Harvard Catalyst Profiles

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Suzanne Walker, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI148752 (WALKER, SUZANNE) Jan 1, 2020 - Dec 31, 2024
    Discovery and characterization of new bacterial cell wall targets and inhibitors to treat resistant infections
    Role: Principal Investigator
  2. R01AI139011 (LOSICK, RICHARD MARC) May 11, 2018 - Apr 30, 2023
    Release of Extracellular DNA during Biofilm Formation in Staphylococcus aureus
    Role: Co-Principal Investigator
  3. U19AI109764 (KASPER, DENNIS L.) Mar 1, 2014 - Jun 30, 2019
    Innovative Platforms for Antimicrobial Therapy and Vaccine Development
    Role: Co-Principal Investigator
  4. R03TW009424 (WALKER, SUZANNE) Mar 11, 2013 - Feb 29, 2016
    Enabling Biotechnologies to Generate Novel Phosphoglycolipid Antibiotics
    Role: Principal Investigator
  5. R01AI099144 (BERNHARDT, THOMAS G) Jun 1, 2012 - May 31, 2019
    Identifying and validating new antibiotic targets in cell wall synthesis pathways
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Itkonen HM, Poulose N, Steele RE, Martin SES, Levine ZG, Duveau DY, Carelli R, Singh R, Urbanucci A, Loda M, Thomas CJ, Mills IG, Walker S. Inhibition of O-GlcNAc Transferase Renders Prostate Cancer Cells Dependent on CDK9. Mol Cancer Res. 2020 10; 18(10):1512-1521. PMID: 32611550.
    Citations: 10     Fields:    Translation:HumansCells
  2. Janetzko J, Walker S. Aspartate Glycosylation Triggers Isomerization to Isoaspartate. J Am Chem Soc. 2017 03 08; 139(9):3332-3335. PMID: 28207246.
    Citations: 8     Fields:    Translation:HumansCells
  3. Schaefer K, Matano LM, Qiao Y, Kahne D, Walker S. In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins. Nat Chem Biol. 2017 04; 13(4):396-401. PMID: 28166208.
    Citations: 32     Fields:    Translation:Cells
  4. Janetzko J, Trauger SA, Lazarus MB, Walker S. How the glycosyltransferase OGT catalyzes amide bond cleavage. Nat Chem Biol. 2016 Nov; 12(11):899-901. PMID: 27618188.
    Citations: 16     Fields:    Translation:HumansCells
  5. Meeske AJ, Riley EP, Robins WP, Uehara T, Mekalanos JJ, Kahne D, Walker S, Kruse AC, Bernhardt TG, Rudner DZ. SEDS proteins are a widespread family of bacterial cell wall polymerases. Nature. 2016 09 29; 537(7622):634-638. PMID: 27525505.
    Citations: 186     Fields:    Translation:Cells
  6. Levine ZG, Walker S. The Biochemistry of O-GlcNAc Transferase: Which Functions Make It Essential in Mammalian Cells? Annu Rev Biochem. 2016 Jun 02; 85:631-57. PMID: 27294441.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  7. Lee W, Schaefer K, Qiao Y, Srisuknimit V, Steinmetz H, Müller R, Kahne D, Walker S. The Mechanism of Action of Lysobactin. J Am Chem Soc. 2016 Jan 13; 138(1):100-3. PMID: 26683668.
    Citations: 21     Fields:    Translation:Cells
  8. Pasquina L, Santa Maria JP, McKay Wood B, Moussa SH, Matano LM, Santiago M, Martin SE, Lee W, Meredith TC, Walker S. A synthetic lethal approach for compound and target identification in Staphylococcus aureus. Nat Chem Biol. 2016 Jan; 12(1):40-5. PMID: 26619249.
    Citations: 31     Fields:    Translation:Cells
  9. Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19; 10(6):1392-7. PMID: 25751766.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  10. Schirner K, Eun YJ, Dion M, Luo Y, Helmann JD, Garner EC, Walker S. Lipid-linked cell wall precursors regulate membrane association of bacterial actin MreB. Nat Chem Biol. 2015 Jan; 11(1):38-45. PMID: 25402772.
