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Kellie Rae Machlus, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL151494 (MACHLUS, KELLIE RAE) Apr 20, 2021 - Mar 31, 2026
    The Biogenesis of Platelet-Derived Extracellular Vesicles and their Impact on Megakaryocyte Maturation
    Role: Principal Investigator
  2. R03DK124746 (MACHLUS, KELLIE RAE) Feb 10, 2021 - Jan 31, 2023
    The Role of CCL5 in Hematopoietic Stem Cell Activation and Skewing
    Role: Principal Investigator
  3. K01DK111515 (MACHLUS, KELLIE RAE) Sep 14, 2016 - May 31, 2021
    Molecular mechanisms of megakaryocyte differentiation and maturation during inflammation
    Role: Principal Investigator
  4. F32HL118865 (MACHLUS, KELLIE RAE) Jan 1, 2014 - Dec 31, 2016
    Identification of molecular pathways that initiate proplatelet formation
    Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Khan AO, Rodriguez-Romera A, Reyat JS, Olijnik AA, Colombo M, Wang G, Wen WX, Sousos N, Murphy LC, Grygielska B, Perrella G, Mahony CB, Ling RE, Elliott NE, Simoglou Karali C, Stone AP, Kemble S, Cutler EA, Fielding AK, Croft AP, Bassett D, Poologasundarampillai G, Roy A, Gooding S, Rayes J, Machlus KR, Psaila B. Human bone marrow organoids for disease modelling, discovery and validation of therapeutic targets in hematological malignancies. Cancer Discov. 2022 Nov 09. PMID: 36351055.
    Citations: 1     Fields:    
  2. Stone AP, Nikols E, Freire D, Machlus KR. The pathobiology of platelet and megakaryocyte extracellular vesicles: A (c)lot has changed. J Thromb Haemost. 2022 07; 20(7):1550-1558. PMID: 35506218.
    Citations: 1     Fields:    Translation:HumansCells
  3. Desai C, Koupenova M, Machlus KR, Sen Gupta A. Beyond the thrombus: Platelet-inspired nanomedicine approaches in inflammation, immune response, and cancer. J Thromb Haemost. 2022 07; 20(7):1523-1534. PMID: 35441793; PMCID: PMC9321119.
    Citations:    Fields:    Translation:HumansCells
  4. Krishnaswamy S, Ageno W, Arabi Y, Barbui T, Cannegieter S, Carrier M, Cleuren AC, Collins P, Panicot-Dubois L, Freedman JE, Freson K, Hogg P, James AH, Kretz CA, Lavin M, Leebeek FWG, Li W, Maas C, Machlus K, Makris M, Martinelli I, Medved L, Neerman-Arbez M, O'Donnell JS, O'Sullivan J, Rajpurkar M, Schroeder V, Spiegel PC, Stanworth SJ, Green L, Undas A. Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress. Res Pract Thromb Haemost. 2021 Jul; 5(5):e12532. PMID: 34296056.
    Citations: 1     
  5. Chang WC, Jackson JW, Machlus KR, Wolberg AS, Ovanesov MV. Fluorescence artifact correction in the thrombin generation assay: Necessity for correction algorithms in procoagulant samples. Res Pract Thromb Haemost. 2021 Mar; 5(3):447-455. PMID: 33870030; PMCID: PMC8035796.
  6. Boilard E, Machlus KR. Location is everything when it comes to megakaryocyte function. J Clin Invest. 2021 01 04; 131(1). PMID: 33393510.
    Citations: 5     Fields:    Translation:AnimalsCells
  7. Melki I, Allaeys I, Tessandier N, Mailhot B, Cloutier N, Campbell RA, Rowley JW, Salem D, Zufferey A, Laroche A, Lévesque T, Patey N, Rauch J, Lood C, Droit A, McKenzie SE, Machlus KR, Rondina MT, Lacroix S, Fortin PR, Boilard E. Fc?RIIA expression accelerates nephritis and increases platelet activation in systemic lupus erythematosus. Blood. 2020 12 17; 136(25):2933-2945. PMID: 33331924.
    Citations: 6     Fields:    Translation:AnimalsCells
  8. Khan AO, Stapley RJ, Pike JA, Wijesinghe SN, Reyat JS, Almazni I, Machlus KR, Morgan NV. Novel gene variants in patients with platelet-based bleeding using combined exome sequencing and RNAseq murine expression data. J Thromb Haemost. 2021 01; 19(1):262-268. PMID: 33021027.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  9. Puhm F, Boilard E, Machlus KR. Platelet Extracellular Vesicles: Beyond the Blood. Arterioscler Thromb Vasc Biol. 2021 01; 41(1):87-96. PMID: 33028092; PMCID: PMC7769913.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  10. Chang WC, Jackson JW, Machlus KR, Wolberg AS, Ovanesov MV. Comparative Analysis of Thrombin Calibration Algorithms and Correction for Thrombin-a2macroglobulin Activity. J Clin Med. 2020 Sep 24; 9(10). PMID: 32987791.
