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Last Name

profilePascal Kaeser, M.D.

TitleAssistant Professor of Neurobiology
InstitutionHarvard Medical School
AddressHarvard Medical School
Neurobiology Goldenson Bldg
220 Longwood Ave
Boston MA 02115
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Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01NS103484     (KAESER, PASCAL SIMON)Aug 1, 2017 - Apr 30, 2021
Architecture and function of striatal dopamine release machinery
Role: Principal Investigator

R01MH113349     (KAESER, PASCAL SIMON)Mar 13, 2017 - Dec 31, 2021
Dissecting the assembly of vertebrate neurotransmitter release sites
Role: Principal Investigator

R01NS083898     (KAESER, PASCAL SIMON)Jul 1, 2014 - May 31, 2019
Molecular Dissection of Active Zone Functions in Neurotransmitter Release
Role: Principal Investigator

K01DA029044     (KAESER, PASCAL SIMON)Apr 1, 2010 - Mar 31, 2015
Function of RIM-dependent Synaptic Plasticity in Cocaine-induced Behaviors
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Fioravante D, Chu Y, de Jong AP, Leitges M, Kaeser PS, Regehr WG. Retraction: Protein kinase C is a calcium sensor for presynaptic short-term plasticity. Elife. 2018 03 07; 7. PMID: 29512487.
    View in: PubMed
  2. Wong MY, Liu C, Wang SSH, Roquas ACF, Fowler SC, Kaeser PS. Liprin-a3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses. Proc Natl Acad Sci U S A. 2018 Feb 27; 115(9):2234-2239. PMID: 29439199.
    View in: PubMed
  3. Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser PS. Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites. Cell. 2018 Feb 08; 172(4):706-718.e15. PMID: 29398114.
    View in: PubMed
  4. Held RG, Kaeser PS. ELKS active zone proteins as multitasking scaffolds for secretion. Open Biol. 2018 Feb; 8(2). PMID: 29491150.
    View in: PubMed
  5. Biederer T, Kaeser PS, Blanpied TA. Transcellular Nanoalignment of Synaptic Function. Neuron. 2017 Nov 01; 96(3):680-696. PMID: 29096080.
    View in: PubMed
  6. Wang Y, Woehrstein JB, Donoghue N, Dai M, Avendaño MS, Schackmann RCJ, Zoeller JJ, Wang SSH, Tillberg PW, Park D, Lapan SW, Boyden ES, Brugge JS, Kaeser PS, Church GM, Agasti SS, Jungmann R, Yin P. Rapid Sequential in Situ Multiplexing with DNA Exchange Imaging in Neuronal Cells and Tissues. Nano Lett. 2017 Oct 11; 17(10):6131-6139. PMID: 28933153.
    View in: PubMed
  7. Kawabe H, Mitkovski M, Kaeser PS, Hirrlinger J, Opazo F, Nestvogel D, Kalla S, Fejtova A, Verrier SE, Bungers SR, Cooper BH, Varoqueaux F, Wang Y, Nehring RB, Gundelfinger ED, Rosenmund C, Rizzoli SO, Südhof TC, Rhee JS, Brose N. Correction: ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones. J Cell Biol. 2017 04 03; 216(4):1205. PMID: 28289090.
    View in: PubMed
  8. Kawabe H, Mitkovski M, Kaeser PS, Hirrlinger J, Opazo F, Nestvogel D, Kalla S, Fejtova A, Verrier SE, Bungers SR, Cooper BH, Varoqueaux F, Wang Y, Nehring RB, Gundelfinger ED, Rosenmund C, Rizzoli SO, Südhof TC, Rhee JS, Brose N. ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones. J Cell Biol. 2017 04 03; 216(4):1143-1161. PMID: 28264913.
    View in: PubMed
  9. Kaeser PS, Regehr WG. The readily releasable pool of synaptic vesicles. Curr Opin Neurobiol. 2017 Apr; 43:63-70. PMID: 28103533.
    View in: PubMed
  10. Wang SSH, Held RG, Wong MY, Liu C, Karakhanyan A, Kaeser PS. Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking. Neuron. 2016 Aug 17; 91(4):777-791. PMID: 27537483; PMCID: PMC4991631 [Available on 08/17/17].
  11. Held RG, Liu C, Kaeser PS. ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains. Elife. 2016 06 02; 5. PMID: 27253063; PMCID: PMC4935463.
  12. Han Y, Babai N, Kaeser P, Südhof TC, Schneggenburger R. RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse. J Neurophysiol. 2015 Jan 01; 113(1):255-63. PMID: 25343783; PMCID: PMC4380487.
  13. Liu C, Bickford LS, Held RG, Nyitrai H, Südhof TC, Kaeser PS. The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons. J Neurosci. 2014 Sep 10; 34(37):12289-303. PMID: 25209271; PMCID: PMC4160768.
  14. Lacoste B, Comin CH, Ben-Zvi A, Kaeser PS, Xu X, Costa Lda F, Gu C. Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex. Neuron. 2014 Sep 03; 83(5):1117-30. PMID: 25155955; PMCID: PMC4166422.
  15. Fioravante D, Chu Y, de Jong AP, Leitges M, Kaeser PS, Regehr WG. Protein kinase C is a calcium sensor for presynaptic short-term plasticity. Elife. 2014 Aug 05; 3:e03011. PMID: 25097249.
    View in: PubMed
