Jeffrey Andrew Sparks, M.D.
Title Associate Professor of Medicine Institution Brigham and Women's Hospital Address Brigham and Women's Hospital Rheumatology 45 Francis St Boston MA 02115
ORCID
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Biography
University of Arkansas, Fayetteville, AR | BS | 2003 | Physics |
University of Arkansas for Medical Sciences, Little Rock, AR | MD | 2007 | Medicine |
Washington University, St. Louis, MO | | 2010 | Internal Medicine |
Harvard Medical School, Boston, MA | MMSc | 2014 | Patient-oriented research |
Brigham and Women's Hospital, Boston, MA | | 2014 | Rheumatology |
2012
BWH Fellow Teaching Award
2013
ACR Distinguished Fellow Award
2014
RRF Scientist Development Award
2014 - 2021
NIH Loan Repayment Award
2016
BWH DOM Chair's Research Award
2017
BWH DOM Early Career Mentoring Award
2019
HMS Program Award for Culture of Excellence in Mentoring
2021
EULAR Clinical Abstract Award
2021
BWH DOM Chair's Research Award

Overview
Our group has an overall focus on using patient-oriented and epidemiologic research studies to evaluate the etiology, outcomes, and public health burden of rheumatic diseases such as rheumatoid arthritis (RA). In particular, we perform studies to evaluate the genetic, environmental, serologic, and familial risk factors for RA, clinical trials for RA prevention, RA outcomes research focusing on the respiratory burden of RA, evaluate the effect of metabolic factors such as weight loss on RA outcomes, and investigate rheumatic manifestations of osseous sarcoidosis. We use large population-based studies for these studies, including the Nurses’ Health Studies, the Studies for the Etiology of RA, the Partners electronic medical record, the Brigham RA Sequential Study, and pharmacy claims databases. We also perform clinical trials including the Personalized Risk Estimator for RA (PRE-RA) Family Study, the Strategy to Prevent the Onset of Clinically-Apparent RA (StopRA), and the Cardiovascular Inflammation Reduction Trial (CIRT).

Mentoring
Available: 04/05/22, Expires: 07/01/25
We are currently focusing on the interplay between lung inflammation/fibrosis and rheumatoid arthritis susceptibility and outcomes. We hypothesize that immune tolerance loss and RA-related autoantibody production occur at mucosal surfaces of the lung contributing to both RA risk and outcomes. Students may assist in investigating risk factors and outcomes of RA-associated interstitial lung diseases and bronchiectasis. Also, the team is testing the hypotheses using a variety of study designs, such as the Nurses' Health Studies, a large institutional RA registry, EMR data, pharmacy claims data, the Mass General Brigham Biobank, and clinical trials.

Research
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R01AR080659
(SPARKS, JEFFREY ANDREW; WALLACE, ZACHARY)
Feb 1, 2023 - Jan 31, 2028
Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic Diseases
Role: Multi-Principal Investigator
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Llura Gund Award for Rheumatoid Arthritis Research
(SPARKS, JEFFREY ANDREW)
Aug 1, 2022 - Jul 31, 2024
Brigham and Women's Hospital Division of Rheumatology, Inflammation, and Immunity
Immunologic and Clinical Sequelae after COVID-19 in Patients with Rheumatoid Arthritis
Role: Principal Investigator
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R01AR077607
(SPARKS, JEFFREY ANDREW)
Sep 27, 2021 - Jun 30, 2026
Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung Disease
Role: Principal Investigator
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P30AR070253
(NIGROVIC, PETER; KARLSON, ELIZABETH; SPARKS, JEFFREY ANDREW)
Aug 1, 2021 - Jul 31, 2026
Joint Biology Consortium Resource-based Center
Role: Multi-Principal Investigator
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R Bridge Award
(SPARKS, JEFFREY ANDREW)
Aug 10, 2020 - Aug 9, 2022
Rheumatology Research Foundation
Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung Disease
Role: Principal Investigator
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R03AR075886
(SPARKS, JEFFREY ANDREW)
Jul 3, 2019 - Jun 30, 2021
Respiratory Diseases, Genetics, and Rheumatoid Arthritis Risk
Role: Principal Investigator
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K Supplement Award
(SPARKS, JEFFREY ANDREW)
Sep 5, 2018 - Sep 4, 2020
Rheumatology Research Foundation
Rheumatoid Arthritis-Related Autoantibodies and Respiratory Function/Structure
Role: Principal Investigator
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K23AR069688
(SPARKS, JEFFREY ANDREW)
May 1, 2016 - Apr 30, 2021
Rheumatoid Arthritis and Respiratory Outcomes in Prospective Cohorts
Role: Principal Investigator
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Scientist Development Award
(SPARKS, JEFFREY ANDREW)
Jul 1, 2014 - Jun 30, 2017
Rheumatology Research Foundation
Methotrexate Use and Infection in Rheumatoid Arthritis
Role: Principal Investigator

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