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Jeffrey Andrew Sparks, M.D.

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Biography
University of Arkansas, Fayetteville, ARBS2003Physics
University of Arkansas for Medical Sciences, Little Rock, ARMD2007Medicine
Washington University, St. Louis, MO2010Internal Medicine
Harvard Medical School, Boston, MAMMSc2014Patient-oriented research
Brigham and Women's Hospital, Boston, MA2014Rheumatology
2012
BWH Fellow Teaching Award
2013
ACR Distinguished Fellow Award
2014
RRF Scientist Development Award
2014
NIH Loan Repayment Award
2016
NIH K23 Mentored Patient-Oriented Career Development Award
2016
BWH DOM Chair's Research Award
2017
BWH DOM Early Career Mentoring Award
2018
RRF K Supplement Award
2020
RRF R Bridge Award

Overview
Our group has an overall focus on using patient-oriented and epidemiologic research studies to evaluate the etiology, outcomes, and public health burden of rheumatic diseases such as rheumatoid arthritis (RA). In particular, we perform studies to evaluate the genetic, environmental, serologic, and familial risk factors for RA, clinical trials for RA prevention, RA outcomes research focusing on the respiratory burden of RA, evaluate the effect of metabolic factors such as weight loss on RA outcomes, and investigate rheumatic manifestations of osseous sarcoidosis. We use large population-based studies for these studies, including the Nurses’ Health Studies, the Studies for the Etiology of RA, the Partners electronic medical record, the Brigham RA Sequential Study, and pharmacy claims databases. We also perform clinical trials including the Personalized Risk Estimator for RA (PRE-RA) Family Study, the Strategy to Prevent the Onset of Clinically-Apparent RA (StopRA), and the Cardiovascular Inflammation Reduction Trial (CIRT).

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R Bridge Award (SPARKS, JEFFREY ANDREW) Aug 10, 2020 - Aug 9, 2022
    Rheumatology Research Foundation
    Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung Disease
    Role: Principal Investigator
  2. R03AR075886 (SPARKS, JEFFREY ANDREW) Jul 3, 2019 - Jun 30, 2021
    NIH/NIAMS
    Respiratory Diseases, Genetics, and Rheumatoid Arthritis Risk
    Role: Principal Investigator
  3. K Supplement Award (SPARKS, JEFFREY ANDREW) Sep 5, 2018 - Sep 4, 2020
    Rheumatology Research Foundation
    Rheumatoid Arthritis-Related Autoantibodies and Respiratory Function/Structure
    Role: Principal Investigator
  4. K23AR069688 (SPARKS, JEFFREY ANDREW) May 1, 2016 - Apr 30, 2021
    NIH/NIAMS
    Rheumatoid Arthritis and Respiratory Outcomes in Prospective Cohorts
    Role: Principal Investigator
  5. Scientist Development Award (SPARKS, JEFFREY ANDREW) Jul 1, 2014 - Jun 30, 2017
    Rheumatology Research Foundation
    Methotrexate Use and Infection in Rheumatoid Arthritis
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Cui J, Raychaudhuri S, Karlson EW, Speyer C, Malspeis S, Guan H, Sparks JA, Ni H, Liu X, Stevens E, Williams JN, Davenport EE, Knevel R, Costenbader KH. Interactions Between Genome-Wide Genetic Factors and Smoking Influencing Risk of Systemic Lupus Erythematosus. Arthritis Rheumatol. 2020 Sep 23. PMID: 32969204.
    Citations:    
  2. Barbhaiya M, Tedeschi S, Sparks JA, Leatherwood C, Karlson EW, Willett WC, Lu B, Costenbader KH. Association of Dietary Quality with Risk of Incident Systemic Lupus Erythematosus in the Nurses' Health Studies. Arthritis Care Res (Hoboken). 2020 Sep 16. PMID: 32936999.
    Citations:    
  3. Sparks JA, Malspeis S, Hahn J, Wang J, Roberts AL, Kubzansky LD, Costenbader KH. Depression and subsequent risk for incident rheumatoid arthritis among women. Arthritis Care Res (Hoboken). 2020 Sep 16. PMID: 32937012.
    Citations:    
  4. Singh N, Baer RJ, Swaminathan M, Saurabh S, Sparks JA, Bandoli G, Flowers E, Jelliffe-Pawlowski LL, Ryckman KK. Pregnancy after bariatric surgery in women with rheumatic diseases and association with adverse birth outcomes. Surg Obes Relat Dis. 2020.
  5. Huang S, Doyle TJ, Hammer MM, Byrne SC, Huang W, Marshall AA, Iannaccone CK, Huang J, Feathers V, Weinblatt ME, Dellaripa PF, Shadick NA, Sparks JA. Rheumatoid arthritis-related lung disease detected on clinical chest computed tomography imaging: Prevalence, risk factors, and impact on mortality. Semin Arthritis Rheum. 2020.
  6. Huang S, Kronzer VL, Dellaripa PF, Deane KD, Bolster MB, Nagaraja V, Khanna D, Doyle TJ, Sparks JA. Rheumatoid arthritis-associated interstitial lung disease: Current update on prevalence, risk factors, and pharmacologic treatment. Curr Treatm Opt Rheumatol. 2020.
  7. Sattui SE, Liew JW, Graef ER, Coler-Reilly A, Berenbaum F, Duarte-García A, Harrison C, Konig MF, Korsten P, Putman MS, Robinson PC, Sirotich E, Ugarte-Gil MF, Webb K, Young KJ, Kim AHJ, Sparks JA. Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19. Expert Rev Clin Immunol. 2020 07; 16(7):659-666. PMID: 32620062.
    Citations:    
  8. Duarte-García A, Graef ER, Liew JW, Konig MF, Kim AH, Sparks JA. Response to: 'Correspondence on 'Festina lente: hydroxychloroquine, COVID-19and the role of the rheumatologist' by Graef et al' by Lo et al. Ann Rheum Dis. 2020 Aug 07. PMID: 32769149.
