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Jeffrey Andrew Sparks, M.D.

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Biography
University of Arkansas, Fayetteville, ARBS2003Physics
University of Arkansas for Medical Sciences, Little Rock, ARMD2007Medicine
Washington University, St. Louis, MO2010Internal Medicine
Harvard Medical School, Boston, MAMMSc2014Patient-oriented research
Brigham and Women's Hospital, Boston, MA2014Rheumatology
2012
BWH Fellow Teaching Award
2013
ACR Distinguished Fellow Award
2014
RRF Scientist Development Award
2014
NIH Loan Repayment Award
2016
NIH K23 Mentored Patient-Oriented Career Development Award
2016
BWH DOM Chair's Research Award
2017
BWH DOM Early Career Mentoring Award
2018
RRF K Supplement Award

Overview
Our group has an overall focus on using patient-oriented and epidemiologic research studies to evaluate the etiology, outcomes, and public health burden of rheumatic diseases such as rheumatoid arthritis (RA). In particular, we perform studies to evaluate the genetic, environmental, serologic, and familial risk factors for RA, clinical trials for RA prevention, RA outcomes research focusing on the respiratory burden of RA, evaluate the effect of metabolic factors such as weight loss on RA outcomes, and investigate rheumatic manifestations of osseous sarcoidosis. We use large population-based studies for these studies, including the Nurses’ Health Studies, the Studies for the Etiology of RA, the Partners electronic medical record, the Brigham RA Sequential Study, and pharmacy claims databases. We also perform clinical trials including the Personalized Risk Estimator for RA (PRE-RA) Family Study, the Strategy to Prevent the Onset of Clinically-Apparent RA (StopRA), and the Cardiovascular Inflammation Reduction Trial (CIRT).

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K Supplement Award (SPARKS, JEFFREY ANDREW) Sep 5, 2018 - Sep 4, 2020
    Rheumatology Research Foundation
    Rheumatoid Arthritis-Related Autoantibodies and Respiratory Function/Structure
    Role: Principal Investigator
  2. K23AR069688 (SPARKS, JEFFREY ANDREW) May 1, 2016 - Apr 30, 2021
    NIH/NIAMS
    Rheumatoid Arthritis and Respiratory Outcomes in Prospective Cohorts
    Role: Principal Investigator
  3. Scientist Development Award (SPARKS, JEFFREY ANDREW) Jul 1, 2014 - Jun 30, 2017
    Rheumatology Research Foundation
    Methotrexate Use and Infection in Rheumatoid Arthritis
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Prado MG, Iversen MD, Yu Z, Miller Kroouze R, Triedman NA, Kalia SS, Lu B, Green RC, Karlson EW, Sparks JA. Effectiveness of a Web-Based Personalized Rheumatoid Arthritis Risk Tool With or Without a Health Educator for Knowledge of Rheumatoid Arthritis Risk Factors. Arthritis Care Res (Hoboken). 2018 Oct; 70(10):1421-1430. PMID: 29316383.
    View in: PubMed
  2. Sparks JA, Barbhaiya M, Tedeschi SK, Leatherwood CL, Tabung FK, Speyer CB, Malspeis S, Costenbader KH, Karlson EW, Lu B. Inflammatory dietary pattern and risk of developing rheumatoid arthritis in women. Clin Rheumatol. 2018 Aug 14. PMID: 30109509.
    View in: PubMed
  3. Kimsey L, Weissman JS, Patel A, Drew A, Koehlmoos T, Sparks JA. Delay in initiation of DMARD or anti-inflammatory therapy in patients newly diagnosed with rheumatoid arthritis: An analysis of United States Military Health System TRICARE beneficiaries. Semin Arthritis Rheum. 2018 Jul 18. PMID: 30190154.
    View in: PubMed
  4. Miller ER, Fanta CH, McSparron JI, Pan B, Coblyn JS, Sparks JA. Musculoskeletal and pulmonary outcomes of sarcoidosis after initial presentation of osseous involvement. Sarcoidosis Vasc Diffuse Lung Dis. 2018.
