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profileAnthony Rosenzweig, M.D.

TitleEvelyn and James Jenks and Paul Dudley White Professor of Medicine in the Field of Cardiology
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Cardiology
55 Fruit St
Boston MA 02114
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Collapse Mentoring 
Collapse completed student projects
Myostatin levels in patients with type II diabetes
Summer, 07/01/03 - 08/31/03
Transcription Factor Profiling of Pathologic and Physiologic Cardiac Hypertrophy
Summer, 06/01/09 - 08/28/09

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01HL135886     (ROSENZWEIG, ANTHONY)Dec 24, 2016 - Nov 30, 2020
NIH/NHLBI
Role of miR-222 in pathological hypertrophy and heart failure
Role: Principal Investigator

R01HL122987     (ROSENZWEIG, ANTHONY)Aug 25, 2014 - May 31, 2019
NIH/NHLBI
Does Exercise Induce Cardiomyogenesis?
Role: Principal Investigator

UH3TR000901     (DAS, SAUMYA)Aug 1, 2013 - Jul 31, 2018
NIH/NCATS
Plasma miRNA predictors of adverse mechanical and electrical remodeling after MI
Role: Co-Principal Investigator

UH2TR000901     (DAS, SAUMYA)Aug 1, 2013 - Jul 31, 2015
NIH/NCATS
Plasma miRNA predictors of adverse mechanical and electrical remodeling after MI
Role: Co-Principal Investigator

R21HL114352     (ROSENZWEIG, ANTHONY)Feb 1, 2013 - Jan 31, 2015
NIH/NHLBI
Micro-RNA regulation of the cardiac exercise response
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Roh J, Houstis N, Rosenzweig A. Why Don't We Have Proven Treatments for HFpEF? Circ Res. 2017 Apr 14; 120(8):1243-1245. PMID: 28408453.
    View in: PubMed
  2. Liu X, Platt C, Rosenzweig A. The Role of MicroRNAs in the Cardiac Response to Exercise. Cold Spring Harb Perspect Med. 2017 Apr 07. PMID: 28389519.
    View in: PubMed
  3. Bezzerides VJ, Zhang A, Xiao L, Simonson B, Khedkar SA, Baba S, Ottaviano F, Lynch S, Hessler K, Rigby AC, Milan D, Das S, Rosenzweig A. Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders. Sci Rep. 2017 Mar 23; 7(1):346. PMID: 28336914.
    View in: PubMed
  4. Simonson B, Subramanya V, Chan MC, Zhang A, Franchino H, Ottaviano F, Mishra MK, Knight AC, Hunt D, Ghiran I, Khurana TS, Kontaridis MI, Rosenzweig A, Das S. DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress. Sci Signal. 2017 Feb 28; 10(468). PMID: 28246202.
    View in: PubMed
  5. Shi J, Bei Y, Kong X, Liu X, Lei Z, Xu T, Wang H, Xuan Q, Chen P, Xu J, Che L, Liu H, Zhong J, Sluijter JP, Li X, Rosenzweig A, Xiao J. miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury. Theranostics. 2017; 7(3):664-676. PMID: 28255358.
    View in: PubMed
  6. Lerchenmüller C, Heißenberg J, Damilano F, Bezzeridis VJ, Krämer I, Bochaton-Piallat ML, Hirschberg K, Busch M, Katus HA, Peppel K, Rosenzweig A, Busch H, Boerries M, Most P. S100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling. Arterioscler Thromb Vasc Biol. 2016 Sep; 36(9):1854-67. PMID: 27386938; PMCID: PMC5001879 [Available on 09/01/17].
  7. Bezzerides VJ, Platt C, Lerchenmüller C, Paruchuri K, Oh NL, Xiao C, Cao Y, Mann N, Spiegelman BM, Rosenzweig A. CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury. JCI Insight. 2016 Jun 16; 1(9). PMID: 27430023.
    View in: PubMed
  8. Melman YF, Shah R, Danielson K, Xiao J, Simonson B, Barth A, Chakir K, Lewis GD, Lavender Z, Truong QA, Kleber A, Das R, Rosenzweig A, Wang Y, Kass D, Singh JP, Das S. Response to Letter Regarding Article, "Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study". Circulation. 2016 Feb 09; 133(6):e389-e390. PMID: 26858296; PMCID: PMC4749158 [Available on 02/09/17].