    Citations:    
  9. Ugarte-Gil MF, Konig MF, Korsten P, Berenbaum F, Kim AH, Sparks JA. Response to: 'Hydroxychloroquine ineffective for COVID-19 prophylaxis in lupus and rheumatoid arthritis' by Singer et al. Ann Rheum Dis. 2020 Aug 05. PMID: 32759257.
    Citations:    
  10. Sparks JA, Dellaripa PF, Glynn RJ, Paynter NP, Xu C, Ridker PM, Solomon DH. Pulmonary adverse events of low-dose methotrexate in the randomized double-blind placebo-controlled Cardiovascular Inflammation Reduction Trial. Arthritis Rheumatol. 2020 Aug 02. PMID: 32741143.
    Citations:    
  11. Putman M, Chock YPE, Tam H, Kim AHJ, Sattui SE, Berenbaum F, Danila MI, Korsten P, Sanchez-Alvarez C, Sparks JA, Coates LC, Palmerlee C, Peirce A, Jayatilleke A, Johnson SR, Kilian A, Liew J, Prokop LJ, Murad MH, Grainger R, Wallace ZS, Duarte-García A. Antirheumatic Disease Therapies for the Treatment of COVID-19: A Systematic Review and Meta-analysis. Arthritis Rheumatol. 2020 Aug 02. PMID: 32741139.
    Citations:    
  12. Scheetz MH, Konig MF, Robinson PC, Sparks JA, Kim AHJ. A Pharmacokinetics-Informed Approach to Navigating Hydroxychloroquine Shortages in Patients With Rheumatic Disease During the COVID-19 Pandemic. ACR Open Rheumatol. 2020 Jul 29. PMID: 32725866.
    Citations:    
  13. Kilian A, Chock YP, Huang IJ, Graef ER, Upton LA, Khilnani A, Krupnikova SDS, Almaghlouth I, Cappelli LC, Fernandez-Ruiz R, Frankel BA, Frankovich J, Harrison C, Kumar B, Monga K, Vega JAR, Singh N, Sparks JA, Sullo E, Young KJ, Duarte-Garcia A, Putman M, Johnson S, Grainger R, Wallace ZS, Liew JW, Jayatilleke A. Acute respiratory viral adverse events during use of antirheumatic disease therapies: A scoping review. Semin Arthritis Rheum. 2020 Jul 22; 50(5):1191-1201. PMID: 32931985.
    Citations:    
  14. Solomon DH, Sparks JA. Adverse Effects of Low-Dose Methotrexate. Ann Intern Med. 2020 Jul 21; 173(2):167. PMID: 32687751.
    Citations:    
  15. Marchand NE, Sparks JA, Tedeschi SK, Malspeis S, Costenbader KH, Karlson EW, Lu B. Abdominal Obesity in Comparison with General Obesity and Risk of Developing Rheumatoid Arthritis in Women. J Rheumatol. 2020 Jul 15. PMID: 32669445.
    Citations:    
  16. D'Silva KM, Serling-Boyd N, Wallwork R, Hsu TY, Sparks JA, Wallace ZS. Response to: 'COVID-19 in patients with rheumatic diseases: what is the real mortality risk?' by Marques et al. Ann Rheum Dis. 2020 Jul 13. PMID: 32660976.
    Citations:    
  17. Liew JW, Graef ER, Sparks JA, Kim AH. Response to: 'Emergency arising from patients' fear of taking antimalarials during these COVID-19 times: are antimalarials as unsafe for cardiovascular health as recent reports suggest?' by Santos-Moreno et al. Ann Rheum Dis. 2020 Jul 09. PMID: 32647030.
    Citations:    
  18. Hahn J, Leatherwood C, Malspeis S, Liu X, Lu B, Roberts AL, Sparks JA, Karlson EW, Feldman CH, Munroe ME, James JA, Kubzansky LD, Costenbader KH. Associations between Smoking and Systemic Lupus Erythematosus (SLE)-Related Cytokines and Chemokines among US Female Nurses. Arthritis Care Res (Hoboken). 2020 Jul 03. PMID: 32619290.
    Citations:    
  19. Yuan J, Zhang C, Sparks JA, Malspeis S, Tsoi KK, Kim JH, Fisher BA, Gao F, Sumerlin T, Liu Y, Liu Y, Pan Y, He Y, Sung JJY. Regular use of proton pump inhibitor and risk of rheumatoid arthritis in women: a prospective cohort study. Aliment Pharmacol Ther. 2020 08; 52(3):449-458. PMID: 32598046.
    Citations:    
  20. D'Silva KM, Serling-Boyd N, Wallwork R, Hsu T, Sparks JA, Wallace ZS. Response to: 'Incidence of severe COVID-19 in a Spanish cohort of 1037 patients with rheumatic diseases treated with biologics and JAK-inhibitors' by Jovani et al. Ann Rheum Dis. 2020 Jun 25. PMID: 32586919.
    Citations:    
  21. D'Silva KM, Serling-Boyd N, Wallwork R, Hsu T, Sparks JA, Wallace ZS. Response to: 'COVID-19 in patients with rheumatological diseases treated with Anti-TNF' by Brito et al and 'Clinical characteristics and outcomes of patients with COVID-19 and rheumatic disease in China 'hot spot' versus in US 'hot spot': similarities and differences' by Zhao et al. Ann Rheum Dis. 2020 Jun 16. PMID: 32546600.
    Citations:    
  22. Hahn J, Leatherwood C, Malspeis S, Liu X, Lu B, Roberts AL, Sparks JA, Karlson EW, Feldman CH, Munroe ME, James JA, Kubzansky LD, Costenbader KH. Associations between daily alcohol consumption and systemic lupus erythematosus-related cytokines and chemokines among US female nurses without SLE. Lupus. 2020 Jul; 29(8):976-982. PMID: 32507075.
