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Kellie Rae Machlus, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K01DK111515 (MACHLUS, KELLIE RAE) Sep 14, 2016 - May 31, 2021
    NIH/NIDDK
    Molecular mechanisms of megakaryocyte differentiation and maturation during inflammation
    Role: Principal Investigator
  2. F32HL118865 (MACHLUS, KELLIE RAE) Jan 1, 2014 - Dec 31, 2016
    NIH/NHLBI
    Identification of molecular pathways that initiate proplatelet formation
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Johnson KE, Ceglowski JR, Roweth HG, Forward JA, Tippy MD, El-Husayni S, Kulenthirarajan R, Malloy MW, Machlus KR, Chen WY, Italiano JE, Battinelli EM. Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis. Blood Adv. 2019 Jan 22; 3(2):198-211. PMID: 30670536.
    Citations:    
  2. French SL, Machlus KR. Tyrosyl-tRNA synthetase drives megakaryopoiesis independently of thrombopoietin signaling. J Thromb Haemost. 2019 Jan 11. PMID: 30632668.
    Citations:    Fields:    
  3. Roweth HG, Parvin S, Machlus KR. Megakaryocyte modification of platelets in thrombocytopenia. Curr Opin Hematol. 2018 Sep; 25(5):410-415. PMID: 29985173.
    Citations:    Fields:    
  4. Vijey P, Posorske B, Machlus KR. In vitro culture of murine megakaryocytes from fetal liver-derived hematopoietic stem cells. Platelets. 2018 Sep; 29(6):583-588. PMID: 30047825.
    Citations:    Fields:    Translation:HumansCells
  5. Fager AM, Machlus KR, Ezban M, Hoffman M. Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity. J Thromb Haemost. 2018 Sep; 16(9):1817-1829. PMID: 29879294.
    Citations: 1     Fields:    
  6. Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E. Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):E1550-E1559. PMID: 29386381.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  7. Zufferey A, Speck ER, Machlus KR, Aslam R, Guo L, McVey MJ, Kim M, Kapur R, Boilard E, Italiano JE, Semple JW. Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets. Blood Adv. 2017 Sep 12; 1(20):1773-1785. PMID: 29296823.
    Citations: 2     
  8. Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE, Weyrich AS, Bear JE, Bergmeier W. Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice. Blood Adv. 2017 Aug 08; 1(18):1398-1408. PMID: 29104956.
    Citations:    
  9. Machlus KR, Wu SK, Vijey P, Soussou TS, Liu ZJ, Shacham E, Unger TJ, Kashyap T, Klebanov B, Sola-Visner M, Crochiere M, Italiano JE, Landesman Y. Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis. Blood. 2017 08 31; 130(9):1132-1143. PMID: 28630120.
    Citations: 1     Fields:    Translation:AnimalsCellsCTClinical Trials
  10. Machlus KR, Battinelli EM. RBCs pin platelets against the (thrombus) wall. Blood. 2017 05 04; 129(18):2460-2461. PMID: 28473411.
    Citations: 1     Fields:    Translation:HumansCells
  11. Johnson KE, Forward JA, Tippy MD, Ceglowski JR, El-Husayni S, Kulenthirarajan R, Machlus KR, Mayer EL, Italiano JE, Battinelli EM. Tamoxifen Directly Inhibits Platelet Angiogenic Potential and Platelet-Mediated Metastasis. Arterioscler Thromb Vasc Biol. 2017 04; 37(4):664-674. PMID: 28153880.
    Citations: 8     Fields:    Translation:HumansCells
  12. Machlus KR, Wu SK, Stumpo DJ, Soussou TS, Paul DS, Campbell RA, Kalwa H, Michel T, Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE. Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation. Blood. 2016 Mar 17; 127(11):1468-80. PMID: 26744461; PMCID: PMC4797023.
    Citations: 3     Fields:    Translation:AnimalsCells
  13. Machlus KR, Johnson KE, Kulenthirarajan R, Forward JA, Tippy MD, Soussou TS, El-Husayni SH, Wu SK, Wang S, Watnick RS, Italiano JE, Battinelli EM. CCL5 derived from platelets increases megakaryocyte proplatelet formation. Blood. 2016 Feb 18; 127(7):921-6. PMID: 26647394; PMCID: PMC4760093.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  14. Barbieri SS, Petrucci G, Tarantino E, Amadio P, Rocca B, Pesce M, Machlus KR, Ranelletti FO, Gianellini S, Weksler B, Italiano JE, Tremoli E. Abnormal megakaryopoiesis and platelet function in cyclooxygenase-2-deficient mice. Thromb Haemost. 2015 Nov 25; 114(6):1218-29. PMID: 26272103.
