Harvard Catalyst Profiles

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Wesley Philip Wong, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R21CA212827 (WONG, WESLEY PHILIP) Mar 7, 2017 - Feb 28, 2021
    NIH
    Single-molecule mechanical detection of protein and microRNA cancer biomarkers
    Role: Principal Investigator
  2. R35GM119537 (WONG, WESLEY PHILIP) Sep 1, 2016 - May 31, 2026
    NIH
    Mechanical forces in nanoscale biology: From hemostasis to single-molecule centrifugation
    Role: Principal Investigator
  3. R21GM107907 (WONG, WESLEY PHILIP) Aug 1, 2014 - Apr 30, 2017
    NIH
    Bringing mechanobiology to the benchtop with single-molecule centrifugation
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Luo Y, Chang J, Yang D, Bryan JS, MacIsaac M, Pressé S, Wong WP. Resolving Molecular Heterogeneity with Single-Molecule Centrifugation. J Am Chem Soc. 2023 02 15; 145(6):3276-3282. PMID: 36716175; PMCID: PMC9936575.
    Citations:    Fields:    Translation:HumansAnimals
  2. Bergal HT, Jiang Y, Yang D, Springer TA, Wong WP. Conformation of von Willebrand factor in shear flow revealed with stroboscopic single-molecule imaging. Blood. 2022 12 08; 140(23):2490-2499. PMID: 36040485; PMCID: PMC9837445.
    Citations: 1     Fields:    
  3. Fu H, Jiang Y, Wong WP, Springer TA. Single-molecule imaging of von Willebrand factor reveals tension-dependent self-association. Blood. 2021 12 09; 138(23):2425-2434. PMID: 34882208; PMCID: PMC8662069.
    Citations:    Fields:    Translation:HumansCells
  4. Shrestha P, Yang D, Tomov TE, MacDonald JI, Ward A, Bergal HT, Krieg E, Cabi S, Luo Y, Nathwani B, Johnson-Buck A, Shih WM, Wong WP. Single-molecule mechanical fingerprinting with DNA nanoswitch calipers. Nat Nanotechnol. 2021 12; 16(12):1362-1370. PMID: 34675411; PMCID: PMC8678201.
    Citations: 3     Fields:    Translation:Cells
  5. Oliveira-Jr GP, Barbosa RH, Thompson L, Pinckney B, Murphy-Thornley M, Lu S, Jones J, Hansen CH, Tigges J, Wong WP, Ghiran IC. Electrophoretic mobility shift as a molecular beacon-based readout for miRNA detection. Biosens Bioelectron. 2021 Oct 01; 189:113307. PMID: 34062334; PMCID: PMC8461749.
    Citations:    Fields:    Translation:Cells
  6. Mulhall EM, Ward A, Yang D, Koussa MA, Corey DP, Wong WP. Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection. Nat Commun. 2021 02 08; 12(1):849. PMID: 33558532.
    Citations: 4     Fields:    Translation:AnimalsCells
  7. Chandrasekaran AR, MacIsaac M, Vilcapoma J, Hansen CH, Yang D, Wong WP, Halvorsen K. DNA Nanoswitch Barcodes for Multiplexed Biomarker Profiling. Nano Lett. 2021 01 13; 21(1):469-475. PMID: 33395311; PMCID: PMC8059342.
    Citations: 4     Fields:    
  8. Jiang Y, Feldman T, Bakx JAM, Yang D, Wong WP. Stretching DNA to twice the normal length with single-molecule hydrodynamic trapping. Lab Chip. 2020 05 19; 20(10):1780-1791. PMID: 32301470.
    Citations: 1     Fields:    Translation:Cells
  9. Huoh YS, Wu B, Park S, Yang D, Bansal K, Greenwald E, Wong WP, Mathis D, Hur S. Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance. Nat Commun. 2020 04 02; 11(1):1625. PMID: 32242017.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  10. Jiang Y, Fu H, Springer TA, Wong WP. Electrostatic Steering Enables Flow-Activated Von Willebrand Factor to Bind Platelet Glycoprotein, Revealed by Single-Molecule Stretching and Imaging. J Mol Biol. 2019 03 29; 431(7):1380-1396. PMID: 30797858; PMCID: PMC6936110.
    Citations: 7     Fields:    Translation:HumansCells
  11. Nathwani B, Shih WM, Wong WP. Force Spectroscopy and Beyond: Innovations and Opportunities. Biophys J. 2018 12 18; 115(12):2279-2285. PMID: 30447991.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  12. Yang D, Wong WP. Repurposing a Benchtop Centrifuge for High-Throughput Single-Molecule Force Spectroscopy. Methods Mol Biol. 2018; 1665:353-366. PMID: 28940079; PMCID: PMC5640162.