    Citations:    
  23. Graef ER, Liew JW, Kim AH, Sparks JA. Response to: 'Case series of acute arthritis in COVID-19 admission' by López-González et al. Ann Rheum Dis. 2020 May 29. PMID: 32471896.
    Citations:    
  24. Gianfrancesco M, Hyrich KL, Al-Adely S, Carmona L, Danila MI, Gossec L, Izadi Z, Jacobsohn L, Katz P, Lawson-Tovey S, Mateus EF, Rush S, Schmajuk G, Simard J, Strangfeld A, Trupin L, Wysham KD, Bhana S, Costello W, Grainger R, Hausmann JS, Liew JW, Sirotich E, Sufka P, Wallace ZS, Yazdany J, Machado PM, Robinson PC. Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry. Ann Rheum Dis. 2020 07; 79(7):859-866. PMID: 32471903.
    Citations:    
  25. D'Silva KM, Serling-Boyd N, Wallwork R, Hsu T, Fu X, Gravallese EM, Choi HK, Sparks JA, Wallace ZS. Clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) and rheumatic disease: a comparative cohort study from a US 'hot spot'. Ann Rheum Dis. 2020 09; 79(9):1156-1162. PMID: 32457048.
    Citations:    
  26. Cho SK, Doyle TJ, Lee H, Jin Y, Tong AY, Ortiz AJS, Sparks JA, Kim SC. Validation of claims-based algorithms to identify interstitial lung disease in patients with rheumatoid arthritis. Semin Arthritis Rheum. 2020 Aug; 50(4):592-597. PMID: 32480097.
    Citations:    
  27. Graef ER, Liew JW, Kim AH, Sparks JA. Response to: 'Antimalarial use and arrhythmias in COVID-19 and rheumatic patients: a matter of dose and inflammation?' by Erre et al. Ann Rheum Dis. 2020 May 18. PMID: 32424027.
    Citations:    
  28. Prisco LC, Martin LW, Sparks JA. Inhalants other than personal cigarette smoking and risk for developing rheumatoid arthritis. Curr Opin Rheumatol. 2020 05; 32(3):279-288. PMID: 32141952.
    Citations:    
  29. Ingraham NE, Boulware D, Sparks MA, Schacker T, Benson B, Sparks JA, Murray T, Connett J, Chipman JG, Charles A, Tignanelli CJ. Shining a light on the evidence for hydroxychloroquine in SARS-CoV-2. Crit Care. 2020 04 28; 24(1):182. PMID: 32345336.
    Citations:    
  30. Chu SH, Cui J, Sparks JA, Lu B, Tedeschi SK, Speyer CB, Moss L, Feser ML, Kelmenson LB, Mewshaw EA, Edison JD, Deane KD, Clish C, Lasky-Su J, Karlson EW, Costenbader KH. Circulating plasma metabolites and risk of rheumatoid arthritis in the Nurses' Health Study. Rheumatology (Oxford). 2020 Apr 20. PMID: 32310291.
    Citations:    
  31. Graef ER, Liew JW, Putman MS, Simard JF, Sirotich E, Berenbaum F, Duarte-García A, Grainger R, Harrison C, Konig MF, Korsten P, Proulx L, Richards DP, Robinson PC, Sattui SE, Ugarte-Gil MF, Young KJ, Kim AH, Sparks JA. Festina lente: hydroxychloroquine, COVID-19 and the role of the rheumatologist. Ann Rheum Dis. 2020 06; 79(6):734-736. PMID: 32295786.
    Citations:    
  32. Centor RM, Kim AH, Sparks JA. Web Exclusive. Annals On Call - COVID-19: Is Chloroquine the Answer? Ann Intern Med. 2020 05 05; 172(9):OC1. PMID: 32271869.
    Citations:    
  33. Ford JA, Liu X, Chu SH, Lu B, Cho MH, Silverman EK, Costenbader KH, Camargo CA, Sparks JA. Asthma, Chronic Obstructive Pulmonary Disease, and Subsequent Risk for Incident Rheumatoid Arthritis Among Women: A Prospective Cohort Study. Arthritis Rheumatol. 2020 05; 72(5):704-713. PMID: 32129572.
    Citations:    
  34. Kronzer VL, Wang L, Liu H, Davis JM, Sparks JA, Crowson CS. Investigating the impact of disease and health record duration on the eMERGE algorithm for rheumatoid arthritis. J Am Med Inform Assoc. 2020 Apr 01; 27(4):601-605. PMID: 32134444.
    Citations:    
  35. Huang S, He X, Doyle TJ, Zaccardelli A, Marshall AA, Friedlander HM, Blaustein RB, Smith EA, Cui J, Iannaccone CK, Mahmoud TG, Weinblatt ME, Dellaripa PF, Shadick NA, Sparks JA. Correction to: Association of rheumatoid arthritis-related autoantibodies with pulmonary function test abnormalities in a rheumatoid arthritis registry. Clin Rheumatol. 2020 04; 39(4):1371-1372. PMID: 32020443.
    Citations:    
  36. Kim AHJ, Sparks JA, Liew JW, Putman MS, Berenbaum F, Duarte-García A, Graef ER, Korsten P, Sattui SE, Sirotich E, Ugarte-Gil MF, Webb K, Grainger R. A Rush to Judgment? Rapid Reporting and Dissemination of Results and Its Consequences Regarding the Use of Hydroxychloroquine for COVID-19. Ann Intern Med. 2020 06 16; 172(12):819-821. PMID: 32227189.
    Citations:    
  37. Mahler M, Martinez-Prat L, Sparks JA, Deane KD. Precision medicine in the care of rheumatoid arthritis: Focus on prediction and prevention of future clinically-apparent disease. Autoimmun Rev. 2020 May; 19(5):102506. PMID: 32173516.