    Citations: 3     Fields:    Translation:AnimalsCells
  15. Noh JY, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan SK, Chou ST, Machlus KR, Italiano JE, Kyba M, Finkelstein D, Ulirsch JC, Sankaran VG, French DL, Poncz M, Weiss MJ. Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. J Clin Invest. 2015 Jun; 125(6):2369-74. PMID: 25961454; PMCID: PMC4497743.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  16. Feng Q, Shabrani N, Thon JN, Huo H, Thiel A, Machlus KR, Kim K, Brooks J, Li F, Luo C, Kimbrel EA, Wang J, Kim KS, Italiano J, Cho J, Lu SJ, Lanza R. Scalable generation of universal platelets from human induced pluripotent stem cells. Stem Cell Reports. 2014 Nov 11; 3(5):817-31. PMID: 25418726; PMCID: PMC4235139.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  17. Thon JN, Mazutis L, Wu S, Sylman JL, Ehrlicher A, Machlus KR, Feng Q, Lu S, Lanza R, Neeves KB, Weitz DA, Italiano JE. Platelet bioreactor-on-a-chip. Blood. 2014 Sep 18; 124(12):1857-67. PMID: 25606631; PMCID: PMC4168343.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  18. Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE, Christensen H, Kahr WH, Li DY, Weyrich AS. Proteasome function is required for platelet production. J Clin Invest. 2014 Sep; 124(9):3757-66. PMID: 25061876; PMCID: PMC4151230.
    Citations: 11     Fields:    Translation:HumansAnimals
  19. Thon JN, Mazutis L, Wu S, Sylman JL, Ehrlicher A, Machlus KR, Feng Q, Lu S, Lanza R, Neeves KB, Weitz DA, Italiano JE. Platelet bioreactor-on-a-chip. Blood. 2014 Jul 21. PMID: 25049277.
    Citations:    
  20. Machlus KR, Thon JN, Italiano JE. Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation. Br J Haematol. 2014 Apr; 165(2):227-36. PMID: 24499183.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  21. Battinelli EM, Markens BA, Kulenthirarajan RA, Machlus KR, Flaumenhaft R, Italiano JE. Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response. Blood. 2014 Jan 02; 123(1):101-12. PMID: 24065244; PMCID: PMC3879901.
    Citations: 26     Fields:    Translation:HumansCells
  22. Machlus KR, Italiano JE. The incredible journey: From megakaryocyte development to platelet formation. J Cell Biol. 2013 Jun 10; 201(6):785-96. PMID: 23751492; PMCID: PMC3678154.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  23. Aleman MM, Walton BL, Byrnes JR, Wang JG, Heisler MJ, Machlus KR, Cooley BC, Wolberg AS. Elevated prothrombin promotes venous, but not arterial, thrombosis in mice. Arterioscler Thromb Vasc Biol. 2013 Aug; 33(8):1829-36. PMID: 23723374; PMCID: PMC3779620.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  24. Thon JN, Peters CG, Machlus KR, Aslam R, Rowley J, Macleod H, Devine MT, Fuchs TA, Weyrich AS, Semple JW, Flaumenhaft R, Italiano JE. T granules in human platelets function in TLR9 organization and signaling. J Cell Biol. 2012 Aug 20; 198(4):561-74. PMID: 22908309; PMCID: PMC3514030.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  25. Wolberg AS, Aleman MM, Leiderman K, Machlus KR. Procoagulant activity in hemostasis and thrombosis: Virchow's triad revisited. Anesth Analg. 2012 Feb; 114(2):275-85. PMID: 22104070; PMCID: PMC3264782.
    Citations: 29     Fields:    Translation:HumansCells
  26. Machlus KR, Lin FC, Wolberg AS. Procoagulant activity induced by vascular injury determines contribution of elevated factor VIII to thrombosis and thrombus stability in mice. Blood. 2011 Oct 06; 118(14):3960-8. PMID: 21828144; PMCID: PMC3193271.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  27. Gray LD, Hussey MA, Larson BM, Machlus KR, Campbell RA, Koch G, Ezban M, Hedner U, Wolberg AS. Recombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma. Thromb Res. 2011 Dec; 128(6):570-6. PMID: 21561645; PMCID: PMC3156970.
    Citations: 7     Fields:    Translation:HumansAnimals
  28. Machlus KR, Aleman MM, Wolberg AS. Update on venous thromboembolism: risk factors, mechanisms, and treatments. Arterioscler Thromb Vasc Biol. 2011 Mar; 31(3):476-8. PMID: 21325668; PMCID: PMC3044436.
    Citations: 1     Fields:    Translation:HumansAnimals
  29. Machlus KR, Cardenas JC, Church FC, Wolberg AS. Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice. Blood. 2011 May 05; 117(18):4953-63. PMID: 21355090; PMCID: PMC3100702.
    Citations: 29     Fields:    Translation:HumansAnimals
  30. Campbell RA, Machlus KR, Wolberg AS. Smoking out the cause of thrombosis. Arterioscler Thromb Vasc Biol. 2010 Jan; 30(1):7-8. PMID: 20018940.
    Citations:    Fields:    Translation:Humans
  31. Machlus KR, Colby EA, Wu JR, Koch GG, Key NS, Wolberg AS. Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram. Thromb Haemost. 2009 Nov; 102(5):936-44. PMID: 19888532; PMCID: PMC2904819.
    Citations: 20     Fields:    Translation:Humans
  32. Ollivier V, Wang J, Manly D, Machlus KR, Wolberg AS, Jandrot-Perrus M, Mackman N. Detection of endogenous tissue factor levels in plasma using the calibrated automated thrombogram assay. Thromb Res. 2010 Jan; 125(1):90-6. PMID: 19345399; PMCID: PMC2826585.
    Citations: 15     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.