Harvard Catalyst Profiles

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Rani Sarkis, M.D.

Title
Institution
Department
Address
Profile Picture

Biography
awards and honors
2006
Alpha Omega Alpha
2009
Resident Research Award
2011
Resident Research Award
2015
Young Investigator Award
2019 - 2020
Junior Investigator Award
2024
Edward B Bromfield Award
2024
Distinguished Clinician

Overview

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. K23NS119798 (SARKIS, RANI) Sep 1, 2021 - Jun 30, 2026
    NIH
    The contribution of late onset unexplained epilepsy to cognitive decline and its interaction with vascular and Alzheimer's disease pathologies
    Role: Principal Investigator
  2. (Rani Sarkis) Jul 1, 2019 - Dec 30, 2021
    American Epilepsy Society
    The Cognitive and Imaging Characteristics of Late Onset Idiopathic Epilepsy
    Role Description: This study will enroll patients with unexplained, late-onset seizures and compare their brain imaging, genetic tests, brain-wave testing and cognitive performance to healthy controls of the same age from the Harvard Aging Brain Study to identify causes and consequences of seizures in the elderly.
    Role: PI

Featured Content
Featured Videos
  • Epilepsy and Memory
  • Living with epilepsy
  • Late Onset Epilepsy
  • Webinar: Epilepsy in Older Adults
  • Webinar: Antiseizure Medications 101
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Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 78 total Publications Show all
  1. Sarkis RA. Epilepsy and Amyloid: The Plot Thickens… So Will the Brain Thin? Epilepsy Curr. 2025 Apr 16; 15357597251333160. PMID: 40256119.
    Citations: Article has an altmetric score of 3
  2. Ji GJ, Fox MD, Morton-Dutton M, Wang Y, Sun J, Hu P, Chen X, Jiang Y, Zhu C, Tian Y, Zhang Z, Akkad H, Nordberg J, Joutsa J, Torres Diaz CV, Groppa S, Gonzalez-Escamilla G, Toledo M, Dalic LJ, Archer JS, Selway R, Stavropoulos I, Valentin A, Yang J, Isbaine F, Gross RE, Park S, Gregg NM, Cukiert A, Middlebrooks EH, Dosenbach NUF, Turner J, Warren AEL, Chua MMJ, Cohen AL, Larivière S, Neudorfer C, Horn A, Sarkis RA, Bubrick EJ, Fisher RS, Rolston JD, Wang K, Schaper FLWVJ. A generalized epilepsy network derived from brain abnormalities and deep brain stimulation. Nat Commun. 2025 Mar 24; 16(1):2783. PMID: 40128186.
    Citations: Article has an altmetric score of 114
  3. Sarkis RA, Orozco J, Lemus HN, Hankerson A, Liu L, Lam AD, Johnson E, Stufflebeam S, Viswanathan A, Amariglio RE, Purandare M, Trouten P, Young GS, Locascio JJ, Pennell PB, Marshall GA. Late-onset unexplained seizures are associated with cognitive impairment and lower amygdala volumes. Brain Commun. 2025; 7(1):fcaf050. PMID: 39944741.
    Citations: Article has an altmetric score of 13
  4. Elyaman W, Stern LJ, Jiang N, Dressman D, Bradley P, Klatzmann D, Bradshaw EM, Farber DL, Kent SC, Chizari S, Funk K, Devanand D, Thakur KT, Raj T, Dalahmah OA, Sarkis RA, Weiner HL, Shneider NA, Przedborski S. Exploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium. Alzheimers Dement. 2025 Jan 27; e14548. PMID: 39868844.
    Citations: Article has an altmetric score of 3
    Fields: NeuNeurologyPsyPsychiatry
  5. Zawar I, Reyes A, Arrotta K, Lam AD, Sarkis R, Hermann BP, Busch RM, Kapur J, Johnson E, Tavella-Burka S, McDonald CR, Punia V. Analysis of practical judgment in older adults with epilepsy: An exploratory, multicenter cohort study. Epilepsia. 2024 Dec 17. PMID: 39688241.
    Citations: Article has an altmetric score of 4
    Fields: BraBrainNeuNeurology