    Citations: 37     Fields:    Translation:Cells
  11. Qiao Y, Lebar MD, Schirner K, Schaefer K, Tsukamoto H, Kahne D, Walker S. Detection of lipid-linked peptidoglycan precursors by exploiting an unexpected transpeptidase reaction. J Am Chem Soc. 2014 Oct 22; 136(42):14678-81. PMID: 25291014.
    Citations: 49     Fields:    Translation:Cells
  12. Lebar MD, May JM, Meeske AJ, Leiman SA, Lupoli TJ, Tsukamoto H, Losick R, Rudner DZ, Walker S, Kahne D. Reconstitution of peptidoglycan cross-linking leads to improved fluorescent probes of cell wall synthesis. J Am Chem Soc. 2014 Aug 06; 136(31):10874-7. PMID: 25036369.
    Citations: 45     Fields:    Translation:Cells
  13. Ortiz-Meoz RF, Merbl Y, Kirschner MW, Walker S. Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated. J Am Chem Soc. 2014 Apr 02; 136(13):4845-8. PMID: 24580054.
    Citations: 18     Fields:    Translation:HumansCells
  14. Lupoli TJ, Lebar MD, Markovski M, Bernhardt T, Kahne D, Walker S. Lipoprotein activators stimulate Escherichia coli penicillin-binding proteins by different mechanisms. J Am Chem Soc. 2014 Jan 08; 136(1):52-5. PMID: 24341982.
    Citations: 36     Fields:    Translation:Cells
  15. Lazarus MB, Jiang J, Kapuria V, Bhuiyan T, Janetzko J, Zandberg WF, Vocadlo DJ, Herr W, Walker S. HCF-1 is cleaved in the active site of O-GlcNAc transferase. Science. 2013 Dec 06; 342(6163):1235-9. PMID: 24311690.
    Citations: 82     Fields:    Translation:HumansCells
  16. Rebets Y, Lupoli T, Qiao Y, Schirner K, Villet R, Hooper D, Kahne D, Walker S. Moenomycin resistance mutations in Staphylococcus aureus reduce peptidoglycan chain length and cause aberrant cell division. ACS Chem Biol. 2014 Feb 21; 9(2):459-67. PMID: 24255971.
    Citations: 25     Fields:    Translation:HumansCells
  17. Lebar MD, Lupoli TJ, Tsukamoto H, May JM, Walker S, Kahne D. Forming cross-linked peptidoglycan from synthetic gram-negative Lipid II. J Am Chem Soc. 2013 Mar 27; 135(12):4632-5. PMID: 23480167.
    Citations: 26     Fields:    Translation:Cells
  18. Gampe CM, Tsukamoto H, Doud EH, Walker S, Kahne D. Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors. J Am Chem Soc. 2013 Mar 13; 135(10):3776-9. PMID: 23448584.
    Citations: 11     Fields:    Translation:Cells
  19. Brown S, Santa Maria JP, Walker S. Wall teichoic acids of gram-positive bacteria. Annu Rev Microbiol. 2013; 67:313-36. PMID: 24024634.
    Citations: 281     Fields:    Translation:HumansAnimalsCells
  20. Lazarus MB, Jiang J, Gloster TM, Zandberg WF, Whitworth GE, Vocadlo DJ, Walker S. Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nat Chem Biol. 2012 Dec; 8(12):966-8. PMID: 23103939.
    Citations: 58     Fields:    Translation:HumansCells
  21. Jiang J, Lazarus MB, Pasquina L, Sliz P, Walker S. A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase. Nat Chem Biol. 2011 Nov 13; 8(1):72-7. PMID: 22082911.
    Citations: 38     Fields:    Translation:HumansCells
  22. Lupoli TJ, Tsukamoto H, Doud EH, Wang TS, Walker S, Kahne D. Transpeptidase-mediated incorporation of D-amino acids into bacterial peptidoglycan. J Am Chem Soc. 2011 Jul 20; 133(28):10748-51. PMID: 21682301.
    Citations: 50     Fields:    Translation:Cells
  23. Wang TS, Lupoli TJ, Sumida Y, Tsukamoto H, Wu Y, Rebets Y, Kahne DE, Walker S. Primer preactivation of peptidoglycan polymerases. J Am Chem Soc. 2011 Jun 08; 133(22):8528-30. PMID: 21568328.