  9. Roh J, Rhee J, Chaudhari V, Rosenzweig A. The Role of Exercise in Cardiac Aging: From Physiology to Molecular Mechanisms. Circ Res. 2016 Jan 22; 118(2):279-95. PMID: 26838314; PMCID: PMC4914047 [Available on 01/22/17].
  10. Soonpaa MH, Zebrowski DC, Platt C, Rosenzweig A, Engel FB, Field LJ. Cardiomyocyte Cell-Cycle Activity during Preadolescence. Cell. 2015 Nov 05; 163(4):781-2. PMID: 26544927.
    View in: PubMed
  11. Melman YF, Shah R, Danielson K, Xiao J, Simonson B, Barth A, Chakir K, Lewis GD, Lavender Z, Truong QA, Kleber A, Das R, Rosenzweig A, Wang Y, Kass D, Singh JP, Das S. Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study. Circulation. 2015 Jun 23; 131(25):2202-2216. PMID: 25995320; PMCID: PMC4479965.
  12. Liu X, Xiao J, Zhu H, Wei X, Platt C, Damilano F, Xiao C, Bezzerides V, Boström P, Che L, Zhang C, Spiegelman BM, Rosenzweig A. miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell Metab. 2015 Apr 07; 21(4):584-95. PMID: 25863248; PMCID: PMC4393846.
  13. Tao L, Shen S, Fu S, Fang H, Wang X, Das S, Sluijter JP, Rosenzweig A, Zhou Y, Kong X, Xiao J, Li X. Traditional Chinese Medication Qiliqiangxin attenuates cardiac remodeling after acute myocardial infarction in mice. Sci Rep. 2015 Feb 11; 5:8374. PMID: 25669146; PMCID: PMC4648480.
  14. Platt C, Houstis N, Rosenzweig A. Using exercise to measure and modify cardiac function. Cell Metab. 2015 Feb 03; 21(2):227-236. PMID: 25651177; PMCID: PMC4317572.
  15. Wei X, Liu X, Rosenzweig A. What do we know about the cardiac benefits of exercise? Trends Cardiovasc Med. 2015 Aug; 25(6):529-36. PMID: 25661031; PMCID: PMC4490154.
  16. Katz MY, Kusakari Y, Aoyagi H, Higa JK, Xiao CY, Abdelkarim AZ, Marh K, Aoyagi T, Rosenzweig A, Lozanoff S, Matsui T. Three-dimensional myocardial scarring along myofibers after coronary ischemia-reperfusion revealed by computerized images of histological assays. Physiol Rep. 2014 Jul 16; 2(7). PMID: 25347856; PMCID: PMC4187547.
  17. Vernochet C, Damilano F, Mourier A, Bezy O, Mori MA, Smyth G, Rosenzweig A, Larsson NG, Kahn CR. Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications. FASEB J. 2014 Oct; 28(10):4408-19. PMID: 25005176; PMCID: PMC4202105.
  18. North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. EMBO J. 2014 Jul 01; 33(13):1438-53. PMID: 24825348; PMCID: PMC4194088.
  19. Lerchenmüller C, Rosenzweig A. Mechanisms of exercise-induced cardiac growth. Drug Discov Today. 2014 Jul; 19(7):1003-9. PMID: 24637046.
    View in: PubMed
  20. Ryall KA, Bezzerides VJ, Rosenzweig A, Saucerman JJ. Phenotypic screen quantifying differential regulation of cardiac myocyte hypertrophy identifies CITED4 regulation of myocyte elongation. J Mol Cell Cardiol. 2014 Jul; 72:74-84. PMID: 24613264; PMCID: PMC4078663.
  21. Dai J, Matsui T, Abel ED, Dedhar S, Gerszten RE, Seidman CE, Seidman JG, Rosenzweig A. Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice. Circ Heart Fail. 2014 Jan; 7(1):184-93. PMID: 24319095; PMCID: PMC3950354.
  22. Zarrinpashneh E, Poggioli T, Sarathchandra P, Lexow J, Monassier L, Terracciano C, Lang F, Damilano F, Zhou JQ, Rosenzweig A, Rosenthal N, Santini MP. Ablation of SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarction. PLoS One. 2013; 8(11):e80268. PMID: 24265802; PMCID: PMC3827188.
  23. Coelho-Filho OR, Shah RV, Mitchell R, Neilan TG, Moreno H, Simonson B, Kwong R, Rosenzweig A, Das S, Jerosch-Herold M. Quantification of cardiomyocyte hypertrophy by cardiac magnetic resonance: implications for early cardiac remodeling. Circulation. 2013 Sep 10; 128(11):1225-33. PMID: 23912910.
