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Jeffrey Andrew Sparks, M.D.

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Biography
education and training
University of Arkansas, Fayetteville, ARBS2003Physics
University of Arkansas for Medical Sciences, Little Rock, ARMD2007Medicine
Barnes-Jewish Hospital, Washington University School of Medicine, St. Louis, MO2010Internal Medicine
Harvard Medical School, Boston, MAMMSc2014Patient-oriented research
Brigham and Women's Hospital, Boston, MA2014Rheumatology
awards and honors
2012
BWH Fellow Teaching Award
2013
ACR Distinguished Fellow Award
2014
RRF Scientist Development Award
2014 - 2021
NIH Loan Repayment Award
2016
BWH DOM Chair's Research Award
2017
BWH DOM Early Career Mentoring Award
2019
HMS Program Award for Culture of Excellence in Mentoring
2021
EULAR Clinical Abstract Award
2021
BWH DOM Chair's Research Award

Overview
overview
Our group has an overall focus on using patient-oriented and epidemiologic research studies to evaluate the etiology, outcomes, and public health burden of rheumatic diseases such as rheumatoid arthritis (RA). In particular, our research themes are: 1) RA risk and outcomes related to pulmonary disease, 2) outcomes of COVID-19 among patients with rheumatic diseases, and 3) rheumatic immune-related adverse events from immunotherapy for cancer treatment.

Mentoring
current student opportunities
Available: 04/05/22, Expires: 07/01/25

We are currently focusing on the interplay between lung inflammation/fibrosis and rheumatoid arthritis susceptibility and outcomes. We hypothesize that immune tolerance loss and RA-related autoantibody production occur at mucosal surfaces of the lung contributing to both RA risk and outcomes. Students may assist in investigating risk factors and outcomes of RA-associated interstitial lung diseases and bronchiectasis. Also, the team is testing the hypotheses using a variety of study designs, such as the Nurses' Health Studies, a large institutional RA registry, EMR data, pharmacy claims data, the Mass General Brigham Biobank, and clinical trials.


Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AR080659 (SPARKS, JEFFREY ANDREW) Feb 1, 2023 - Jan 31, 2028
    NIH
    Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic Diseases
    Role: Principal Investigator
  2. Llura Gund Award for Rheumatoid Arthritis Research (SPARKS, JEFFREY ANDREW) Aug 1, 2022 - Jul 31, 2024
    Brigham and Women's Hospital Division of Rheumatology, Inflammation, and Immunity
    Immunologic and Clinical Sequelae after COVID-19 in Patients with Rheumatoid Arthritis
    Role: Principal Investigator
  3. R01HL155522 (WASHKO, GEORGE; SPARKS, JEFFREY ANDREW) Apr 15, 2022 - Mar 31, 2027
    NIH
    Rheumatoid Arthritis-associated Parenchymal Lung Disease: Clinical and Molecular Phenotypes
    Role: Multi-Principal Investigator
  4. R01AR077607 (SPARKS, JEFFREY ANDREW) Sep 27, 2021 - Jun 30, 2026
    NIH
    Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung Disease
    Role: Principal Investigator
  5. P30AR070253 (NIGROVIC, PETER; SPARKS, JEFFREY ANDREW) Aug 1, 2021 - Jul 31, 2026
    NIH
    Joint Biology Consortium Resource-based Center
    Role: Multi-Principal Investigator

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Bibliographic
selected publications
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© 2025 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.