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Ismail Syed, Ph.D.

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  1. K01DK118041 (SYED, ISMAIL) Jul 1, 2018 - Jun 30, 2021
    NIH
    A Novel Class of Lipids as Potential Therapeutic Agents to Promote Pancreatic Beta cell Survival and Prevent Type 1 Diabetes.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hammarstedt A, Syed I, Vijayakumar A, Eliasson B, Gogg S, Kahn BB, Smith U. Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids. Sci Rep. 2018 Oct 25; 8(1):15757. PMID: 30361530.
    Citations:    Fields:    
  2. Syed I, Lee J, Peroni OD, Yore MM, Moraes-Vieira PM, Santoro A, Wellenstein K, Smith U, McGraw TE, Saghatelian A, Kahn BB. Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects. Cell Metab. 2018 Oct 02; 28(4):543-546. PMID: 30244974.
    Citations:    Fields:    
  3. Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, Saghatelian A, Kahn BB. Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metab. 2018 Feb 06; 27(2):419-427.e4. PMID: 29414687.
    Citations: 3     Fields:    
  4. Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell Rep. 2017 Oct 24; 21(4):1021-1035. PMID: 29069585.
    Citations: 3     Fields:    Translation:AnimalsCells
  5. Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. J Am Chem Soc. 2017 04 05; 139(13):4943-4947. PMID: 28350171.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  6. Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Holm LM, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A, Smith U. Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance. Sci Rep. 2017 02 27; 7:43515. PMID: 28240264.
    Citations: 2     Fields:    Translation:AnimalsCells
  7. Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry. 2016 08 23; 55(33):4636-41. PMID: 27509211.
    Citations: 3     Fields:    
  8. Zhang T, Chen S, Syed I, Ståhlman M, Kolar MJ, Homan EA, Chu Q, Smith U, Borén J, Kahn BB, Saghatelian A. A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids. Nat Protoc. 2016 Apr; 11(4):747-63. PMID: 26985573.
    Citations: 6     Fields:    Translation:HumansAnimals
  9. Parmar MS, Meer AA, Syed I. Biphasic Roles of a Small G-Protein, RAC1 in Pancreatic ?-Cell. Gastro Open Journal. 2015; 1(3):79-88.
    View Publication
  10. Parmar MS, Syed I, Gray JP, Ray SD. Curcumin, Hesperidin, and Rutin Selectively Interfere with Apoptosis Signaling and Attenuate Streptozotocin-Induced Oxidative Stress-Mediated Hyperglycemia. Curr Neurovasc Res. 2015; 12(4):363-74. PMID: 26265154.
    Citations: 5     Fields:    Translation:AnimalsCells
  11. Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A. Data-driven synthesis of proteolysis-resistant peptide hormones. J Am Chem Soc. 2014 Dec 24; 136(51):17710-3. PMID: 25496053.
    Citations: 1     Fields:    Translation:AnimalsCells
  12. Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 2014 Oct 09; 159(2):318-32. PMID: 25303528.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  13. Moraes-Vieira PM, Yore MM, Dwyer PM, Syed I, Aryal P, Kahn BB. RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab. 2014 Mar 04; 19(3):512-26. PMID: 24606904; PMCID: PMC4078000.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  14. Kowluru RA, Kowluru A, Veluthakal R, Mohammad G, Syed I, Santos JM, Mishra M. TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy. Diabetologia. 2014 May; 57(5):1047-56. PMID: 24554007.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  15. Syed I, Szulc ZM, Ogretmen B, Kowluru A. L- threo -C6-pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 ß-cells. Cell Physiol Biochem. 2012; 30(4):1051-8. PMID: 23052231.
    Citations: 4     Fields:    Translation:AnimalsCells
  16. Arora DK, Syed I, Machhadieh B, McKenna CE, Kowluru A. Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic ß cells. Islets. 2012 Sep-Oct; 4(5):354-8. PMID: 23114750.
