity. Kidney Int. 2011 Apr; 79(8):883-96. PMID: 21228767; PMCID: PMC3612886.
  24. Rask-Madsen C, King GL. Diabetes: Podocytes lose their footing. Nature. 2010 Nov 04; 468(7320):42-4. PMID: 21048754.
    View in: PubMed
  25. Cao L, Arany PR, Kim J, Rivera-Feliciano J, Wang YS, He Z, Rask-Madsen C, King GL, Mooney DJ. Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice. Biomaterials. 2010 Dec; 31(34):9048-56. PMID: 20800279; PMCID: PMC2949444.
  26. Kveiborg B, Hermann TS, Major-Pedersen A, Christiansen B, Rask-Madsen C, Raunsø J, Køber L, Torp-Pedersen C, Dominguez H. Metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study. Cardiovasc Diabetol. 2010 May 25; 9:21. PMID: 20500877; PMCID: PMC2893119.
  27. Rask-Madsen C, Li Q, Freund B, Feather D, Abramov R, Wu IH, Chen K, Yamamoto-Hiraoka J, Goldenbogen J, Sotiropoulos KB, Clermont A, Geraldes P, Dall'Osso C, Wagers AJ, Huang PL, Rekhter M, Scalia R, Kahn CR, King GL. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab. 2010 May 05; 11(5):379-89. PMID: 20444418; PMCID: PMC3020149.
  28. Rask-Madsen C, King GL. Kidney complications: factors that protect the diabetic vasculature. Nat Med. 2010 Jan; 16(1):40-1. PMID: 20057426.
    View in: PubMed
  29. Geraldes P, Yagi K, Ohshiro Y, He Z, Maeno Y, Yamamoto-Hiraoka J, Rask-Madsen C, Chung SW, Perrella MA, King GL. Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. J Biol Chem. 2008 Dec 05; 283(49):34327-36. PMID: 18854316; PMCID: PMC2590690.
  30. Major-Pedersen A, Ihlemann N, Hermann TS, Christiansen B, Kveiborg B, Dominguez H, Nielsen D, Rask-Madsen C, Svendsen OL, Køber L, Torp-Pedersen C. Effects of acute and chronic attenuation of postprandial hyperglycemia on postglucose-load endothelial function in insulin resistant individuals: is stimulation of first phase insulin secretion beneficial for the endothelial function? Horm Metab Res. 2008 Sep; 40(9):607-13. PMID: 18792871.
    View in: PubMed
  31. Rask-Madsen C, King GL. More sugar, less blood vessels: another piece in the puzzle of increased cardiovascular risk in diabetes. Arterioscler Thromb Vasc Biol. 2008 Apr; 28(4):608-10. PMID: 18354093; PMCID: PMC3232058.
  32. Rask-Madsen C, King GL. Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells. Arterioscler Thromb Vasc Biol. 2008 May; 28(5):919-24. PMID: 18323518; PMCID: PMC3340425.
  33. Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Alemán JO, Suzuki R, Scapa EF, Agarwal C, Carey MC, Stephanopoulos G, Cohen DE, King GL, Ginsberg HN, Kahn CR. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab. 2008 Feb; 7(2):125-34. PMID: 18249172; PMCID: PMC4251554.
  34. Rask-Madsen C, King GL. Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes. Nat Clin Pract Endocrinol Metab. 2007 Jan; 3(1):46-56. PMID: 17179929.
    View in: PubMed
  35. Clermont AC, Cahill M, Salti H, Rook SL, Rask-Madsen C, Goddard L, Wong JS, Bursell D, Bursell SE, Aiello LP. Hepatocyte growth factor induces retinal vascular permeability via MAP-kinase and PI-3 kinase without altering retinal hemodynamics. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2701-8. PMID: 16723489.
    View in: PubMed
  36. Sotiropoulos KB, Clermont A, Yasuda Y, Rask-Madsen C, Mastumoto M, Takahashi J, Della Vecchia K, Kondo T, Aiello LP, King GL. Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain. FASEB J. 2006 Jun; 20(8):1203-5. PMID: 16672634.
    View in: PubMed
  37. Naruse K, Rask-Madsen C, Takahara N, Ha SW, Suzuma K, Way KJ, Jacobs JR, Clermont AC, Ueki K, Ohshiro Y, Zhang J, Goldfine AB, King GL. Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes. 2006 Mar; 55(3):691-8. PMID: 16505232.
    View in: PubMed
  38. Hermann TS, Li W, Dominguez H, Ihlemann N, Rask-Madsen C, Major-Pedersen A, Nielsen DB, Hansen KW, Hawkins M, Kober L, Torp-Pedersen C. Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes. J Clin Endocrinol Metab. 2006 Mar; 91(3):1001-8. PMID: 16352688.
    View in: PubMed
  39. Pedersen OD, Abildstrøm SZ, Ottesen MM, Rask-Madsen C, Bagger H, Køber L, Torp-Pedersen C. Increased risk of sudden and non-sudden cardiovascular death in patients with atrial fibrillation/flutter following acute myocardial infarction. Eur Heart J. 2006 Feb; 27(3):290-5. PMID: 16267070.