    Citations: 2     
  11. Butov KR, Osipova EY, Mikhalkin NB, Trubina NM, Panteleev MA, Machlus KR. In vitro megakaryocyte culture from human bone marrow aspirates as a research and diagnostic tool. Platelets. 2021 Oct 03; 32(7):928-935. PMID: 32936668; PMCID: PMC9295913.
    Citations: 1     Fields:    Translation:HumansCells
  12. French SL, Vijey P, Karhohs KW, Wilkie AR, Horin LJ, Ray A, Posorske B, Carpenter AE, Machlus KR, Italiano JE. High-content, label-free analysis of proplatelet production from megakaryocytes. J Thromb Haemost. 2020 10; 18(10):2701-2711. PMID: 32662223; PMCID: PMC7988437.
    Citations: 3     Fields:    Translation:HumansCells
  13. Melki I, Allaeys I, Tessandier N, Mailhot B, Cloutier N, Campbell RA, Rowley JW, Salem D, Zufferey A, Laroche A, Lévesque T, Patey N, Rauch J, Lood C, Droit A, McKenzie SE, Machlus KR, Rondina MT, Lacroix S, Fortin P, Boilard E. Fc?RIIA expression aggravates nephritis and increases platelet activation in systemic lupus erythematosus in mice. Blood. 2020 Aug 07. PMID: 32766888.
    Citations:    Fields:    
  14. French SL, Butov KR, Allaeys I, Canas J, Morad G, Davenport P, Laroche A, Trubina NM, Italiano JE, Moses MA, Sola-Visner M, Boilard E, Panteleev MA, Machlus KR. Platelet-derived extracellular vesicles infiltrate and modify the bone marrow during inflammation. Blood Adv. 2020 07 14; 4(13):3011-3023. PMID: 32614966.
    Citations: 28     Fields:    Translation:AnimalsCells
  15. Cushman M, Barnes GD, Creager MA, Diaz JA, Henke PK, Machlus KR, Nieman MT, Wolberg AS. Venous Thromboembolism Research Priorities: A Scientific Statement From the American Heart Association and the International Society on Thrombosis and Haemostasis. Circulation. 2020 08 11; 142(6):e85-e94. PMID: 32776842.
    Citations: 2     Fields:    Translation:Humans
  16. Cushman M, Barnes GD, Creager MA, Diaz JA, Henke PK, Machlus KR, Nieman MT, Wolberg AS. Venous thromboembolism research priorities: A scientific statement from the American Heart Association and the International Society on Thrombosis and Haemostasis. Res Pract Thromb Haemost. 2020 Jul; 4(5):714-721. PMID: 32685877.
    Citations: 4     
  17. Taylor KA, Machlus KR. Blood and Bone: The quarantine chronicles. Res Pract Thromb Haemost. 2020 Jul; 4(5):727-730. PMID: 32685879; PMCID: PMC7354405.
    Citations: 5     
  18. Asquith NL, Machlus KR. Teamwork makes the dream work in thrombopoiesis. Blood. 2019 09 05; 134(10):791-792. PMID: 31488457.
    Citations:    Fields:    Translation:Animals
  19. Couldwell G, Machlus KR. Modulation of megakaryopoiesis and platelet production during inflammation. Thromb Res. 2019 Jul; 179:114-120. PMID: 31128560.
    Citations: 15     Fields:    Translation:HumansCells
  20. Noetzli LJ, French SL, Machlus KR. New Insights Into the Differentiation of Megakaryocytes From Hematopoietic Progenitors. Arterioscler Thromb Vasc Biol. 2019 07; 39(7):1288-1300. PMID: 31043076; PMCID: PMC6594866.
    Citations: 49     Fields:    Translation:HumansCells
  21. Cunin P, Bouslama R, Machlus KR, Martínez-Bonet M, Lee PY, Wactor A, Nelson-Maney N, Morris A, Guo L, Weyrich A, Sola-Visner M, Boilard E, Italiano JE, Nigrovic PA. Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. Elife. 2019 05 01; 8. PMID: 31042146.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  22. Johnson KE, Ceglowski JR, Roweth HG, Forward JA, Tippy MD, El-Husayni S, Kulenthirarajan R, Malloy MW, Machlus KR, Chen WY, Italiano JE, Battinelli EM. Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis. Blood Adv. 2019 01 22; 3(2):198-211. PMID: 30670536; PMCID: PMC6341186.
    Citations: 17     Fields:    Translation:HumansCells
  23. French SL, Machlus KR. Tyrosyl-tRNA synthetase drives megakaryopoiesis independently of thrombopoietin signaling. J Thromb Haemost. 2019 04; 17(4):564-566. PMID: 30632668.