    Citations: 16     Fields:    Translation:Cells
  24. Lazarus MB, Nam Y, Jiang J, Sliz P, Walker S. Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature. 2011 Jan 27; 469(7331):564-7. PMID: 21240259.
    Citations: 179     Fields:    Translation:HumansCells
  25. Doud EH, Perlstein DL, Wolpert M, Cane DE, Walker S. Two distinct mechanisms for TIM barrel prenyltransferases in bacteria. J Am Chem Soc. 2011 Feb 09; 133(5):1270-3. PMID: 21214173.
    Citations: 8     Fields:    Translation:Cells
  26. Campbell J, Singh AK, Santa Maria JP, Kim Y, Brown S, Swoboda JG, Mylonakis E, Wilkinson BJ, Walker S. Synthetic lethal compound combinations reveal a fundamental connection between wall teichoic acid and peptidoglycan biosyntheses in Staphylococcus aureus. ACS Chem Biol. 2011 Jan 21; 6(1):106-16. PMID: 20961110.
    Citations: 112     Fields:    Translation:AnimalsCells
  27. Fuse S, Tsukamoto H, Yuan Y, Wang TS, Zhang Y, Bolla M, Walker S, Sliz P, Kahne D. Functional and structural analysis of a key region of the cell wall inhibitor moenomycin. ACS Chem Biol. 2010 Jul 16; 5(7):701-11. PMID: 20496948.
    Citations: 12     Fields:    Translation:Cells
  28. Perlstein DL, Wang TS, Doud EH, Kahne D, Walker S. The role of the substrate lipid in processive glycan polymerization by the peptidoglycan glycosyltransferases. J Am Chem Soc. 2010 Jan 13; 132(1):48-9. PMID: 20017480.
    Citations: 24     Fields:    Translation:Animals
  29. Lupoli TJ, Taniguchi T, Wang TS, Perlstein DL, Walker S, Kahne DE. Studying a cell division amidase using defined peptidoglycan substrates. J Am Chem Soc. 2009 Dec 30; 131(51):18230-1. PMID: 19957935.
    Citations: 13     Fields:    Translation:Cells
  30. Swoboda JG, Meredith TC, Campbell J, Brown S, Suzuki T, Bollenbach T, Malhowski AJ, Kishony R, Gilmore MS, Walker S. Discovery of a small molecule that blocks wall teichoic acid biosynthesis in Staphylococcus aureus. ACS Chem Biol. 2009 Oct 16; 4(10):875-83. PMID: 19689117.
    Citations: 60     Fields:    Translation:Cells
  31. Yuan Y, Fuse S, Ostash B, Sliz P, Kahne D, Walker S. Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design. ACS Chem Biol. 2008 Jul 18; 3(7):429-36. PMID: 18642800.
    Citations: 25     Fields:    Translation:Cells
  32. Meredith TC, Swoboda JG, Walker S. Late-stage polyribitol phosphate wall teichoic acid biosynthesis in Staphylococcus aureus. J Bacteriol. 2008 Apr; 190(8):3046-56. PMID: 18281399.
    Citations: 43     Fields:    Translation:Cells
  33. Brown S, Zhang YH, Walker S. A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps. Chem Biol. 2008 Jan; 15(1):12-21. PMID: 18215769.
    Citations: 53     Fields:    Translation:Cells
  34. Gross BJ, Swoboda JG, Walker S. A strategy to discover inhibitors of O-linked glycosylation. J Am Chem Soc. 2008 Jan 16; 130(2):440-1. PMID: 18092786.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  35. Perlstein DL, Zhang Y, Wang TS, Kahne DE, Walker S. The direction of glycan chain elongation by peptidoglycan glycosyltransferases. J Am Chem Soc. 2007 Oct 24; 129(42):12674-5. PMID: 17914829.
    Citations: 33     Fields:    Translation:Cells
  36. Barrett D, Wang TS, Yuan Y, Zhang Y, Kahne D, Walker S. Analysis of glycan polymers produced by peptidoglycan glycosyltransferases. J Biol Chem. 2007 Nov 02; 282(44):31964-71. PMID: 17704540.