    View in: PubMed
  24. Kang KT, Coggins M, Xiao C, Rosenzweig A, Bischoff J. Human vasculogenic cells form functional blood vessels and mitigate adverse remodeling after ischemia reperfusion injury in rats. Angiogenesis. 2013 Oct; 16(4):773-84. PMID: 23666122; PMCID: PMC3773287.
  25. Rosenzweig A. Medicine. Cardiac regeneration. Science. 2012 Dec 21; 338(6114):1549-50. PMID: 23258880.
    View in: PubMed
  26. Mann N, Rosenzweig A. Can exercise teach us how to treat heart disease? Circulation. 2012 Nov 27; 126(22):2625-35. PMID: 23184282; PMCID: PMC4000019.
  27. Das S, Aiba T, Rosenberg M, Hessler K, Xiao C, Quintero PA, Ottaviano FG, Knight AC, Graham EL, Boström P, Morissette MR, del Monte F, Begley MJ, Cantley LC, Ellinor PT, Tomaselli GF, Rosenzweig A. Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. Circulation. 2012 Oct 30; 126(18):2208-19. PMID: 23019294; PMCID: PMC3484211.
  28. Aoyagi T, Kusakari Y, Xiao CY, Inouye BT, Takahashi M, Scherrer-Crosbie M, Rosenzweig A, Hara K, Matsui T. Cardiac mTOR protects the heart against ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2012 Jul; 303(1):H75-85. PMID: 22561297; PMCID: PMC3404649.
  29. Lähteenvuo J, Rosenzweig A. Effects of aging on angiogenesis. Circ Res. 2012 Apr 27; 110(9):1252-64. PMID: 22539758; PMCID: PMC4101916.
  30. Rosenberg MA, Das S, Quintero Pinzon P, Knight AC, Sosnovik DE, Ellinor PT, Rosenzweig A. A Novel Transgenic Mouse Model of Cardiac Hypertrophy and Atrial Fibrillation. J Atr Fibrillation. 2012 Feb-Mar; 4(5):415. PMID: 28496713.
    View in: PubMed
  31. Rosenberg MA, Das S, Pinzon PQ, Knight AC, Sosnovik DE, Ellinor PT, Rosenzweig A. A Novel Transgenic Mouse Model of Cardiac Hypertrophy and Atrial Fibrillation. J Atr Fibrillation. 2012 Feb; 2(9):1-15. PMID: 23243484.
    View in: PubMed
  32. Coggins M, Rosenzweig A. The fire within: cardiac inflammatory signaling in health and disease. Circ Res. 2012 Jan 06; 110(1):116-25. PMID: 22223209.
    View in: PubMed
  33. Wara AK, Foo S, Croce K, Sun X, Icli B, Tesmenitsky Y, Esen F, Lee JS, Subramaniam M, Spelsberg TC, Lev EI, Leshem-Lev D, Pande RL, Creager MA, Rosenzweig A, Feinberg MW. TGF-ß1 signaling and Krüppel-like factor 10 regulate bone marrow-derived proangiogenic cell differentiation, function, and neovascularization. Blood. 2011 Dec 08; 118(24):6450-60. PMID: 21828131; PMCID: PMC3236126.
  34. Wara AK, Croce K, Foo S, Sun X, Icli B, Tesmenitsky Y, Esen F, Rosenzweig A, Feinberg MW. Bone marrow-derived CMPs and GMPs represent highly functional proangiogenic cells: implications for ischemic cardiovascular disease. Blood. 2011 Dec 08; 118(24):6461-4. PMID: 21828132; PMCID: PMC3236127.
  35. Bezzerides V, Rosenzweig A. Saying yes to exercise and NO to cardiac injury. Circ Res. 2011 Jun 10; 108(12):1414-6. PMID: 21659650; PMCID: PMC3151616.
  36. Jin Y, Wu J, Song X, Song Q, Cully BL, Messmer-Blust A, Xu M, Foo SY, Rosenzweig A, Li J. RTEF-1, an upstream gene of hypoxia-inducible factor-1a, accelerates recovery from ischemia. J Biol Chem. 2011 Jun 24; 286(25):22699-705. PMID: 21540178; PMCID: PMC3121413.
  37. Lv H, Havari E, Pinto S, Gottumukkala RV, Cornivelli L, Raddassi K, Matsui T, Rosenzweig A, Bronson RT, Smith R, Fletcher AL, Turley SJ, Wucherpfennig K, Kyewski B, Lipes MA. Impaired thymic tolerance to a-myosin directs autoimmunity to the heart in mice and humans. J Clin Invest. 2011 Apr; 121(4):1561-73. PMID: 21436590; PMCID: PMC3069776.