    Citations:    
  38. Solomon DH, Glynn RJ, Karlson EW, Lu F, Corrigan C, Colls J, Xu C, MacFadyen J, Barbhaiya M, Berliner N, Dellaripa PF, Everett BM, Pradhan AD, Hammond SP, Murray M, Rao DA, Ritter SY, Rutherford A, Sparks JA, Stratton J, Suh DH, Tedeschi SK, Vanni KMM, Paynter NP, Ridker PM. Adverse Effects of Low-Dose Methotrexate: A Randomized Trial. Ann Intern Med. 2020 03 17; 172(6):369-380. PMID: 32066146.
    Citations:    
  39. Sparks JA. No association of bariatric surgery with reduced rheumatoid arthritis risk: where do we go from here? Rheumatology (Oxford). 2020 02 01; 59(2):275-276. PMID: 31687773.
    Citations:    
  40. Zaccardelli A, Liu X, Ford JA, Cui J, Lu B, Chu SH, Schur PH, Speyer CB, Costenbader KH, Robinson WH, Sokolove J, Karlson EW, Camargo CA, Sparks JA. Elevated anti-citrullinated protein antibodies prior to rheumatoid arthritis diagnosis and risks for chronic obstructive pulmonary disease or asthma. Arthritis Care Res (Hoboken). 2020 Jan 21. PMID: 31961487.
    Citations:    
  41. Friedlander HM, Ford JA, Zaccardelli A, Terrio AV, Cho MH, Sparks JA. Obstructive lung diseases and risk of rheumatoid arthritis. Expert Rev Clin Immunol. 2020 Jan; 16(1):37-50. PMID: 31774329.
    Citations:    
  42. Yoshida K, Lin TC, Wei M, Malspeis S, Chu SH, Camargo CA, Raby BA, Choi HK, Tedeschi SK, Barbhaiya M, Lu B, Costenbader KH, Karlson EW, Sparks JA. The roles of post-diagnosis accumulation of morbidities and lifestyle changes on excess total and cause-specific mortality risk in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2019 Dec 07. PMID: 31811708.
    Citations:    
  43. Ford JA, Liu X, Marshall AA, Zaccardelli A, Prado MG, Wiyarand C, Lu B, Karlson EW, Schur PH, Deane KD, Sparks JA. Impact of Cyclic Citrullinated Peptide Antibody Level on Progression to Rheumatoid Arthritis in Clinically Tested Cyclic Citrullinated Peptide Antibody-Positive Patients Without Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2019 12; 71(12):1583-1592. PMID: 30570827.
    Citations:    Fields:    
  44. Kronzer VL, Crowson CS, Sparks JA, Myasoedova E, Davis J. Family history of rheumatologic, autoimmune, and non-autoimmune diseases and risk of rheumatoid arthritis. Arthritis Care Res (Hoboken). 2019 Nov 30. PMID: 31785183.
    Citations:    
  45. Zaccardelli A, Liu X, Ford JA, Cui J, Lu B, Chu SH, Schur PH, Speyer CB, Costenbader KH, Robinson WH, Sokolove J, Karlson EW, Camargo CA, Sparks JA. Asthma and elevation of anti-citrullinated protein antibodies prior to the onset of rheumatoid arthritis. Arthritis Res Ther. 2019 11 21; 21(1):246. PMID: 31753003.
    Citations:    
  46. Kronzer VL, Crowson CS, Sparks JA, Myasoedova E, Davis JM. Comorbidities As Risk Factors for Rheumatoid Arthritis and Their Accrual After Diagnosis. Mayo Clin Proc. 2019 12; 94(12):2488-2498. PMID: 31759675.
    Citations:    
  47. Kang EH, Jin Y, Desai RJ, Liu J, Sparks JA, Kim SC. Risk of exacerbation of pulmonary comorbidities in patients with rheumatoid arthritis after initiation of abatacept versus TNF inhibitors: A cohort study. Semin Arthritis Rheum. 2020 06; 50(3):401-408. PMID: 31813561.
    Citations:    
  48. Tedeschi SK, Barbhaiya M, Sparks JA, Karlson EW, Kubzansky LD, Roberts AL, Willett WC, Lu B, Costenbader KH. Dietary patterns and risk of systemic lupus erythematosus in women. Lupus. 2020 Jan; 29(1):67-73. PMID: 31718449.
    Citations:    
  49. Huang S, He X, Doyle TJ, Zaccardelli A, Marshall AA, Friedlander HM, Blaustein RB, Smith EA, Cui J, Iannaccone CK, Mahmoud TG, Weinblatt ME, Dellaripa PF, Shadick NA, Sparks JA. Association of rheumatoid arthritis-related autoantibodies with pulmonary function test abnormalities in a rheumatoid arthritis registry. Clin Rheumatol. 2019 12; 38(12):3401-3412. PMID: 31410660.
    Citations:    
  50. Sparks JA, He X, Huang J, Fletcher EA, Zaccardelli A, Friedlander HM, Gill RR, Hatabu H, Nishino M, Murphy DJ, Iannaccone CK, Mahmoud TG, Frits ML, Lu B, Rosas IO, Dellaripa PF, Weinblatt ME, Karlson EW, Shadick NA, Doyle TJ. Rheumatoid Arthritis Disease Activity Predicting Incident Clinically Apparent Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Prospective Cohort Study. Arthritis Rheumatol. 2019 09; 71(9):1472-1482. PMID: 30951251.
    Citations:    
  51. Liu X, Tedeschi SK, Lu B, Zaccardelli A, Speyer CB, Costenbader KH, Karlson EW, Sparks JA. Long-Term Physical Activity and Subsequent Risk for Rheumatoid Arthritis Among Women: A Prospective Cohort Study. Arthritis Rheumatol. 2019 09; 71(9):1460-1471. PMID: 30920773.