  6. Sarkis RA. The RNS Crystal Ball Sees Seizure Improvement in Your Future With This Medication. Epilepsy Curr. 2024 Sep-Oct; 24(5):336-338. PMID: 39508025; PMCID: PMC11536407.
    Citations: Article has an altmetric score of 1
  7. Lam AD, Thibault EG, Mayblyum DV, Hsieh S, Pellerin KR, Sternberg EJ, Viswanathan A, Buss S, Sarkis RA, Jacobs HIL, Johnson KA, Sperling RA. Association of Seizure Foci and Location of Tau and Amyloid Deposition and Brain Atrophy in Patients With Alzheimer Disease and Seizures. Neurology. 2024 Nov 12; 103(9):e209920. PMID: 39331846; PMCID: PMC11441794.
    Citations: 2 Article has an altmetric score of 3
    Fields: NeuNeurologyTranslation:Humans
  8. Jha R, Chua MMJ, Sarkis R, Tobochnik S, Rolston JD. Predictors of SOZ localization, subsequent surgical intervention, and seizure outcomes in iEEG. Ann Clin Transl Neurol. 2024 Jul; 11(7):1787-1797. PMID: 38831617; PMCID: PMC11251470.
    Citations:
    Fields: NeuNeurologyTranslation:Humans
  9. Moguilner SG, Berezuk C, Bender AC, Pellerin KR, Gomperts SN, Cash SS, Sarkis RA, Lam AD. Sleep functional connectivity, hyperexcitability, and cognition in Alzheimer's disease. Alzheimers Dement. 2024 06; 20(6):4234-4249. PMID: 38764252; PMCID: PMC11180941.
    Citations: 1 Article has an altmetric score of 7
    Fields: NeuNeurologyPsyPsychiatryTranslation:Humans
  10. Sarkis RA. The Winners of the Cerebral Amyloid Angiopathy Epilepsy Prize Are: Blood and Inflammation. Epilepsy Curr. 2024 Mar-Apr; 24(2):93-95. PMID: 39280060; PMCID: PMC11394421.
    Citations: Article has an altmetric score of 12
  11. Bender AC, Jaleel A, Pellerin KR, Moguilner S, Sarkis RA, Cash SS, Lam AD. Altered Sleep Microarchitecture and Cognitive Impairment in Patients With Temporal Lobe Epilepsy. Neurology. 2023 Dec 04; 101(23):e2376-e2387. PMID: 37848332; PMCID: PMC10752648.
    Citations: 3 Article has an altmetric score of 13
    Fields: NeuNeurologyTranslation:Humans
  12. Sarkis RA. Update in Progress: Cognitive Phenotypes in Temporal Lobe Epilepsy. Epilepsy Curr. 2023 Nov-Dec; 23(6):363-365. PMID: 38269342; PMCID: PMC10805095.
    Citations: Article has an altmetric score of 1
  13. Lemus HN, Sarkis RA. Interictal epileptiform discharges in Alzheimer's disease: prevalence, relevance, and controversies. Front Neurol. 2023; 14:1261136. PMID: 37808503; PMCID: PMC10551146.
    Citations: 2 Article has an altmetric score of 19
  14. Chua MMJ, Vissani M, Liu DD, Schaper FLWVJ, Warren AEL, Caston R, Dworetzky BA, Bubrick EJ, Sarkis RA, Cosgrove GR, Rolston JD. Initial case series of a novel sensing deep brain stimulation device in drug-resistant epilepsy and consistent identification of alpha/beta oscillatory activity: A feasibility study. Epilepsia. 2023 10; 64(10):2586-2603. PMID: 37483140.
    Citations: 2 Article has an altmetric score of 18
    Fields: BraBrainNeuNeurologyTranslation:Humans
  15. Sarkis RA, Lam AD, Pavlova M, Locascio JJ, Putta S, Puri N, Pham J, Yih A, Marshall GA, Stickgold R. Epilepsy and sleep characteristics are associated with diminished 24-h memory retention in older adults with epilepsy. Epilepsia. 2023 10; 64(10):2771-2780. PMID: 37392445; PMCID: PMC10592425.
    Citations: 2 Article has an altmetric score of 12
    Fields: BraBrainNeuNeurologyTranslation:Humans
  16. Sarkis RA. Anti-Seizure Medications on Trial Again: Accused of Parkinson's Disease! Epilepsy Curr. 2023 Sep-Oct; 23(5):277-279. PMID: 37901782; PMCID: PMC10601026.
    Citations: Article has an altmetric score of 3