  5. Ricciotti E, Castro C, Tang SY, Briggs WTE, West JA, Malik D, Rhoades SD, Meng H, Li X, Lahens NF, Sparks JA, Karlson EW, Weljie AM, Griffin JL, FitzGerald GA. Cyclooxygenase-2, Asymmetric Dimethylarginine and the Cardiovascular Hazard from NSAIDs. Circulation. 2018 Jun 21. PMID: 29930022.
    View in: PubMed
  6. Luo D, Wang P, Lu F, Elias J, Sparks JA, Lee YC. Mobile Apps for Individuals With Rheumatoid Arthritis: A Systematic Review. J Clin Rheumatol. 2018 Jun 21. PMID: 29933327.
    View in: PubMed
  7. Sparks JA, Lesperance T, Accortt NA, Solomon DH. Subsequent Cardiovascular Events Among Patients with Rheumatoid Arthritis, Psoriatic Arthritis, or Psoriasis: Patterns of Disease-Modifying Antirheumatic Drug Treatment. Arthritis Care Res (Hoboken). 2018 May 25. PMID: 29799667.
    View in: PubMed
  8. Hejblum BP, Cui J, Lahey LJ, Cagan A, Sparks JA, Sokolove J, Cai T, Liao KP. Association Between Anti-Citrullinated Fibrinogen Antibodies and Coronary Artery Disease in Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2018 Jul; 70(7):1113-1117. PMID: 28992379.
    View in: PubMed
  9. Sparks JA, Iversen MD, Yu Z, Triedman NA, Prado MG, Miller Kroouze R, Kalia SS, Atkinson ML, Mody EA, Helfgott SM, Todd DJ, Dellaripa PF, Bermas BL, Costenbader KH, Deane KD, Lu B, Green RC, Karlson EW. Disclosure of Personalized Rheumatoid Arthritis Risk Using Genetics, Biomarkers, and Lifestyle Factors to Motivate Health Behavior Improvements: A Randomized Controlled Trial. Arthritis Care Res (Hoboken). 2018 Jun; 70(6):823-833. PMID: 29024454.
    View in: PubMed
  10. Sparks JA, Karlson EW. Reply. Arthritis Rheumatol. 2018 Apr; 70(4):627-628. PMID: 29342505.
    View in: PubMed
  11. Ogdie A, Sparks JA, Angeles-Han ST, Bush K, Castelino FV, Golding A, Jiang Y, Kahlenberg JM, Kim AHJ, Lee YC, Machireddy K, Ombrello MJ, Shah AA, Wallace ZS, Nigrovic PA, Makris UE. Barriers and Facilitators of Mentoring for Trainees and Early Career Investigators in Rheumatology Research: Current State, Identification of Needs, and Road Map to an Inter-Institutional Adult Rheumatology Mentoring Program. Arthritis Care Res (Hoboken). 2018 Mar; 70(3):445-453. PMID: 28544766.
    View in: PubMed
  12. Sparks JA, Costenbader KH. Rheumatoid arthritis in 2017: Protective dietary and hormonal factors brought to light. Nat Rev Rheumatol. 2018 Feb; 14(2):71-72. PMID: 29323341.
    View in: PubMed
  13. Kreps DJ, Halperin F, Desai SP, Zhang ZZ, Losina E, Olson AT, Karlson EW, Bermas BL, Sparks JA. Association of weight loss with improved disease activity in patients with rheumatoid arthritis: A retrospective analysis using electronic medical record data. Int J Clin Rheumtol. 2018; 13(1):1-10. PMID: 29606976.
    View in: PubMed
  14. Sparks JA, Chang SC, Nguyen UDT, Barbhaiya M, Tedeschi SK, Lu B, Costenbader KH, Zhang Y, Choi HK, Karlson EW. Smoking Behavior Changes in the Early Rheumatoid Arthritis Period and Risk of Mortality During Thirty-Six Years of Prospective Followup. Arthritis Care Res (Hoboken). 2018 Jan; 70(1):19-29. PMID: 28464477.
    View in: PubMed
  15. Sparks JA, Chang SC, Nguyen US, Barbhaiya M, Tedeschi SK, Lu B, Kreps DJ, Costenbader KH, Zhang Y, Choi HK, Karlson EW. Weight Change During the Early Rheumatoid Arthritis Period and Risk of Subsequent Mortality in Women With Rheumatoid Arthritis and Matched Comparators. Arthritis Rheumatol. 2018 Jan; 70(1):18-29. PMID: 29193837.