    Citations:    
  52. Kronzer VL, Crowson CS, Sparks JA, Vassallo R, Davis JM. Investigating Asthma, Allergic Disease, Passive Smoke Exposure, and Risk of Rheumatoid Arthritis. Arthritis Rheumatol. 2019 08; 71(8):1217-1224. PMID: 30747496.
    Citations:    
  53. Liu X, Tedeschi SK, Barbhaiya M, Leatherwood CL, Speyer CB, Lu B, Costenbader KH, Karlson EW, Sparks JA. Impact and Timing of Smoking Cessation on Reducing Risk of Rheumatoid Arthritis Among Women in the Nurses' Health Studies. Arthritis Care Res (Hoboken). 2019 07; 71(7):914-924. PMID: 30790475.
    Citations:    
  54. Zaccardelli A, Friedlander HM, Ford JA, Sparks JA. Potential of Lifestyle Changes for Reducing the Risk of Developing Rheumatoid Arthritis: Is an Ounce of Prevention Worth a Pound of Cure? Clin Ther. 2019 07; 41(7):1323-1345. PMID: 31196646.
    Citations:    
  55. Xiang L, Teo EPS, Low AHL, Leung YY, Fong W, Xin X, Gandhi M, Kwan YH, Uy EJB, Sparks JA, Karlson EW, Thumboo J. Cross-cultural adaptation of the connective tissue disease screening questionnaire and development of a Chinese version in a multi-ethnic Asian population. Clin Rheumatol. 2019 Sep; 38(9):2383-2397. PMID: 31037459.
    Citations:    
  56. Chang HH, Ho CH, Tomita B, Silva AA, Sparks JA, Karlson EW, Rao DA, Lee YC, Ho IC. Utilizing a PTPN22 gene signature to predict response to targeted therapies in rheumatoid arthritis. J Autoimmun. 2019 07; 101:121-130. PMID: 31030958.
    Citations:    
  57. Sparks JA, Lesperance T, Accortt NA, Solomon DH. Subsequent Cardiovascular Events Among Patients With Rheumatoid Arthritis, Psoriatic Arthritis, or Psoriasis: Patterns of Disease-Modifying Antirheumatic Drug Treatment. Arthritis Care Res (Hoboken). 2019 04; 71(4):512-520. PMID: 29799667.
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  58. Luo D, Wang P, Lu F, Elias J, Sparks JA, Lee YC. Mobile Apps for Individuals With Rheumatoid Arthritis: A Systematic Review. J Clin Rheumatol. 2019 Apr; 25(3):133-141. PMID: 29933327.
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  59. Sparks JA, Doyle TJ, He X, Pan B, Iannaccone C, Frits ML, Dellaripa PF, Rosas IO, Lu B, Weinblatt ME, Shadick NA, Karlson EW. Incidence and predictors of dyspnea on exertion in a prospective cohort of patients with rheumatoid arthritis. ACR Open Rheumatol. 2019 Mar; 1(1):4-15. PMID: 30923795.
    Citations:    
  60. Miller ER, Fanta CH, McSparron JI, Pan B, Coblyn JS, Sparks JA. Musculoskeletal and pulmonary outcomes of sarcoidosis after initial presentation of osseous involvement. Sarcoidosis Vasc Diffuse Lung Dis. 2019; 36(1):60-73. PMID: 30918438.
    Citations:    
  61. Sparks JA, O'Reilly ÉJ, Barbhaiya M, Tedeschi SK, Malspeis S, Lu B, Willett WC, Costenbader KH, Karlson EW. Association of fish intake and smoking with risk of rheumatoid arthritis and age of onset: a prospective cohort study. BMC Musculoskelet Disord. 2019 Jan 05; 20(1):2. PMID: 30611246.
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  62. Sparks JA. Rheumatoid Arthritis. Ann Intern Med. 2019 01 01; 170(1):ITC1-ITC16. PMID: 30596879.
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  63. Marshall AA, Zaccardelli A, Yu Z, Prado MG, Liu X, Miller Kroouze R, Kalia SS, Green RC, Triedman NA, Lu B, Deane KD, Iversen MD, Karlson EW, Sparks JA. Effect of communicating personalized rheumatoid arthritis risk on concern for developing RA: A randomized controlled trial. Patient Educ Couns. 2019 05; 102(5):976-983. PMID: 30558852.
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  64. Al-Rousan T, Sparks JA, Pettinger M, Chlebowski R, Manson JE, Kauntiz AM, Wallace R. Menopausal hormone therapy and the incidence of carpal tunnel syndrome in postmenopausal women: Findings from the Women's Health Initiative. PLoS One. 2018; 13(12):e0207509. PMID: 30513095.
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  65. Ricciotti E, Castro C, Tang SY, Briggs WTE, West JA, Malik D, Rhoades SD, Meng H, Li X, Lahens NF, Sparks JA, Karlson EW, Weljie AM, Griffin JL, FitzGerald GA. Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs. Circulation. 2018 11 20; 138(21):2367-2378. PMID: 29930022.
    Citations:    
  66. Ridker PM, Everett BM, Pradhan A, MacFadyen JG, Solomon DH, Zaharris E, Mam V, Hasan A, Rosenberg Y, Iturriaga E, Gupta M, Tsigoulis M, Verma S, Clearfield M, Libby P, Goldhaber SZ, Seagle R, Ofori C, Saklayen M, Butman S, Singh N, Le May M, Bertrand O, Johnston J, Paynter NP, Glynn RJ. Low-Dose Methotrexate for the Prevention of Atherosclerotic Events. N Engl J Med. 2019 02 21; 380(8):752-762. PMID: 30415610.