  38. Astapova I, Vella KR, Ramadoss P, Holtz KA, Rodwin BA, Liao XH, Weiss RE, Rosenberg MA, Rosenzweig A, Hollenberg AN. The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis. Mol Endocrinol. 2011 Feb; 25(2):212-24. PMID: 21239618; PMCID: PMC3386544.
  39. Ashida N, Senbanerjee S, Kodama S, Foo SY, Coggins M, Spencer JA, Zamiri P, Shen D, Li L, Sciuto T, Dvorak A, Gerszten RE, Lin CP, Karin M, Rosenzweig A. IKKß regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways. Nat Commun. 2011; 2:318. PMID: 21587235; PMCID: PMC3113230.
  40. Boström P, Mann N, Wu J, Quintero PA, Plovie ER, Panáková D, Gupta RK, Xiao C, MacRae CA, Rosenzweig A, Spiegelman BM. C/EBPß controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell. 2010 Dec 23; 143(7):1072-83. PMID: 21183071; PMCID: PMC3035164.
  41. Hafner AV, Dai J, Gomes AP, Xiao CY, Palmeira CM, Rosenzweig A, Sinclair DA. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY). 2010 Dec; 2(12):914-23. PMID: 21212461; PMCID: PMC3034180.
  42. Rosenzweig A. Illuminating the potential of pluripotent stem cells. N Engl J Med. 2010 Oct 07; 363(15):1471-2. PMID: 20925550.
    View in: PubMed
  43. Song X, Kusakari Y, Xiao CY, Kinsella SD, Rosenberg MA, Scherrer-Crosbie M, Hara K, Rosenzweig A, Matsui T. mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1256-66. PMID: 20861467; PMCID: PMC3006320.
  44. Cook SA, Varela-Carver A, Mongillo M, Kleinert C, Khan MT, Leccisotti L, Strickland N, Matsui T, Das S, Rosenzweig A, Punjabi P, Camici PG. Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction. Eur Heart J. 2010 Jan; 31(1):100-11. PMID: 19797329; PMCID: PMC2800920.
  45. Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L. Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia. Circ Cardiovasc Imaging. 2009 Nov; 2(6):460-7. PMID: 19920044; PMCID: PMC2780438.
  46. Kusakari Y, Xiao CY, Himes N, Kinsella SD, Takahashi M, Rosenzweig A, Matsui T. Myocyte injury along myofibers in left ventricular remodeling after myocardial infarction. Interact Cardiovasc Thorac Surg. 2009 Dec; 9(6):951-5. PMID: 19776081; PMCID: PMC2877192.
  47. Morissette MR, Cook SA, Buranasombati C, Rosenberg MA, Rosenzweig A. Myostatin inhibits IGF-I-induced myotube hypertrophy through Akt. Am J Physiol Cell Physiol. 2009 Nov; 297(5):C1124-32. PMID: 19759331; PMCID: PMC2777401.
  48. Dubach JM, Das S, Rosenzweig A, Clark HA. Visualizing sodium dynamics in isolated cardiomyocytes using fluorescent nanosensors. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16145-50. PMID: 19805271; PMCID: PMC2752587.
  49. Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A. Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure. Circ Cardiovasc Imaging. 2009 Nov; 2(6):468-75. PMID: 19920045; PMCID: PMC2782621.
  50. Foo SY, Heller ER, Wykrzykowska J, Sullivan CJ, Manning-Tobin JJ, Moore KJ, Gerszten RE, Rosenzweig A. Vascular effects of a low-carbohydrate high-protein diet. Proc Natl Acad Sci U S A. 2009 Sep 08; 106(36):15418-23. PMID: 19706393; PMCID: PMC2741266.
  51. Harjes DI, Dubach JM, Rosenzweig A, Das S, Clark HA. Ion-selective optodes measure extracellular potassium flux in excitable cells. Macromol Rapid Commun. 2010 Jan 18; 31(2):217-21. PMID: 21590894; PMCID: PMC3483785.
  52. Morissette MR, Stricker JC, Rosenberg MA, Buranasombati C, Levitan EB, Mittleman MA, Rosenzweig A. Effects of myostatin deletion in aging mice. Aging Cell. 2009 Sep; 8(5):573-83. PMID: 19663901; PMCID: PMC2764272.