    View in: PubMed
  16. Nguyen UDT, Zhang Y, Lu N, Louie-Gao Q, Niu J, Ogdie A, Gelfand JM, LaValley MP, Dubreuil M, Sparks JA, Karlson EW, Choi HK. Smoking paradox in the development of psoriatic arthritis among patients with psoriasis: a population-based study. Ann Rheum Dis. 2018 Jan; 77(1):119-123. PMID: 29102956.
    View in: PubMed
  17. Barbhaiya M, Tedeschi SK, Lu B, Malspeis S, Kreps D, Sparks JA, Karlson EW, Costenbader KH. Cigarette smoking and the risk of systemic lupus erythematosus, overall and by anti-double stranded DNA antibody subtype, in the Nurses' Health Study cohorts. Ann Rheum Dis. 2018 Feb; 77(2):196-202. PMID: 28988206.
    View in: PubMed
  18. Bengtsson C, Malspeis S, Orellana C, Sparks JA, Costenbader KH, Karlson EW. Association Between Menopausal Factors and the Risk of Seronegative and Seropositive Rheumatoid Arthritis: Results From the Nurses' Health Studies. Arthritis Care Res (Hoboken). 2017 11; 69(11):1676-1684. PMID: 28085997.
    View in: PubMed
  19. Sparks JA, Lin TC, Camargo CA, Barbhaiya M, Tedeschi SK, Costenbader KH, Raby BA, Choi HK, Karlson EW. Rheumatoid arthritis and risk of chronic obstructive pulmonary disease or asthma among women: A marginal structural model analysis in the Nurses' Health Study. Semin Arthritis Rheum. 2018 04; 47(5):639-648. PMID: 29037522.
    View in: PubMed
  20. Barbhaiya M, Dong Y, Sparks JA, Losina E, Costenbader KH, Katz JN. Administrative Algorithms to identify Avascular necrosis of bone among patients undergoing upper or lower extremity magnetic resonance imaging: a validation study. BMC Musculoskelet Disord. 2017 Jun 19; 18(1):268. PMID: 28629385.
    View in: PubMed
  21. Patel RV, Winter RW, Chan WW, Sparks JA. Isolated gastric sarcoidosis: a rare entity. BMJ Case Rep. 2017 Jun 08; 2017. PMID: 28596201.
    View in: PubMed
  22. Tedeschi SK, Barbhaiya M, Malspeis S, Lu B, Sparks JA, Karlson EW, Willett W, Costenbader KH. Obesity and the risk of systemic lupus erythematosus among women in the Nurses' Health Studies. Semin Arthritis Rheum. 2017 12; 47(3):376-383. PMID: 28688713.
    View in: PubMed
  23. Liao KP, Sparks JA, Hejblum BP, Kuo IH, Cui J, Lahey LJ, Cagan A, Gainer VS, Liu W, Cai TT, Sokolove J, Cai T. Phenome-Wide Association Study of Autoantibodies to Citrullinated and Noncitrullinated Epitopes in Rheumatoid Arthritis. Arthritis Rheumatol. 2017 04; 69(4):742-749. PMID: 27792870.
    View in: PubMed
  24. Barbhaiya M, Lu B, Sparks JA, Malspeis S, Chang SC, Karlson EW, Costenbader KH. Influence of Alcohol Consumption on the Risk of Systemic Lupus Erythematosus Among Women in the Nurses' Health Study Cohorts. Arthritis Care Res (Hoboken). 2017 03; 69(3):384-392. PMID: 27273851.
    View in: PubMed
  25. Sparks JA, Barbhaiya M, Karlson EW, Ritter SY, Raychaudhuri S, Corrigan CC, Lu F, Selhub J, Chasman DI, Paynter NP, Ridker PM, Solomon DH. Investigating methotrexate toxicity within a randomized double-blinded, placebo-controlled trial: Rationale and design of the Cardiovascular Inflammation Reduction Trial-Adverse Events (CIRT-AE) Study. Semin Arthritis Rheum. 2017 08; 47(1):133-142. PMID: 28284844.
