Harvard Catalyst Profiles

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James Jeiwen Chou, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35GM140887 (CHOU, JAMES JEIWEN) May 1, 2021 - Feb 28, 2026
    Structural and Functional Roles of the Membrane-Related Components of Single-Pass Membrane Proteins
    Role: Principal Investigator
  2. R01AI150709 (CHOU, JAMES JEIWEN) Feb 1, 2020 - Jan 31, 2025
    Role: Principal Investigator
  3. R01HL130143 (CHOU, JAMES JEIWEN) Feb 1, 2017 - Jan 31, 2021
    Molecular Architecture Of The Mitochondrial Calcium Uniporter
    Role: Principal Investigator
  4. R01AI127193 (CHEN, BING) May 20, 2016 - Jun 30, 2026
    Structure-function studies of the membrane-interacting domains of HIV-1 Env spike
    Role: Co-Principal Investigator
  5. R01GM116898 (CHOU, JAMES JEIWEN) Jan 1, 2016 - Dec 31, 2019
    Function and mechanism of the HCV p7 channel and its therapeutic potential
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. OuYang B, Xie S, Berardi MJ, Zhao X, Dev J, Yu W, Sun B, Chou JJ. Unusual architecture of the p7 channel from hepatitis C virus. Nature. 2013 Jun 27; 498(7455):521-5. PMID: 23739335.
    Citations: 80     Fields:    Translation:Cells
  2. Bellot G, McClintock MA, Chou JJ, Shih WM. DNA nanotubes for NMR structure determination of membrane proteins. Nat Protoc. 2013 Apr; 8(4):755-70. PMID: 23589936.
  3. Bellot G, McClintock MA, Chou JJ, Shih WM. DNA nanotubes for NMR structure determination of membrane proteins. Nat Protoc. 2013 Apr; 8(4):755-70. PMID: 23518667.
    Citations: 11     Fields:    Translation:Cells
  4. Chou JJ, Sounier R. Solution nuclear magnetic resonance spectroscopy. Methods Mol Biol. 2013; 955:495-517. PMID: 23132077.
    Citations:    Fields:    
  5. Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P. Molecular basis for interaction of let-7 microRNAs with Lin28. Cell. 2011 Nov 23; 147(5):1080-91. PMID: 22078496.
    Citations: 170     Fields:    Translation:AnimalsCells
  6. Berardi MJ, Shih WM, Harrison SC, Chou JJ. Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching. Nature. 2011 Jul 24; 476(7358):109-13. PMID: 21785437.
    Citations: 108     Fields:    Translation:AnimalsCells
  7. Pielak RM, Chou JJ. Kinetic analysis of the M2 proton conduction of the influenza virus. J Am Chem Soc. 2010 Dec 22; 132(50):17695-7. PMID: 21090748.
    Citations: 25     Fields:    Translation:Cells
  8. Call ME, Wucherpfennig KW, Chou JJ. The structural basis for intramembrane assembly of an activating immunoreceptor complex. Nat Immunol. 2010 Nov; 11(11):1023-9. PMID: 20890284.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  9. Pielak RM, Chou JJ. Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel. Biochem Biophys Res Commun. 2010 Oct 08; 401(1):58-63. PMID: 20833142.
    Citations: 39     Fields:    Translation:HumansCells
  10. Pielak RM, Chou JJ. Influenza M2 proton channels. Biochim Biophys Acta. 2011 Feb; 1808(2):522-9. PMID: 20451491.
    Citations: 53     Fields:    Translation:Cells
  11. Pielak RM, Chou JJ. Flu channel drug resistance: a tale of two sites. Protein Cell. 2010 Mar; 1(3):246-58. PMID: 21203971.
    Citations: 20     Fields:    Translation:HumansCells
  12. Wang J, Pielak RM, McClintock MA, Chou JJ. Solution structure and functional analysis of the influenza B proton channel. Nat Struct Mol Biol. 2009 Dec; 16(12):1267-71. PMID: 19898475.
    Citations: 54     Fields:    Translation:Cells
  13. Pielak RM, Schnell JR, Chou JJ. Mechanism of drug inhibition and drug resistance of influenza A M2 channel. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7379-84. PMID: 19383794.
    Citations: 99     Fields:    Translation:HumansCells
  14. Sharma AK, Zhou GP, Kupferman J, Surks HK, Christensen EN, Chou JJ, Mendelsohn ME, Rigby AC. Probing the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase. J Biol Chem. 2008 Nov 21; 283(47):32860-9. PMID: 18782776.
    Citations: 21     Fields:    Translation:Cells
  15. Shen H, Chou JJ. MemBrain: improving the accuracy of predicting transmembrane helices. PLoS One. 2008 Jun 11; 3(6):e2399. PMID: 18545655.
    Citations: 38     Fields:    Translation:Cells
  16. Schnell JR, Chou JJ. Structure and mechanism of the M2 proton channel of influenza A virus. Nature. 2008 Jan 31; 451(7178):591-5. PMID: 18235503.
    Citations: 347     Fields:    Translation:Cells
  17. Oxenoid K, Rice AJ, Chou JJ. Comparing the structure and dynamics of phospholamban pentamer in its unphosphorylated and pseudo-phosphorylated states. Protein Sci. 2007 Sep; 16(9):1977-83. PMID: 17766390.
    Citations: 12     Fields:    Translation:HumansCells
  18. Mansy SS, Zhang J, Kümmerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC. Structure and evolutionary analysis of a non-biological ATP-binding protein. J Mol Biol. 2007 Aug 10; 371(2):501-13. PMID: 17583732.
    Citations: 4     Fields:    Translation:Cells
  19. Douglas SM, Chou JJ, Shih WM. DNA-nanotube-induced alignment of membrane proteins for NMR structure determination. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6644-8. PMID: 17404217.
    Citations: 109     Fields:    Translation:Cells
  20. Call ME, Schnell JR, Xu C, Lutz RA, Chou JJ, Wucherpfennig KW. The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. Cell. 2006 Oct 20; 127(2):355-68. PMID: 17055436.
    Citations: 74     Fields:    Translation:HumansCells
  21. Wei RR, Schnell JR, Larsen NA, Sorger PK, Chou JJ, Harrison SC. Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Structure. 2006 Jun; 14(6):1003-9. PMID: 16765893.
    Citations: 58     Fields:    Translation:Cells
  22. Schnell JR, Zhou GP, Zweckstetter M, Rigby AC, Chou JJ. Rapid and accurate structure determination of coiled-coil domains using NMR dipolar couplings: application to cGMP-dependent protein kinase Ialpha. Protein Sci. 2005 Sep; 14(9):2421-8. PMID: 16131665.
    Citations: 15     Fields:    Translation:HumansCells
  23. Oxenoid K, Chou JJ. The structure of phospholamban pentamer reveals a channel-like architecture in membranes. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):10870-5. PMID: 16043693.
    Citations: 106     Fields:    Translation:HumansCells
  24. Wang J, Schnell JR, Chou JJ. Amantadine partition and localization in phospholipid membrane: a solution NMR study. Biochem Biophys Res Commun. 2004 Nov 05; 324(1):212-7. PMID: 15465004.
    Citations: 22     Fields:    Translation:Cells
  25. Chou JJ, Baber JL, Bax A. Characterization of phospholipid mixed micelles by translational diffusion. J Biomol NMR. 2004 Jul; 29(3):299-308. PMID: 15213428.
    Citations: 53     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.