    Citations:    Fields:    
  67. Prado MG, Iversen MD, Yu Z, Miller Kroouze R, Triedman NA, Kalia SS, Lu B, Green RC, Karlson EW, Sparks JA. Effectiveness of a Web-Based Personalized Rheumatoid Arthritis Risk Tool With or Without a Health Educator for Knowledge of Rheumatoid Arthritis Risk Factors. Arthritis Care Res (Hoboken). 2018 10; 70(10):1421-1430. PMID: 29316383.
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  68. Sparks JA, Barbhaiya M, Tedeschi SK, Leatherwood CL, Tabung FK, Speyer CB, Malspeis S, Costenbader KH, Karlson EW, Lu B. Inflammatory dietary pattern and risk of developing rheumatoid arthritis in women. Clin Rheumatol. 2019 Jan; 38(1):243-250. PMID: 30109509.
    Citations:    Fields:    
  69. Kimsey L, Weissman JS, Patel A, Drew A, Koehlmoos T, Sparks JA. Delay in initiation of DMARD or anti-inflammatory therapy in patients newly diagnosed with rheumatoid arthritis: An analysis of United States Military Health System TRICARE beneficiaries. Semin Arthritis Rheum. 2019 04; 48(5):821-827. PMID: 30190154.
    Citations:    Fields:    
  70. Hejblum BP, Cui J, Lahey LJ, Cagan A, Sparks JA, Sokolove J, Cai T, Liao KP. Association Between Anti-Citrullinated Fibrinogen Antibodies and Coronary Artery Disease in Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2018 07; 70(7):1113-1117. PMID: 28992379.
    Citations:    Fields:    
  71. Sparks JA, Iversen MD, Yu Z, Triedman NA, Prado MG, Miller Kroouze R, Kalia SS, Atkinson ML, Mody EA, Helfgott SM, Todd DJ, Dellaripa PF, Bermas BL, Costenbader KH, Deane KD, Lu B, Green RC, Karlson EW. Disclosure of Personalized Rheumatoid Arthritis Risk Using Genetics, Biomarkers, and Lifestyle Factors to Motivate Health Behavior Improvements: A Randomized Controlled Trial. Arthritis Care Res (Hoboken). 2018 06; 70(6):823-833. PMID: 29024454.
    Citations: 2     Fields:    
  72. Sparks JA, Karlson EW. Reply. Arthritis Rheumatol. 2018 04; 70(4):627-628. PMID: 29342505.
    Citations:    Fields:    
  73. Ogdie A, Sparks JA, Angeles-Han ST, Bush K, Castelino FV, Golding A, Jiang Y, Kahlenberg JM, Kim AHJ, Lee YC, Machireddy K, Ombrello MJ, Shah AA, Wallace ZS, Nigrovic PA, Makris UE. Barriers and Facilitators of Mentoring for Trainees and Early Career Investigators in Rheumatology Research: Current State, Identification of Needs, and Road Map to an Inter-Institutional Adult Rheumatology Mentoring Program. Arthritis Care Res (Hoboken). 2018 03; 70(3):445-453. PMID: 28544766.
    Citations:    Fields:    Translation:Humans
  74. Sparks JA, Costenbader KH. Rheumatoid arthritis in 2017: Protective dietary and hormonal factors brought to light. Nat Rev Rheumatol. 2018 02; 14(2):71-72. PMID: 29323341.
    Citations:    Fields:    
  75. Kreps DJ, Halperin F, Desai SP, Zhang ZZ, Losina E, Olson AT, Karlson EW, Bermas BL, Sparks JA. Association of weight loss with improved disease activity in patients with rheumatoid arthritis: A retrospective analysis using electronic medical record data. Int J Clin Rheumtol. 2018; 13(1):1-10. PMID: 29606976.
    Citations:    
  76. Sparks JA, Chang SC, Nguyen UDT, Barbhaiya M, Tedeschi SK, Lu B, Costenbader KH, Zhang Y, Choi HK, Karlson EW. Smoking Behavior Changes in the Early Rheumatoid Arthritis Period and Risk of Mortality During Thirty-Six Years of Prospective Followup. Arthritis Care Res (Hoboken). 2018 01; 70(1):19-29. PMID: 28464477.
    Citations: 1     Fields:    Translation:Humans
  77. Sparks JA, Chang SC, Nguyen US, Barbhaiya M, Tedeschi SK, Lu B, Kreps DJ, Costenbader KH, Zhang Y, Choi HK, Karlson EW. Weight Change During the Early Rheumatoid Arthritis Period and Risk of Subsequent Mortality in Women With Rheumatoid Arthritis and Matched Comparators. Arthritis Rheumatol. 2018 01; 70(1):18-29. PMID: 29193837.
    Citations: 1     Fields:    Translation:Humans
  78. Nguyen UDT, Zhang Y, Lu N, Louie-Gao Q, Niu J, Ogdie A, Gelfand JM, LaValley MP, Dubreuil M, Sparks JA, Karlson EW, Choi HK. Smoking paradox in the development of psoriatic arthritis among patients with psoriasis: a population-based study. Ann Rheum Dis. 2018 Jan; 77(1):119-123. PMID: 29102956.
    Citations:    Fields:    Translation:Humans
  79. Barbhaiya M, Tedeschi SK, Lu B, Malspeis S, Kreps D, Sparks JA, Karlson EW, Costenbader KH. Cigarette smoking and the risk of systemic lupus erythematosus, overall and by anti-double stranded DNA antibody subtype, in the Nurses' Health Study cohorts. Ann Rheum Dis. 2018 02; 77(2):196-202. PMID: 28988206.
    Citations: 2     Fields:    Translation:Humans
  80. Bengtsson C, Malspeis S, Orellana C, Sparks JA, Costenbader KH, Karlson EW. Association Between Menopausal Factors and the Risk of Seronegative and Seropositive Rheumatoid Arthritis: Results From the Nurses' Health Studies. Arthritis Care Res (Hoboken). 2017 11; 69(11):1676-1684. PMID: 28085997.