    Citations: 1     Fields:    Translation:Cells
  24. Roweth HG, Parvin S, Machlus KR. Megakaryocyte modification of platelets in thrombocytopenia. Curr Opin Hematol. 2018 09; 25(5):410-415. PMID: 29985173.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  25. Vijey P, Posorske B, Machlus KR. In vitro culture of murine megakaryocytes from fetal liver-derived hematopoietic stem cells. Platelets. 2018 Sep; 29(6):583-588. PMID: 30047825; PMCID: PMC6323647.
    Citations: 6     Fields:    Translation:HumansCells
  26. Fager AM, Machlus KR, Ezban M, Hoffman M. Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity. J Thromb Haemost. 2018 09; 16(9):1817-1829. PMID: 29879294; PMCID: PMC6166658.
    Citations: 6     Fields:    Translation:HumansCells
  27. Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E. Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):E1550-E1559. PMID: 29386381; PMCID: PMC5816207.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  28. Zufferey A, Speck ER, Machlus KR, Aslam R, Guo L, McVey MJ, Kim M, Kapur R, Boilard E, Italiano JE, Semple JW. Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets. Blood Adv. 2017 Sep 12; 1(20):1773-1785. PMID: 29296823.
    Citations: 38     Fields:    
  29. Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE, Weyrich AS, Bear JE, Bergmeier W. Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice. Blood Adv. 2017 Aug 08; 1(18):1398-1408. PMID: 29104956.
    Citations: 13     Fields:    
  30. Machlus KR, Wu SK, Vijey P, Soussou TS, Liu ZJ, Shacham E, Unger TJ, Kashyap T, Klebanov B, Sola-Visner M, Crochiere M, Italiano JE, Landesman Y. Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis. Blood. 2017 08 31; 130(9):1132-1143. PMID: 28630120; PMCID: PMC5580272.
    Citations: 14     Fields:    Translation:AnimalsCellsCTClinical Trials
  31. Machlus KR, Battinelli EM. RBCs pin platelets against the (thrombus) wall. Blood. 2017 05 04; 129(18):2460-2461. PMID: 28473411.
    Citations: 1     Fields:    Translation:HumansCells
  32. Johnson KE, Forward JA, Tippy MD, Ceglowski JR, El-Husayni S, Kulenthirarajan R, Machlus KR, Mayer EL, Italiano JE, Battinelli EM. Tamoxifen Directly Inhibits Platelet Angiogenic Potential and Platelet-Mediated Metastasis. Arterioscler Thromb Vasc Biol. 2017 04; 37(4):664-674. PMID: 28153880; PMCID: PMC5364056.
    Citations: 22     Fields:    Translation:HumansCells
  33. Machlus KR, Wu SK, Stumpo DJ, Soussou TS, Paul DS, Campbell RA, Kalwa H, Michel T, Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE. Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation. Blood. 2016 Mar 17; 127(11):1468-80. PMID: 26744461; PMCID: PMC4797023.
    Citations: 17     Fields:    Translation:AnimalsCells
  34. Machlus KR, Johnson KE, Kulenthirarajan R, Forward JA, Tippy MD, Soussou TS, El-Husayni SH, Wu SK, Wang S, Watnick RS, Italiano JE, Battinelli EM. CCL5 derived from platelets increases megakaryocyte proplatelet formation. Blood. 2016 Feb 18; 127(7):921-6. PMID: 26647394; PMCID: PMC4760093.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  35. Barbieri SS, Petrucci G, Tarantino E, Amadio P, Rocca B, Pesce M, Machlus KR, Ranelletti FO, Gianellini S, Weksler B, Italiano JE, Tremoli E. Abnormal megakaryopoiesis and platelet function in cyclooxygenase-2-deficient mice. Thromb Haemost. 2015 Nov 25; 114(6):1218-29. PMID: 26272103.
    Citations: 6     Fields:    Translation:AnimalsCells
  36. Noh JY, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan SK, Chou ST, Machlus KR, Italiano JE, Kyba M, Finkelstein D, Ulirsch JC, Sankaran VG, French DL, Poncz M, Weiss MJ. Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. J Clin Invest. 2015 Jun; 125(6):2369-74. PMID: 25961454; PMCID: PMC4497743.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  37. Feng Q, Shabrani N, Thon JN, Huo H, Thiel A, Machlus KR, Kim K, Brooks J, Li F, Luo C, Kimbrel EA, Wang J, Kim KS, Italiano J, Cho J, Lu SJ, Lanza R. Scalable generation of universal platelets from human induced pluripotent stem cells. Stem Cell Reports. 2014 Nov 11; 3(5):817-31. PMID: 25418726; PMCID: PMC4235139.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  38. Thon JN, Mazutis L, Wu S, Sylman JL, Ehrlicher A, Machlus KR, Feng Q, Lu S, Lanza R, Neeves KB, Weitz DA, Italiano JE. Platelet bioreactor-on-a-chip. Blood. 2014 Sep 18; 124(12):1857-67. PMID: 25606631; PMCID: PMC4168343.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  39. Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE, Christensen H, Kahr WH, Li DY, Weyrich AS. Proteasome function is required for platelet production. J Clin Invest. 2014 Sep; 124(9):3757-66. PMID: 25061876; PMCID: PMC4151230.
