Harvard Catalyst Profiles

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Ismail Syed, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Rubin de Celis MF, Garcia-Martin R, Syed I, Lee J, Aguayo-Mazzucato C, Bonner-Weir S, Kahn BB. PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53. Proc Natl Acad Sci U S A. 2022 11 22; 119(47):e2206923119. PMID: 36375063; PMCID: PMC9704710.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  2. Aryal P, Syed I, Lee J, Patel R, Nelson AT, Siegel D, Saghatelian A, Kahn BB. Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs). J Lipid Res. 2021; 62:100108. PMID: 34418413; PMCID: PMC8479484.
    Citations: 1     Fields:    Translation:HumansCells
  3. Sandhu B, Perez-Matos MC, Tran S, Singhal G, Syed I, Feldbrügge L, Mitsuhashi S, Pelletier J, Huang J, Yalcin Y, Csizmadia E, Tiwari-Heckler S, Enjyoji K, Sévigny J, Maratos-Flier E, Robson SC, Jiang ZG. Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism. Metabolism. 2021 05; 118:154731. PMID: 33631144; PMCID: PMC8052311.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Syed I, Rubin de Celis MF, Mohan JF, Moraes-Vieira PM, Vijayakumar A, Nelson AT, Siegel D, Saghatelian A, Mathis D, Kahn BB. PAHSAs attenuate immune responses and promote ß cell survival in autoimmune diabetic mice. J Clin Invest. 2019 08 05; 129(9):3717-3731. PMID: 31380811; PMCID: PMC6715391.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  5. Hammarstedt A, Syed I, Vijayakumar A, Eliasson B, Gogg S, Kahn BB, Smith U. Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids. Sci Rep. 2018 10 25; 8(1):15757. PMID: 30361530.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  6. Syed I, Lee J, Peroni OD, Yore MM, Moraes-Vieira PM, Santoro A, Wellenstein K, Smith U, McGraw TE, Saghatelian A, Kahn BB. Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects. Cell Metab. 2018 10 02; 28(4):543-546. PMID: 30244974; PMCID: PMC6542592.
    Citations: 13     Fields:    Translation:Animals
  7. Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, Saghatelian A, Kahn BB. Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metab. 2018 02 06; 27(2):419-427.e4. PMID: 29414687.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  8. Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell Rep. 2017 Oct 24; 21(4):1021-1035. PMID: 29069585; PMCID: PMC5771491.
    Citations: 48     Fields:    Translation:AnimalsCells
  9. Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. J Am Chem Soc. 2017 04 05; 139(13):4943-4947. PMID: 28350171; PMCID: PMC5568760.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  10. Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Holm LM, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A, Smith U. Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance. Sci Rep. 2017 02 27; 7:43515. PMID: 28240264.
    Citations: 11     Fields:    Translation:AnimalsCells
  11. Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry. 2016 08 23; 55(33):4636-41. PMID: 27509211.
    Citations: 26     Fields:    
  12. Zhang T, Chen S, Syed I, Ståhlman M, Kolar MJ, Homan EA, Chu Q, Smith U, Borén J, Kahn BB, Saghatelian A. A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids. Nat Protoc. 2016 Apr; 11(4):747-63. PMID: 26985573.
    Citations: 26     Fields:    Translation:HumansAnimals
  13. Parmar MS, Meer AA, Syed I. Biphasic Roles of a Small G-Protein, RAC1 in Pancreatic ?-Cell. Gastro Open Journal. 2015; 1(3):79-88. View Publication.
  14. Parmar MS, Syed I, Gray JP, Ray SD. Curcumin, Hesperidin, and Rutin Selectively Interfere with Apoptosis Signaling and Attenuate Streptozotocin-Induced Oxidative Stress-Mediated Hyperglycemia. Curr Neurovasc Res. 2015; 12(4):363-74. PMID: 26265154.
    Citations: 10     Fields:    Translation:AnimalsCells
  15. Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A. Data-driven synthesis of proteolysis-resistant peptide hormones. J Am Chem Soc. 2014 Dec 24; 136(51):17710-3. PMID: 25496053.
    Citations: 2     Fields:    Translation:AnimalsCells
  16. Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 2014 Oct 09; 159(2):318-32. PMID: 25303528.
    Citations: 269     Fields:    Translation:HumansAnimalsCells
  17. Moraes-Vieira PM, Yore MM, Dwyer PM, Syed I, Aryal P, Kahn BB. RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab. 2014 Mar 04; 19(3):512-26. PMID: 24606904; PMCID: PMC4078000.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  18. Kowluru RA, Kowluru A, Veluthakal R, Mohammad G, Syed I, Santos JM, Mishra M. TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy. Diabetologia. 2014 May; 57(5):1047-56. PMID: 24554007.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  19. Syed I, Szulc ZM, Ogretmen B, Kowluru A. L- threo -C6-pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 ß-cells. Cell Physiol Biochem. 2012; 30(4):1051-8. PMID: 23052231.