    Citations:    Fields:    Translation:Humans
  81. Sparks JA, Lin TC, Camargo CA, Barbhaiya M, Tedeschi SK, Costenbader KH, Raby BA, Choi HK, Karlson EW. Rheumatoid arthritis and risk of chronic obstructive pulmonary disease or asthma among women: A marginal structural model analysis in the Nurses' Health Study. Semin Arthritis Rheum. 2018 04; 47(5):639-648. PMID: 29037522.
    Citations: 2     Fields:    Translation:Humans
  82. Barbhaiya M, Dong Y, Sparks JA, Losina E, Costenbader KH, Katz JN. Administrative Algorithms to identify Avascular necrosis of bone among patients undergoing upper or lower extremity magnetic resonance imaging: a validation study. BMC Musculoskelet Disord. 2017 Jun 19; 18(1):268. PMID: 28629385.
    Citations:    Fields:    Translation:Humans
  83. Patel RV, Winter RW, Chan WW, Sparks JA. Isolated gastric sarcoidosis: a rare entity. BMJ Case Rep. 2017 Jun 08; 2017. PMID: 28596201.
    Citations:    Fields:    Translation:Humans
  84. Tedeschi SK, Barbhaiya M, Malspeis S, Lu B, Sparks JA, Karlson EW, Willett W, Costenbader KH. Obesity and the risk of systemic lupus erythematosus among women in the Nurses' Health Studies. Semin Arthritis Rheum. 2017 12; 47(3):376-383. PMID: 28688713.
    Citations: 1     Fields:    Translation:Humans
  85. Liao KP, Sparks JA, Hejblum BP, Kuo IH, Cui J, Lahey LJ, Cagan A, Gainer VS, Liu W, Cai TT, Sokolove J, Cai T. Phenome-Wide Association Study of Autoantibodies to Citrullinated and Noncitrullinated Epitopes in Rheumatoid Arthritis. Arthritis Rheumatol. 2017 04; 69(4):742-749. PMID: 27792870.
    Citations: 5     Fields:    Translation:Humans
  86. Barbhaiya M, Lu B, Sparks JA, Malspeis S, Chang SC, Karlson EW, Costenbader KH. Influence of Alcohol Consumption on the Risk of Systemic Lupus Erythematosus Among Women in the Nurses' Health Study Cohorts. Arthritis Care Res (Hoboken). 2017 03; 69(3):384-392. PMID: 27273851.
    Citations: 4     Fields:    Translation:Humans
  87. Sparks JA, Barbhaiya M, Karlson EW, Ritter SY, Raychaudhuri S, Corrigan CC, Lu F, Selhub J, Chasman DI, Paynter NP, Ridker PM, Solomon DH. Investigating methotrexate toxicity within a randomized double-blinded, placebo-controlled trial: Rationale and design of the Cardiovascular Inflammation Reduction Trial-Adverse Events (CIRT-AE) Study. Semin Arthritis Rheum. 2017 08; 47(1):133-142. PMID: 28284844.
    Citations: 3     Fields:    Translation:Humans
  88. Hu Y, Sparks JA, Malspeis S, Costenbader KH, Hu FB, Karlson EW, Lu B. Long-term dietary quality and risk of developing rheumatoid arthritis in women. Ann Rheum Dis. 2017 Aug; 76(8):1357-1364. PMID: 28137914.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  89. Hu Y, Cui J, Sparks JA, Malspeis S, Costenbader KH, Karlson EW, Lu B. Circulating carotenoids and subsequent risk of rheumatoid arthritis in women. Clin Exp Rheumatol. 2017 Mar-Apr; 35(2):309-312. PMID: 28079511.
    Citations: 2     Fields:    Translation:Humans
  90. Chang HH, Liu GY, Dwivedi N, Sun B, Okamoto Y, Kinslow JD, Deane KD, Demoruelle MK, Norris JM, Thompson PR, Sparks JA, Rao DA, Karlson EW, Hung HC, Holers VM, Ho IC. A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22. JCI Insight. 2016 Oct 20; 1(17):e90045. PMID: 27777982.
    Citations: 4     Fields:    Translation:HumansCells
  91. Tedeschi SK, Cui J, Arkema EV, Robinson WH, Sokolove J, Lingampalli N, Sparks JA, Karlson EW, Costenbader KH. Elevated BMI and antibodies to citrullinated proteins interact to increase rheumatoid arthritis risk and shorten time to diagnosis: A nested case-control study of women in the Nurses' Health Studies. Semin Arthritis Rheum. 2017 06; 46(6):692-698. PMID: 27939764.
    Citations: 2     Fields:    Translation:Humans
  92. Sparks JA, Chang SC, Karlson EW. Reply. Arthritis Care Res (Hoboken). 2016 08; 68(8):1211-2. PMID: 26814444.
    Citations: 1     Fields:    
  93. Sparks JA, Chang SC, Deane KD, Gan RW, Kristen Demoruelle M, Feser ML, Moss L, Buckner JH, Keating RM, Costenbader KH, Gregersen PK, Weisman MH, Mikuls TR, O'Dell JR, Michael Holers V, Norris JM, Karlson EW. Associations of Smoking and Age With Inflammatory Joint Signs Among Unaffected First-Degree Relatives of Rheumatoid Arthritis Patients: Results From Studies of the Etiology of Rheumatoid Arthritis. Arthritis Rheumatol. 2016 08; 68(8):1828-38. PMID: 26866831.
    Citations: 9     Fields:    Translation:Humans
  94. Sparks JA, Krumme AA, Shrank WH, Matlin OS, Brill G, Pezalla EJ, Choudhry NK, Solomon DH. Brief Report: Intensification to Triple Therapy After Treatment With Nonbiologic Disease-Modifying Antirheumatic Drugs for Rheumatoid Arthritis in the United States From 2009 to 2014. Arthritis Rheumatol. 2016 07; 68(7):1588-95. PMID: 26866506.