  53. An X, Jin Y, Guo H, Foo SY, Cully BL, Wu J, Zeng H, Rosenzweig A, Li J. Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor. Circulation. 2009 Aug 18; 120(7):617-27. PMID: 19652095; PMCID: PMC2837511.
  54. Das S, Makino S, Melman YF, Shea MA, Goyal SB, Rosenzweig A, Macrae CA, Ellinor PT. Mutation in the S3 segment of KCNQ1 results in familial lone atrial fibrillation. Heart Rhythm. 2009 Aug; 6(8):1146-53. PMID: 19632626; PMCID: PMC3038671.
  55. Sosnovik DE, Wang R, Dai G, Wang T, Aikawa E, Novikov M, Rosenzweig A, Gilbert RJ, Wedeen VJ. Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium. Circ Cardiovasc Imaging. 2009 May; 2(3):206-12. PMID: 19808594; PMCID: PMC2760045.
  56. Luckey SW, Walker LA, Smyth T, Mansoori J, Messmer-Kratzsch A, Rosenzweig A, Olson EN, Leinwand LA. The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2009 May; 46(5):739-47. PMID: 19233194; PMCID: PMC2701230.
  57. Hoenig MR, Bianchi C, Rosenzweig A, Sellke FW. Decreased vascular repair and neovascularization with ageing: mechanisms and clinical relevance with an emphasis on hypoxia-inducible factor-1. Curr Mol Med. 2008 Dec; 8(8):754-67. PMID: 19075673.
    View in: PubMed
  58. Hoenig MR, Bianchi C, Rosenzweig A, Sellke FW. The cardiac microvasculature in hypertension, cardiac hypertrophy and diastolic heart failure. Curr Vasc Pharmacol. 2008 Oct; 6(4):292-300. PMID: 18855717.
    View in: PubMed
  59. Lewis GD, Wei R, Liu E, Yang E, Shi X, Martinovic M, Farrell L, Asnani A, Cyrille M, Ramanathan A, Shaham O, Berriz G, Lowry PA, Palacios IF, Tasan M, Roth FP, Min J, Baumgartner C, Keshishian H, Addona T, Mootha VK, Rosenzweig A, Carr SA, Fifer MA, Sabatine MS, Gerszten RE. Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. J Clin Invest. 2008 Oct; 118(10):3503-12. PMID: 18769631; PMCID: PMC2525696.
  60. Farrar CT, Dai G, Novikov M, Rosenzweig A, Weissleder R, Rosen BR, Sosnovik DE. Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging. NMR Biomed. 2008 Jun; 21(5):453-63. PMID: 17918777; PMCID: PMC2629945.
  61. Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, Baek KH, Rosenzweig A, Spiegelman BM. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature. 2008 Feb 21; 451(7181):1008-12. PMID: 18288196.
    View in: PubMed
  62. Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell. 2007 Sep 21; 130(6):1095-107. PMID: 17889652; PMCID: PMC3366687.
  63. Rosenzweig A. Scanning the genome for coronary risk. N Engl J Med. 2007 Aug 02; 357(5):497-9. PMID: 17634453.
    View in: PubMed
  64. Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V. Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation. 2007 Mar 20; 115(11):1384-91. PMID: 17339546.
    View in: PubMed
  65. Rosenzweig A. Cardiac cell therapy--mixed results from mixed cells. N Engl J Med. 2006 Sep 21; 355(12):1274-7. PMID: 16990391.
    View in: PubMed
  66. Kerkelä R, Grazette L, Yacobi R, Iliescu C, Patten R, Beahm C, Walters B, Shevtsov S, Pesant S, Clubb FJ, Rosenzweig A, Salomon RN, Van Etten RA, Alroy J, Durand JB, Force T. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med. 2006 Aug; 12(8):908-16. PMID: 16862153.
    View in: PubMed
  67. Arany Z, Novikov M, Chin S, Ma Y, Rosenzweig A, Spiegelman BM. Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Proc Natl Acad Sci U S A. 2006 Jun 27; 103(26):10086-91. PMID: 16775082; PMCID: PMC1502510.
  68. Morissette MR, Cook SA, Foo S, McKoy G, Ashida N, Novikov M, Scherrer-Crosbie M, Li L, Matsui T, Brooks G, Rosenzweig A. Myostatin regulates cardiomyocyte growth through modulation of Akt signaling. Circ Res. 2006 Jul 07; 99(1):15-24. PMID: 16763166; PMCID: PMC2901846.
  69. Zhu X, Zhao H, Graveline AR, Buys ES, Schmidt U, Bloch KD, Rosenzweig A, Chao W. MyD88 and NOS2 are essential for toll-like receptor 4-mediated survival effect in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2006 Oct; 291(4):H1900-9. PMID: 16648192.
