Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Hua-Jun Feng, Ph.D., M.D.

Title
Institution
Department
Address
Phone

Overview

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Feng HJ, Forman SA. Comparison of aßd and aß? GABAA receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacol Res. 2018 Jul; 133:289-300. PMID: 29294355.
    View in: PubMed
  2. Zhang H, Zhao H, Zeng C, Van Dort C, Faingold CL, Taylor NE, Solt K, Feng HJ. Optogenetic activation of 5-HT neurons in the dorsal raphe suppresses seizure-induced respiratory arrest and produces anticonvulsant effect in the DBA/1 mouse SUDEP model. Neurobiol Dis. 2018 Feb; 110:47-58. PMID: 29141182.
    View in: PubMed
  3. Zhao H, Cotten JF, Long X, Feng HJ. The effect of atomoxetine, a selective norepinephrine reuptake inhibitor, on respiratory arrest and cardiorespiratory function in the DBA/1 mouse model of SUDEP. Epilepsy Res. 2017 11; 137:139-144. PMID: 28844345.
    View in: PubMed
  4. Zhang H, Zhao H, Feng HJ. Atomoxetine, a norepinephrine reuptake inhibitor, reduces seizure-induced respiratory arrest. Epilepsy Behav. 2017 08; 73:6-9. PMID: 28605634.
    View in: PubMed
  5. Faingold CL, Randall M, Zeng C, Peng S, Long X, Feng HJ. Serotonergic agents act on 5-HT3 receptors in the brain to block seizure-induced respiratory arrest in the DBA/1 mouse model of SUDEP. Epilepsy Behav. 2016 11; 64(Pt A):166-170. PMID: 27743549.
    View in: PubMed
  6. Botzolakis EJ, Gurba KN, Lagrange AH, Feng HJ, Stanic AK, Hu N, Macdonald RL. Comparison of ?-Aminobutyric Acid, Type A (GABAA), Receptor aß? and aßd Expression Using Flow Cytometry and Electrophysiology: EVIDENCE FOR ALTERNATIVE SUBUNIT STOICHIOMETRIES AND ARRANGEMENTS. J Biol Chem. 2016 Sep 23; 291(39):20440-61. PMID: 27493204.
    View in: PubMed
  7. Zhang H, Zhao H, Yang X, Xue Q, Cotten JF, Feng HJ. 5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest. Epilepsia. 2016 08; 57(8):1228-35. PMID: 27302625.
    View in: PubMed
  8. Feng HJ, Faingold CL. Abnormalities of serotonergic neurotransmission in animal models of SUDEP. Epilepsy Behav. 2017 06; 71(Pt B):174-180. PMID: 26272185.
    View in: PubMed
  9. Liu K, Jounaidi Y, Forman SA, Feng HJ. Etomidate uniquely modulates the desensitization of recombinant a1ß3d GABA(A) receptors. Neuroscience. 2015 Aug 06; 300:307-13. PMID: 26028470; PMCID: PMC4484732.
  10. Zeng C, Long X, Cotten JF, Forman SA, Solt K, Faingold CL, Feng HJ. Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice. Epilepsy Behav. 2015 Apr; 45:1-7. PMID: 25771493; PMCID: PMC4424071.
  11. Feng HJ, Jounaidi Y, Haburcak M, Yang X, Forman SA. Etomidate produces similar allosteric modulation in a1ß3d and a1ß3?2L GABA(A) receptors. Br J Pharmacol. 2014 Feb; 171(3):789-98. PMID: 24199598; PMCID: PMC3969089.
  12. Feng HJ, Kao C, Gallagher MJ, Jansen ED, Mahadevan-Jansen A, Konrad PE, Macdonald RL. Alteration of GABAergic neurotransmission by pulsed infrared laser stimulation. J Neurosci Methods. 2010 Sep 30; 192(1):110-4. PMID: 20654645; PMCID: PMC3096872.
  13. Ding L, Feng HJ, Macdonald RL, Botzolakis EJ, Hu N, Gallagher MJ. GABA(A) receptor alpha1 subunit mutation A322D associated with autosomal dominant juvenile myoclonic epilepsy reduces the expression and alters the composition of wild type GABA(A) receptors. J Biol Chem. 2010 Aug 20; 285(34):26390-405. PMID: 20551311; PMCID: PMC2924069.
  14. Feng HJ, Macdonald RL. Barbiturates require the N terminus and first transmembrane domain of the delta subunit for enhancement of alpha1beta3delta GABAA receptor currents. J Biol Chem. 2010 Jul 30; 285(31):23614-21. PMID: 20525684; PMCID: PMC2911329.
  15. Botzolakis EJ, Maheshwari A, Feng HJ, Lagrange AH, Shaver JH, Kassebaum NJ, Venkataraman R, Baudenbacher F, Macdonald RL. Achieving synaptically relevant pulses of neurotransmitter using PDMS microfluidics. J Neurosci Methods. 2009 Mar 15; 177(2):294-302. PMID: 19013195; PMCID: PMC3786708.