    Citations: 1     Fields:    Translation:Humans
  95. Sparks JA, Chang SC, Liao KP, Lu B, Fine AR, Solomon DH, Costenbader KH, Karlson EW. Rheumatoid Arthritis and Mortality Among Women During 36 Years of Prospective Follow-Up: Results From the Nurses' Health Study. Arthritis Care Res (Hoboken). 2016 06; 68(6):753-62. PMID: 26473946.
    Citations: 15     Fields:    Translation:Humans
  96. Sparks JA, Karlson EW. The Roles of Cigarette Smoking and the Lung in the Transitions Between Phases of Preclinical Rheumatoid Arthritis. Curr Rheumatol Rep. 2016 Mar; 18(3):15. PMID: 26951253.
    Citations: 6     Fields:    Translation:Humans
  97. Sparks JA, Halperin F, Karlson JC, Karlson EW, Bermas BL. Impact of Bariatric Surgery on Patients With Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2015 Dec; 67(12):1619-26. PMID: 26018243.
    Citations: 7     Fields:    Translation:Humans
  98. Wong JC, Sparks JA, Doyle TJ, Paulson VA, Milligan TA, Prasad S. Systemic sarcoidosis presenting as Harlequin and Horner syndrome. Neurol Clin Pract. 2015 Dec; 5(6):524-527. PMID: 26716065.
    Citations:    
  99. Kim K, Jiang X, Cui J, Lu B, Costenbader KH, Sparks JA, Bang SY, Lee HS, Okada Y, Raychaudhuri S, Alfredsson L, Bae SC, Klareskog L, Karlson EW. Interactions between amino acid-defined major histocompatibility complex class II variants and smoking in seropositive rheumatoid arthritis. Arthritis Rheumatol. 2015 Oct; 67(10):2611-23. PMID: 26098791.
    Citations: 17     Fields:    Translation:Humans
  100. Hu CH, Curry EJ, Matzkin EG, Todd DJ, Cai AN, Milner DA, Sparks JA. Monoarthritis in a 28-Year-Old Man With Juvenile Idiopathic Arthritis. Arthritis Care Res (Hoboken). 2015 Sep; 67(9):1328-1334. PMID: 25832772.
    Citations:    Fields:    Translation:HumansAnimals
  101. Sparks JA, Chen CY, Hiraki LT, Malspeis S, Costenbader KH, Karlson EW. Contributions of familial rheumatoid arthritis or lupus and environmental factors to risk of rheumatoid arthritis in women: a prospective cohort study. Arthritis Care Res (Hoboken). 2014 Oct; 66(10):1438-46. PMID: 25103278.
    Citations: 12     Fields:    Translation:Humans
  102. Sparks JA, Costenbader KH. Genetics, environment, and gene-environment interactions in the development of systemic rheumatic diseases. Rheum Dis Clin North Am. 2014 Nov; 40(4):637-57. PMID: 25437282.
    Citations: 16     Fields:    Translation:HumansPHPublic Health
  103. Sparks JA, Iversen MD, Miller Kroouze R, Mahmoud TG, Triedman NA, Kalia SS, Atkinson ML, Lu B, Deane KD, Costenbader KH, Green RC, Karlson EW. Personalized Risk Estimator for Rheumatoid Arthritis (PRE-RA) Family Study: rationale and design for a randomized controlled trial evaluating rheumatoid arthritis risk education to first-degree relatives. Contemp Clin Trials. 2014 Sep; 39(1):145-57. PMID: 25151341.
    Citations: 6     Fields:    Translation:Humans
  104. Lu B, Hiraki LT, Sparks JA, Malspeis S, Chen CY, Awosogba JA, Arkema EV, Costenbader KH, Karlson EW. Being overweight or obese and risk of developing rheumatoid arthritis among women: a prospective cohort study. Ann Rheum Dis. 2014 Nov; 73(11):1914-22. PMID: 25057178.
    Citations: 28     Fields:    Translation:Humans
  105. Hu Y, Costenbader KH, Gao X, Al-Daabil M, Sparks JA, Solomon DH, Hu FB, Karlson EW, Lu B. Sugar-sweetened soda consumption and risk of developing rheumatoid arthritis in women. Am J Clin Nutr. 2014 Sep; 100(3):959-67. PMID: 25030783.
    Citations: 13     Fields:    Translation:Humans
  106. Sparks JA, McSparron JI, Shah N, Aliabadi P, Paulson V, Fanta CH, Coblyn JS. Osseous sarcoidosis: clinical characteristics, treatment, and outcomes--experience from a large, academic hospital. Semin Arthritis Rheum. 2014 Dec; 44(3):371-9. PMID: 25129260.
    Citations: 6     Fields:    Translation:Humans
  107. Sparks JA, Chen CY, Jiang X, Askling J, Hiraki LT, Malspeis S, Klareskog L, Alfredsson L, Costenbader KH, Karlson EW. Improved performance of epidemiologic and genetic risk models for rheumatoid arthritis serologic phenotypes using family history. Ann Rheum Dis. 2015 Aug; 74(8):1522-9. PMID: 24685909.
    Citations: 11     Fields:    Translation:Humans
  108. Sparks JA, Brennan DC, Lawrence SJ. Smoking association with influenza infection in renal transplant recipients. Transpl Infect Dis. 2014 Feb; 16(1):153-7. PMID: 24215425.
    Citations: 1     Fields:    Translation:Humans
  109. Lautenbach DM, Christensen KD, Sparks JA, Green RC. Communicating genetic risk information for common disorders in the era of genomic medicine. Annu Rev Genomics Hum Genet. 2013; 14:491-513. PMID: 24003856.
    Citations: 33     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.