    View in: PubMed
  26. Hu Y, Sparks JA, Malspeis S, Costenbader KH, Hu FB, Karlson EW, Lu B. Long-term dietary quality and risk of developing rheumatoid arthritis in women. Ann Rheum Dis. 2017 Aug; 76(8):1357-1364. PMID: 28137914.
    View in: PubMed
  27. Hu Y, Cui J, Sparks JA, Malspeis S, Costenbader KH, Karlson EW, Lu B. Circulating carotenoids and subsequent risk of rheumatoid arthritis in women. Clin Exp Rheumatol. 2017 Mar-Apr; 35(2):309-312. PMID: 28079511.
    View in: PubMed
  28. Chang HH, Liu GY, Dwivedi N, Sun B, Okamoto Y, Kinslow JD, Deane KD, Demoruelle MK, Norris JM, Thompson PR, Sparks JA, Rao DA, Karlson EW, Hung HC, Holers VM, Ho IC. A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22. JCI Insight. 2016 10 20; 1(17):e90045. PMID: 27777982.
    View in: PubMed
  29. Tedeschi SK, Cui J, Arkema EV, Robinson WH, Sokolove J, Lingampalli N, Sparks JA, Karlson EW, Costenbader KH. Elevated BMI and antibodies to citrullinated proteins interact to increase rheumatoid arthritis risk and shorten time to diagnosis: A nested case-control study of women in the Nurses' Health Studies. Semin Arthritis Rheum. 2017 06; 46(6):692-698. PMID: 27939764.
    View in: PubMed
  30. Sparks JA, Chang SC, Karlson EW. Reply. Arthritis Care Res (Hoboken). 2016 08; 68(8):1211-2. PMID: 26814444.
    View in: PubMed
  31. Sparks JA, Chang SC, Deane KD, Gan RW, Kristen Demoruelle M, Feser ML, Moss L, Buckner JH, Keating RM, Costenbader KH, Gregersen PK, Weisman MH, Mikuls TR, O'Dell JR, Michael Holers V, Norris JM, Karlson EW. Associations of Smoking and Age With Inflammatory Joint Signs Among Unaffected First-Degree Relatives of Rheumatoid Arthritis Patients: Results From Studies of the Etiology of Rheumatoid Arthritis. Arthritis Rheumatol. 2016 08; 68(8):1828-38. PMID: 26866831.
    View in: PubMed
  32. Sparks JA, Krumme AA, Shrank WH, Matlin OS, Brill G, Pezalla EJ, Choudhry NK, Solomon DH. Brief Report: Intensification to Triple Therapy After Treatment With Nonbiologic Disease-Modifying Antirheumatic Drugs for Rheumatoid Arthritis in the United States From 2009 to 2014. Arthritis Rheumatol. 2016 07; 68(7):1588-95. PMID: 26866506.
    View in: PubMed
  33. Sparks JA, Chang SC, Liao KP, Lu B, Fine AR, Solomon DH, Costenbader KH, Karlson EW. Rheumatoid Arthritis and Mortality Among Women During 36 Years of Prospective Follow-Up: Results From the Nurses' Health Study. Arthritis Care Res (Hoboken). 2016 06; 68(6):753-62. PMID: 26473946.
    View in: PubMed
  34. Sparks JA, Karlson EW. The Roles of Cigarette Smoking and the Lung in the Transitions Between Phases of Preclinical Rheumatoid Arthritis. Curr Rheumatol Rep. 2016 Mar; 18(3):15. PMID: 26951253; PMCID: PMC4941234 [Available on 03/01/17].
  35. Sparks JA, Halperin F, Karlson JC, Karlson EW, Bermas BL. Impact of Bariatric Surgery on Patients With Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2015 Dec; 67(12):1619-26. PMID: 26018243; PMCID: PMC4662646 [Available on 12/01/16].
  36. Wong JC, Sparks JA, Doyle TJ, Paulson VA, Milligan TA, Prasad S. Systemic sarcoidosis presenting as Harlequin and Horner syndrome. Neurol Clin Pract. 2015 Dec; 5(6):524-527. PMID: 26716065.