    View in: PubMed
  70. Nahrendorf M, Hu K, Frantz S, Jaffer FA, Tung CH, Hiller KH, Voll S, Nordbeck P, Sosnovik D, Gattenlöhner S, Novikov M, Dickneite G, Reed GL, Jakob P, Rosenzweig A, Bauer WR, Weissleder R, Ertl G. Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction. Circulation. 2006 Mar 07; 113(9):1196-202. PMID: 16505171; PMCID: PMC4066325.
  71. Hataishi R, Rodrigues AC, Neilan TG, Morgan JG, Buys E, Shiva S, Tambouret R, Jassal DS, Raher MJ, Furutani E, Ichinose F, Gladwin MT, Rosenzweig A, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M. Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H379-84. PMID: 16443673.
    View in: PubMed
  72. Matsui T, Nagoshi T, Hong EG, Luptak I, Hartil K, Li L, Gorovits N, Charron MJ, Kim JK, Tian R, Rosenzweig A. Effects of chronic Akt activation on glucose uptake in the heart. Am J Physiol Endocrinol Metab. 2006 May; 290(5):E789-97. PMID: 16352665.
    View in: PubMed
  73. Rosenzweig A. Circulating endothelial progenitors--cells as biomarkers. N Engl J Med. 2005 Sep 08; 353(10):1055-7. PMID: 16148292.
    View in: PubMed
  74. Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med. 2005 Sep; 54(3):718-24. PMID: 16086367.
    View in: PubMed
  75. Nagoshi T, Matsui T, Aoyama T, Leri A, Anversa P, Li L, Ogawa W, del Monte F, Gwathmey JK, Grazette L, Hemmings BA, Hemmings B, Kass DA, Champion HC, Rosenzweig A. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest. 2005 Aug; 115(8):2128-38. PMID: 16007268; PMCID: PMC1172227.
  76. Grazette LP, Rosenzweig A. Role of apoptosis in heart failure. Heart Fail Clin. 2005 Jul; 1(2):251-61. PMID: 17386850.
    View in: PubMed
  77. Chao W, Shen Y, Li L, Zhao H, Meiler SE, Cook SA, Rosenzweig A. Fas-associated death-domain protein inhibits TNF-alpha mediated NF-kappaB activation in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2005 Nov; 289(5):H2073-80. PMID: 15980038.
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  78. Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, Spiegelman BM. Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab. 2005 Apr; 1(4):259-71. PMID: 16054070.
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  79. Morissette MR, Rosenzweig A. Targeting survival signaling in heart failure. Curr Opin Pharmacol. 2005 Apr; 5(2):165-70. PMID: 15780826.
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  80. Aoyama T, Matsui T, Novikov M, Park J, Hemmings B, Rosenzweig A. Serum and glucocorticoid-responsive kinase-1 regulates cardiomyocyte survival and hypertrophic response. Circulation. 2005 Apr 05; 111(13):1652-9. PMID: 15795328.
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  81. Chao W, Shen Y, Zhu X, Zhao H, Novikov M, Schmidt U, Rosenzweig A. Lipopolysaccharide improves cardiomyocyte survival and function after serum deprivation. J Biol Chem. 2005 Jun 10; 280(23):21997-2005. PMID: 15793310.
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  82. Matsui T, Rosenzweig A. Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. J Mol Cell Cardiol. 2005 Jan; 38(1):63-71. PMID: 15623422.
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  83. Grazette LP, Boecker W, Matsui T, Semigran M, Force TL, Hajjar RJ, Rosenzweig A. Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathy. J Am Coll Cardiol. 2004 Dec 07; 44(11):2231-8. PMID: 15582322.
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  84. Friedrich EB, Liu E, Sinha S, Cook S, Milstone DS, MacRae CA, Mariotti M, Kuhlencordt PJ, Force T, Rosenzweig A, St-Arnaud R, Dedhar S, Gerszten RE. Integrin-linked kinase regulates endothelial cell survival and vascular development. Mol Cell Biol. 2004 Sep; 24(18):8134-44. PMID: 15340074; PMCID: PMC515035.
  85. Boecker W, Bernecker OY, Wu JC, Zhu X, Sawa T, Grazette L, Rosenzweig A, del Monte F, Schmidt U, Hajjar RJ. Cardiac-specific gene expression facilitated by an enhanced myosin light chain promoter. Mol Imaging. 2004 Apr; 3(2):69-75. PMID: 15296671.