    Citations: 43     Fields:    Translation:Cells
  37. Leimkuhler C, Fridman M, Lupoli T, Walker S, Walsh CT, Kahne D. Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A. J Am Chem Soc. 2007 Aug 29; 129(34):10546-50. PMID: 17685523.
    Citations: 6     Fields:    Translation:Cells
  38. Yuan Y, Barrett D, Zhang Y, Kahne D, Sliz P, Walker S. Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5348-53. PMID: 17360321.
    Citations: 52     Fields:    Translation:AnimalsCells
  39. Ostash B, Saghatelian A, Walker S. A streamlined metabolic pathway for the biosynthesis of moenomycin A. Chem Biol. 2007 Mar; 14(3):257-67. PMID: 17379141.
    Citations: 51     Fields:    Translation:Cells
  40. Zhang Y, Fechter EJ, Wang TS, Barrett D, Walker S, Kahne DE. Synthesis of heptaprenyl-lipid IV to analyze peptidoglycan glycosyltransferases. J Am Chem Soc. 2007 Mar 21; 129(11):3080-1. PMID: 17323951.
    Citations: 30     Fields:    Translation:Cells
  41. Zhang YH, Ginsberg C, Yuan Y, Walker S. Acceptor substrate selectivity and kinetic mechanism of Bacillus subtilis TagA. Biochemistry. 2006 Sep 12; 45(36):10895-904. PMID: 16953575.
    Citations: 16     Fields:    Translation:Cells
  42. Tiyanont K, Doan T, Lazarus MB, Fang X, Rudner DZ, Walker S. Imaging peptidoglycan biosynthesis in Bacillus subtilis with fluorescent antibiotics. Proc Natl Acad Sci U S A. 2006 Jul 18; 103(29):11033-8. PMID: 16832063.
    Citations: 112     Fields:    Translation:Cells
  43. Love KR, Swoboda JG, Noren CJ, Walker S. Enabling glycosyltransferase evolution: a facile substrate-attachment strategy for phage-display enzyme evolution. Chembiochem. 2006 May; 7(5):753-6. PMID: 16550625.
    Citations: 6     Fields:    Translation:Cells
  44. Fang X, Tiyanont K, Zhang Y, Wanner J, Boger D, Walker S. The mechanism of action of ramoplanin and enduracidin. Mol Biosyst. 2006 Jan; 2(1):69-76. PMID: 16880924.
    Citations: 33     Fields:    Translation:Cells
  45. Gross BJ, Kraybill BC, Walker S. Discovery of O-GlcNAc transferase inhibitors. J Am Chem Soc. 2005 Oct 26; 127(42):14588-9. PMID: 16231908.
    Citations: 104     Fields:    Translation:HumansCells
  46. Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S. In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides. J Am Chem Soc. 2005 Oct 19; 127(41):14128-9. PMID: 16218575.
    Citations: 19     Fields:    Translation:Cells
  47. Ostash B, Walker S. Bacterial transglycosylase inhibitors. Curr Opin Chem Biol. 2005 Oct; 9(5):459-66. PMID: 16118062.
    Citations: 31     Fields:    Translation:Cells
  48. Leimkuhler C, Chen L, Barrett D, Panzone G, Sun B, Falcone B, Oberthür M, Donadio S, Walker S, Kahne D. Differential inhibition of Staphylococcus aureus PBP2 by glycopeptide antibiotics. J Am Chem Soc. 2005 Mar 16; 127(10):3250-1. PMID: 15755121.
    Citations: 14     Fields:    Translation:Cells
  49. Barrett D, Leimkuhler C, Chen L, Walker D, Kahne D, Walker S. Kinetic characterization of the glycosyltransferase module of Staphylococcus aureus PBP2. J Bacteriol. 2005 Mar; 187(6):2215-7. PMID: 15743972.
    Citations: 21     Fields:    Translation:Cells
  50. Walker S, Chen L, Hu Y, Rew Y, Shin D, Boger DL. Chemistry and biology of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity. Chem Rev. 2005 Feb; 105(2):449-76. PMID: 15700952.
    Citations: 46     Fields:    Translation:Cells
  51. Lee HY, Chung HS, Hang C, Khosla C, Walsh CT, Kahne D, Walker S. Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway. J Am Chem Soc. 2004 Aug 18; 126(32):9924-5. PMID: 15303858.
    Citations: 5     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.