    Citations: 4     Fields:    Translation:HumansAnimals
  17. Syed I, Rathod J, Parmar M, Corcoran GB, Ray SD. Matrix metalloproteinase-9, -10, and -12, MDM2 and p53 expression in mouse liver during dimethylnitrosamine-induced oxidative stress and genomic injury. Mol Cell Biochem. 2012 Jun; 365(1-2):351-61. PMID: 22441882.
    Citations: 5     Fields:    Translation:Animals
  18. Syed I, Kyathanahalli CN, Jayaram B, Govind S, Rhodes CJ, Kowluru RA, Kowluru A. Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes. 2011 Nov; 60(11):2843-52. PMID: 21911753; PMCID: PMC3198065.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  19. Jayaram B, Syed I, Singh A, Subasinghe W, Kyathanahalli CN, Kowluru A. Isoprenylcysteine carboxyl methyltransferase facilitates glucose-induced Rac1 activation, ROS generation and insulin secretion in INS 832/13 ß-cells. Islets. 2011 Mar-Apr; 3(2):48-57. PMID: 21346419.
    Citations: 2     Fields:    Translation:AnimalsCells
  20. Jayaram B, Syed I, Kyathanahalli CN, Rhodes CJ, Kowluru A. Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets. Biochem Pharmacol. 2011 Apr 15; 81(8):1016-27. PMID: 21276423.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  21. Syed I, Kyathanahalli CN, Kowluru A. Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation. Am J Physiol Regul Integr Comp Physiol. 2011 Mar; 300(3):R756-62. PMID: 21228337; PMCID: PMC3064276.
    Citations: 8     Fields:    Translation:AnimalsCells
  22. Subasinghe W, Syed I, Kowluru A. Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic ß-cells: evidence for regulation by Rac1. Am J Physiol Regul Integr Comp Physiol. 2011 Jan; 300(1):R12-20. PMID: 20943855; PMCID: PMC3023281.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  23. Kamath V, Kyathanahalli CN, Jayaram B, Syed I, Olson LK, Ludwig K, Klumpp S, Krieglstein J, Kowluru A. Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells. Am J Physiol Endocrinol Metab. 2010 Aug; 299(2):E276-86. PMID: 20501872.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  24. Syed I, Jayaram B, Subasinghe W, Kowluru A. Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic beta-cells. Biochem Pharmacol. 2010 Sep 15; 80(6):874-83. PMID: 20493824; PMCID: PMC2919057.
    Citations: 14     Fields:    Translation:AnimalsCells
  25. Kowluru A, Veluthakal R, Rhodes CJ, Kamath V, Syed I, Koch BJ. Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. Diabetes. 2010 Apr; 59(4):967-77. PMID: 20071600.
    Citations: 13     Fields:    Translation:AnimalsCells
  26. Ray SD, Parmar M, Syed I, Rathod J, Zinkovsky D, Bulku E, Gigliotti J, Hackman RM, Stohs SJ. Long term exposure effect of a unique metabolic nutrition system containing a diverse group of phytochemicals on serum chemistry and genomic and non-genomic changes in the liver of female B6C3F1 mice. Phytother Res. 2008 Apr; 22(4):458-71. PMID: 18386253.
    Citations: 1     Fields:    Translation:AnimalsCells
  27. Parmar M, Ismail S and Ray SD. A Triple Bioflavonoid Mixture Modulates Pro- and Anti-Apoptotic Gene Expression During Streptozocin (STZ)-Induced Oxidative Stress in the Mouse Liver. The Toxicologist. 2008; 1(97).
  28. Rathod J, Ismail S, Parmar M, Ray SD. Modulation of matrix metallo proteases and MDM2 during acute dimethylnitrosamine (DMN)-induced nephrotoxicity in mice. The FASEB Journal. 2007; (21):730-732.
  29. Bulku E, Rathod J, Ismail S, Parmar M and Ray SD. Antiapoptotic and Antinecrotic Properties of Bioflavonoids Curcumin and Rutin. Am J of Pharmaceutical Education. 2007; 3(71):60.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.