  17. Chemali Z, Gifford A, Sarkis RA. On epilepsy and education: Challenges faced when compiling global research. Epilepsy Behav. 2023 Jul; 144:109263. PMID: 37267842.
    Citations: Article has an altmetric score of 8
    Fields: BehBehavioral SciencesNeuNeurologyTranslation:Humans
  18. Sarkis RA, Gifford A, Chemali Z. On epilepsy and education: Global perspectives and knowledge of epilepsy. Epilepsy Behav. 2023 Jul; 144:109265. PMID: 37244220.
    Citations: Article has an altmetric score of 10
    Fields: BehBehavioral SciencesNeuNeurologyTranslation:Humans
  19. Sarkis RA. Anti-Epileptogenesis: Some Roads Lead to Losartan. Epilepsy Curr. 2023 May-Jun; 23(3):159-161. PMID: 37334421; PMCID: PMC10273821.
    Citations: Article has an altmetric score of 2
  20. Jing J, Ge W, Hong S, Fernandes MB, Lin Z, Yang C, An S, Struck AF, Herlopian A, Karakis I, Halford JJ, Ng MC, Johnson EL, Appavu BL, Sarkis RA, Osman G, Kaplan PW, Dhakar MB, Arcot Jayagopal L, Sheikh Z, Taraschenko O, Schmitt S, Haider HA, Kim JA, Swisher CB, Gaspard N, Cervenka MC, Rodriguez Ruiz AA, Lee JW, Tabaeizadeh M, Gilmore EJ, Nordstrom K, Yoo JY, Holmes MG, Herman ST, Williams JA, Pathmanathan J, Nascimento FA, Fan Z, Nasiri S, Shafi MM, Cash SS, Hoch DB, Cole AJ, Rosenthal ES, Zafar SF, Sun J, Westover MB. Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation. Neurology. 2023 04 25; 100(17):e1750-e1762. PMID: 36878708; PMCID: PMC10136013.
    Citations: 11 Article has an altmetric score of 12
    Fields: NeuNeurologyTranslation:Humans
  21. Azami H, Moguilner S, Penagos H, Sarkis RA, Arnold SE, Gomperts SN, Lam AD. EEG Entropy in REM Sleep as a Physiologic Biomarker in Early Clinical Stages of Alzheimer's Disease. J Alzheimers Dis. 2023; 91(4):1557-1572. PMID: 36641682; PMCID: PMC10039707.
    Citations: 4 Article has an altmetric score of 14
    Fields: GerGeriatricsNeuNeurologyTranslation:Humans
  22. Sarkis RA, Gale SA, Yang HS, Lam AD, Singhal T, Cicero S, Willment K, McGinnis SM. Utility of Amyloid Positron Emission Tomography Imaging in Older Adults With Epilepsy and Cognitive Decline. Am J Alzheimers Dis Other Demen. 2023 Jan-Dec; 38:15333175231160005. PMID: 36892007; PMCID: PMC10580726.
    Citations: 1 Article has an altmetric score of 12
    Fields: NeuNeurologyTranslation:Humans
  23. Jing J, Ge W, Struck AF, Fernandes MB, Hong S, An S, Fatima S, Herlopian A, Karakis I, Halford JJ, Ng MC, Johnson EL, Appavu BL, Sarkis RA, Osman G, Kaplan PW, Dhakar MB, Jayagopal LA, Sheikh Z, Taraschenko O, Schmitt S, Haider HA, Kim JA, Swisher CB, Gaspard N, Cervenka MC, Rodriguez Ruiz AA, Lee JW, Tabaeizadeh M, Gilmore EJ, Nordstrom K, Yoo JY, Holmes MG, Herman ST, Williams JA, Pathmanathan J, Nascimento FA, Fan Z, Nasiri S, Shafi MM, Cash SS, Hoch DB, Cole AJ, Rosenthal ES, Zafar SF, Sun J, Westover MB. Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs. Neurology. 2023 04 25; 100(17):e1737-e1749. PMID: 36460472; PMCID: PMC10136018.
    Citations: 5 Article has an altmetric score of 8
    Fields: NeuNeurologyTranslation:Humans
  24. Lemus HN, Sarkis RA. Epilepsy care in nursing facilities: Knowledge gaps and opportunities. Epilepsy Behav. 2023 01; 138:108997. PMID: 36442262.
    Citations: 1 Article has an altmetric score of 13
    Fields: BehBehavioral SciencesNeuNeurologyTranslation:Humans
  25. Sarkis RA. fMRI to Predict Naming Decline: Can We Improve the Grade From a C to an A? Epilepsy Curr. 2022 Nov-Dec; 22(6):345-347. PMID: 36426181; PMCID: PMC9661605.
    Citations: Article has an altmetric score of 2
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© 2025 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.