    View in: PubMed
  40. Abildstrom SZ, Ottesen MM, Rask-Madsen C, Andersen PK, Rosthøj S, Torp-Pedersen C, Køber L. Sudden cardiovascular death following myocardial infarction: the importance of left ventricular systolic dysfunction and congestive heart failure. Int J Cardiol. 2005 Sep 30; 104(2):184-9. PMID: 16168812.
    View in: PubMed
  41. Dominguez H, Storgaard H, Rask-Madsen C, Steffen Hermann T, Ihlemann N, Baunbjerg Nielsen D, Spohr C, Kober L, Vaag A, Torp-Pedersen C. Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes. J Vasc Res. 2005 Nov-Dec; 42(6):517-25. PMID: 16155368.
    View in: PubMed
  42. Rask-Madsen C, King GL. Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance. Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):487-96. PMID: 15637306.
    View in: PubMed
  43. Hermann TS, Ihlemann N, Dominguez H, Rask-Madsen C, Kober L, Torp-Pedersen C. Prolonged local forearm hyperinsulinemia induces sustained enhancement of nitric oxide-dependent vasodilation in healthy subjects. Endothelium. 2004 Sep-Dec; 11(5-6):231-9. PMID: 15763942.
    View in: PubMed
  44. Ihlemann N, Rask-Madsen C, Køber L, Torp-Pedersen C. Vascular insulin response is preserved in non-diabetic patients with coronary artery disease, despite endothelial dysfunction. Scand Cardiovasc J. 2004 Mar; 38(1):22-7. PMID: 15204243.
    View in: PubMed
  45. Rask-Madsen C, Domínguez H, Ihlemann N, Hermann T, Køber L, Torp-Pedersen C. Tumor necrosis factor-alpha inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans. Circulation. 2003 Oct 14; 108(15):1815-21. PMID: 14530204.
    View in: PubMed
  46. Ihlemann N, Rask-Madsen C, Perner A, Dominguez H, Hermann T, Køber L, Torp-Pedersen C. Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects. Am J Physiol Heart Circ Physiol. 2003 Aug; 285(2):H875-82. PMID: 12730050.
    View in: PubMed
  47. Hermann TS, Rask-Madsen C, Ihlemann N, Domínguez H, Jensen CB, Storgaard H, Vaag AA, Kober L, Torp-Pedersen C. Normal insulin-stimulated endothelial function and impaired insulin-stimulated muscle glucose uptake in young adults with low birth weight. J Clin Endocrinol Metab. 2003 Mar; 88(3):1252-7. PMID: 12629115.
    View in: PubMed
  48. Abildstrom SZ, Rask-Madsen C, Ottesen MM, Andersen PK, Rosthøj S, Torp-Pedersen C, Køber L. Impact of age and sex on sudden cardiovascular death following myocardial infarction. Heart. 2002 Dec; 88(6):573-8. PMID: 12433881; PMCID: PMC1767447.
  49. Sørensen CR, Brendorp B, Rask-Madsen C, Køber L, Kjøller E, Torp-Pedersen C. The prognostic importance of creatinine clearance after acute myocardial infarction. Eur Heart J. 2002 Jun; 23(12):948-52. PMID: 12069449.
    View in: PubMed
  50. Rask-Madsen C, Ihlemann N, Krarup T, Christiansen E, Kober L, Nervil Kistorp C, Torp-Pedersen C. Insulin therapy improves insulin-stimulated endothelial function in patients with type 2 diabetes and ischemic heart disease. Diabetes. 2001 Nov; 50(11):2611-8. PMID: 11679442.
    View in: PubMed
  51. Domínguez H, Torp-Pedersen C, Koeber L, Rask-Madsen C. Prognostic value of exercise testing in a cohort of patients followed for 15 years after acute myocardial infarction. Eur Heart J. 2001 Feb; 22(4):300-6. PMID: 11161948.
    View in: PubMed
  52. Melchior T, Rask-Madsen C, Torp-Pedersen C, Hildebrandt P, Køber L, Jensen G. The impact of heart failure on prognosis of diabetic and non-diabetic patients with myocardial infarction: a 15-year follow-up study. Eur J Heart Fail. 2001 Jan; 3(1):83-90. PMID: 11163740.
    View in: PubMed
  53. Rask-Madsen C, Jensen G, Køber L, Melchior T, Torp-Pedersen C, Hildebrand P. Age-related mortality, clinical heart failure, and ventricular fibrillation in 4259 Danish patients after acute myocardial infarction. Eur Heart J. 1997 Sep; 18(9):1426-31. PMID: 9458448.
    View in: PubMed
  54. Rask-Madsen C, Svendsen LB, Bondesen S, Hjortrup A, Kirkegård P. Diagnostic and therapeutic ERCP after liver transplantation. Transplant Proc. 1994 Jun; 26(3):1796. PMID: 8030142.
    View in: PubMed
  55. Bresnick WH, Rask-Madsen C, Hogan DL, Koss MA, Isenberg JI. The effect of acute emotional stress on gastric acid secretion in normal subjects and duodenal ulcer patients. J Clin Gastroenterol. 1993 Sep; 17(2):117-22. PMID: 8409313.
    View in: PubMed
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