Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Last Name

profileJames Jeiwen Chou, Ph.D.

TitleProfessor of Biological Chemistry and Molecular Pharmacology
InstitutionHarvard Medical School
DepartmentBiological Chemistry & Molecular Pharmacology
Harvard Medical School
250 Longwood Ave
Boston MA 02115
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01HL130143     (CHOU, JAMES J)Feb 1, 2017 - Jan 31, 2021
Molecular Architecture Of The Mitochondrial Calcium Uniporter
Role: Principal Investigator

R01AI127193     (CHEN, BING)May 20, 2016 - Apr 30, 2021
Structure-function studies of the membrane-interacting domains of HIV-1 Env spike
Role: Co-Principal Investigator

R01GM116898     (CHOU, JAMES J)Jan 1, 2016 - Dec 31, 2019
Function and mechanism of the HCV p7 channel and its therapeutic potential
Role: Principal Investigator

R56AI112960     (CHOU, JAMES J)Jul 15, 2014 - Jun 30, 2015
Function and mechanism of the HCV p7 channel and its therapeutic potential
Role: Principal Investigator

P01HL103526     (SPRINGER, TIMOTHY A)Aug 20, 2011 - Jun 30, 2016
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. OuYang B, Xie S, Berardi MJ, Zhao X, Dev J, Yu W, Sun B, Chou JJ. Unusual architecture of the p7 channel from hepatitis C virus. Nature. 2013 Jun 27; 498(7455):521-5. PMID: 23739335; PMCID: PMC3725310.
  2. Bellot G, McClintock MA, Chou JJ, Shih WM. DNA nanotubes for NMR structure determination of membrane proteins. Nat Protoc. 2013 Apr; 8(4):755-70. PMID: 23589936.
    View in: PubMed
  3. Bellot G, McClintock MA, Chou JJ, Shih WM. DNA nanotubes for NMR structure determination of membrane proteins. Nat Protoc. 2013 Apr; 8(4):755-70. PMID: 23518667; PMCID: PMC3843643.
  4. Chou JJ, Sounier R. Solution nuclear magnetic resonance spectroscopy. Methods Mol Biol. 2013; 955:495-517. PMID: 23132077.
    View in: PubMed
  5. Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P. Molecular basis for interaction of let-7 microRNAs with Lin28. Cell. 2011 Nov 23; 147(5):1080-91. PMID: 22078496; PMCID: PMC3277843.
  6. Berardi MJ, Shih WM, Harrison SC, Chou JJ. Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching. Nature. 2011 Jul 24; 476(7358):109-13. PMID: 21785437; PMCID: PMC3150631.
  7. Pielak RM, Chou JJ. Kinetic analysis of the M2 proton conduction of the influenza virus. J Am Chem Soc. 2010 Dec 22; 132(50):17695-7. PMID: 21090748; PMCID: PMC3183502.
  8. Call ME, Wucherpfennig KW, Chou JJ. The structural basis for intramembrane assembly of an activating immunoreceptor complex. Nat Immunol. 2010 Nov; 11(11):1023-9. PMID: 20890284; PMCID: PMC3215083.
  9. Pielak RM, Chou JJ. Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel. Biochem Biophys Res Commun. 2010 Oct 08; 401(1):58-63. PMID: 20833142; PMCID: PMC3215091.
  10. Pielak RM, Chou JJ. Influenza M2 proton channels. Biochim Biophys Acta. 2011 Feb; 1808(2):522-9. PMID: 20451491; PMCID: PMC3108042.
  11. Pielak RM, Chou JJ. Flu channel drug resistance: a tale of two sites. Protein Cell. 2010 Mar; 1(3):246-58. PMID: 21203971; PMCID: PMC4875082.
  12. Wang J, Pielak RM, McClintock MA, Chou JJ. Solution structure and functional analysis of the influenza B proton channel. Nat Struct Mol Biol. 2009 Dec; 16(12):1267-71. PMID: 19898475; PMCID: PMC3148584.
  13. Pielak RM, Schnell JR, Chou JJ. Mechanism of drug inhibition and drug resistance of influenza A M2 channel. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7379-84. PMID: 19383794; PMCID: PMC2678642.
  14. Sharma AK, Zhou GP, Kupferman J, Surks HK, Christensen EN, Chou JJ, Mendelsohn ME, Rigby AC. Probing the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase. J Biol Chem. 2008 Nov 21; 283(47):32860-9. PMID: 18782776; PMCID: PMC2583292.
  15. Shen H, Chou JJ. MemBrain: improving the accuracy of predicting transmembrane helices. PLoS One. 2008 Jun 11; 3(6):e2399. PMID: 18545655; PMCID: PMC2396505.
  16. Schnell JR, Chou JJ. Structure and mechanism of the M2 proton channel of influenza A virus. Nature. 2008 Jan 31; 451(7178):591-5. PMID: 18235503; PMCID: PMC3108054.
  17. Oxenoid K, Rice AJ, Chou JJ. Comparing the structure and dynamics of phospholamban pentamer in its unphosphorylated and pseudo-phosphorylated states. Protein Sci. 2007 Sep; 16(9):1977-83. PMID: 17766390; PMCID: PMC2206959.
  18. Mansy SS, Zhang J, K├╝mmerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC. Structure and evolutionary analysis of a non-biological ATP-binding protein. J Mol Biol. 2007 Aug 10; 371(2):501-13. PMID: 17583732.
    View in: PubMed
  19. Douglas SM, Chou JJ, Shih WM. DNA-nanotube-induced alignment of membrane proteins for NMR structure determination. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6644-8. PMID: 17404217; PMCID: PMC1871839.
  20. Call ME, Schnell JR, Xu C, Lutz RA, Chou JJ, Wucherpfennig KW. The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. Cell. 2006 Oct 20; 127(2):355-68. PMID: 17055436; PMCID: PMC3466601.
  21. Wei RR, Schnell JR, Larsen NA, Sorger PK, Chou JJ, Harrison SC. Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Structure. 2006 Jun; 14(6):1003-9. PMID: 16765893.
    View in: PubMed
  22. Schnell JR, Zhou GP, Zweckstetter M, Rigby AC, Chou JJ. Rapid and accurate structure determination of coiled-coil domains using NMR dipolar couplings: application to cGMP-dependent protein kinase Ialpha. Protein Sci. 2005 Sep; 14(9):2421-8. PMID: 16131665; PMCID: PMC2253468.
  23. Oxenoid K, Chou JJ. The structure of phospholamban pentamer reveals a channel-like architecture in membranes. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):10870-5. PMID: 16043693; PMCID: PMC1182456.
  24. Wang J, Schnell JR, Chou JJ. Amantadine partition and localization in phospholipid membrane: a solution NMR study. Biochem Biophys Res Commun. 2004 Nov 05; 324(1):212-7. PMID: 15465004.
    View in: PubMed
  25. Chou JJ, Baber JL, Bax A. Characterization of phospholipid mixed micelles by translational diffusion. J Biomol NMR. 2004 Jul; 29(3):299-308. PMID: 15213428.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at For faculty personal and demographic information, contact HMS Office for Faculty Affairs at
Chou's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
Co-Authors Expand Description
Similar People Expand Description
Same Department Expand Description
Physical Neighbors Expand Description