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  86. Shiraishi I, Melendez J, Ahn Y, Skavdahl M, Murphy E, Welch S, Schaefer E, Walsh K, Rosenzweig A, Torella D, Nurzynska D, Kajstura J, Leri A, Anversa P, Sussman MA. Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ Res. 2004 Apr 16; 94(7):884-91. PMID: 14988230.
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  87. Kuhlencordt PJ, Rosel E, Gerszten RE, Morales-Ruiz M, Dombkowski D, Atkinson WJ, Han F, Preffer F, Rosenzweig A, Sessa WC, Gimbrone MA, Ertl G, Huang PL. Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells. Am J Physiol Cell Physiol. 2004 May; 286(5):C1195-202. PMID: 15075219.
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  88. Torella D, Rota M, Nurzynska D, Musso E, Monsen A, Shiraishi I, Zias E, Walsh K, Rosenzweig A, Sussman MA, Urbanek K, Nadal-Ginard B, Kajstura J, Anversa P, Leri A. Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ Res. 2004 Mar 05; 94(4):514-24. PMID: 14726476.
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  89. Cook SA, Novikov MS, Ahn Y, Matsui T, Rosenzweig A. A20 is dynamically regulated in the heart and inhibits the hypertrophic response. Circulation. 2003 Aug 12; 108(6):664-7. PMID: 12900338.
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  90. Yasuhara S, Zhu Y, Matsui T, Tipirneni N, Yasuhara Y, Kaneki M, Rosenzweig A, Martyn JA. Comparison of comet assay, electron microscopy, and flow cytometry for detection of apoptosis. J Histochem Cytochem. 2003 Jul; 51(7):873-85. PMID: 12810838.
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  91. Li W, Rosenzweig A, Huber BT. Differential T-cell activation by B7-1 expression. Immunology. 2003 Jul; 109(3):336-42. PMID: 12807478; PMCID: PMC1782986.
  92. Haq S, Kilter H, Michael A, Tao J, O'Leary E, Sun XM, Walters B, Bhattacharya K, Chen X, Cui L, Andreucci M, Rosenzweig A, Guerrero JL, Patten R, Liao R, Molkentin J, Picard M, Bonventre JV, Force T. Deletion of cytosolic phospholipase A2 promotes striated muscle growth. Nat Med. 2003 Jul; 9(7):944-51. PMID: 12808451.
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  93. Rosenzweig A. Vectors for cardiovascular gene therapy. J Mol Cell Cardiol. 2003 Jul; 35(7):731-3. PMID: 12818562.
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  94. Matsui T, Rosenzweig A. Targeting ischemic cardiac dysfunction through gene transfer. Curr Atheroscler Rep. 2003 May; 5(3):191-5. PMID: 12667431.
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  95. Matsui T, Nagoshi T, Rosenzweig A. Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival. Cell Cycle. 2003 May-Jun; 2(3):220-3. PMID: 12734428.
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  96. Chao W, Matsui T, Novikov MS, Tao J, Li L, Liu H, Ahn Y, Rosenzweig A. Strategic advantages of insulin-like growth factor-I expression for cardioprotection. J Gene Med. 2003 Apr; 5(4):277-86. PMID: 12692862.
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  97. Hajjar RJ, Huq F, Matsui T, Rosenzweig A. Genetic editing of dysfunctional myocardium. Med Clin North Am. 2003 Mar; 87(2):553-67. PMID: 12693739.
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  98. Rosenzweig A. Endothelial progenitor cells. N Engl J Med. 2003 Feb 13; 348(7):581-2. PMID: 12584365.
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  99. Cook SA, Rosenzweig A. DNA microarrays: implications for cardiovascular medicine. Circ Res. 2002 Oct 04; 91(7):559-64. PMID: 12364382.
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  100. Shiojima I, Yefremashvili M, Luo Z, Kureishi Y, Takahashi A, Tao J, Rosenzweig A, Kahn CR, Abel ED, Walsh K. Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem. 2002 Oct 04; 277(40):37670-7. PMID: 12163490.
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  101. Chao W, Shen Y, Li L, Rosenzweig A. Importance of FADD signaling in serum deprivation- and hypoxia-induced cardiomyocyte apoptosis. J Biol Chem. 2002 Aug 30; 277(35):31639-45. PMID: 12063258.
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  102. Cook SA, Matsui T, Li L, Rosenzweig A. Transcriptional effects of chronic Akt activation in the heart. J Biol Chem. 2002 Jun 21; 277(25):22528-33. PMID: 11956204.