  16. Antonny B, Audhya J, l Bagnat M, von Blume J, Briggs JA, Giraudo C, Kaeser PS, Miller E, Reinisch K, Sbalzarini IF, Schuldiner M, Shen J, Takamori S, Verstreken P, Walther T. Directing traffic into the future. Dev Cell. 2013 Dec 09; 27(5):480-4. PMID: 24482802.
    View in: PubMed
  17. Kaeser PS, Regehr WG. Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release. Annu Rev Physiol. 2014; 76:333-63. PMID: 24274737; PMCID: PMC4503208.
  18. Kaeser PS, Deng L, Fan M, Südhof TC. RIM genes differentially contribute to organizing presynaptic release sites. Proc Natl Acad Sci U S A. 2012 Jul 17; 109(29):11830-5. PMID: 22753485; PMCID: PMC3406861.
  19. Narboux-Nême N, Evrard A, Ferezou I, Erzurumlu RS, Kaeser PS, Lainé J, Rossier J, Ropert N, Südhof TC, Gaspar P. Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex. J Neurosci. 2012 May 02; 32(18):6183-96. PMID: 22553025; PMCID: PMC3526954.
  20. Haws ME, Kaeser PS, Jarvis DL, Südhof TC, Powell CM. Region-specific deletions of RIM1 reproduce a subset of global RIM1a(-/-) phenotypes. Genes Brain Behav. 2012 Mar; 11(2):201-13. PMID: 22103334; PMCID: PMC3268893.
  21. Tsetsenis T, Younts TJ, Chiu CQ, Kaeser PS, Castillo PE, Südhof TC. Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):14300-5. PMID: 21844341; PMCID: PMC3161598.
  22. Kaeser PS. Pushing synaptic vesicles over the RIM. Cell Logist. 2011 May; 1(3):106-110. PMID: 21922075.
    View in: PubMed
  23. Han Y, Kaeser PS, Südhof TC, Schneggenburger R. RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone. Neuron. 2011 Jan 27; 69(2):304-16. PMID: 21262468; PMCID: PMC3259453.
  24. Deng L, Kaeser PS, Xu W, Südhof TC. RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13. Neuron. 2011 Jan 27; 69(2):317-31. PMID: 21262469; PMCID: PMC3063404.
  25. Kaeser PS, Deng L, Wang Y, Dulubova I, Liu X, Rizo J, Südhof TC. RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell. 2011 Jan 21; 144(2):282-95. PMID: 21241895; PMCID: PMC3063406.
  26. Blundell J, Kaeser PS, Südhof TC, Powell CM. RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia. J Neurosci. 2010 Apr 14; 30(15):5326-33. PMID: 20392954; PMCID: PMC2860606.
  27. Kaeser PS, Deng L, Chávez AE, Liu X, Castillo PE, Südhof TC. ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. Neuron. 2009 Oct 29; 64(2):227-39. PMID: 19874790; PMCID: PMC2785857.
  28. Kaeser PS, Kwon HB, Chiu CQ, Deng L, Castillo PE, Südhof TC. RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions. J Neurosci. 2008 Dec 10; 28(50):13435-47. PMID: 19074017; PMCID: PMC2701653.
  29. Kaeser PS, Kwon HB, Blundell J, Chevaleyre V, Morishita W, Malenka RC, Powell CM, Castillo PE, Südhof TC. RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14680-5. PMID: 18799741; PMCID: PMC2567150.
  30. Chevaleyre V, Heifets BD, Kaeser PS, Südhof TC, Purpura DP, Castillo PE. Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha. Neuron. 2007 Jun 07; 54(5):801-12. PMID: 17553427; PMCID: PMC2001295.
  31. Schoch S, Mittelstaedt T, Kaeser PS, Padgett D, Feldmann N, Chevaleyre V, Castillo PE, Hammer RE, Han W, Schmitz F, Lin W, Südhof TC. Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. EMBO J. 2006 Dec 13; 25(24):5852-63. PMID: 17124501; PMCID: PMC1698877.
  32. Lu HC, Butts DA, Kaeser PS, She WC, Janz R, Crair MC. Role of efficient neurotransmitter release in barrel map development. J Neurosci. 2006 Mar 08; 26(10):2692-703. PMID: 16525048.
    View in: PubMed
  33. Kaeser PS, Südhof TC. RIM function in short- and long-term synaptic plasticity. Biochem Soc Trans. 2005 Dec; 33(Pt 6):1345-9. PMID: 16246115.
    View in: PubMed
  34. Huang YY, Zakharenko SS, Schoch S, Kaeser PS, Janz R, Südhof TC, Siegelbaum SA, Kandel ER. Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9365-70. PMID: 15967982; PMCID: PMC1166627.
  35. Lonart G, Schoch S, Kaeser PS, Larkin CJ, Südhof TC, Linden DJ. Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses. Cell. 2003 Oct 03; 115(1):49-60. PMID: 14532002.
    View in: PubMed
  36. Kaeser PS, Klein MA, Schwarz P, Aguzzi A. Efficient lymphoreticular prion propagation requires PrP(c) in stromal and hematopoietic cells. J Virol. 2001 Aug; 75(15):7097-106. PMID: 11435590; PMCID: PMC114438.
  37. Klein MA, Kaeser PS, Schwarz P, Weyd H, Xenarios I, Zinkernagel RM, Carroll MC, Verbeek JS, Botto M, Walport MJ, Molina H, Kalinke U, Acha-Orbea H, Aguzzi A. Complement facilitates early prion pathogenesis. Nat Med. 2001 Apr; 7(4):488-92. PMID: 11283678.
    View in: PubMed
  38. Aguzzi A, Montrasio F, Kaeser PS. Prions: health scare and biological challenge. Nat Rev Mol Cell Biol. 2001 Feb; 2(2):118-26. PMID: 11252953.
    View in: PubMed
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