    Citations: 25     Fields:    Translation:HumansAnimals
  40. Thon JN, Mazutis L, Wu S, Sylman JL, Ehrlicher A, Machlus KR, Feng Q, Lu S, Lanza R, Neeves KB, Weitz DA, Italiano JE. Platelet bioreactor-on-a-chip. Blood. 2014 Jul 21. PMID: 25049277.
  41. Machlus KR, Thon JN, Italiano JE. Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation. Br J Haematol. 2014 Apr; 165(2):227-36. PMID: 24499183.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  42. Battinelli EM, Markens BA, Kulenthirarajan RA, Machlus KR, Flaumenhaft R, Italiano JE. Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response. Blood. 2014 Jan 02; 123(1):101-12. PMID: 24065244; PMCID: PMC3879901.
    Citations: 41     Fields:    Translation:HumansCells
  43. Machlus KR, Italiano JE. The incredible journey: From megakaryocyte development to platelet formation. J Cell Biol. 2013 Jun 10; 201(6):785-96. PMID: 23751492.
    Citations: 240     Fields:    Translation:HumansAnimalsCells
  44. Aleman MM, Walton BL, Byrnes JR, Wang JG, Heisler MJ, Machlus KR, Cooley BC, Wolberg AS. Elevated prothrombin promotes venous, but not arterial, thrombosis in mice. Arterioscler Thromb Vasc Biol. 2013 Aug; 33(8):1829-36. PMID: 23723374.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  45. Thon JN, Peters CG, Machlus KR, Aslam R, Rowley J, Macleod H, Devine MT, Fuchs TA, Weyrich AS, Semple JW, Flaumenhaft R, Italiano JE. T granules in human platelets function in TLR9 organization and signaling. J Cell Biol. 2012 Aug 20; 198(4):561-74. PMID: 22908309.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  46. Wolberg AS, Aleman MM, Leiderman K, Machlus KR. Procoagulant activity in hemostasis and thrombosis: Virchow's triad revisited. Anesth Analg. 2012 Feb; 114(2):275-85. PMID: 22104070; PMCID: PMC3264782.
    Citations: 81     Fields:    Translation:HumansCells
  47. Machlus KR, Lin FC, Wolberg AS. Procoagulant activity induced by vascular injury determines contribution of elevated factor VIII to thrombosis and thrombus stability in mice. Blood. 2011 Oct 06; 118(14):3960-8. PMID: 21828144; PMCID: PMC3193271.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  48. Gray LD, Hussey MA, Larson BM, Machlus KR, Campbell RA, Koch G, Ezban M, Hedner U, Wolberg AS. Recombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma. Thromb Res. 2011 Dec; 128(6):570-6. PMID: 21561645.
    Citations: 10     Fields:    Translation:HumansAnimals
  49. Machlus KR, Aleman MM, Wolberg AS. Update on venous thromboembolism: risk factors, mechanisms, and treatments. Arterioscler Thromb Vasc Biol. 2011 Mar; 31(3):476-8. PMID: 21325668.
    Citations: 5     Fields:    Translation:HumansAnimals
  50. Machlus KR, Cardenas JC, Church FC, Wolberg AS. Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice. Blood. 2011 May 05; 117(18):4953-63. PMID: 21355090; PMCID: PMC3100702.
    Citations: 68     Fields:    Translation:HumansAnimals
  51. Campbell RA, Machlus KR, Wolberg AS. Smoking out the cause of thrombosis. Arterioscler Thromb Vasc Biol. 2010 Jan; 30(1):7-8. PMID: 20018940.
    Citations: 1     Fields:    Translation:Humans
  52. Machlus KR, Colby EA, Wu JR, Koch GG, Key NS, Wolberg AS. Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram. Thromb Haemost. 2009 Nov; 102(5):936-44. PMID: 19888532.
    Citations: 37     Fields:    Translation:Humans
  53. Ollivier V, Wang J, Manly D, Machlus KR, Wolberg AS, Jandrot-Perrus M, Mackman N. Detection of endogenous tissue factor levels in plasma using the calibrated automated thrombogram assay. Thromb Res. 2010 Jan; 125(1):90-6. PMID: 19345399.
    Citations: 21     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.