    Citations: 1     Fields:    
  13. Hansen CH, Yang D, Koussa MA, Wong WP. Nanoswitch-linked immunosorbent assay (NLISA) for fast, sensitive, and specific protein detection. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):10367-10372. PMID: 28893984; PMCID: PMC5625919.
    Citations: 14     Fields:    Translation:HumansCells
  14. Fu H, Jiang Y, Yang D, Scheiflinger F, Wong WP, Springer TA. Flow-induced elongation of von Willebrand factor precedes tension-dependent activation. Nat Commun. 2017 08 23; 8(1):324. PMID: 28831047.
    Citations: 57     Fields:    Translation:HumansCells
  15. Yang D, Wong WP. Small but Mighty: Nanoparticles Probe Cellular Signaling Pathways. Dev Cell. 2016 06 06; 37(5):397-8. PMID: 27270039.
    Citations: 1     Fields:    Translation:HumansCells
  16. Yang D, Ward A, Halvorsen K, Wong WP. Multiplexed single-molecule force spectroscopy using a centrifuge. Nat Commun. 2016 Mar 17; 7:11026. PMID: 26984516.
    Citations: 30     Fields:    Translation:Cells
  17. Koussa MA, Halvorsen K, Ward A, Wong WP. DNA nanoswitches: a quantitative platform for gel-based biomolecular interaction analysis. Nat Methods. 2015 Feb; 12(2):123-126. PMID: 25486062; PMCID: PMC4336243.
    Citations: 25     Fields:    Translation:Cells
  18. Koussa MA, Sotomayor M, Wong WP. Protocol for sortase-mediated construction of DNA-protein hybrids and functional nanostructures. Methods. 2014 May 15; 67(2):134-41. PMID: 24568941.
    Citations: 11     Fields:    Translation:Cells
  19. Zhao W, Cui CH, Bose S, Guo D, Shen C, Wong WP, Halvorsen K, Farokhzad OC, Teo GS, Phillips JA, Dorfman DM, Karnik R, Karp JM. Bioinspired multivalent DNA network for capture and release of cells. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19626-31. PMID: 23150586.
    Citations: 54     Fields:    Translation:HumansCells
  20. Pelletier J, Halvorsen K, Ha BY, Paparcone R, Sandler SJ, Woldringh CL, Wong WP, Jun S. Physical manipulation of the Escherichia coli chromosome reveals its soft nature. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):E2649-56. PMID: 22984156.
    Citations: 65     Fields:    Translation:Cells
  21. Halvorsen K, Wong WP. Binary DNA nanostructures for data encryption. PLoS One. 2012; 7(9):e44212. PMID: 22984477.
    Citations: 7     Fields:    
  22. Halvorsen K, Schaak D, Wong WP. Nanoengineering a single-molecule mechanical switch using DNA self-assembly. Nanotechnology. 2011 Dec 09; 22(49):494005. PMID: 22101354.
    Citations: 22     Fields:    
  23. Halvorsen K, Wong WP. Massively parallel single-molecule manipulation using centrifugal force. Biophys J. 2010 Jun 02; 98(11):L53-5. PMID: 20513382.
    Citations: 28     Fields:    Translation:Cells
  24. Cheng D, Halvorsen K, Wong WP. Note: High-precision microsphere sorting using velocity sedimentation. Rev Sci Instrum. 2010 Feb; 81(2):026106. PMID: 20192523.
    Citations: 2     Fields:    
  25. Zhang X, Halvorsen K, Zhang CZ, Wong WP, Springer TA. Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor. Science. 2009 Jun 05; 324(5932):1330-4. PMID: 19498171.
    Citations: 199     Fields:    Translation:HumansCells
  26. Wong WP, Halvorsen K. Beyond the frame rate: measuring high-frequency fluctuations with light-intensity modulation. Opt Lett. 2009 Feb 01; 34(3):277-9. PMID: 19183630.
    Citations: 4     Fields:    
  27. Heinrich V, Wong WP, Halvorsen K, Evans E. Imaging biomolecular interactions by fast three-dimensional tracking of laser-confined carrier particles. Langmuir. 2008 Feb 19; 24(4):1194-203. PMID: 18198910.
    Citations: 7     Fields:    Translation:HumansAnimals
  28. Wong WP, Halvorsen K. The effect of integration time on fluctuation measurements: calibrating an optical trap in the presence of motion blur. Opt Express. 2006 Dec 11; 14(25):12517-31. PMID: 19529687.
    Citations: 41     Fields:    
  29. Wong WP, Evans E. Biological physics: rare returns on lost effort. Nature. 2005 Sep 08; 437(7056):198-9. PMID: 16148917.
    Citations:    Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.