    Citations: 6     Fields:    Translation:AnimalsCells
  20. Arora DK, Syed I, Machhadieh B, McKenna CE, Kowluru A. Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic ß cells. Islets. 2012 Sep-Oct; 4(5):354-8. PMID: 23114750.
    Citations: 10     Fields:    Translation:HumansAnimals
  21. Syed I, Rathod J, Parmar M, Corcoran GB, Ray SD. Matrix metalloproteinase-9, -10, and -12, MDM2 and p53 expression in mouse liver during dimethylnitrosamine-induced oxidative stress and genomic injury. Mol Cell Biochem. 2012 Jun; 365(1-2):351-61. PMID: 22441882.
    Citations: 5     Fields:    Translation:Animals
  22. Syed I, Kyathanahalli CN, Jayaram B, Govind S, Rhodes CJ, Kowluru RA, Kowluru A. Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes. 2011 Nov; 60(11):2843-52. PMID: 21911753; PMCID: PMC3198065.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  23. Jayaram B, Syed I, Singh A, Subasinghe W, Kyathanahalli CN, Kowluru A. Isoprenylcysteine carboxyl methyltransferase facilitates glucose-induced Rac1 activation, ROS generation and insulin secretion in INS 832/13 ß-cells. Islets. 2011 Mar-Apr; 3(2):48-57. PMID: 21346419.
    Citations: 7     Fields:    Translation:AnimalsCells
  24. Jayaram B, Syed I, Kyathanahalli CN, Rhodes CJ, Kowluru A. Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets. Biochem Pharmacol. 2011 Apr 15; 81(8):1016-27. PMID: 21276423; PMCID: PMC3073812.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  25. Syed I, Kyathanahalli CN, Kowluru A. Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation. Am J Physiol Regul Integr Comp Physiol. 2011 Mar; 300(3):R756-62. PMID: 21228337.
    Citations: 25     Fields:    Translation:AnimalsCells
  26. Subasinghe W, Syed I, Kowluru A. Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic ß-cells: evidence for regulation by Rac1. Am J Physiol Regul Integr Comp Physiol. 2011 Jan; 300(1):R12-20. PMID: 20943855.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  27. Kamath V, Kyathanahalli CN, Jayaram B, Syed I, Olson LK, Ludwig K, Klumpp S, Krieglstein J, Kowluru A. Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells. Am J Physiol Endocrinol Metab. 2010 Aug; 299(2):E276-86. PMID: 20501872.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  28. Syed I, Jayaram B, Subasinghe W, Kowluru A. Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic beta-cells. Biochem Pharmacol. 2010 Sep 15; 80(6):874-83. PMID: 20493824.
    Citations: 34     Fields:    Translation:AnimalsCells
  29. Kowluru A, Veluthakal R, Rhodes CJ, Kamath V, Syed I, Koch BJ. Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. Diabetes. 2010 Apr; 59(4):967-77. PMID: 20071600; PMCID: PMC2844844.
    Citations: 30     Fields:    Translation:AnimalsCells
  30. Ray SD, Parmar M, Syed I, Rathod J, Zinkovsky D, Bulku E, Gigliotti J, Hackman RM, Stohs SJ. Long term exposure effect of a unique metabolic nutrition system containing a diverse group of phytochemicals on serum chemistry and genomic and non-genomic changes in the liver of female B6C3F1 mice. Phytother Res. 2008 Apr; 22(4):458-71. PMID: 18386253.
    Citations: 3     Fields:    Translation:AnimalsCells
  31. Parmar M, Ismail S and Ray SD. A Triple Bioflavonoid Mixture Modulates Pro- and Anti-Apoptotic Gene Expression During Streptozocin (STZ)-Induced Oxidative Stress in the Mouse Liver. The Toxicologist. 2008; 1(97).
  32. Rathod J, Ismail S, Parmar M, Ray SD. Modulation of matrix metallo proteases and MDM2 during acute dimethylnitrosamine (DMN)-induced nephrotoxicity in mice. The FASEB Journal. 2007; (21):730-732.
  33. Bulku E, Rathod J, Ismail S, Parmar M and Ray SD. Antiapoptotic and Antinecrotic Properties of Bioflavonoids Curcumin and Rutin. Am J of Pharmaceutical Education. 2007; 3(71):60.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.