  16. Feng HJ, Botzolakis EJ, Macdonald RL. Context-dependent modulation of alphabetagamma and alphabetadelta GABA A receptors by penicillin: implications for phasic and tonic inhibition. Neuropharmacology. 2009 Jan; 56(1):161-73. PMID: 18775733; PMCID: PMC2661208.
  17. Feng HJ, Faingold CL. The effects of chronic ethanol administration on amygdala neuronal firing and ethanol withdrawal seizures. Neuropharmacology. 2008 Oct; 55(5):648-53. PMID: 18614185; PMCID: PMC2650855.
  18. Feng HJ, Mathews GC, Kao C, Macdonald RL. Alterations of GABA A-receptor function and allosteric modulation during development of status epilepticus. J Neurophysiol. 2008 Mar; 99(3):1285-93. PMID: 18216225.
    View in: PubMed
  19. Feng HJ, Kang JQ, Song L, Dibbens L, Mulley J, Macdonald RL. Delta subunit susceptibility variants E177A and R220H associated with complex epilepsy alter channel gating and surface expression of alpha4beta2delta GABAA receptors. J Neurosci. 2006 Feb 01; 26(5):1499-506. PMID: 16452673.
    View in: PubMed
  20. Macdonald RL, Kang JQ, Gallagher MJ, Feng HJ. GABA(A) receptor mutations associated with generalized epilepsies. Adv Pharmacol. 2006; 54:147-69. PMID: 17175814.
    View in: PubMed
  21. Macdonald RL, Gallagher MJ, Feng HJ, Kang J. GABA(A) receptor epilepsy mutations. Biochem Pharmacol. 2004 Oct 15; 68(8):1497-506. PMID: 15451392.
    View in: PubMed
  22. Feng HJ, Macdonald RL. Multiple actions of propofol on alphabetagamma and alphabetadelta GABAA receptors. Mol Pharmacol. 2004 Dec; 66(6):1517-24. PMID: 15331770.
    View in: PubMed
  23. Feng HJ, Bianchi MT, Macdonald RL. Pentobarbital differentially modulates alpha1beta3delta and alpha1beta3gamma2L GABAA receptor currents. Mol Pharmacol. 2004 Oct; 66(4):988-1003. PMID: 15247320.
    View in: PubMed
  24. Feng HJ, Macdonald RL. Proton modulation of alpha 1 beta 3 delta GABAA receptor channel gating and desensitization. J Neurophysiol. 2004 Sep; 92(3):1577-85. PMID: 15152020.
    View in: PubMed
  25. Dibbens LM, Feng HJ, Richards MC, Harkin LA, Hodgson BL, Scott D, Jenkins M, Petrou S, Sutherland GR, Scheffer IE, Berkovic SF, Macdonald RL, Mulley JC. GABRD encoding a protein for extra- or peri-synaptic GABAA receptors is a susceptibility locus for generalized epilepsies. Hum Mol Genet. 2004 Jul 01; 13(13):1315-9. PMID: 15115768.
    View in: PubMed
  26. Macdonald RL, Bianchi MT, Bianch MT, Feng H. Mutations linked to generalized epilepsy in humans reduce GABA(A) receptor current. Exp Neurol. 2003 Nov; 184 Suppl 1:S58-67. PMID: 14597328.
    View in: PubMed
  27. Raisinghani M, Feng HJ, Faingold CL. Glutamatergic activation of the amygdala differentially mimics the effects of audiogenic seizure kindling in two substrains of genetically epilepsy-prone rats. Exp Neurol. 2003 Oct; 183(2):516-22. PMID: 14552892.
    View in: PubMed
  28. Feng HJ, Faingold CL. Synaptic plasticity in the pathway from the medial geniculate body to the lateral amygdala is induced by seizure repetition. Brain Res. 2002 Aug 16; 946(2):198-205. PMID: 12137922.
    View in: PubMed
  29. Feng HJ, Faingold CL. Repeated generalized audiogenic seizures induce plastic changes on acoustically evoked neuronal firing in the amygdala. Brain Res. 2002 Apr 05; 932(1-2):61-9. PMID: 11911862.
    View in: PubMed
  30. Feng HJ, Naritoku DK, Randall ME, Faingold CL. Modulation of audiogenically kindled seizures by gamma-aminobutyric acid-related mechanisms in the amygdala. Exp Neurol. 2001 Dec; 172(2):477-81. PMID: 11716572.
    View in: PubMed
  31. Feng HJ, Faingold CL. Modulation of audiogenic seizures by histamine and adenosine receptors in the inferior colliculus. Exp Neurol. 2000 May; 163(1):264-70. PMID: 10785466.
    View in: PubMed
  32. Feng HJ, Huang SL, Wang W, Zhou HH. The induction effect of rifampicin on activity of mephenytoin 4'-hydroxylase related to M1 mutation of CYP2C19 and gene dose. Br J Clin Pharmacol. 1998 Jan; 45(1):27-9. PMID: 9489590; PMCID: PMC1873992.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Feng's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (175)
Explore
_
Co-Authors (5)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.