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  103. Matsui T, Li L, Wu JC, Cook SA, Nagoshi T, Picard MH, Liao R, Rosenzweig A. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem. 2002 Jun 21; 277(25):22896-901. PMID: 11943770.
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  104. Meiler SE, Hung RR, Gerszten RE, Gianetti J, Li L, Matsui T, Gimbrone MA, Rosenzweig A. Endothelial IKK beta signaling is required for monocyte adhesion under laminar flow conditions. J Mol Cell Cardiol. 2002 Mar; 34(3):349-59. PMID: 11945026.
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  105. Friedrich EB, Sinha S, Li L, Dedhar S, Force T, Rosenzweig A, Gerszten RE. Role of integrin-linked kinase in leukocyte recruitment. J Biol Chem. 2002 May 10; 277(19):16371-5. PMID: 11856758.
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  106. Miller MT, Bachmann BO, Townsend CA, Rosenzweig AC. Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine. Nat Struct Biol. 2001 Aug; 8(8):684-9. PMID: 11473258.
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  107. Baldwin J, Voegtli WC, Khidekel N, Moënne-Loccoz P, Krebs C, Pereira AS, Ley BA, Huynh BH, Loehr TM, Riggs-Gelasco PJ, Rosenzweig AC, Bollinger JM. Rational reprogramming of the R2 subunit of Escherichia coli ribonucleotide reductase into a self-hydroxylating monooxygenase. J Am Chem Soc. 2001 Jul 25; 123(29):7017-30. PMID: 11459480.
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  108. Whittington DA, Rosenzweig AC, Frederick CA, Lippard SJ. Xenon and halogenated alkanes track putative substrate binding cavities in the soluble methane monooxygenase hydroxylase. Biochemistry. 2001 Mar 27; 40(12):3476-82. PMID: 11297413.
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  109. Coufal DE, Blazyk JL, Whittington DA, Wu WW, Rosenzweig AC, Lippard SJ. Sequencing and analysis of the Mmethylococcus capsulatus (Bath) solublemethane monooxygenase genes. Eur J Biochem. 2000 Apr; 267(8):2174-85. PMID: 10759840.
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  110. Lamb AL, Wernimont AK, Pufahl RA, Culotta VC, O'Halloran TV, Rosenzweig AC. Crystal structure of the copper chaperone for superoxide dismutase. Nat Struct Biol. 1999 Aug; 6(8):724-9. PMID: 10426947.
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  111. Portnoy ME, Rosenzweig AC, Rae T, Huffman DL, O'Halloran TV, Culotta VC. Structure-function analyses of the ATX1 metallochaperone. J Biol Chem. 1999 May 21; 274(21):15041-5. PMID: 10329707.
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  112. Rosenzweig AC, Brandstetter H, Whittington DA, Nordlund P, Lippard SJ, Frederick CA. Crystal structures of the methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): implications for substrate gating and component interactions. Proteins. 1997 Oct; 29(2):141-52. PMID: 9329079.
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  113. Takahara PM, Rosenzweig AC, Frederick CA, Lippard SJ. Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin. Nature. 1995 Oct 19; 377(6550):649-52. PMID: 7566180.
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  114. Rosenzweig AC, Nordlund P, Takahara PM, Frederick CA, Lippard SJ. Geometry of the soluble methane monooxygenase catalytic diiron center in two oxidation states. Chem Biol. 1995 Sep; 2(9):409-18. PMID: 9432288.
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  115. Rosenzweig AC, Nordlund P, Takahara PM, Frederick CA, Lippard SJ. Geometry of the soluble methane monooxygenase catalytic diiron center in two oxidation states. Chem Biol. 1995 Jun; 2(6):409-18. PMID: 9383443.
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  116. Bender CJ, Rosenzweig AC, Lippard SJ, Peisach J. Nuclear hyperfine coupling of nitrogen in the coordination sphere of the diiron center of methane monooxygenase hydroxylase. J Biol Chem. 1994 Jun 10; 269(23):15993-8. PMID: 8206895.
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  117. Rosenzweig AC, Frederick CA, Lippard SJ, Nordlund P. Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane. Nature. 1993 Dec 09; 366(6455):537-43. PMID: 8255292.
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  118. Rosenzweig AC, Frederick CA, Lippard SJ. Crystallization and preliminary X-ray analysis of the methane monooxygenase hydroxylase protein from Methylococcus capsulatus (Bath). J Mol Biol. 1992 Sep 20; 227(2):583-5. PMID: 1404375.
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