    View in: PubMed
  37. Kim K, Jiang X, Cui J, Lu B, Costenbader KH, Sparks JA, Bang SY, Lee HS, Okada Y, Raychaudhuri S, Alfredsson L, Bae SC, Klareskog L, Karlson EW. Interactions between amino acid-defined major histocompatibility complex class II variants and smoking in seropositive rheumatoid arthritis. Arthritis Rheumatol. 2015 Oct; 67(10):2611-23. PMID: 26098791; PMCID: PMC4581918 [Available on 10/01/16].
  38. Hu CH, Curry EJ, Matzkin EG, Todd DJ, Cai AN, Milner DA, Sparks JA. Monoarthritis in a 28-Year-Old Man With Juvenile Idiopathic Arthritis. Arthritis Care Res (Hoboken). 2015 Sep; 67(9):1328-34. PMID: 25832772.
    View in: PubMed
  39. Sparks JA, Chen CY, Hiraki LT, Malspeis S, Costenbader KH, Karlson EW. Contributions of familial rheumatoid arthritis or lupus and environmental factors to risk of rheumatoid arthritis in women: a prospective cohort study. Arthritis Care Res (Hoboken). 2014 Oct; 66(10):1438-46. PMID: 25103278; PMCID: PMC4177324.
  40. Sparks JA, Costenbader KH. Genetics, environment, and gene-environment interactions in the development of systemic rheumatic diseases. Rheum Dis Clin North Am. 2014 Nov; 40(4):637-57. PMID: 25437282; PMCID: PMC4250576.
  41. Sparks JA, Iversen MD, Miller Kroouze R, Mahmoud TG, Triedman NA, Kalia SS, Atkinson ML, Lu B, Deane KD, Costenbader KH, Green RC, Karlson EW. Personalized Risk Estimator for Rheumatoid Arthritis (PRE-RA) Family Study: rationale and design for a randomized controlled trial evaluating rheumatoid arthritis risk education to first-degree relatives. Contemp Clin Trials. 2014 Sep; 39(1):145-57. PMID: 25151341; PMCID: PMC4175164.
  42. Lu B, Hiraki LT, Sparks JA, Malspeis S, Chen CY, Awosogba JA, Arkema EV, Costenbader KH, Karlson EW. Being overweight or obese and risk of developing rheumatoid arthritis among women: a prospective cohort study. Ann Rheum Dis. 2014 Nov; 73(11):1914-22. PMID: 25057178; PMCID: PMC4207219.
  43. Hu Y, Costenbader KH, Gao X, Al-Daabil M, Sparks JA, Solomon DH, Hu FB, Karlson EW, Lu B. Sugar-sweetened soda consumption and risk of developing rheumatoid arthritis in women. Am J Clin Nutr. 2014 Sep; 100(3):959-67. PMID: 25030783; PMCID: PMC4135503.
  44. Sparks JA, McSparron JI, Shah N, Aliabadi P, Paulson V, Fanta CH, Coblyn JS. Osseous sarcoidosis: clinical characteristics, treatment, and outcomes--experience from a large, academic hospital. Semin Arthritis Rheum. 2014 Dec; 44(3):371-9. PMID: 25129260.
    View in: PubMed
  45. Sparks JA, Chen CY, Jiang X, Askling J, Hiraki LT, Malspeis S, Klareskog L, Alfredsson L, Costenbader KH, Karlson EW. Improved performance of epidemiologic and genetic risk models for rheumatoid arthritis serologic phenotypes using family history. Ann Rheum Dis. 2015 Aug; 74(8):1522-9. PMID: 24685909; PMCID: PMC4262726.
  46. Sparks JA, Brennan DC, Lawrence SJ. Smoking association with influenza infection in renal transplant recipients. Transpl Infect Dis. 2014 Feb; 16(1):153-7. PMID: 24215425; PMCID: PMC4147856.
  47. Lautenbach DM, Christensen KD, Sparks JA, Green RC. Communicating genetic risk information for common disorders in the era of genomic medicine. Annu Rev Genomics Hum Genet. 2013; 14:491-513. PMID: 24003856; PMCID: PMC3862080.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.